Lithium-ion power battery has become one of the main power sources for electric vehicles and hybrid electric vehicles because of superior performance compared with other power sources. In order to ensure the safety an...Lithium-ion power battery has become one of the main power sources for electric vehicles and hybrid electric vehicles because of superior performance compared with other power sources. In order to ensure the safety and improve the performance, the maximum operating temperature and local temperature difference of batteries must be maintained in an appropriate range. The effect of temperature on the capacity fade and aging are simply investigated. The electrode structure, including electrode thickness, particle size and porosity, are analyzed. It is found that all of them have significant influences on the heat generation of battery. Details of various thermal management technologies, namely air based, phase change material based, heat pipe based and liquid based, are discussed and compared from the perspective of improving the external heat dissipation. The selection of different battery thermal management(BTM) technologies should be based on the cooling demand and applications, and liquid cooling is suggested being the most suitable method for large-scale battery pack charged/discharged at higher C-rate and in high-temperature environment. The thermal safety in the respect of propagation and suppression of thermal runaway is analyzed.展开更多
背景与目的:华蟾素目前广泛应用于肿瘤的治疗中,由于在80年代上市,未进行临床Ⅰ期研究,无法确定其最大耐受剂量。因此本文旨在观察华蟾素治疗肝细胞癌、肺癌和胰腺癌的最大耐受剂量和不良反应,同时评价治疗疗效。方法:Ⅲ、Ⅳ期肝细胞癌...背景与目的:华蟾素目前广泛应用于肿瘤的治疗中,由于在80年代上市,未进行临床Ⅰ期研究,无法确定其最大耐受剂量。因此本文旨在观察华蟾素治疗肝细胞癌、肺癌和胰腺癌的最大耐受剂量和不良反应,同时评价治疗疗效。方法:Ⅲ、Ⅳ期肝细胞癌、非小细胞肺癌和胰腺癌接受华蟾素治疗,采用静脉滴注,连续14 d,21 d为一疗程。如果没有出现剂量限制性毒性,治疗将持续2个疗程。剂量递增的方案为:10、20、40、60、90和120 m l/(m2.d)。结果:入组15例患者(每个剂量组为3例)中,11例为肝癌,2例胰腺癌和2例肺癌。第五剂量组结束时没有发现剂量限制性毒性(DLT)。其中14例患者可评价疗效,6例(42.9%)为SD,8例(57.1%)为PD。在第一剂量组中,1例肝癌患者肿瘤缩小20%并维持11个月。结论:本研究最高剂量达到常规剂量的8倍,尚未出现剂量限制性毒性。部分患者获得了肿瘤缩小或稳定的疗效。展开更多
The present paper gives an overview of the key project ' South China Sea Monsoon Experiment (SCSMEX)' operated by the Ministry of Science and Technology of China during the period of 1996-2001. The SCSMEX is a...The present paper gives an overview of the key project ' South China Sea Monsoon Experiment (SCSMEX)' operated by the Ministry of Science and Technology of China during the period of 1996-2001. The SCSMEX is a joint atmospheric and oceanic field experiment which aims to better understand the onset, maintenance, and variability of the summer monsoon over the South China Sea (SCS). It is a large-scale international effort with many participating countries and regions cooperatively involved in this experiment. With the field observation in May-August 1998, a large amount of meteorological and oceanic data was acquired, which provides excellent datasets for the study of the SCS monsoon and the East Asian monsoon and their interaction with the ocean. The preliminary research achievements are as follows. (1) The earliest onset of the Asian monsoon over the SCS and Indo-China Peninsula has been well documented. Prom the viewpoint of the synoptic process, its onset is closely related to the early rapid development of a twin cyclone to the east of Sri Lanka. The conceptual modei of the SCS monsoon onset in 1998 was put forward. The 50-year time series of the SCS monsoon onset date was also made. (2) Two major modes, namely the 30-60-day and 10-20-day oscillations were ascertained. The influences of the abnormal SCS monsoon on the precipitation over eastern China and its modes were identifled. A strong (weak) monsoon over the SCS usually leads to less (more) precipitation over the middle and lower reaches of the Yangtze River basin, and more (less) precipitation in North China. (3) During the monsoon onset over the SCS, a wide variety of organized mesoscale convective systems (MCSs) were observed by a Doppler radar array deployed over the northern SCS. The relationship between large-scale circulations and MCSs during the monsoon onset process in 1998 was clearly revealed. It was suggested that there is a kind of positive feedback mechanism between large-scale circulations and MCSs. (4) The SST over the SCS during the early展开更多
Colorectal cancer(CRC) is one of the leading causes of cancer-related death. Surgery, radiotherapy and chemotherapy have been till now the main therapeutic strategies for disease control and improvement of the overall...Colorectal cancer(CRC) is one of the leading causes of cancer-related death. Surgery, radiotherapy and chemotherapy have been till now the main therapeutic strategies for disease control and improvement of the overall survival. Twenty-five per cent(25%) of CRC patients have clinically detectable liver metastases at the initial diagnosis and approximately 50% develop liver metastases during their disease course. Twentythirty per cent(20%-30%) are CRC patients with metastases confined to the liver. Some years ago various studies showed a curative potential for liver metastases resection. For this reason some authors proposed the conversion of unresectable liver metastases to resectable to achieve cure. Since those results were published, a lot of regimens have been studied for resectability potential. Better results could be obtained by the combination of chemotherapy with targeted drugs, such as anti-VEGF and antiEGFR monoclonal antibodies. However an accurate selection for patients to treat with these regimens and to operate for liver metastases is mandatory to reduce the risk of complications. A multidisciplinary team approach represents the best way for a proper patient management. The team needs to include surgeons, oncologists, diagnostic and interventional radiologists with expertise in hepatobiliary disease, molecular pathologists, and clinical nurse specialists. This review summarizes the most important findings on surgery and systemic treatment of CRC-related liver metastases.展开更多
Currently,electromagnetic(EM) pollution poses severe complication toward the operation of electronic devices and biological systems.To this end,it is pertinent to develop novel microwave absorbers through compositiona...Currently,electromagnetic(EM) pollution poses severe complication toward the operation of electronic devices and biological systems.To this end,it is pertinent to develop novel microwave absorbers through compositional and structural design.Porous carbon(PC)materials demonstrate great potential in EM wave absorption due to their ultralow density,large surface area,and excellent dielectric loss ability.However,the large-scale production of PC materials through low-cost and simple synthetic route is a challenge.Deriving PC materials through biomass sources is a sustainable,ubiquitous,and low-cost method,which comes with many desired features,such as hierarchical texture,periodic pattern,and some unique nanoarchitecture.Using the bio-inspired microstructure to manufacture PC materials in mild condition is desirable.In this review,we summarize the EM wave absorption application of biomass-derived PC materials from optimizing structureand designing composition.The corresponding synthetic mechanisms and development prospects are discussed as well.The perspective in this field is given at the end of the article.展开更多
