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新形势·新策略--中药新药及健康产品研发与国际化发展 被引量:16
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作者 蒋宁 齐春会 +21 位作者 曹亮 陈兰英 顾金辉 康永 Inkyeom KIM 连晓媛 陆茵 吕圭源 聂克 齐云 Valérie SCHINI-KERTH Michael SPEDDING Cherry WAINWRIGHT 王月华 肖伟 杨勇 余林中 张丹参 张永鹤 周文霞 杜冠华 张永祥 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2018年第1期1-50,共50页
"2017中国(连云港)国际医药技术大会"于2017年11月15-17日在江苏省连云港市召开。会议期间,中国药理学会中药与天然药物药理专业委员会与江苏康缘药业股份有限公司共同举办了"中药新药及健康产品研发与国际化发展论坛&qu... "2017中国(连云港)国际医药技术大会"于2017年11月15-17日在江苏省连云港市召开。会议期间,中国药理学会中药与天然药物药理专业委员会与江苏康缘药业股份有限公司共同举办了"中药新药及健康产品研发与国际化发展论坛"。中国药理学会理事长兼中药与天然药物药理专业委员会主任委员、国际药理学联合会(IUPHAR)天然药物药理分会主席张永祥教授,中国药理学会前任理事长兼中药与天然药物药理专业委员会副主任委员杜冠华教授和江苏康缘药业股份有限公司董事长、中药与天然药物药理专业委员会副主任委员肖伟担任论坛共同主席。IUPHAR秘书长Michael SPEDDING教授、IUPHAR天然药物药理分会副主席Valérie SCHINI-KERTH教授、英国Robert Gordon大学天然产物研究中心主任Cherry WAINWRIGHT教授和韩国药理学会理事长金仁谦教授等外籍专家、中国药理学会中药与天然药物药理专业委员会委员以及江苏康缘药业股份有限公司主研人员70余人参加了本次论坛。国家卫生和计划生育委员会科技教育司重大专项处顾金辉处长应邀参会。论坛针对中药新药与健康产品研发与国际化发展等有关问题进行了综合讨论。为促进国内外学术交流,本文对部分专家的观点和意见进行了整理,以期为提高我国中药新药与健康产品研发水平及国际化发展起到积极的推动作用。 展开更多
关键词 中药 新药 健康产品 国际化
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A review of CO2 storage in geological formations emphasizing modeling,monitoring and capacity estimation approaches 被引量:11
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作者 Temitope Ajayi Jorge Salgado Gomes Achinta Bera 《Petroleum Science》 SCIE CAS CSCD 2019年第5期1028-1063,共36页
The merits of CO2 capture and storage to the environmental stability of our world should not be underestimated as emissions of greenhouse gases cause serious problems.It represents the only technology that might rid o... The merits of CO2 capture and storage to the environmental stability of our world should not be underestimated as emissions of greenhouse gases cause serious problems.It represents the only technology that might rid our atmosphere of the main anthropogenic gas while allowing for the continuous use of the fossil fuels which still power today’s world.Underground storage of CO2 involves the injection of CO2 into suitable geological formations and the monitoring of the injected plume over time,to ensure containment.Over the last two or three decades,attention has been paid to technology developments of carbon capture and sequestration.Therefore,it is high time to look at the research done so far.In this regard,a high-level review article is required to provide an overview of the status of carbon capture and sequestration research.This article presents a review of CO2 storage technologies which includes a background of essential concepts in storage,the physical processes involved,modeling procedures and simulators used,capacity estimation,measuring monitoring and verification techniques,risks and challenges involved and field-/pilot-scale projects.It is expected that the present review paper will help the researchers to gain a quick knowledge of CO2 sequestration for future research in this field. 展开更多
关键词 CO2 storage Geological formation Modeling for CO2 storage Mechanism of CO2 storage CO2 storage projects
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Lentinan administration alleviates diarrhea of rotavirus-infected weaned pigs via regulating intestinal immunity 被引量:11
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作者 Xiangqi Fan Haiyan Hu +9 位作者 Daiwen Chen Bing Yu Jun He Jie Yu Junqiu Luo Erik Eckhardt Yuheng Luo Jianping Wang Hui Yan Xiangbing Mao 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2021年第3期1125-1137,共13页
Background:Lentinan(LNT)may regulate many important physiological functions of human and animals.This study aimed to verify whether LNT administration could relieve diarrhea via improving gut immunity in rotavirus(RV)... Background:Lentinan(LNT)may regulate many important physiological functions of human and animals.This study aimed to verify whether LNT administration could relieve diarrhea via improving gut immunity in rotavirus(RV)-challenged weaned pigs.Methods:Twenty-eight weaned pigs were randomly fed 2 diets containing 0 or 84 mg/kg LNT product for 19 d(n=14).RV infection was executed on d 15.After extracting polysaccharides from LNT product,its major monosaccharides were analyzed.Then,LNT polysaccharide was used to administrate RV-infected IPEC-J2 cells.Results:Dietary LNT supplementation supported normal function of piglets even when infected with RV,as reflected by reduced growth performance loss and diarrhea prevalence,and maintained gut immunity(P<0.05).The polysaccharide was isolated from LNT product,which molecular weight was 5303 Da,and major monosaccharides included glucose,arabinose and galactose.In RV-infected IPEC-J2 cells,this polysaccharide significantly increased cell viability(P<0.05),and significantly increased anti-virus immunity via regulating pattern recognition receptors and host defense peptides(P<0.05).Conclusion:Those results suggest that LNT administration increases the piglets’resistance to RV-induced stress,likely by supporting intestinal immunity. 展开更多
