Objective: To study the association between serum neuron-specific enolase (NSE) and the extent of brain damage and the outcome after acute traumatic brain injury (TBI). Methods: The release patterns of serum NSE in 78...Objective: To study the association between serum neuron-specific enolase (NSE) and the extent of brain damage and the outcome after acute traumatic brain injury (TBI). Methods: The release patterns of serum NSE in 78 patients after acute TBI were analyzed by using the enzyme linked immunosobent assay. The levels of NSE were compared with Glasgow coma scale, the category of brain injury and the outcome after 6 months of injury. Results: There were different NSE values in patients with minor (12.96 μg/L±2.39 μg/L), moderate (23.44 μg/L±5.33 μg/L) and severe brain injury (42.68 μg/L±4.57 μg/L). After severe TBI, the concentration of NSE in patients with epidural hematomas was 13.38 μg/L±4.01 μg/L, 24.03 μg/L±2.85 μg/L in brain contusion without surgical intervention group, 55.20 μg/L±6.35 μg/L in brain contusion with surgical intervention group, and 83.85 μg/L±15.82 μg/L in diffuse brain swelling group. There were close correlations between NSE values and Glasgow coma scale (r=-0.608, P<0.01) and the extent of brain injury (r=0.75, P<0.01). Patients with poor outcome had significantly higher initial and peak NSE values than those with good outcome (66.40 μg/L±9.46 μg/L, 94.24 μg/L±13.75 μg/L vs 32.16 μg/L±4.21 μg/L, 34.08 μg/L±4.40 μg/L, P<0.01, respectively). Initial NSE values were negatively related to the outcome (r=-0.501, P<0.01). Most patients with poor outcomes had persisting or secondary elevated NSE values. Conclusions: Serum NSE is one of the valuable neurobiochemical markers for assessment of the severity of brain injury and outcome prediction.展开更多
Objective: To investigate the therapeutic potency of recombinant human Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in a rabbit myocardial infarction model. Methods: A myocardial infarction was created by...Objective: To investigate the therapeutic potency of recombinant human Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in a rabbit myocardial infarction model. Methods: A myocardial infarction was created by the ligation of the major ventricular branch of the left coronary artery in rabbits. After myocardial infarction, the animals were randomly assigned to GM-CSF treatment group, untreated groups and sham-operated group. The rabbits of the treated group were injected into GM-CSF by subcutaneous administration, 10 μg/kg/day, once a day for 5 days. The untreated and sham-operated group received a equal saline in the same manner as treated group. Six weeks later echocardiography and haemodynamic assessment were undertaken to assesse cardiac function. The size of the infarct region of the heart were also studied. Results: The untreated group exhibited significant higher left ventricle end-diastolic pressure, higher central venous pressure, and with significant lower mean blood pressure, lower peak first derivative of left ventricle pressure (dP/dt) than the sham group. Also, Rabbits in untreated group display significant systolic dysfunction shown by the decreased ejection fraction, diastolic dysfunction shown by increasing in the ratio of E wave to A wave (E/A), and display left ventricle enlargement. However, GS-CSF singnificantly prevented heart dysfunction, left ventricle enlargement, and reduced infarct size in treatment group. Conclusion: Administration GM-CSF after cardiac infarction can improve heart function. These findings indicate the technique may be a novel and simple therapeutic method for ischemic myocardium.展开更多
Over twenty thousand lightning location data obtained by using Lightning Location System(LLS) from Lanzhou and Beijing regions have been analysed to ascertain the characteristics of ground flashes in both regions. The...Over twenty thousand lightning location data obtained by using Lightning Location System(LLS) from Lanzhou and Beijing regions have been analysed to ascertain the characteristics of ground flashes in both regions. The strength of positive flashes is 5 times higher in Lanzhou than in Beijing. The strength of positive flashes is 3 times and 2.2 times as large as negative flashes in Beijing and in Lanzhou respectively. It has been found that the strength of positive and negative flashes is submitted to the normal distribution, and is independent of the characteristics of thunderstorm. So the lightning strength obtained by DF may be used to forecast the coming of thunderstorm. Although the stroke number in both regions decreases as exponent regulation, the maximum number of return stroke for one lightning in Beijing is more than that in Lanzhou. The peak flash rate occurs in late afternoon for both regions, but the maximum and minimum flash rate appeared an hour earlier in Beijing than in Lanzhou.The relationship between DF display and lightning radiation electric field, discharge current is obtained.展开更多