In particle sizing by light extinction method, the regularization parameter plays an important role in applying regularization to find the solution to ill-posed inverse problems. We combine the generalized cross-valid...In particle sizing by light extinction method, the regularization parameter plays an important role in applying regularization to find the solution to ill-posed inverse problems. We combine the generalized cross-validation （GCV） and L-curve criteria with the Twomey-NNLS algorithm in parameter optimization. Numerical simulation and experimental validation show that the resistance of the newly developed algorithms to measurement errors can be improved leading to stable inversion results for unimodal particle size distribution.展开更多
Ⅰ. INTRODUCTION Bednorz and Müller have discovered possible superconductivity around 35K in Ba-La-Cu-O systems. Uchida and Takagi et al. have observed Meissner effect and determined superconductivity in the syst...Ⅰ. INTRODUCTION Bednorz and Müller have discovered possible superconductivity around 35K in Ba-La-Cu-O systems. Uchida and Takagi et al. have observed Meissner effect and determined superconductivity in the system. Within a few months, several groups have reported their successful results. Chu et al. pushed the T_c(onset) of Ba-La-Cu-O to 52K under hydrostatic pressure. Cava et al. obtained nearly single superconducting phase展开更多
The incidence of biliary injury after laparoscopic cholecystectomy(LC) has shown a declining trend though it may still be twice that as with open cholecystectomy. Major biliary or vasculobiliary injury is associated w...The incidence of biliary injury after laparoscopic cholecystectomy(LC) has shown a declining trend though it may still be twice that as with open cholecystectomy. Major biliary or vasculobiliary injury is associated with significant morbidity. As prevention is the best strategy, the concept of a culture of safe cholecystectomy has been recently introduced to educate surgeons and apprise them of basic tenets of safe performance of LC. Various aspects of safe cholecystectomy include:(1) thorough knowledge of relevant anatomy, various anatomical landmarks, and anatomical variations;(2) an understanding of the mechanisms involved in biliary/vascular injury, the most important being the misidentification injury;(3) identification of various preoperative and intraoperative predictors of difficult cholecystectomy;(4) proper gallbladder retraction;(5) safe use of various energy devices;(6) understanding the critical view of safety, including its doublet view and documentation;(7) awareness of various error traps(e.g., fundus first technique);(8) use of various bailout strategies(e.g., subtotal cholecystectomy) in difficult gallbladder cases;(9) use of intraoperative imaging techniques(e.g., intraoperative cholangiogram) to ascertain correct anatomy; and(10) understanding the concept of time-out.Surgeons should be facile with these aspects of this culture of safety in cholecystectomy in an attempt to reduce the incidence of biliary/vascular injury during LC.展开更多
A novel technique for separating hydrogen from (H2 + CH4) gas mixtures through hydrate formation/dissociation was proposed. In this work, a systematic experimental study was performed on the separation of hydrogen fro...A novel technique for separating hydrogen from (H2 + CH4) gas mixtures through hydrate formation/dissociation was proposed. In this work, a systematic experimental study was performed on the separation of hydrogen from (H2 + CH4) feed mixtures with various hydrogen contents (mole fraction x = 40%–90%). The experimental results showed that the hydrogen content could be enriched to as high as ～94% for various feed mixtures using the proposed hydrate technology under a temperature slightly above 0°C and a pressure below 5.0 MPa. With the addition of a small amount of suitable additives, the rate of hydrate formation could be increased significantly. Anti-agglomeration was used to disperse hydrate particles into the condensate phase. Instead of preventing hydrate growth (as in the kinetic inhibitor tests), hydrates were allowed to form, but only as small dispersed particles. Anti-agglomeration could keep hydrate particles suspended in a range of condensate types at 1°C and 5 MPa in the water-in-oil emulsion.展开更多
N,N-dibutyldiglycol amic acid （HL1） and N,N-dioctyldiglycol nmic acid （HLu） were synthesized and characterized by conventional spectroscopic methods. These molecules were examined as extractants for extraction-sep...N,N-dibutyldiglycol amic acid （HL1） and N,N-dioctyldiglycol nmic acid （HLu） were synthesized and characterized by conventional spectroscopic methods. These molecules were examined as extractants for extraction-separation of La（Ⅲ）, Eu（Ⅲ） and Er（Ⅲ）, as representative ions of light, middle and heavy rare earths, from aqueous chloride solutions. The analysis of the extraction equilibria revealed that the extracted species of lanthanum and europium ions by both of the extractants had a 1：3 metal to ligand ratio It was suggested that erbium ions were extracted into the organic phase via the formation ofEr（LIor Ⅱ）2Cl complexes. The effect of the organic diluents on the extraction-separation efficiency of the studied rare earths by HLI and HLⅡ was investigated by comparing the results obtained in dichloromethane and carbon tetrachloride. Regardless to the diluent used, the order of selectivity presented by the investigated extractants was Er（Ⅲ）〉Eu（Ⅲ）〉La（Ⅲ）. It is noteworthy that, a significant enhancement in separation of the studied rare earths by the extractants was achieved in their competitive extraction experiments with respect to that obtained in single component extraction experiments. Applicability of the extractants for the removal of rare earth ions from spent Ni-MH batteries was tested by removal ofLa（Ⅲ）, Eu（Ⅲ） and Er（Ⅲ） ions from simulated leach solution of such batteries.展开更多