关键词 Gut immunity IPEC-J2 cells LENTINAN ROTAVIRUS Weaned pigs
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Estimates of Maize Plant Density from UAV RGB Images Using Faster-RCNN Detection Model:Impact of the Spatial Resolution 被引量:9
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作者 K.Velumani R.Lopez-Lozano +4 位作者 S.Madec W.Guo J.Gillet A.Comar F.Baret 《Plant Phenomics》 SCIE 2021年第1期181-196,共16页
Early-stage plant density is an essential trait that determines the fate of a genotype under given environmental conditions and management practices.The use of RGB images taken from UAVs may replace the traditional vi... Early-stage plant density is an essential trait that determines the fate of a genotype under given environmental conditions and management practices.The use of RGB images taken from UAVs may replace the traditional visual counting in fields with improved throughput,accuracy,and access to plant localization.However,high-resolution images are required to detect the small plants present at the early stages.This study explores the impact of image ground sampling distance(GSD)on the performances of maize plant detection at three-to-five leaves stage using Faster-RCNN object detection algorithm.Data collected at high resolution(GSD≈0:3 cm)over six contrasted sites were used for model training.Two additional sites with images acquired both at high and low(GSD≈0:6 cm)resolutions were used to evaluate the model performances.Results show that Faster-RCNN achieved very good plant detection and counting(rRMSE=0:08)performances when native high-resolution images are used both for training and validation.Similarly,good performances were observed(rRMSE=0:11)when the model is trained over synthetic low-resolution images obtained by downsampling the native training high-resolution images and applied to the synthetic low-resolution validation images.Conversely,poor performances are obtained when the model is trained on a given spatial resolution and applied to another spatial resolution.Training on a mix of high-and low-resolution images allows to get very good performances on the native high-resolution(rRMSE=0:06)and synthetic low-resolution(rRMSE=0:10)images.However,very low performances are still observed over the native low-resolution images(rRMSE=0:48),mainly due to the poor quality of the native low-resolution images.Finally,an advanced super resolution method based on GAN(generative adversarial network)that introduces additional textural information derived from the native high-resolution images was applied to the native low-resolution validation images.Results show some significant improvement(rRMSE=0:22)compared to bi 展开更多
关键词 RCNN FASTER IMAGE
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致密砂岩衰减岩石物理图板分析:储层微裂隙预测 被引量:9
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作者 庞孟强 巴晶 +3 位作者 J.M.Carcione A.Vesnaver 马汝鹏 陈天胜 《地球物理学报》 SCIE EI CAS CSCD 北大核心 2020年第11期4205-4219,共15页
致密砂岩储层普遍具有孔隙度低、微裂隙发育的特点,岩石内部常含有强烈的结构非均质性.致密砂岩发育的微裂隙使储层具有良好的连通性,促成高饱和气的天然气成藏.针对川西某探区须家河组高含气饱和度致密砂岩,本文选取致密砂岩岩心样本,... 致密砂岩储层普遍具有孔隙度低、微裂隙发育的特点,岩石内部常含有强烈的结构非均质性.致密砂岩发育的微裂隙使储层具有良好的连通性,促成高饱和气的天然气成藏.针对川西某探区须家河组高含气饱和度致密砂岩,本文选取致密砂岩岩心样本,进行了不同围压下的超声波实验测量.考虑储层完全饱气情况下的粒间孔隙、微裂隙双重孔隙结构,采用Biot-Rayleigh双重孔隙方程,构建致密砂岩岩石物理模型,进而分析了裂隙含量对纵波频散和衰减的影响.基于地震波衰减,构建了致密砂岩多尺度岩石物理图板.采用谱比法和改进频移法估算致密砂岩样本及储层衰减,对超声和地震频带下的图板进行校正.将校正后的图板应用到研究工区,选取二维测线和三维区块,进行储层孔隙度和裂隙含量的定量预测.对比实际资料进行分析,结果显示,本文预测的孔隙度和裂隙含量与三口测井的孔隙度曲线和实际产气情况基本吻合,基于孔隙-裂隙衰减岩石物理模型有效地预测了优质储层的分布区域. 展开更多
关键词 致密砂岩 微裂隙预测 衰减 岩石物理图板 孔隙度 双重孔隙介质模型
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Global Wheat Head Detection 2021:An Improved Dataset for Benchmarking Wheat Head Detection Methods 被引量:8
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作者 Etienne David Mario Serouart +34 位作者 Daniel Smith Simon Madec Kaaviya Velumani Shouyang Liu Xu Wang Francisco Pinto Shahameh Shafiee Izzat SATahir Hisashi Tsujimoto Shuhei Nasuda Bangyou Zheng Norbert Kirchgessner Helge Aasen Andreas Hund Pouria Sadhegi-Tehran Koichi Nagasawa Goro Ishikawa Sébastien Dandrifosse Alexis Carlier Benjamin Dumont Benoit Mercatoris Byron Evers Ken Kuroki Haozhou Wang Masanori Ishii Minhajul ABadhon Curtis Pozniak David Shaner LeBauer Morten Lillemo Jesse Poland Scott Chapman Benoit de Solan Frédéric Baret Ian Stavness Wei Guo 《Plant Phenomics》 SCIE 2021年第1期277-285,共9页