Pediatric autoimmune neuropsychiatric disorders associated with or without streptococcal and other bacterial infections (PANDAS/CANS) are emerging as a featured pediatric disorder. Although there is some controversy r...Pediatric autoimmune neuropsychiatric disorders associated with or without streptococcal and other bacterial infections (PANDAS/CANS) are emerging as a featured pediatric disorder. Although there is some controversy regarding treatment approaches, especially related to the behavioral sequelae, we have hypothesized in other published work that it is characterized by the rapid onset of Reward Deficiency Syndrome (RDS) in children. We propose utilizing a multi-systems biological approach involving the coupling of genetic addiction risk testing and pro-dopamine regulation (KB220/POLYGEN®) to help induce “dopamine homeostasis” in patients with PANDAS, especially those with known DNA-induced hypodopaminergia. This case study examines a 12-year-old Caucasian male with no prior psychiatric issues who presented with a sudden onset of severe anxiety, depression, emotional liability, and suicidal ideation. The patient underwent genotyping and the genetic addiction risk score (GARS) testing, which revealed risk polymorphisms in the dopamine D2 (-DRD2/ANKK (Taq1A), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) genes. These polymorphisms have been linked to hypodopaminergia. The patient was subsequently placed on research ID-KB220ZPBMPOLY (POLYGEN®), and albeit the possibility of bias, based upon self and parental assessment, a marked rapid improvement in psychiatric symptoms was observed. In the second phase of treatment (102 days utilizing KB220), the patient received standard antibody testing, which was positive for Lyme. Antibacterial therapy started immediately, and KB220z was discontinued to provide a wash-out period. A monotonic trend analysis was performed on each outcome measure, and a consistently decreasing trend was observed utilizing antibacterial therapy. Our recommendation, albeit only one case, is to utilize and further research a combined therapeutic approach, involving precision-guided DNA testing and pro-dopamine regulation along with antibacterial therapy, as well as glutathione to address offensive enhanced展开更多
Herein,the successful preparation of a singleatom catalyst V-N-C using vanadium-doped zeolitic imidazolate framework(ZIF)-8 as a precursor is reported.The experimental results showed that the V-N-C had a good promotin...Herein,the successful preparation of a singleatom catalyst V-N-C using vanadium-doped zeolitic imidazolate framework(ZIF)-8 as a precursor is reported.The experimental results showed that the V-N-C had a good promoting effect on the hydrogen storage performance of MgH_(2),and the optimal addition amount of V-N-C was 10wt%.The hydrogenation and dehydrogenation apparent activation energies of 10 wt%V-N-C-catalyzed MgH_(2)were reduced by 44.9 and 53.5 kJ·mol^(-1),respectively,compared to those of additive-free MgH_(2).The 10 wt%V-N-C-catalyzed MgH_(2)could reabsorb 5.92 wt%of hydrogen in 50 min at 150℃,with a capacity retention rate of 99.1%after 30 cycles of hydrogen absorption and desorption.Mechanism analysis showed that V-N-C was partially transformed into VN and metallic V when it was milled with MgH_(2);the in-situ-formed VN and metallic V played an important role in improving the hydrogen storage performance of MgH_(2).This approach provides a potential solution for obtaining high-performance Mg-based hydrogen storage materials through synergistic interactions between V,N and C.展开更多
The intracavity photon density is assumed to be of Gaussian spatial distributions and its longitudinal variation is also considered in the rate equations for a laser diode (LD) end-pumped passively Q-switched Nd:YVO4 ...The intracavity photon density is assumed to be of Gaussian spatial distributions and its longitudinal variation is also considered in the rate equations for a laser diode (LD) end-pumped passively Q-switched Nd:YVO4 laser with GaAs saturable absorber. These space-dependent rate equations are solved numerically. The dependences of pulse width, pulse repetition rate, single-pulse energy, and peak power on incident pump power are obtained. In the experiment, the LD end-pumped passively Q-switched Nd:YVO4 laser with GaAs saturable absorber is realized and the experimental results are consistent with the numerical solutions.展开更多
