The studypresents theHalfMax InsertionHeuristic (HMIH) as a novel approach to solving theTravelling SalesmanProblem (TSP). The goal is to outperform existing techniques such as the Farthest Insertion Heuristic (FIH) a...The studypresents theHalfMax InsertionHeuristic (HMIH) as a novel approach to solving theTravelling SalesmanProblem (TSP). The goal is to outperform existing techniques such as the Farthest Insertion Heuristic (FIH) andNearest Neighbour Heuristic (NNH). The paper discusses the limitations of current construction tour heuristics,focusing particularly on the significant margin of error in FIH. It then proposes HMIH as an alternative thatminimizes the increase in tour distance and includes more nodes. HMIH improves tour quality by starting withan initial tour consisting of a ‘minimum’ polygon and iteratively adding nodes using our novel Half Max routine.The paper thoroughly examines and compares HMIH with FIH and NNH via rigorous testing on standard TSPbenchmarks. The results indicate that HMIH consistently delivers superior performance, particularly with respectto tour cost and computational efficiency. HMIH’s tours were sometimes 16% shorter than those generated by FIHand NNH, showcasing its potential and value as a novel benchmark for TSP solutions. The study used statisticalmethods, including Friedman’s Non-parametric Test, to validate the performance of HMIH over FIH and NNH.This guarantees that the identified advantages are statistically significant and consistent in various situations. Thiscomprehensive analysis emphasizes the reliability and efficiency of the heuristic, making a compelling case for itsuse in solving TSP issues. The research shows that, in general, HMIH fared better than FIH in all cases studied,except for a few instances (pr439, eil51, and eil101) where FIH either performed equally or slightly better thanHMIH. HMIH’s efficiency is shown by its improvements in error percentage (δ) and goodness values (g) comparedto FIH and NNH. In the att48 instance, HMIH had an error rate of 6.3%, whereas FIH had 14.6% and NNH had20.9%, indicating that HMIH was closer to the optimal solution. HMIH consistently showed superior performanceacross many benchmarks, with lower percentage error and highe展开更多
Male infertility has become a problem worldwide,and recent research has emphasized the development of more effective therapy options.Among natural compounds,rutin has been widely studied for its potential to treat dys...Male infertility has become a problem worldwide,and recent research has emphasized the development of more effective therapy options.Among natural compounds,rutin has been widely studied for its potential to treat dysfunction related to male infertility,including a reduction in sperm quality,spermatogenesis disruption and structural disruption in the testis.A thorough review of scientific literature published in several databases,including Google Scholar,PubMed/MEDLINE and Scopus,was used to synthesize the present state of research on the role of rutin in male reproductive health.Rutin has been shown to possess antiapoptotic,antioxidant and anti-inflammatory activities,among others,which are crucial in the management of male infertility.Numerous investigations have shown that rutin protects against male infertility and have explored the underlying mechanisms involved.The present review,therefore,assesses the therapeutic mechanisms involved in male infertility treatment using rutin.Rutin was able to mitigate the induced oxidative stress,apoptosis,inflammation,and related physiological processes that can cause testicular dysfunction.展开更多
The testis is an immune-privileged organ susceptible to oxidative stress and inflammation,two major factors implicated in male infertility.A reduction in the concentration and activities of testicular function biomark...The testis is an immune-privileged organ susceptible to oxidative stress and inflammation,two major factors implicated in male infertility.A reduction in the concentration and activities of testicular function biomarkers has been shown to correlate with impaired hypothalamic-pituitary-testicular axis and oxidative stress.However,the use of natural products to ameliorate these oxidative stress-induced changes may be essential to improving male reproductive function.Quercetin possesses several pharmacological activities that may help to combat cellular reproduction-related assaults,such as altered sperm function and reproductive hormone dysfunction,and dysregulated testicular apoptosis,oxidative stress,and inflammation.Studies have shown that quercetin ameliorates testicular toxicity,largely by inhibiting the generation of reactive oxygen species,with the aid of the two antioxidant pharmacophores present in its ring structure.The radical-scavenging property of quercetin may alter signal transduction of oxidative stress-induced apoptosis,prevent inflammation,and increase sperm quality in relation to the hormonal concentration.In this review,the therapeutic potential of quercetin in mediating male reproductive health is discussed.展开更多