The Global Wheat Head Detection(GWHD)dataset was created in 2020 and has assembled 193,634 labelled wheat heads from 4700 RGB images acquired from various acquisition platforms and 7 countries/institutions.With an ass... The Global Wheat Head Detection(GWHD)dataset was created in 2020 and has assembled 193,634 labelled wheat heads from 4700 RGB images acquired from various acquisition platforms and 7 countries/institutions.With an associated competition hosted in Kaggle,GWHD_2020 has successfully attracted attention from both the computer vision and agricultural science communities.From this first experience,a few avenues for improvements have been identified regarding data size,head diversity,and label reliability.To address these issues,the 2020 dataset has been reexamined,relabeled,and complemented by adding 1722 images from 5 additional countries,allowing for 81,553 additional wheat heads.We now release in 2021 a new version of the Global Wheat Head Detection dataset,which is bigger,more diverse,and less noisy than the GWHD_2020 version. 展开更多
关键词 WHEAT adding RELEASE
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Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation 被引量:8
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作者 Fahima Madouri Noelline Guillou +12 位作者 Louis Fauconnier Tiffany Marchiol Nathalie Rouxel Pauline Chenuet Aurelie Ledru Lionel Apetoh Franc¸ois Ghiringhelli Mathias Chamaillard Song Guo Zheng Fabrice Trovero Valerie F.J.Quesniaux Bernhard Ryffel Dieudonnee Togbe 《Journal of Molecular Cell Biology》 SCIE CAS CSCD 2015年第4期351-365,共15页
The cysteine protease caspase-1(Casp-1)contributes to innate immunity through the assembly of NLRP3,NLRC4,AIM2,and NLRP6 inflammasomes.Here we ask whether caspase-1 activation plays a regulatory role in house dust mit... The cysteine protease caspase-1(Casp-1)contributes to innate immunity through the assembly of NLRP3,NLRC4,AIM2,and NLRP6 inflammasomes.Here we ask whether caspase-1 activation plays a regulatory role in house dust mite(HDM)-induced experimental allergic airway inflammation.We report enhanced airway inflammation in caspase-1-deficient mice exposed toHDMwith a marked eosinophil recruitment,increased expression of IL-4,IL-5,IL-13,aswell as full-length and bioactive IL-33.Furthermore,mice deficient for NLRP3 failed to control eosinophil influx in the airways and displayed augmented Th2 cytokine and chemokine levels,suggesting that the NLPR3 inflammasome complex controls HDM-induced inflammation.IL-33 neutralization by administration of soluble ST2 receptor inhibited the enhanced allergic inflammation,while administration of recombinant IL-33 during challenge phase enhanced allergic inflammation in caspase-1-deficient mice.Therefore,we show that caspase-1,NLRP3,and ASC,but not NLRC4,contribute to the upregulation of allergic lung inflammation.Moreover,we cannot exclude an effect of caspase-11,because caspase-1-deficient mice are deficient for both caspases.Mechanistically,absence of caspase-1 is associated with increased expression of IL-33,uric acid,and spleen tyrosine kinase(Syk)production.This study highlights acritical role of caspase-1 activation andNLPR3/ASCinflammasomecomplex in the down-modulation of IL-33 in vivo and in vitro,thereby regulating Th2 response in HDM-induced allergic lung inflammation. 展开更多
关键词 house dust mite allergic asthma CASPASE-1 inflammasomes IL-33 spleen tyrosine kinase(Syk) uric acid
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CDISC标准介绍及在中国的应用 被引量:7
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作者 吴崇胜 包文俊 +3 位作者 王军 彭瑞玲 邓亚中 张子豹 《药学学报》 CAS CSCD 北大核心 2015年第11期1428-1433,共6页
经过近20年的开发和持续版本升级改进,临床数据交换标准协会(CDISC)已经制定了一套可用于全球临床研究的数据标准,涵盖临床研究的全流程。CDISC标准可提高临床研究和药物评审的质量和效率,便于各方交流研究数据和试验结果。CDISC标准已... 经过近20年的开发和持续版本升级改进,临床数据交换标准协会(CDISC)已经制定了一套可用于全球临床研究的数据标准,涵盖临床研究的全流程。CDISC标准可提高临床研究和药物评审的质量和效率,便于各方交流研究数据和试验结果。CDISC标准已被多个监管机构用于数据递交标准格式要求或正考虑采用,并在各国业界得到越来越广泛的使用。国内也逐步使用CDISC标准,目前正在进行进一步研究和测试CDISC标准作为中国数据递交格式要求的可行性和路线图。 展开更多
关键词 CDISC标准 数据递交格式 临床试验数据标准化
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Thermo-mechanical and micro-structural properties of xylanase containing whole wheat bread 被引量:7
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作者 G.Ghoshal U.S.Shivhare U.C.Banerjee 《Food Science and Human Wellness》 SCIE 2016年第4期219-229,共11页