To improve the goodness of fitting 57Fe M?ssbauer spectra of ferromagnetic amorphous alloys, two problems should be resolved:（ⅰ）How to analyse the asymmetry of peak amplitudes and peak widths in the spectrum about ...To improve the goodness of fitting 57Fe M?ssbauer spectra of ferromagnetic amorphous alloys, two problems should be resolved:（ⅰ）How to analyse the asymmetry of peak amplitudes and peak widths in the spectrum about the spectrum centre; （ⅱ） how to correct the parameters concerned, e. g. the peak area ratio and peak widths in basic subspectra and the average isomer shift, in fitting spectra with the Hesse method or the Window method. In the present note the asym-展开更多
In this paper, we report a high peak power passively Q-switched laser-diode-end-pumped Nd:YVO_4/Cr^(4+):YAG laser polarized along the C axis, generating 4.23-W average power and 18-kW peak power (144-μJ pulse power) ...In this paper, we report a high peak power passively Q-switched laser-diode-end-pumped Nd:YVO_4/Cr^(4+):YAG laser polarized along the C axis, generating 4.23-W average power and 18-kW peak power (144-μJ pulse power) with 8.0-ns time duration (29.4-kHz repetition rate) at 1064 nm while the pump power is 21.2 W.展开更多
How the dynamics in soil loss(SL) and sedimentation are affected by land use/cover change(LULCC) has long been one of the most important issues in watershed management worldwide, especially in fragile mountainous rive...How the dynamics in soil loss(SL) and sedimentation are affected by land use/cover change(LULCC) has long been one of the most important issues in watershed management worldwide, especially in fragile mountainous river basins. This study aimed to investigate the impact of LULCC on SL and sediment export(SE) in eastern regions of the Koshi River basin(KRB), Nepal, from 1990 to 2021. The Random Forest classifier in the Google Earth Engine platform was employed for land use/land cover(LULC) classification, and the Integrated Valuation Ecosystem Services and Trade-offs(InVEST) Sediment Delivery Ratio model was used for SL and SE modeling. The results showed that there was a pronounced increase in forest land(4.12%), grassland(2.35%), and shrubland(3.68%) at the expense of agricultural land(10.32%) in KRB over the last three decades. Thus, the mean SL and SE rates decreased by 48% and 60%, respectively, from 1990 to 2021. The conversion of farmland to vegetated lands has greatly contributed to the decrease in SL and SE rates. Furthermore, the rates of SL and SE showed considerable spatiotemporal variations under different LULC types, topographic factors(slope aspect and gradient), and sub-watersheds. The higher rates of SL and SE in the study area were observed mostly in slope gradient classes between 8° and 35°(accounting for 83%–91%) and sunny and semi-sunny slope aspects(SE, S, E, and SW)(accounting for 57%–65%). Although the general mean rate of SL presented a decreasing trend in the study area, the current mean SL rate(23.33 t ha^(-1)yr^(-1)) in 2021 is still far beyond the tolerable SL rate of both the global(10 Mg ha^(-1)yr^(-1)) and the Himalayan region(15 t ha^(-1)yr^(-1)). Therefore, landscape restoration measures should be integrated with other watershed management strategies and upscaled to hotspot areas to regulate basin sediment flux and secure ecosystem service sustainability.展开更多
Increased accuracy of proton beam delivery provides additional benefits to the patients undergo the treatment.A prompt gamma imaging detector can provide additional information during the treatment,as the prompt gamma...Increased accuracy of proton beam delivery provides additional benefits to the patients undergo the treatment.A prompt gamma imaging detector can provide additional information during the treatment,as the prompt gammas produced by the interactions between protons and human tissues are related to the range and profile of the beam in the patient.This paper makes a Monte Carlo feasibility study for a pixelated prompt gamma imaging detector which can not only measure the proton range but also merge the beam profile and 3D beam image inside the patient.FLUKA simulation result shows that this detector can reduce background noise and measure the range and beam profile by using of grated shielding material,vertical gammas selection and a 5MeV energy window.展开更多