Tuning and optimization of electronic structures and related reaction energetics are critical toward the rational design of efficient electrocatalysts.Herein,experimental and theoretical calculation demonstrate the or...Tuning and optimization of electronic structures and related reaction energetics are critical toward the rational design of efficient electrocatalysts.Herein,experimental and theoretical calculation demonstrate the originally inert N site within polyaniline(PANI)can be activated for hydrogen evolution by proper d-πinterfacial electronic coupling with metal oxide.As a result,the assynthesized WO3 assemblies@PANI via a facile redox-induced assembly and in situ polymerization,exhibits the electrocatalytic production of hydrogen better than other control samples including W18O49@PANI and most of the reported nobel-metal-free electrocatalysts,with low overpotential of 74 mV at 10 mA·cm−2 and small Tafel slope of 46 mV·dec−1 in 0.5M H2SO4(comparable to commercial Pt/C).The general efficacy of this methodology is also validated by extension to other metal oxides such as MoO3 with similar improvements.展开更多
Various process residues represent a kind of biomass resource already concentrated but containing water as much as 60 wt.%. These materials are generally treated as waste or simply combusted directly to generate heat....Various process residues represent a kind of biomass resource already concentrated but containing water as much as 60 wt.%. These materials are generally treated as waste or simply combusted directly to generate heat. Recently, we attempted to convert them into middle caloric gas to substitute for natural gas, as a chemical or a high-rank gaseous fuel for advanced combustion utilities. Such conversion is implemented through dual fluidized bed gasification （DFBG）. Concerning the high water content of the fuels, DFBG was suggested to accomplish either with high-efficiency fuel drying in advance or direct decoupling of fuel drying/pyrolysis from char gasification and tar/hydrocarbon reforming. Along with fuel drying, calcium-based catalyst can be impregnated into the fuel, without much additional cost, to increase the fuel＇s gasification reactivity and to reduce tar formation. This article reports the Ca impregnation method and its resulting effects on gasification reactivity and tar suppression ability. Meanwhile, the principle of directly gasifying wet fuel with decoupled dual fluidized bed gasification （D-DFBG） is also highlighted.展开更多
A new reactor with integrated conventional slurry stirred reactor and ceramic external membrane emulsification system, was introduced in this paper. Toluene and toluene containing surfactant was separately used as dis...A new reactor with integrated conventional slurry stirred reactor and ceramic external membrane emulsification system, was introduced in this paper. Toluene and toluene containing surfactant was separately used as dispersed phase for preparation of emulsions. Two kinds of emulsions were prepared and compared. The volume average sizes of prepared emulsions were 3.53μm and 3.6μm respectively. The results showed that the droplet sizes of two kinds of emulsions were similar, but the monodispersed emulsion was only obtained with addition of surfactant into the dispersed phase.展开更多
There remain a number of unsolved problems about chemical reactions, and it is significant to explore new detection methods because they always offer some unique information about reactions from new points of view. Fo...There remain a number of unsolved problems about chemical reactions, and it is significant to explore new detection methods because they always offer some unique information about reactions from new points of view. For the first time, the solidification course of a modified two-component acrylic structural adhesive is measured by using reed-vibration mechanical spectroscopy for liquids （RMS-L） in this work, and results show that there are four sequential processes of mechanical spectra with time. The in-depth analyses indicate that RMS-L can detect in real-time the generation and disappearance of active free radicals, as well as the chemical cross-link processes in the adhesive. This kind of real-time detection will undoubtedly facilitate the study of the chemical reaction dynamics controlled by free radicals.展开更多
Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and produce aggressive malignancies that causes millions of deaths every year.With the new understanding of the molecular mechanism(s)...Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and produce aggressive malignancies that causes millions of deaths every year.With the new understanding of the molecular mechanism(s)of disease progression,our knowledge about the disease is snowballing,leading to the evolution of many new therapeutic regimes and their successive trials.In the past few decades,various combinations of therapies have been pro-posed and are presently employed in the treatment of diverse cancers.Targeted drug therapy,immunotherapy,and personalized medicines are now largely being employed,which were not common a few years back.The field of cancer discoveries and therapeutics are evolving fast as cancer type-specific biomarkers are progressively being identified and several types of cancers are nowadays undergoing systematic therapies,extending patients’disease-free survival thereafter.Although growing evidence shows that a systematic and targeted approach could be the future of cancer medicine,chemotherapy remains a largely opted therapeutic option despite its known side effects on the patient’s physical and psychological health.Chemother-apeutic agents/pharmaceuticals served a great purpose over the past few decades and have remained the frontline choice for advanced-stage malignancies where surgery and/or radiation therapy cannot be prescribed due to specific reasons.The present report succinctly reviews the existing and contemporary advancements in chemotherapy and assesses the status of the enrolled drugs/pharmaceuticals;it also comprehensively discusses the emerging role of specific/targeted therapeutic strategies that are presently being employed to achieve better clinical success/survival rate in cancer patients.展开更多
Immune checkpoint inhibitors(ICIs)are widely used due to their effectiveness in treating various tumors.Immune-related adverse events(irAEs)are defined as adverse effects resulting from ICI treatment.Gastrointestinal ...Immune checkpoint inhibitors(ICIs)are widely used due to their effectiveness in treating various tumors.Immune-related adverse events(irAEs)are defined as adverse effects resulting from ICI treatment.Gastrointestinal irAEs are a common type of irAEs characterized by intestinal side effects,such as diarrhea and colitis,which may lead to the cessation of ICIs.Although irAE gastritis is rarely reported,it may lead to serious complications such as gastrorrhagia.Furthermore,irAE gastritis is often difficult to identify early due to its diverse symptoms.Although steroid hormones and immunosuppressants are commonly used to reverse irAEs,the best regimen and dosage for irAE gastritis remains uncertain.In addition,the risk of recurrence of irAE gastritis after the reuse of ICIs should be considered.In this editorial,strategies such as early identification,pathological diagnosis,mana-gement interventions,and immunotherapy rechallenge are discussed to enable clinicians to better manage irAE gastritis and improve the prognosis of these patients.展开更多