Xylanase is a hemicellulase that can hydrolyses the complex polysaccharides.Hemicelluloses are main components of cell walls of cereal grains.Moreover,hemicelluloses are considered as potential sources of mono-and oli... Xylanase is a hemicellulase that can hydrolyses the complex polysaccharides.Hemicelluloses are main components of cell walls of cereal grains.Moreover,hemicelluloses are considered as potential sources of mono-and oligosaccharides.In this study,influence of xylanase on the physicochemical properties and sensory qualities of the whole wheat bread during storage was investigated.Studies of whole wheat bread on microstructure,texture,thermotics,Scanning Electron Microscopic(SEM),X-Ray Diffraction(XRD)were conducted at ambient temperature of 25 and 4◦C respectively.During storage at different temperatures,bread containing xylanase exhibited less firmness but larger volume with whiter crumb color and longer shelf life as compared to control bread.Results of firmness,enthalpy,Fourier Transformation Infra Red(FTIR)and X-Ray Diffraction(XRD)studies suggested a lower staling rate of bread containing xylanase as compared to control one.Bread containing xylanase showed a smoother surface and more uniform pore size than the control.Significant differences in microstructure of control and bread containing xylanase were observed which might be attributed due to the change in water starch gluten interaction.These differences were also found to be interrelated to the textural properties of bread.Better sensory features were achieved in bread containing xylanase. 展开更多
关键词 BREAD FIRMNESS ENZYME TEXTURE Microstructure
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基于野外可见近红外光谱和水分影响校正算法的土壤剖面有机碳预测 被引量:6
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作者 李硕 李春莲 +2 位作者 陈颂超 徐冬云 史舟 《光谱学与光谱分析》 SCIE EI CAS CSCD 北大核心 2021年第4期1234-1239,共6页
土壤是陆地碳循环的中枢,充分发挥土壤固碳潜力有助于减缓全球气候变化。土壤有机碳(SOC)的高度分异性同时体现在空间和垂直分布上,但是许多前期研究往往只考虑了空间分异,而忽略了垂直分异。尤其在青藏高原这种高寒山区,土壤样品采集... 土壤是陆地碳循环的中枢,充分发挥土壤固碳潜力有助于减缓全球气候变化。土壤有机碳(SOC)的高度分异性同时体现在空间和垂直分布上,但是许多前期研究往往只考虑了空间分异,而忽略了垂直分异。尤其在青藏高原这种高寒山区,土壤样品采集难度较大且费用昂贵。可见近红外(Vis-NIR)光谱作为传统土壤实验室化学分析的辅助手段,能够较为快速和精准地估测SOC含量。但是土壤水分等环境因素会掩盖或改变SOC的Vis-NIR光谱吸收特征进而削弱模型预测精度。外部参数正交化(EPO)和分段直接标准化(PDS)算法可以有效校正水分对光谱的影响,但其在野外新鲜土柱上的表现还不得而知。本研究旨在探索不同水分影响校正算法对野外剖面土壤光谱的校正能力,对采自中国青藏高原海拔2900~4500 m色季拉山的共26个1 m深土柱。沿深度以5 cm×5 cm为测量单元,从各单元中心采集共计386个野外原状湿样Vis-NIR光谱,并在实验室内测得相应386个研磨干样的Vis-NIR光谱以及SOC含量。经EPO和PDS算法校正土壤水分对光谱的影响后,通过随机森林建立土壤光谱和SOC含量的定量预测模型,并使用靴襻法评估不同校正处理下预测模型的不确定。土柱整体及垂直分布的精度结果表明,经PDS法转换的农田和草地土柱湿样光谱均表现出良好的水分校正效果,而EPO法仅对农田土柱有效。水分影响校正算法在不同土壤深度上也存在显著差异,EPO和PDS对农田和草地表层样本的水分校正均效果明显。两种校正方法的效果显示出地类和土层深度的依赖性。本研究为利用Vis-NIR光谱技术在高寒山区野外快速准确估算土壤碳含量的垂直分异提供了必要参考。 展开更多
关键词 土壤有机碳 外部参数正交化 分段直接标准化 随机森林 青藏高原
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一种新颖的气相紫外吸收傅立叶变换水质氨氮在线分析仪 被引量:4
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作者 侯传嘉 王欣 《现代仪器》 2008年第2期50-53,共4页
本文利用气相紫外吸收傅立叶变换的方法研制出水质氨氮在线分析仪,在测量地表水和废水时该法选择性高,几乎没有干扰,技术先进,结构合理,带有远程传输功能,同时这还是一台模块式的仪器,可以测量最多至12个参数。与传统方法相比,具有维护... 本文利用气相紫外吸收傅立叶变换的方法研制出水质氨氮在线分析仪,在测量地表水和废水时该法选择性高,几乎没有干扰,技术先进,结构合理,带有远程传输功能,同时这还是一台模块式的仪器,可以测量最多至12个参数。与传统方法相比,具有维护量小、运行费用低、耐色度和浊度干扰、无需每天标定标液等优点,已在污水处理厂、大型钢铁厂和化肥厂排水水质检测中得到广泛的应用。 展开更多
关键词 氨氮在线分析仪 水质 气相紫外吸收 傅立叶变换 紫外
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Depleted uranium oxide supported nickel catalyst for autothermal CO_(2)methanation in non-adiabatic reactor under induction heating 被引量:1
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作者 Lai Truong-Phuoc Jean-Mario Nhut +7 位作者 Loïc Vidal Cuong Duong-Viet Sécou Sall Corinne Petit Christophe Sutter Mehdi Arab Alex Jourdan Cuong Pham-Huu 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第10期310-323,I0010,共15页
Undoped nickel-based catalysts supported on depleted uranium oxide allow one to carry out CO_(2)methanation process under extremely low reaction temperature under atmospheric pressure and powered by a contactless indu... Undoped nickel-based catalysts supported on depleted uranium oxide allow one to carry out CO_(2)methanation process under extremely low reaction temperature under atmospheric pressure and powered by a contactless induction heating.By adjusting the reaction conditions,the catalyst is able to perform CO_(2)methanation reaction under autothermal process operated inside a non-adiabatic reactor,without any external energy supply.Such autothermal process is possible thanks to the high apparent density of the UO_x which allows one to confine the reaction heat in a small catalyst volume in order to confine the exothermicity of the reaction inside the catalyst and to operate the reaction at equilibrium heat in-heat out.Such autothermal operation mode allows one to significantly reduce the complexity of the process compared to that operated using adiabatic reactor,where complete insulation is required to prevent heat disequilibrium,in order to reduce as much as possible,the heat exchange with the external medium.The catalyst displays an extremely high stability as a function of time on stream as no apparent deactivation.It is expected that such new catalyst with unprecedented catalytic performance could open new era in the field of heterogeneous catalysis where traditional supports show their limitations to operate catalytic processes under severe reaction conditions. 展开更多