The 2,2,6,6-tetramethylpiperidine nitroxide radicals have been receiving more and more attention from people owing to their thermal stability and application for protecting polymer materials from photo-oxidation and p...The 2,2,6,6-tetramethylpiperidine nitroxide radicals have been receiving more and more attention from people owing to their thermal stability and application for protecting polymer materials from photo-oxidation and photo-degradation. In their EI mass spectra the relative intensity of the peak of the nitroxide radical with mass number (FW+1) is usually greater than that calculated according to its natural abundance of elemental composition of the FW peak, and sometimes even greater than that of the FW peak. Therefore, it was difficult to assign the formula weight (FW) of nitroxide radical by the EI method.展开更多
Studies were performed in 20 patients with breast cancer, who received 26 cycles of high-dose cisplatin (100 mg/m2, IV. drip). In twenty-five cycles of them urinary Alb, IgG and NAG showed abnormal values. The patient...Studies were performed in 20 patients with breast cancer, who received 26 cycles of high-dose cisplatin (100 mg/m2, IV. drip). In twenty-five cycles of them urinary Alb, IgG and NAG showed abnormal values. The patients were divided into low-nephrotoxicity and high-nephrotoxicity groups by the degree of renal dysfunction. Thirty-five percent of the patients exhibited high-nephrotoxicity. These patients had significantly higher plasma and/ or urinary Pt peak levels during cisplatin (CP) infusion than did low-nephrotoxicity. 70 - 80% of the patients developed significant nephrotoxicity when urinary Pt peak level rose up to 40 fig/ml or plasma Pt peak level >4 μg/ml. It is quite important to reduce nephrotoxicity that urinary Pt level is controlled below 40 μg/ml and plasma Pt level <4 μg/ml. It is suggested that urine output should be maintained over 300 ml/hr during 2 hours before and after the end of infusion and >100 ml/hr during 3 days after the infusion. That may keep the nephrotoxicity of CP in less serious degree and easy to recover.展开更多
As a current popular method,intelligent detection of cracks is of great significance to road safety,so deep learning has gradually attracted attention in the field of crack image detection.The nonlinear structure,low ...As a current popular method,intelligent detection of cracks is of great significance to road safety,so deep learning has gradually attracted attention in the field of crack image detection.The nonlinear structure,low contrast and discontinuity of cracks bring great challenges to existing crack detection methods based on deep learning.Therefore,an end-to-end deep convolutional neural network(AttentionCrack)is proposed for automatic crack detection to overcome the inaccuracy of boundary location between crack and non-crack pixels.The AttentionCrack network is built on U-Net based encoder-decoder architecture,and an attention mechanism is incorporated into the multi-scale convolutional feature to enhance the recognition of crack region.Additionally,a dilated convolution module is introduced in the encoder-decoder architecture to reduce the loss of crack detail due to the pooling operation in the encoder network.Furthermore,since up-sampling will lead to the loss of crack boundary information in the decoder network,a depthwise separable residual module is proposed to capture the boundary information of pavement crack.The AttentionCrack net on public pavement crack image datasets named CrackSegNet and Crack500 is trained and tested,the results demonstrate that the AttentionCrack achieves F1 score over 0.70 on the CrackSegNet and 0.71 on the Crack500 in average and outperforms the current state-of-the-art methods.展开更多
The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Wester...The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011.展开更多
Double-copy retroviral vector containing human factor Ⅸ cDNA driven by human cytomegalovirus enhancer-promoter was constructed. The vector was introduced into the amphotropic packaging cell line PA317. The recombinan...Double-copy retroviral vector containing human factor Ⅸ cDNA driven by human cytomegalovirus enhancer-promoter was constructed. The vector was introduced into the amphotropic packaging cell line PA317. The recombinant virus produced in PA317 was used to transduce skin fibroblasts from a hemophilia B patient. The infected cells produced high levels of biologically active human factor Ⅸ at a rate of 3420 ng/10~6 cells/24 h. These cells were embedded in a collagen matrix and implanted into the peritoneal cavity or subcutaneous space of mice. It was demonstrated that human factor Ⅸ was produced by the implants for at least 12 days in vivo, reaching a peak of 105 ng/ml plasma. Over 90% of the protein was functionally active. This technique has the potential to be developed into a new approach for gene therapy for hemophilia B.展开更多