Background:Immune checkpoint inhibitors(ICIs)are standard treatments for advanced non-small cell lung cancer(NSCLC);however,evidence regarding their relative efficacy and safety is lacking.This study compared the effi...Background:Immune checkpoint inhibitors(ICIs)are standard treatments for advanced non-small cell lung cancer(NSCLC);however,evidence regarding their relative efficacy and safety is lacking.This study compared the efficacy and safety of all currently available ICI treatments in patients with advanced NSCLC to identify optimal treatment regimens.Methods:PubMed,Cochrane Central Register of Controlled Trials(CENTRAL),MEDLINE,and Embase databases were systematically searched for randomized controlled trials(RCTs)published up to August 8,2022.The primary outcomes were overall survival(OS)and progression-free survival(PFS).Secondary outcomes included objective response rate(ORR)and adverse events(AEs).Results:Forty RCTs involving 22,526 patients were selected,and a total of 26 treatment regimens were identified.Treatment with anti-programmed cell death protein-1(anti-PD-1)provided superior OS compared with anti-programmed death ligand 1(anti-PD-L1)treatment.ICIs plus platinum-based chemotherapy(PBC)were superior to ICIs treatment alone,although the addition of PBC increased treatment toxicity.Cemiplimab ranked first for OS and lowest for any-grade AEs in advanced NSCLC patients without PD-L1 selection.Regarding grade≥3 AEs,the toxicity of ICI monotherapy or ICI-ICI combination was consistently lower than that of the other treatments.For patients without PD-L1 selection,cemiplimab showed the best OS,pembrolizumab plus docetaxel(Pem-DXT)showed the best PFS,and atezolizumab plus bevacizumab and PBC(Atezo-Beva-PBC)showed the best ORR.Pembrolizumab plus PBC and Atezo-Beva-PBC were the most likely optimal treatments for OS and PFS in patients with PD-L1 expression<1%,respectively.In patients with PD-L1 expression≥1%,treatment regimens containing anti-PD-1 provided superior OS benefits compared with those of anti-PD-L1 treatment,and sintilimab plus PBC(Sint-PBC)provided the best OS benefit;as for PFS,ICI plus PBC consistently showed greater PFS benefits than ICI or PBC alone.For patients with anti-PD-L1 expression of 1-49%展开更多
A novel thermal management system of cylindrical Li-ion battery with the liquid cooling in flexible microchannel plate was established in the study. The experiments were conducted with R141 b in flexible microchannel ...A novel thermal management system of cylindrical Li-ion battery with the liquid cooling in flexible microchannel plate was established in the study. The experiments were conducted with R141 b in flexible microchannel plates. The cooling system with the flexible aluminum microchannels can effectively transfer heat from battery to the cooling refrigerant R141 b based on flow boiling. A battery module with five cells along flow channel was chosen to study the effects of contact surface area and mass flux on the thermal performance and electrochemical characteristics in the experiments. Three types of structure with different contact areas were studied and their performances were compared with the experiments without cooling structures. The experiments were carried out at the same discharge rate with the inlet mass flow rates of 0–10 kg/h. For the inlet mass flow rate of 5.98 kg/h, the surface temperature and temperature uniformity of battery were the best, and the output voltage and capacity of batteries were higher than those under other mass flow rates. With given inlet mass flow rates, the five series cells exhibited different electrochemical performances, including output voltage and discharge capacity, due to the different refrigerant flow states in the microchannels. Finally, an optimal design was presented with thermal performances, macroscopic electrochemical characteristics, inlet mass flow rates and cooling performance taken into consideration.展开更多
Lithium–sulfur(Li–S) batteries have received widespread attention, and lean electrolyte Li–S batteries have attracted additional interest because of their higher energy densities. This review systematically analyze...Lithium–sulfur(Li–S) batteries have received widespread attention, and lean electrolyte Li–S batteries have attracted additional interest because of their higher energy densities. This review systematically analyzes the effect of the electrolyte-to-sulfur(E/S) ratios on battery energy density and the challenges for sulfur reduction reactions(SRR) under lean electrolyte conditions. Accordingly, we review the use of various polar transition metal sulfur hosts as corresponding solutions to facilitate SRR kinetics at low E/S ratios(< 10 μL mg~(-1)), and the strengths and limitations of different transition metal compounds are presented and discussed from a fundamental perspective. Subsequently, three promising strategies for sulfur hosts that act as anchors and catalysts are proposed to boost lean electrolyte Li–S battery performance. Finally, an outlook is provided to guide future research on high energy density Li–S batteries.展开更多
基金Supported by National Natural Science Foundation of China(No.51376019)
文摘Lithium-ion power battery has become one of the main power sources for electric vehicles and hybrid electric vehicles because of superior performance compared with other power sources. In order to ensure the safety and improve the performance, the maximum operating temperature and local temperature difference of batteries must be maintained in an appropriate range. The effect of temperature on the capacity fade and aging are simply investigated. The electrode structure, including electrode thickness, particle size and porosity, are analyzed. It is found that all of them have significant influences on the heat generation of battery. Details of various thermal management technologies, namely air based, phase change material based, heat pipe based and liquid based, are discussed and compared from the perspective of improving the external heat dissipation. The selection of different battery thermal management(BTM) technologies should be based on the cooling demand and applications, and liquid cooling is suggested being the most suitable method for large-scale battery pack charged/discharged at higher C-rate and in high-temperature environment. The thermal safety in the respect of propagation and suppression of thermal runaway is analyzed.