关键词 CO_(2)methanation Auto-methanation Induction heating Depleted uranium oxide Electrification process Operando DRIFTS
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Effects of paraprobiotics on bile acid metabolism and liver health in largemouth bass(Micropterus salmoides)fed a cottonseed protein concentrate-based diet 被引量:1
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作者 Xiaoze Xie Xiaofang Liang +6 位作者 Hao Wang Qiang Zhu Junjun Wang Ying Chang Eric Leclercq Min Xue Jie Wang 《Animal Nutrition》 SCIE CAS CSCD 2023年第2期302-312,共11页
Cottonseed protein concentrate is a sustainable fishmeal alternative in aquafeed.A 10-week experiment was conducted to investigate the effects of a cottonseed protein concentrate-based diet with and without multi-stra... Cottonseed protein concentrate is a sustainable fishmeal alternative in aquafeed.A 10-week experiment was conducted to investigate the effects of a cottonseed protein concentrate-based diet with and without multi-strain yeast fractions(MsYF)on growth,bile acid metabolism,and health in largemouth bass.Four hundred fish(54.0±0.0 g)were casually distributed into 16 tanks(4 replicates/diet).Fish were fed with 4 iso-nitrogen and iso-energetic diets 3 times daily,including a fishmeal diet(FM),a soy protein concentrate-based diet(SPC;replacing 81%fishmeal protein),a cottonseed protein concentrate-based diet(CPC;replacing 81%fishmeal protein),and a CPC diet supplemented with 800 mg/kg MsYF(CPCY).Results showed that the survival of SPC was the lowest,i.e.,48%,with no apparent diet effect among other treatments;we omitted the SPC in additional analyses.Fish fed cottonseed protein concentrate-based diets showed lower growth than FM(P<0.05).Fish fed CPC showed the highest nuclear dense hepatic phenotypes ratio(50%),followed by CPCY(33%)and FM(17%).Further,dietary CPC increased hepatic total cholesterol and triglyceride levels with concurrently increased cholesterol syn-thesis but decreased triglyceride synthesis-associated transcription levels(P<0.05).Furthermore,di-etary CPC increased bile acid synthesis but decreased bile acid transport-associated transcription levels(P<0.05),and then induced an increment of plasma cholic acid and hepatic chenodeoxycholic acid content and the decrement of genus Romboustia(P<0.05).Regarding the effect of MsYF,fish fed CPCY reduced hepatic lipid accumulation and total plasma bile acid content(P<0.05)compared to CPC,suggesting an improvement in liver health.Also,dietary MsYF could reverse the microbiota community structure showing a similar gut microbial composition to FM.In conclusion,81%of fishmeal protein replaced by cottonseed protein concentrate suppressed growth and liver health,while dietary MsYF might mitigate the negative impact of a high cottonseed protein concentrate level diet on 展开更多
关键词 Cottonseed protein concentrate Multi-yeast strain fractions Micropterus salmoides Liver health Bile acid metabolism Gut microbiota
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Absorption of methionine sources in animals-is there more to know? 被引量:1
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作者 Philippe Becquet Mercedes Vazquez-Anon +4 位作者 Yves Mercier Dolores I.Batonon-Alavo Frances Yan Karen Wedekind Tahir Mahmood 《Animal Nutrition》 SCIE CSCD 2023年第1期159-170,共12页
This literature review evaluates the absorption of methionine (Met) sources such as 2-hydroxy-4-methylthiobutyric acid (HMTBa), its calcium salts (HMTBa-Ca), and DL-methionine (DL-Met) by focusing on the state of know... This literature review evaluates the absorption of methionine (Met) sources such as 2-hydroxy-4-methylthiobutyric acid (HMTBa), its calcium salts (HMTBa-Ca), and DL-methionine (DL-Met) by focusing on the state of knowledge regarding the absorption mechanism, experimental methodology, and factors affecting their absorption. The 2 Met sources differ in mechanism and site of absorption due to differences in their chemical characteristics and enzymatic conversion. This review addresses diffusion- and transport-mediated absorption systems for amino acids and carboxylic compounds, best elucidated by in vitro, ex vivo, and in vivo experimental models. Opportunities and limitations in the use of radioisotopes to depict absorption sites as well as host and microbial metabolism are described. Physiological and environmental conditions that lead to