Objective:To assess the potential of plantain-based diet in modulating testicular toxicities in rats exposed to atrazine.Methods:The plantain-based diet at 50%,25% and 12.5% were prepared from the basal diet by substi...Objective:To assess the potential of plantain-based diet in modulating testicular toxicities in rats exposed to atrazine.Methods:The plantain-based diet at 50%,25% and 12.5% were prepared from the basal diet by substituting the corn starch with plantain fruit pulp flour at different percentages.Wistar rats were fed plantain-based diet in varying concentrations ranging from 12.5% to 50% of the basal diet for 21 days before or after atrazine treatment in a two-phase experiment:preventive and therapeutic phases.The therapeutic model(n=35)had seven groups with 5 rats each,including the control,atrazine,atrazine recovery,atrazine plus plantain-based diet 50%,25%,12.5%,and atrazine plus quercetin groups.The preventive model(n=30)had six groups of 5 rats,consisting of the control,atrazine,50%,25%,12.5% plantain-based diet plus atrazine,and quercetin plus atrazine groups.Gonadal hormones(testosterone,luteinizing hormone and follicle-stimulating hormone),sperm parameters(sperm motility,viability,morphology and concentration),and testicular function indices(protein,cholesterol,glycogen,acid phosphatase,alkaline phosphatase and lactate dehydrogenase)were measured.Results:The gonadal hormones,sperm characteristics,and testicular function indices of the rat testis decreased significantly in the atrazine group alongside degeneration of the histoarchitecture.However,plantain-based diet restored the gonadal hormone concentrations,semen parameters,and testicular function indices in both the preventive and therapeutic models.Conclusions:Treatment with plantain-based diet protects against rat testicular toxicity caused by atrazine via the modulation of gonadal hormones,sperm quality,testicular function index as well as histoarchitecture of rat testes.展开更多
A hydrogen production and conversion plant from wind power was installed in the Sotavento wind farm by Gas Natural and the Galician Government. This facility is the highest electrolysis power installed at the European...A hydrogen production and conversion plant from wind power was installed in the Sotavento wind farm by Gas Natural and the Galician Government. This facility is the highest electrolysis power installed at the European level. It consists of an electrolyser of 300 kW, a piston compressor, a 1,725 Nm3 H2 storage system and an engine of 55 kW. This pilot plant is being operated by Natural Gas in order to extrapolate its behavior to that of an industrial facility capable of managing all the production of Sotavento wind farm following different strategies： balancing, peak-shaving and repowering. In this paper, preliminary results at the facility are presented. The aim of these first tests has been to describe the operation of equipment under operating conditions required in the management of wind power production, in order to understand the behavior of the different equipment and try to make them suitable for this type of applications. This paper shows the difficulty of operating these systems under the wind power requirements.展开更多
基金the Centre of Excellence in Mobile and e-Services,the University of Zululand,Kwadlangezwa,South Africa.
文摘The studypresents theHalfMax InsertionHeuristic (HMIH) as a novel approach to solving theTravelling SalesmanProblem (TSP). The goal is to outperform existing techniques such as the Farthest Insertion Heuristic (FIH) andNearest Neighbour Heuristic (NNH). The paper discusses the limitations of current construction tour heuristics,focusing particularly on the significant margin of error in FIH. It then proposes HMIH as an alternative thatminimizes the increase in tour distance and includes more nodes. HMIH improves tour quality by starting withan initial tour consisting of a ‘minimum’ polygon and iteratively adding nodes using our novel Half Max routine.The paper thoroughly examines and compares HMIH with FIH and NNH via rigorous testing on standard TSPbenchmarks. The results indicate that HMIH consistently delivers superior performance, particularly with respectto tour cost and computational efficiency. HMIH’s tours were sometimes 16% shorter than those generated by FIHand NNH, showcasing its potential and value as a novel benchmark for TSP solutions. The study used statisticalmethods, including Friedman’s Non-parametric Test, to validate the performance of HMIH over FIH and NNH.This guarantees that the identified advantages are statistically significant and consistent in various situations. Thiscomprehensive analysis emphasizes the reliability and efficiency of the heuristic, making a compelling case for itsuse in solving TSP issues. The research shows that, in general, HMIH fared better than FIH in all cases studied,except for a few instances (pr439, eil51, and eil101) where FIH either performed equally or slightly better thanHMIH. HMIH’s efficiency is shown by its improvements in error percentage (δ) and goodness values (g) comparedto FIH and NNH. In the att48 instance, HMIH had an error rate of 6.3%, whereas FIH had 14.6% and NNH had20.9%, indicating that HMIH was closer to the optimal solution. HMIH consistently showed superior performanceacross many benchmarks, with lower percentage error and highe
文摘Male infertility has become a problem worldwide,and recent research has emphasized the development of more effective therapy options.Among natural compounds,rutin has been widely studied for its potential to treat dysfunction related to male infertility,including a reduction in sperm quality,spermatogenesis disruption and structural disruption in the testis.A thorough review of scientific literature published in several databases,including Google Scholar,PubMed/MEDLINE and Scopus,was used to synthesize the present state of research on the role of rutin in male reproductive health.Rutin has been shown to possess antiapoptotic,antioxidant and anti-inflammatory activities,among others,which are crucial in the management of male infertility.Numerous investigations have shown that rutin protects against male infertility and have explored the underlying mechanisms involved.The present review,therefore,assesses the therapeutic mechanisms involved in male infertility treatment using rutin.Rutin was able to mitigate the induced oxidative stress,apoptosis,inflammation,and related physiological processes that can cause testicular dysfunction.