文摘背景与目的:华蟾素目前广泛应用于肿瘤的治疗中,由于在80年代上市,未进行临床Ⅰ期研究,无法确定其最大耐受剂量。因此本文旨在观察华蟾素治疗肝细胞癌、肺癌和胰腺癌的最大耐受剂量和不良反应,同时评价治疗疗效。方法:Ⅲ、Ⅳ期肝细胞癌、非小细胞肺癌和胰腺癌接受华蟾素治疗,采用静脉滴注,连续14 d,21 d为一疗程。如果没有出现剂量限制性毒性,治疗将持续2个疗程。剂量递增的方案为:10、20、40、60、90和120 m l/(m2.d)。结果:入组15例患者(每个剂量组为3例)中,11例为肝癌,2例胰腺癌和2例肺癌。第五剂量组结束时没有发现剂量限制性毒性(DLT)。其中14例患者可评价疗效,6例(42.9%)为SD,8例(57.1%)为PD。在第一剂量组中,1例肝癌患者肿瘤缩小20%并维持11个月。结论:本研究最高剂量达到常规剂量的8倍,尚未出现剂量限制性毒性。部分患者获得了肿瘤缩小或稳定的疗效。
文摘The present paper gives an overview of the key project ' South China Sea Monsoon Experiment (SCSMEX)' operated by the Ministry of Science and Technology of China during the period of 1996-2001. The SCSMEX is a joint atmospheric and oceanic field experiment which aims to better understand the onset, maintenance, and variability of the summer monsoon over the South China Sea (SCS). It is a large-scale international effort with many participating countries and regions cooperatively involved in this experiment. With the field observation in May-August 1998, a large amount of meteorological and oceanic data was acquired, which provides excellent datasets for the study of the SCS monsoon and the East Asian monsoon and their interaction with the ocean. The preliminary research achievements are as follows. (1) The earliest onset of the Asian monsoon over the SCS and Indo-China Peninsula has been well documented. Prom the viewpoint of the synoptic process, its onset is closely related to the early rapid development of a twin cyclone to the east of Sri Lanka. The conceptual modei of the SCS monsoon onset in 1998 was put forward. The 50-year time series of the SCS monsoon onset date was also made. (2) Two major modes, namely the 30-60-day and 10-20-day oscillations were ascertained. The influences of the abnormal SCS monsoon on the precipitation over eastern China and its modes were identifled. A strong (weak) monsoon over the SCS usually leads to less (more) precipitation over the middle and lower reaches of the Yangtze River basin, and more (less) precipitation in North China. (3) During the monsoon onset over the SCS, a wide variety of organized mesoscale convective systems (MCSs) were observed by a Doppler radar array deployed over the northern SCS. The relationship between large-scale circulations and MCSs during the monsoon onset process in 1998 was clearly revealed. It was suggested that there is a kind of positive feedback mechanism between large-scale circulations and MCSs. (4) The SST over the SCS during the early
文摘Colorectal cancer(CRC) is one of the leading causes of cancer-related death. Surgery, radiotherapy and chemotherapy have been till now the main therapeutic strategies for disease control and improvement of the overall survival. Twenty-five per cent(25%) of CRC patients have clinically detectable liver metastases at the initial diagnosis and approximately 50% develop liver metastases during their disease course. Twentythirty per cent(20%-30%) are CRC patients with metastases confined to the liver. Some years ago various studies showed a curative potential for liver metastases resection. For this reason some authors proposed the conversion of unresectable liver metastases to resectable to achieve cure. Since those results were published, a lot of regimens have been studied for resectability potential. Better results could be obtained by the combination of chemotherapy with targeted drugs, such as anti-VEGF and antiEGFR monoclonal antibodies. However an accurate selection for patients to treat with these regimens and to operate for liver metastases is mandatory to reduce the risk of complications. A multidisciplinary team approach represents the best way for a proper patient management. The team needs to include surgeons, oncologists, diagnostic and interventional radiologists with expertise in hepatobiliary disease, molecular pathologists, and clinical nurse specialists. This review summarizes the most important findings on surgery and systemic treatment of CRC-related liver metastases.