changes in gut absorptive capacity and the impact of Met source absorption are also evaluated. This review concludes that any comparison between HMTBa and DL-Met should consider their different behaviors during the absorption phase. Hence, the chemical characteristics of these 2 molecules entail different absorption sites and mechanisms, from passive absorption in the case of HMTBa and HMTBa-Ca to active transporters for DL-Met, HMTBa, and HMTBa-Ca. In addition, the different conversion modes of these 2 molecules further differentiate their absorption modes. Considering these important differences, it is easier to understand the apparent divergence between the conclusions of existing publications. When comparing these 2 molecules, it is recommended to properly adapt to the conditions under which the absorption of Met sources is evaluated. 展开更多
关键词 DL-METHIONINE Hydroxy-analog of methionine 2-Hydroxy-4-methylthiobutyric acid AbsorptionM ethodology
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Multiple magnetic transitions and magnetocaloric effect of Tb_(4)Coln alloy 被引量:1
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作者 Remya U.D. Arun K. +4 位作者 Swathi S. Athul S.R. Andrea Dzubinska Marian Reiffers Nagalakshmi R. 《Journal of Rare Earths》 SCIE EI CAS CSCD 2023年第11期1721-1727,I0003,共8页
We report on the magnetic,magnetocaloric,thermal,and electrical transport properties of Tb_(4)Coln alloy,which crystallizes in two phases,Tb_6Co_(2.1)In_(0.8)(space group Immm)and Tb_(2)In_(0.9)Co_(0.1)(space group P6... We report on the magnetic,magnetocaloric,thermal,and electrical transport properties of Tb_(4)Coln alloy,which crystallizes in two phases,Tb_6Co_(2.1)In_(0.8)(space group Immm)and Tb_(2)In_(0.9)Co_(0.1)(space group P6_(3)/mmc),respectively.The alloy reveals three successive magnetic transitions around T_(1)(163 K),T_(2)(50 K),and T_(3)(29 K),respectively,associated with paramagnetic to ferromagnetic transition and two sequential antiferromagnetic transitions.The low-temperature transition T_(3) follows the first-order magnetic behavior and exhibits the field-induced magnetic transition.Meanwhile,T_(2) and T_(1) are found to be second-order in nature which opens a possibility for hysteresis-free magnetocaloric application.The magnetocaloric properties are determined using different magnetocaloric figures of merits such as-ΔS_(M),ΔT_(ad).RCP,and TEC(10).Additionally,the universal curve behavior in the isothermal entropy change unveils the variation in critical exponents around T_(1) and T_(2) due to the magnetic inhomogeneity in the alloy.Besides,the electrical transport properties of the metallic alloy denote the maximum magnetoresistance of-10%around T_(1). 展开更多
关键词 Multiple magnetic transitions Order of magnetic transition Magnetocaloric effect MAGNETORESISTANCE Universal curve behavior Rare earths
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Superior Properties of Mg–4Y–3RE–Zr Alloy Prepared by Powder Metallurgy 被引量:5
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作者 Jirí Kubásek Drahomír Dvorsky +3 位作者 Miroslav Cavojsky Dalibor Vojtěch Nad'a Beronská Michaela Fousová 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2017年第7期652-660,共9页
Magnesium alloys are important materials for application in the automotive and aviation industries. During the last few years, the number of possible applications as biodegradable implants in medicine has grown. Mg-RE... Magnesium alloys are important materials for application in the automotive and aviation industries. During the last few years, the number of possible applications as biodegradable implants in medicine has grown. Mg-RE(rare earth) alloys belong to the most advanced group of products, offering the best combination of mechanical properties and corrosion resistance. Among these materials, WE43(Mg-Y-Nd)is a very well-known commercial alloy that has been extensively studied for applications at increased temperatures and also in organisms. Although this material has been described, there are still possibilities to improve its properties and subsequently expand its applicability. Powder metallurgy has already been used for the preparation of magnesium alloys with superior mechanical properties and occasionally superior corrosion properties. Therefore, the present paper is oriented toward the preparation of Mg-4Y-3RE-Zr(WE43) alloy by the powder metallurgy technique(WE43-PM) and comparison of the final properties with the product of extrusion of as-cast ingot(WE43-IM). Our processing leads to a partial improvement in the mechanical properties and superior corrosion resistance of WE43-PM. The texture strength of WE43-PM was low, and therefore, anisotropy of mechanical properties was suppressed. 展开更多