Background:To understand the dietary composition of the highly aerial swift(Apodidae),ecologists conventionally depend on the morphological identification of prey items from food boluses or stomach contents,but these ...Background:To understand the dietary composition of the highly aerial swift(Apodidae),ecologists conventionally depend on the morphological identification of prey items from food boluses or stomach contents,but these techniques are often invasive,require expertise in identification,and often cannot produce accurate identifications at the species level.Methods:DNA barcoding was used to analyse the dietary composition of House Swifts(Apus nipalensis)in Hong Kong,China.Faecal samples from five different colonial nest sites were collected between 2019 and 2020.We used universal primers to amplify a region of the cytochrome C oxidase gene from prey DNA in the faecal samples for identification purposes.Results:Ten different orders and 44 families from three different classes of Arthropoda were identified in the collected faecal samples.Hymenoptera,Hemiptera and Diptera were the most prevalent groups of prey found in the samples.Differences in the dietary composition of House Swifts during the breeding(April to September)and nonbreeding(October to March)season were also found.Hymenoptera,particularly ants(Formicidae),were predominant in the diet during the breeding season,whereas Diptera and Hemiptera were predominant during the non-breeding season.Conclusion:The prey groups identified in this study were similar to those identified in a previous study of the diet of House Swift,which also suggests a possible role of House Swifts in reducing the numbers of local insect pests.This study demonstrates the usefulness of applying molecular tools for the dietary analysis of aerial feeders.Conserving local forested areas may be crucial for the maintenance of House Swift population.展开更多
Peak oil theory is a theory concerning long-term oil reserves and the rate of oil production. Peak oil refers to the maximum rate of the production of oil or gas in any area under consideration. Its inevitability is a...Peak oil theory is a theory concerning long-term oil reserves and the rate of oil production. Peak oil refers to the maximum rate of the production of oil or gas in any area under consideration. Its inevitability is analyzed from three aspects. The factors that influence peak oil and their mechanisms are discussed. These include the amount of resources, the discovery maturity of resources, the depletion rate of reserves and the demand for oil. The advance in the study of peak oil in China is divided into three stages. The main characteristics, main researchers, forecast results and research methods are described in each stage. The progress of the study of peak oil in China is summarized and the present problems are analyzed. Finally three development trends of peak oil study in China are presented.展开更多
文摘Objective: To study the association between serum neuron-specific enolase (NSE) and the extent of brain damage and the outcome after acute traumatic brain injury (TBI). Methods: The release patterns of serum NSE in 78 patients after acute TBI were analyzed by using the enzyme linked immunosobent assay. The levels of NSE were compared with Glasgow coma scale, the category of brain injury and the outcome after 6 months of injury. Results: There were different NSE values in patients with minor (12.96 μg/L±2.39 μg/L), moderate (23.44 μg/L±5.33 μg/L) and severe brain injury (42.68 μg/L±4.57 μg/L). After severe TBI, the concentration of NSE in patients with epidural hematomas was 13.38 μg/L±4.01 μg/L, 24.03 μg/L±2.85 μg/L in brain contusion without surgical intervention group, 55.20 μg/L±6.35 μg/L in brain contusion with surgical intervention group, and 83.85 μg/L±15.82 μg/L in diffuse brain swelling group. There were close correlations between NSE values and Glasgow coma scale (r=-0.608, P<0.01) and the extent of brain injury (r=0.75, P<0.01). Patients with poor outcome had significantly higher initial and peak NSE values than those with good outcome (66.40 μg/L±9.46 μg/L, 94.24 μg/L±13.75 μg/L vs 32.16 μg/L±4.21 μg/L, 34.08 μg/L±4.40 μg/L, P<0.01, respectively). Initial NSE values were negatively related to the outcome (r=-0.501, P<0.01). Most patients with poor outcomes had persisting or secondary elevated NSE values. Conclusions: Serum NSE is one of the valuable neurobiochemical markers for assessment of the severity of brain injury and outcome prediction.