基金financial support from the Aeronautics Science Foundation of China(No.:2017ZF52066)National Nature Science Foundation of China(No.:11575085)+4 种基金Qing Lan ProjectSix talent peaks project in Jiangsu Province(No.:XCL-035)Jiangsu 333 talent projectthe Open Research Fund of Jiangsu Provincial Key Laboratory for Nanotechnology of Nanjing Universitythe Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘Currently,electromagnetic(EM) pollution poses severe complication toward the operation of electronic devices and biological systems.To this end,it is pertinent to develop novel microwave absorbers through compositional and structural design.Porous carbon(PC)materials demonstrate great potential in EM wave absorption due to their ultralow density,large surface area,and excellent dielectric loss ability.However,the large-scale production of PC materials through low-cost and simple synthetic route is a challenge.Deriving PC materials through biomass sources is a sustainable,ubiquitous,and low-cost method,which comes with many desired features,such as hierarchical texture,periodic pattern,and some unique nanoarchitecture.Using the bio-inspired microstructure to manufacture PC materials in mild condition is desirable.In this review,we summarize the EM wave absorption application of biomass-derived PC materials from optimizing structureand designing composition.The corresponding synthetic mechanisms and development prospects are discussed as well.The perspective in this field is given at the end of the article.
基金The present work is supported by National Science Foundation of China （NSFC 50376041）the National High Technology Development 863 Program （2006AA03Z349）the ShuGuang project of Shanghai Educational Development Foundation （04SG49）, which are gratefully acknowledged.
文摘In particle sizing by light extinction method, the regularization parameter plays an important role in applying regularization to find the solution to ill-posed inverse problems. We combine the generalized cross-validation （GCV） and L-curve criteria with the Twomey-NNLS algorithm in parameter optimization. Numerical simulation and experimental validation show that the resistance of the newly developed algorithms to measurement errors can be improved leading to stable inversion results for unimodal particle size distribution.
文摘Ⅰ. INTRODUCTION Bednorz and Müller have discovered possible superconductivity around 35K in Ba-La-Cu-O systems. Uchida and Takagi et al. have observed Meissner effect and determined superconductivity in the system. Within a few months, several groups have reported their successful results. Chu et al. pushed the T_c(onset) of Ba-La-Cu-O to 52K under hydrostatic pressure. Cava et al. obtained nearly single superconducting phase
文摘The incidence of biliary injury after laparoscopic cholecystectomy(LC) has shown a declining trend though it may still be twice that as with open cholecystectomy. Major biliary or vasculobiliary injury is associated with significant morbidity. As prevention is the best strategy, the concept of a culture of safe cholecystectomy has been recently introduced to educate surgeons and apprise them of basic tenets of safe performance of LC. Various aspects of safe cholecystectomy include:(1) thorough knowledge of relevant anatomy, various anatomical landmarks, and anatomical variations;(2) an understanding of the mechanisms involved in biliary/vascular injury, the most important being the misidentification injury;(3) identification of various preoperative and intraoperative predictors of difficult cholecystectomy;(4) proper gallbladder retraction;(5) safe use of various energy devices;(6) understanding the critical view of safety, including its doublet view and documentation;(7) awareness of various error traps(e.g., fundus first technique);(8) use of various bailout strategies(e.g., subtotal cholecystectomy) in difficult gallbladder cases;(9) use of intraoperative imaging techniques(e.g., intraoperative cholangiogram) to ascertain correct anatomy; and(10) understanding the concept of time-out.Surgeons should be facile with these aspects of this culture of safety in cholecystectomy in an attempt to reduce the incidence of biliary/vascular injury during LC.
基金the National Natural Science Foundation of China (Grant No. 20176028, 90210020)Huo Yingdong Education Foundation (Grant No. 81064)
文摘A novel technique for separating hydrogen from (H2 + CH4) gas mixtures through hydrate formation/dissociation was proposed. In this work, a systematic experimental study was performed on the separation of hydrogen from (H2 + CH4) feed mixtures with various hydrogen contents (mole fraction x = 40%–90%). The experimental results showed that the hydrogen content could be enriched to as high as ～94% for various feed mixtures using the proposed hydrate technology under a temperature slightly above 0°C and a pressure below 5.0 MPa. With the addition of a small amount of suitable additives, the rate of hydrate formation could be increased significantly. Anti-agglomeration was used to disperse hydrate particles into the condensate phase. Instead of preventing hydrate growth (as in the kinetic inhibitor tests), hydrates were allowed to form, but only as small dispersed particles. Anti-agglomeration could keep hydrate particles suspended in a range of condensate types at 1°C and 5 MPa in the water-in-oil emulsion.
文摘N,N-dibutyldiglycol amic acid （HL1） and N,N-dioctyldiglycol nmic acid （HLu） were synthesized and characterized by conventional spectroscopic methods. These molecules were examined as extractants for extraction-separation of La（Ⅲ）, Eu（Ⅲ） and Er（Ⅲ）, as representative ions of light, middle and heavy rare earths, from aqueous chloride solutions. The analysis of the extraction equilibria revealed that the extracted species of lanthanum and europium ions by both of the extractants had a 1：3 metal to ligand ratio It was suggested that erbium ions were extracted into the organic phase via the formation ofEr（LIor Ⅱ）2Cl complexes. The effect of the organic diluents on the extraction-separation efficiency of the studied rare earths by HLI and HLⅡ was investigated by comparing the results obtained in dichloromethane and carbon tetrachloride. Regardless to the diluent used, the order of selectivity presented by the investigated extractants was Er（Ⅲ）〉Eu（Ⅲ）〉La（Ⅲ）. It is noteworthy that, a significant enhancement in separation of the studied rare earths by the extractants was achieved in their competitive extraction experiments with respect to that obtained in single component extraction experiments. Applicability of the extractants for the removal of rare earth ions from spent Ni-MH batteries was tested by removal ofLa（Ⅲ）, Eu（Ⅲ） and Er（Ⅲ） ions from simulated leach solution of such batteries.
