Metformin hydrochloride and sitagliptin phosphate is the common combination among diabetic drugs.Available dosage forms cannot avoid the dose dumping which leads to the complication such as lactic acidosis,gastrointes...Metformin hydrochloride and sitagliptin phosphate is the common combination among diabetic drugs.Available dosage forms cannot avoid the dose dumping which leads to the complication such as lactic acidosis,gastrointestinal complication,and severe hypoglycemia.Metformin hydrochloride has a very short half-life,i.e.4 hrs,and thus fails to give action for the long period.This leads to the increase number of dosings per day.Single-unit formulations contain the active ingredient within the single tablet or capsule,whereasmultiple-unit dosage forms comprise a number of discrete particles that are combined into one dosage unit.展开更多
Objective: To evaluate the effects of Oscimum sanctum L(O. sanctum), an important medicinal herb, on alcohol withdrawal syndrome in Wistar rats. Methods: Liquid diet with 7.2%, v/v ethanol was administered to the rats...Objective: To evaluate the effects of Oscimum sanctum L(O. sanctum), an important medicinal herb, on alcohol withdrawal syndrome in Wistar rats. Methods: Liquid diet with 7.2%, v/v ethanol was administered to the rats for 21 d. Control group animals received sucrose as an isocaloric liquid diet. After alcohol withdrawal, rats were examined at 6 th and 24 th hour for major withdrawal signs that included anxiety and hyper locomotor activity. Ethanol withdrawal anxiety was tested using elevated plus maze, light and dark model; the hyper locomotor activity using actophotometer. O. sanctum leaf extract(100, 200 and 300 mg/kg, oral) and diazepam(2 mg/kg, i.p) were administered to the treatment group animals 30 min before alcohol withdrawal estimation. Drug treatment was also given 30 min before the second observation at 24 th hour. On the last day of the protocol, rats were sacrificed by cervical dislocation liver, kidney and brain were isolated and preserved in formalin for further histopathological examination. Results: Findings from the present study revealed that O. Sanctum leaf extract treatment at doses 100, 200 and 300 mg/kg, oral had a significant protective effect on signs and symptoms of ethanol withdrawal in alcohol-dependent rats. However, no remarkable pathological and microscopic alterations were observed in histopathological examination. Conclusions: O. sanctum seems to be an active drug for the treatment of alcohol abstinence syndrome.展开更多
文摘Metformin hydrochloride and sitagliptin phosphate is the common combination among diabetic drugs.Available dosage forms cannot avoid the dose dumping which leads to the complication such as lactic acidosis,gastrointestinal complication,and severe hypoglycemia.Metformin hydrochloride has a very short half-life,i.e.4 hrs,and thus fails to give action for the long period.This leads to the increase number of dosings per day.Single-unit formulations contain the active ingredient within the single tablet or capsule,whereasmultiple-unit dosage forms comprise a number of discrete particles that are combined into one dosage unit.
基金supported by Science and Engineering Research Board(SERB)Department of Science and Technology,Government of India(SR/FT/LS–07/2012)
文摘Objective: To evaluate the effects of Oscimum sanctum L(O. sanctum), an important medicinal herb, on alcohol withdrawal syndrome in Wistar rats. Methods: Liquid diet with 7.2%, v/v ethanol was administered to the rats for 21 d. Control group animals received sucrose as an isocaloric liquid diet. After alcohol withdrawal, rats were examined at 6 th and 24 th hour for major withdrawal signs that included anxiety and hyper locomotor activity. Ethanol withdrawal anxiety was tested using elevated plus maze, light and dark model; the hyper locomotor activity using actophotometer. O. sanctum leaf extract(100, 200 and 300 mg/kg, oral) and diazepam(2 mg/kg, i.p) were administered to the treatment group animals 30 min before alcohol withdrawal estimation. Drug treatment was also given 30 min before the second observation at 24 th hour. On the last day of the protocol, rats were sacrificed by cervical dislocation liver, kidney and brain were isolated and preserved in formalin for further histopathological examination. Results: Findings from the present study revealed that O. Sanctum leaf extract treatment at doses 100, 200 and 300 mg/kg, oral had a significant protective effect on signs and symptoms of ethanol withdrawal in alcohol-dependent rats. However, no remarkable pathological and microscopic alterations were observed in histopathological examination. Conclusions: O. sanctum seems to be an active drug for the treatment of alcohol abstinence syndrome.