文摘Objective: To investigate the therapeutic potency of recombinant human Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in a rabbit myocardial infarction model. Methods: A myocardial infarction was created by the ligation of the major ventricular branch of the left coronary artery in rabbits. After myocardial infarction, the animals were randomly assigned to GM-CSF treatment group, untreated groups and sham-operated group. The rabbits of the treated group were injected into GM-CSF by subcutaneous administration, 10 μg/kg/day, once a day for 5 days. The untreated and sham-operated group received a equal saline in the same manner as treated group. Six weeks later echocardiography and haemodynamic assessment were undertaken to assesse cardiac function. The size of the infarct region of the heart were also studied. Results: The untreated group exhibited significant higher left ventricle end-diastolic pressure, higher central venous pressure, and with significant lower mean blood pressure, lower peak first derivative of left ventricle pressure (dP/dt) than the sham group. Also, Rabbits in untreated group display significant systolic dysfunction shown by the decreased ejection fraction, diastolic dysfunction shown by increasing in the ratio of E wave to A wave (E/A), and display left ventricle enlargement. However, GS-CSF singnificantly prevented heart dysfunction, left ventricle enlargement, and reduced infarct size in treatment group. Conclusion: Administration GM-CSF after cardiac infarction can improve heart function. These findings indicate the technique may be a novel and simple therapeutic method for ischemic myocardium.
文摘Over twenty thousand lightning location data obtained by using Lightning Location System(LLS) from Lanzhou and Beijing regions have been analysed to ascertain the characteristics of ground flashes in both regions. The strength of positive flashes is 5 times higher in Lanzhou than in Beijing. The strength of positive flashes is 3 times and 2.2 times as large as negative flashes in Beijing and in Lanzhou respectively. It has been found that the strength of positive and negative flashes is submitted to the normal distribution, and is independent of the characteristics of thunderstorm. So the lightning strength obtained by DF may be used to forecast the coming of thunderstorm. Although the stroke number in both regions decreases as exponent regulation, the maximum number of return stroke for one lightning in Beijing is more than that in Lanzhou. The peak flash rate occurs in late afternoon for both regions, but the maximum and minimum flash rate appeared an hour earlier in Beijing than in Lanzhou.The relationship between DF display and lightning radiation electric field, discharge current is obtained.