文摘The testis is an immune-privileged organ susceptible to oxidative stress and inflammation,two major factors implicated in male infertility.A reduction in the concentration and activities of testicular function biomarkers has been shown to correlate with impaired hypothalamic-pituitary-testicular axis and oxidative stress.However,the use of natural products to ameliorate these oxidative stress-induced changes may be essential to improving male reproductive function.Quercetin possesses several pharmacological activities that may help to combat cellular reproduction-related assaults,such as altered sperm function and reproductive hormone dysfunction,and dysregulated testicular apoptosis,oxidative stress,and inflammation.Studies have shown that quercetin ameliorates testicular toxicity,largely by inhibiting the generation of reactive oxygen species,with the aid of the two antioxidant pharmacophores present in its ring structure.The radical-scavenging property of quercetin may alter signal transduction of oxidative stress-induced apoptosis,prevent inflammation,and increase sperm quality in relation to the hormonal concentration.In this review,the therapeutic potential of quercetin in mediating male reproductive health is discussed.
文摘Objective:To assess the potential of plantain-based diet in modulating testicular toxicities in rats exposed to atrazine.Methods:The plantain-based diet at 50%,25% and 12.5% were prepared from the basal diet by substituting the corn starch with plantain fruit pulp flour at different percentages.Wistar rats were fed plantain-based diet in varying concentrations ranging from 12.5% to 50% of the basal diet for 21 days before or after atrazine treatment in a two-phase experiment:preventive and therapeutic phases.The therapeutic model(n=35)had seven groups with 5 rats each,including the control,atrazine,atrazine recovery,atrazine plus plantain-based diet 50%,25%,12.5%,and atrazine plus quercetin groups.The preventive model(n=30)had six groups of 5 rats,consisting of the control,atrazine,50%,25%,12.5% plantain-based diet plus atrazine,and quercetin plus atrazine groups.Gonadal hormones(testosterone,luteinizing hormone and follicle-stimulating hormone),sperm parameters(sperm motility,viability,morphology and concentration),and testicular function indices(protein,cholesterol,glycogen,acid phosphatase,alkaline phosphatase and lactate dehydrogenase)were measured.Results:The gonadal hormones,sperm characteristics,and testicular function indices of the rat testis decreased significantly in the atrazine group alongside degeneration of the histoarchitecture.However,plantain-based diet restored the gonadal hormone concentrations,semen parameters,and testicular function indices in both the preventive and therapeutic models.Conclusions:Treatment with plantain-based diet protects against rat testicular toxicity caused by atrazine via the modulation of gonadal hormones,sperm quality,testicular function index as well as histoarchitecture of rat testes.
文摘A hydrogen production and conversion plant from wind power was installed in the Sotavento wind farm by Gas Natural and the Galician Government. This facility is the highest electrolysis power installed at the European level. It consists of an electrolyser of 300 kW, a piston compressor, a 1,725 Nm3 H2 storage system and an engine of 55 kW. This pilot plant is being operated by Natural Gas in order to extrapolate its behavior to that of an industrial facility capable of managing all the production of Sotavento wind farm following different strategies： balancing, peak-shaving and repowering. In this paper, preliminary results at the facility are presented. The aim of these first tests has been to describe the operation of equipment under operating conditions required in the management of wind power production, in order to understand the behavior of the different equipment and try to make them suitable for this type of applications. This paper shows the difficulty of operating these systems under the wind power requirements.