基金The authors appreciate the supports from the National Research Foundation(NRF),Prime Minister’s Office,Singapore,under its Campus for Research Excellence and Technological Enterprise(CREATE)programme.We also acknowledge financial support from the academic research fund AcRF tier 2(M4020246,ARC10/15),Ministry of Education,Singapore.
文摘Tuning and optimization of electronic structures and related reaction energetics are critical toward the rational design of efficient electrocatalysts.Herein,experimental and theoretical calculation demonstrate the originally inert N site within polyaniline(PANI)can be activated for hydrogen evolution by proper d-πinterfacial electronic coupling with metal oxide.As a result,the assynthesized WO3 assemblies@PANI via a facile redox-induced assembly and in situ polymerization,exhibits the electrocatalytic production of hydrogen better than other control samples including W18O49@PANI and most of the reported nobel-metal-free electrocatalysts,with low overpotential of 74 mV at 10 mA·cm−2 and small Tafel slope of 46 mV·dec−1 in 0.5M H2SO4(comparable to commercial Pt/C).The general efficacy of this methodology is also validated by extension to other metal oxides such as MoO3 with similar improvements.
基金The Natural Science Foundation of China(NSFC) financed the first period of research on the decoupled dual fluidized bed gasification(20606034,20776144)
文摘Various process residues represent a kind of biomass resource already concentrated but containing water as much as 60 wt.%. These materials are generally treated as waste or simply combusted directly to generate heat. Recently, we attempted to convert them into middle caloric gas to substitute for natural gas, as a chemical or a high-rank gaseous fuel for advanced combustion utilities. Such conversion is implemented through dual fluidized bed gasification （DFBG）. Concerning the high water content of the fuels, DFBG was suggested to accomplish either with high-efficiency fuel drying in advance or direct decoupling of fuel drying/pyrolysis from char gasification and tar/hydrocarbon reforming. Along with fuel drying, calcium-based catalyst can be impregnated into the fuel, without much additional cost, to increase the fuel＇s gasification reactivity and to reduce tar formation. This article reports the Ca impregnation method and its resulting effects on gasification reactivity and tar suppression ability. Meanwhile, the principle of directly gasifying wet fuel with decoupled dual fluidized bed gasification （D-DFBG） is also highlighted.
基金the National Basic Research Program of China (No. 2003CB615700) the National Natural Science Foundation of China (No. 20125618).
文摘A new reactor with integrated conventional slurry stirred reactor and ceramic external membrane emulsification system, was introduced in this paper. Toluene and toluene containing surfactant was separately used as dispersed phase for preparation of emulsions. Two kinds of emulsions were prepared and compared. The volume average sizes of prepared emulsions were 3.53μm and 3.6μm respectively. The results showed that the droplet sizes of two kinds of emulsions were similar, but the monodispersed emulsion was only obtained with addition of surfactant into the dispersed phase.
基金supported by the Natural Science Foundations of Xinjiang Automatic Region, China (Grant Nos. 200821104, 2009211B16, and 2010211B16)the Support Program of Science and Technology of Xinjiang Automatic Region, China (Grant No. 201091112)the West-Light Foundation of the Chinese Academy of Sciences (Grant No. RCPY200906)
文摘There remain a number of unsolved problems about chemical reactions, and it is significant to explore new detection methods because they always offer some unique information about reactions from new points of view. For the first time, the solidification course of a modified two-component acrylic structural adhesive is measured by using reed-vibration mechanical spectroscopy for liquids （RMS-L） in this work, and results show that there are four sequential processes of mechanical spectra with time. The in-depth analyses indicate that RMS-L can detect in real-time the generation and disappearance of active free radicals, as well as the chemical cross-link processes in the adhesive. This kind of real-time detection will undoubtedly facilitate the study of the chemical reaction dynamics controlled by free radicals.
基金funded by"Agencia Canaria de Inves-tigación,Innovación y Sociedad de la Información(ACIISI)del Gobierno de Canarias"(No.ProID2020010134),óCaja Canarias(Project No.2019SP43).
文摘Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and produce aggressive malignancies that causes millions of deaths every year.With the new understanding of the molecular mechanism(s)of disease progression,our knowledge about the disease is snowballing,leading to the evolution of many new therapeutic regimes and their successive trials.In the past few decades,various combinations of therapies have been pro-posed and are presently employed in the treatment of diverse cancers.Targeted drug therapy,immunotherapy,and personalized medicines are now largely being employed,which were not common a few years back.The field of cancer discoveries and therapeutics are evolving fast as cancer type-specific biomarkers are progressively being identified and several types of cancers are nowadays undergoing systematic therapies,extending patients’disease-free survival thereafter.Although growing evidence shows that a systematic and targeted approach could be the future of cancer medicine,chemotherapy remains a largely opted therapeutic option despite its known side effects on the patient’s physical and psychological health.Chemother-apeutic agents/pharmaceuticals served a great purpose over the past few decades and have remained the frontline choice for advanced-stage malignancies where surgery and/or radiation therapy cannot be prescribed due to specific reasons.The present report succinctly reviews the existing and contemporary advancements in chemotherapy and assesses the status of the enrolled drugs/pharmaceuticals;it also comprehensively discusses the emerging role of specific/targeted therapeutic strategies that are presently being employed to achieve better clinical success/survival rate in cancer patients.
基金Supported by Joint Funds for the Innovation of Science and Technology,Fujian Province,China,No.2021Y9227Natural Science Foundation of Fujian Province,China,No.2023J011254+2 种基金The Science Foundation for The Excellent Youth Scholars of Fujian Provincial Health Commission,China,No.2022ZQNZD009The Special Research Funds for Local Science and Technology Development Guided by Central Government,Fujian Province,China,No.2023L3020Fujian Medical University Student Innovation and Entrepreneurship Training Project,China,No.JC2023191.