关键词 Magnesium alloys REEs(rare earth elements) Powder metallurgy Mechanical properties Corrosion
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SegVeg: Segmenting RGB Images into Green and Senescent Vegetation by Combining Deep and Shallow Methods 被引量:3
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作者 Mario Serouart Simon Madec +4 位作者 Etienne David Kaaviya Velumani Raul LopezLozano Marie Weiss Frederic Baret 《Plant Phenomics》 SCIE EI 2022年第1期26-42,共17页
Pixel segmentation of high-resolution RGB images into chlorophyll-active or nonactive vegetation classes is a first step often required before estimating key traits of interest.We have developed the SegVeg approach fo... Pixel segmentation of high-resolution RGB images into chlorophyll-active or nonactive vegetation classes is a first step often required before estimating key traits of interest.We have developed the SegVeg approach for semantic segmentation of RGB images into three classes(background,green,and senescent vegetation).This is achieved in two steps:A U-net model is first trained on a very large dataset to separate whole vegetation from background.The green and senescent vegetation pixels are then separated using SVM,a shallow machine learning technique,trained over a selection of pixels extracted from images.The performances of the SegVeg approach is then compared to a 3-class U-net model trained using weak supervision over RGB images segmented with SegVeg as groundtruth masks.Results show that the SegVeg approach allows to segment accurately the three classes.However,some confusion is observed mainly between the background and senescent vegetation,particularly over the dark and bright regions of the images.The U-net model achieves similar performances,with slight degradation over the green vegetation:the SVM pixel-based approach provides more precise delineation of the green and senescent patches as compared to the convolutional nature of U-net.The use of the components of several color spaces allows to better classify the vegetation pixels into green and senescent.Finally,the models are used to predict the fraction of three classes over whole images or regularly spaced grid-pixels.Results show that green fraction is very well estimated(R^(2)=0.94)by the SegVeg model,while the senescent and background fractions show slightly degraded performances(R^(2)=0.70 and 0.73,respectively)with a mean 95%confidence error interval of 2.7%and 2.1%for the senescent vegetation and background,versus 1%for green vegetation.We have made SegVeg publicly available as a ready-to-use script and model,along with the entire annotated grid-pixels dataset.We thus hope to render segmentation accessible to a broad audience by requiring neither 展开更多
关键词 DEEP offering RENDER
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Investigation and Benefits of the Use of Enzymes for Unbleached Kraft Recycling Wet Strength Paper at Lab and Industrial Scale
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作者 Audrey Bajul-Baradon Terence Nguema-Nkili +1 位作者 Anais Sanfaute Gilles Bajul 《材料科学与工程(中英文A版)》 2023年第4期83-95,共13页
The deterioration of recycled fibers especially unbleached kraft with high wet strength resin content due to the irreversible structural changes caused by drying and added chemicals makes the raw material difficult to... The deterioration of recycled fibers especially unbleached kraft with high wet strength resin content due to the irreversible structural changes caused by drying and added chemicals makes the raw material difficult to repulp.The mechanical effect in the pulper over time with chemical treatment has a negative impact on the recycled fibers.At lab scale,different compositions of enzymatic treatment C022L were under investigation to select the most efficient laccase Lacc1,Lacc2 or Lacc3 and to observe the impact of lipases during repulping at low and high consistencies.Pulp disintegration at different times was evaluated to define the level of rejects and to analyze the morphology of fibers after treatments.These results were more significant for Lacc2,by increasing the pulp consistency to 15%in the pulper.Combining lipases with CELODASE 022L appeared to decrease the efficiency of enzymes.The results showed a high reduction of energy power with the enzymatic treatment and a significant reduction of fines level in fibers’suspension.The most efficient version of C022L was used at industrial scale to compare directly with the standard conditions used in a paper mill. 展开更多
关键词 Energy ENZYMES RECYCLING unbleached kraft paper wet strength resin.