文摘Pediatric autoimmune neuropsychiatric disorders associated with or without streptococcal and other bacterial infections (PANDAS/CANS) are emerging as a featured pediatric disorder. Although there is some controversy regarding treatment approaches, especially related to the behavioral sequelae, we have hypothesized in other published work that it is characterized by the rapid onset of Reward Deficiency Syndrome (RDS) in children. We propose utilizing a multi-systems biological approach involving the coupling of genetic addiction risk testing and pro-dopamine regulation (KB220/POLYGEN®) to help induce “dopamine homeostasis” in patients with PANDAS, especially those with known DNA-induced hypodopaminergia. This case study examines a 12-year-old Caucasian male with no prior psychiatric issues who presented with a sudden onset of severe anxiety, depression, emotional liability, and suicidal ideation. The patient underwent genotyping and the genetic addiction risk score (GARS) testing, which revealed risk polymorphisms in the dopamine D2 (-DRD2/ANKK (Taq1A), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) genes. These polymorphisms have been linked to hypodopaminergia. The patient was subsequently placed on research ID-KB220ZPBMPOLY (POLYGEN®), and albeit the possibility of bias, based upon self and parental assessment, a marked rapid improvement in psychiatric symptoms was observed. In the second phase of treatment (102 days utilizing KB220), the patient received standard antibody testing, which was positive for Lyme. Antibacterial therapy started immediately, and KB220z was discontinued to provide a wash-out period. A monotonic trend analysis was performed on each outcome measure, and a consistently decreasing trend was observed utilizing antibacterial therapy. Our recommendation, albeit only one case, is to utilize and further research a combined therapeutic approach, involving precision-guided DNA testing and pro-dopamine regulation along with antibacterial therapy, as well as glutathione to address offensive enhanced
基金financially supported by the National Natural Science Foundation of China(Nos.52261038 and 51861002)Nanning Excellent Young Talents Cultivation Project of Scientific and Technological Innovation and Entrepreneurship(No.RC20220102)。
文摘Herein,the successful preparation of a singleatom catalyst V-N-C using vanadium-doped zeolitic imidazolate framework(ZIF)-8 as a precursor is reported.The experimental results showed that the V-N-C had a good promoting effect on the hydrogen storage performance of MgH_(2),and the optimal addition amount of V-N-C was 10wt%.The hydrogenation and dehydrogenation apparent activation energies of 10 wt%V-N-C-catalyzed MgH_(2)were reduced by 44.9 and 53.5 kJ·mol^(-1),respectively,compared to those of additive-free MgH_(2).The 10 wt%V-N-C-catalyzed MgH_(2)could reabsorb 5.92 wt%of hydrogen in 50 min at 150℃,with a capacity retention rate of 99.1%after 30 cycles of hydrogen absorption and desorption.Mechanism analysis showed that V-N-C was partially transformed into VN and metallic V when it was milled with MgH_(2);the in-situ-formed VN and metallic V played an important role in improving the hydrogen storage performance of MgH_(2).This approach provides a potential solution for obtaining high-performance Mg-based hydrogen storage materials through synergistic interactions between V,N and C.
基金This work was supported by the Science and Technol- ogy Development Program of Shandong Province (No. 013060102).
文摘The intracavity photon density is assumed to be of Gaussian spatial distributions and its longitudinal variation is also considered in the rate equations for a laser diode (LD) end-pumped passively Q-switched Nd:YVO4 laser with GaAs saturable absorber. These space-dependent rate equations are solved numerically. The dependences of pulse width, pulse repetition rate, single-pulse energy, and peak power on incident pump power are obtained. In the experiment, the LD end-pumped passively Q-switched Nd:YVO4 laser with GaAs saturable absorber is realized and the experimental results are consistent with the numerical solutions.
文摘To improve the goodness of fitting 57Fe M?ssbauer spectra of ferromagnetic amorphous alloys, two problems should be resolved:（ⅰ）How to analyse the asymmetry of peak amplitudes and peak widths in the spectrum about the spectrum centre; （ⅱ） how to correct the parameters concerned, e. g. the peak area ratio and peak widths in basic subspectra and the average isomer shift, in fitting spectra with the Hesse method or the Window method. In the present note the asym-
文摘In this paper, we report a high peak power passively Q-switched laser-diode-end-pumped Nd:YVO_4/Cr^(4+):YAG laser polarized along the C axis, generating 4.23-W average power and 18-kW peak power (144-μJ pulse power) with 8.0-ns time duration (29.4-kHz repetition rate) at 1064 nm while the pump power is 21.2 W.