文摘Immune checkpoint inhibitors(ICIs)are widely used due to their effectiveness in treating various tumors.Immune-related adverse events(irAEs)are defined as adverse effects resulting from ICI treatment.Gastrointestinal irAEs are a common type of irAEs characterized by intestinal side effects,such as diarrhea and colitis,which may lead to the cessation of ICIs.Although irAE gastritis is rarely reported,it may lead to serious complications such as gastrorrhagia.Furthermore,irAE gastritis is often difficult to identify early due to its diverse symptoms.Although steroid hormones and immunosuppressants are commonly used to reverse irAEs,the best regimen and dosage for irAE gastritis remains uncertain.In addition,the risk of recurrence of irAE gastritis after the reuse of ICIs should be considered.In this editorial,strategies such as early identification,pathological diagnosis,mana-gement interventions,and immunotherapy rechallenge are discussed to enable clinicians to better manage irAE gastritis and improve the prognosis of these patients.
文摘Background:Immune checkpoint inhibitors(ICIs)are standard treatments for advanced non-small cell lung cancer(NSCLC);however,evidence regarding their relative efficacy and safety is lacking.This study compared the efficacy and safety of all currently available ICI treatments in patients with advanced NSCLC to identify optimal treatment regimens.Methods:PubMed,Cochrane Central Register of Controlled Trials(CENTRAL),MEDLINE,and Embase databases were systematically searched for randomized controlled trials(RCTs)published up to August 8,2022.The primary outcomes were overall survival(OS)and progression-free survival(PFS).Secondary outcomes included objective response rate(ORR)and adverse events(AEs).Results:Forty RCTs involving 22,526 patients were selected,and a total of 26 treatment regimens were identified.Treatment with anti-programmed cell death protein-1(anti-PD-1)provided superior OS compared with anti-programmed death ligand 1(anti-PD-L1)treatment.ICIs plus platinum-based chemotherapy(PBC)were superior to ICIs treatment alone,although the addition of PBC increased treatment toxicity.Cemiplimab ranked first for OS and lowest for any-grade AEs in advanced NSCLC patients without PD-L1 selection.Regarding grade≥3 AEs,the toxicity of ICI monotherapy or ICI-ICI combination was consistently lower than that of the other treatments.For patients without PD-L1 selection,cemiplimab showed the best OS,pembrolizumab plus docetaxel(Pem-DXT)showed the best PFS,and atezolizumab plus bevacizumab and PBC(Atezo-Beva-PBC)showed the best ORR.Pembrolizumab plus PBC and Atezo-Beva-PBC were the most likely optimal treatments for OS and PFS in patients with PD-L1 expression<1%,respectively.In patients with PD-L1 expression≥1%,treatment regimens containing anti-PD-1 provided superior OS benefits compared with those of anti-PD-L1 treatment,and sintilimab plus PBC(Sint-PBC)provided the best OS benefit;as for PFS,ICI plus PBC consistently showed greater PFS benefits than ICI or PBC alone.For patients with anti-PD-L1 expression of 1-49%
基金supported by National Natural Science Foundation of China(No.51776015)。
文摘A novel thermal management system of cylindrical Li-ion battery with the liquid cooling in flexible microchannel plate was established in the study. The experiments were conducted with R141 b in flexible microchannel plates. The cooling system with the flexible aluminum microchannels can effectively transfer heat from battery to the cooling refrigerant R141 b based on flow boiling. A battery module with five cells along flow channel was chosen to study the effects of contact surface area and mass flux on the thermal performance and electrochemical characteristics in the experiments. Three types of structure with different contact areas were studied and their performances were compared with the experiments without cooling structures. The experiments were carried out at the same discharge rate with the inlet mass flow rates of 0–10 kg/h. For the inlet mass flow rate of 5.98 kg/h, the surface temperature and temperature uniformity of battery were the best, and the output voltage and capacity of batteries were higher than those under other mass flow rates. With given inlet mass flow rates, the five series cells exhibited different electrochemical performances, including output voltage and discharge capacity, due to the different refrigerant flow states in the microchannels. Finally, an optimal design was presented with thermal performances, macroscopic electrochemical characteristics, inlet mass flow rates and cooling performance taken into consideration.
基金the Research Foundation-Flanders (FWO) for a Research Project (G0B3218N)the financial support by the National Natural Science Foundation of China (22005054)+3 种基金Natural Science Foundation of Fujian Province (2021J01149)State Key Laboratory of Structural Chemistry (20200007)Sichuan Science and Technology Program (project No.: 2022ZYD0016 and 2023JDRC0013)the National Natural Science Foundation of China (project No. 21776120)。
文摘Lithium–sulfur(Li–S) batteries have received widespread attention, and lean electrolyte Li–S batteries have attracted additional interest because of their higher energy densities. This review systematically analyzes the effect of the electrolyte-to-sulfur(E/S) ratios on battery energy density and the challenges for sulfur reduction reactions(SRR) under lean electrolyte conditions. Accordingly, we review the use of various polar transition metal sulfur hosts as corresponding solutions to facilitate SRR kinetics at low E/S ratios(< 10 μL mg~(-1)), and the strengths and limitations of different transition metal compounds are presented and discussed from a fundamental perspective. Subsequently, three promising strategies for sulfur hosts that act as anchors and catalysts are proposed to boost lean electrolyte Li–S battery performance. Finally, an outlook is provided to guide future research on high energy density Li–S batteries.