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Multifunctional characteristics of 3D printed polymer nanocomposites under monotonic and cyclic compression
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作者 Pawan Verma Jabir Ubaid +2 位作者 Fahad Alam Suleyman Deveci S.Kumar 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第12期13-22,共10页
This study presents the multifunctional characteristics of multi-walled carbon nanotube(MWCNT)/polypropylene random copolymer(PPR) composites enabled via fused filament fabrication(FFF) under monotonic and quasi-stati... This study presents the multifunctional characteristics of multi-walled carbon nanotube(MWCNT)/polypropylene random copolymer(PPR) composites enabled via fused filament fabrication(FFF) under monotonic and quasi-static cyclic compression. Utilizing in-house MWCNT-engineered PPR filament feedstocks, both bulk and cellular composites were realized. The morphological features of nanocomposites were examined via scanning electron microscopy, which reveals that MWCNTs are uniformly dispersed. The uniformly dispersed MWCNTs forms an electrically conductive network within the PPR matrix, and the resulting nanocomposite shows good electrical conductivity(~10^(-1)S/cm), improved mechanical performance(modulus increases by 125% and compressive strength increases by 25% for 8 wt% MWCNT loading) and pronounced piezoresistive response(gauge factor of 27.9-8.5 for bulk samples)under compression. The influence of strain rate on the piezoresistive response of bulk samples(4 wt% of MWCNT) under compression was also measured. Under repeated cyclic compression(2% constant strain amplitude), the nanocomposite exhibited stable piezoresistive performance up to 100 cycles. The piezoresistive response under repeated cyclic loading with increasing strain amplitude of was also assessed.The gauge factor of BCC and FCC cellular composites(4 wt% of MWCNT) with a relative density of 30%was observed to be 46.4 and 30.2 respectively, under compression. The higher sensitivity of the BCC plate-lattice could be attributed to its higher degree of stretching-dominated deformation behavior than the FCC plate-lattice, which exhibits bending-dominated behavior. The 3D printed cellular PPR/MWCNT composites structures were found to show excellent piezoresistive self-sensing characteristics and open new avenues for in situ structural health monitoring in various applications. 展开更多
关键词 Carbon nanotubes Nanoengineered polymer composites 3D printing Piezoresistive self-sensing Lattice structures
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A systematic review of metabolism of methionine sources in animals:One parameter does not convey a comprehensive story
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作者 Philippe Becquet Mercedes Vazquez-Anon +4 位作者 Yves Mercier Karen Wedekind Tahir Mahmood Dolores I.Batonon-Alavo Frances Yan 《Animal Nutrition》 SCIE CAS CSCD 2023年第2期31-49,共19页
The goal of this review article,based on a systematic literature search,is to critically assess the state of knowledge and experimental methodologies used to delineate the conversion and metabolism of the 2 methionine... The goal of this review article,based on a systematic literature search,is to critically assess the state of knowledge and experimental methodologies used to delineate the conversion and metabolism of the 2 methionine(Met)sources DL-methionine(DL-Met)and DL-2-hydroxy-4-(methylthio)butanoic acid(HMTBa).The difference in the chemical structures of HMTBa and DL-Met indicates that these molecules are absorbed and metabolized differently in animals.This review explores the methodologies used to describe the 2-step enzymatic conversion of the 3 enantiomers(D-HMTBa,L-HMTBa and D-Met)to L-Met,as well as the site of conversion at the organ and tissue levels.Extensive work was published documenting the conversion of HMTBa and D-Met into L-Met and,consequently,the incorporation into protein using a variety of in vitro techniques,such as tissue homogenates,cell lines,primary cell lines,and everted gut sacs of individual tissues.These studies illustrated the role of the liver,kidney,and intestine in the con-version of Met precursors into L-Met.A combination of in vivo studies using stable isotopes and infusions provided evidence of the wide conversion of HMTBa to L-Met by all tissues and how some tissues are net users of HMTBa,whereas others are net secreters of L-Met derived from HMTBa.Conversion of D-Met to L-Met in organs other than the liver and kidney is poorly documented.The methodology cited in the literature to determine conversion efficiency ranged from measurements of urinary,fecal,and respiratory excretion to plasma concentration and tissue incorporation of isotopes after intraperitoneal and oral in-fusions.Differences observed between these methodologies reflect differences in the metabolism of Met sources rather than differences in conversion efficiency.The factors affecting conversion efficiency are explored in this paper and are mostly associated with extreme dietary conditions,such as noncommercial crystalline diets that are very deficient in total sulfur amino acids with respect to requirements.Impli-cations 展开更多
关键词 DL-METHIONINE Hydroxy-analog of methionine 2-Hydroxy-4-(methylthio)butanoic acid Conversion METABOLISM Methodology
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