基金Chinese Academy of Sciences (CAS) Overseas Institution Platform Project,No.131C11KYSB20200033。
文摘How the dynamics in soil loss(SL) and sedimentation are affected by land use/cover change(LULCC) has long been one of the most important issues in watershed management worldwide, especially in fragile mountainous river basins. This study aimed to investigate the impact of LULCC on SL and sediment export(SE) in eastern regions of the Koshi River basin(KRB), Nepal, from 1990 to 2021. The Random Forest classifier in the Google Earth Engine platform was employed for land use/land cover(LULC) classification, and the Integrated Valuation Ecosystem Services and Trade-offs(InVEST) Sediment Delivery Ratio model was used for SL and SE modeling. The results showed that there was a pronounced increase in forest land(4.12%), grassland(2.35%), and shrubland(3.68%) at the expense of agricultural land(10.32%) in KRB over the last three decades. Thus, the mean SL and SE rates decreased by 48% and 60%, respectively, from 1990 to 2021. The conversion of farmland to vegetated lands has greatly contributed to the decrease in SL and SE rates. Furthermore, the rates of SL and SE showed considerable spatiotemporal variations under different LULC types, topographic factors(slope aspect and gradient), and sub-watersheds. The higher rates of SL and SE in the study area were observed mostly in slope gradient classes between 8° and 35°(accounting for 83%–91%) and sunny and semi-sunny slope aspects(SE, S, E, and SW)(accounting for 57%–65%). Although the general mean rate of SL presented a decreasing trend in the study area, the current mean SL rate(23.33 t ha^(-1)yr^(-1)) in 2021 is still far beyond the tolerable SL rate of both the global(10 Mg ha^(-1)yr^(-1)) and the Himalayan region(15 t ha^(-1)yr^(-1)). Therefore, landscape restoration measures should be integrated with other watershed management strategies and upscaled to hotspot areas to regulate basin sediment flux and secure ecosystem service sustainability.
文摘Increased accuracy of proton beam delivery provides additional benefits to the patients undergo the treatment.A prompt gamma imaging detector can provide additional information during the treatment,as the prompt gammas produced by the interactions between protons and human tissues are related to the range and profile of the beam in the patient.This paper makes a Monte Carlo feasibility study for a pixelated prompt gamma imaging detector which can not only measure the proton range but also merge the beam profile and 3D beam image inside the patient.FLUKA simulation result shows that this detector can reduce background noise and measure the range and beam profile by using of grated shielding material,vertical gammas selection and a 5MeV energy window.
基金supported in part by the National Science Fund China(81571317)the Science Foundation of Shanghai Mental Health Center(SMHCRSD01)+1 种基金the Beijing Training Project for the Leading Talents in S&T(Z151100000315020)a grant from the Beijing Municipal Science&Technology Commission Grant(Z161100000216138)
文摘背景:精神分裂症存在情感体验和表达障碍。然而,大多数以往研究往往只局限于情感体验(尤其是快感缺乏)或只针对表达。较少有同时研究精神分裂症患者情感体验和表达。目的 :本研究旨在考察精神分裂症患者的快感体验和情感表达。尤其是,特别关注精神分裂症患者的情感障碍(包括快感体验和表达)和阴性症状之间的关系。方法 :150例患者完成了愉快情绪体验量表(Temporal Experience of Pleasure Scale)和情感表达量表(Emotional Expressivity Scale)的评估。结果 :精神分裂症患者表现出快感缺乏,但情感表达的能力完整。以阴性症状为主的精神分裂症患者在期待性愉快体验,尤其是抽象性期待愉快体验上的缺损更为明显结论:研究结果表明,精神分裂症患者存在出快感缺乏,但他们表达情感的能力似乎完好无损。快感缺乏尤以阴性症状为主的精神分裂症患者更为突出。
文摘The 2,2,6,6-tetramethylpiperidine nitroxide radicals have been receiving more and more attention from people owing to their thermal stability and application for protecting polymer materials from photo-oxidation and photo-degradation. In their EI mass spectra the relative intensity of the peak of the nitroxide radical with mass number (FW+1) is usually greater than that calculated according to its natural abundance of elemental composition of the FW peak, and sometimes even greater than that of the FW peak. Therefore, it was difficult to assign the formula weight (FW) of nitroxide radical by the EI method.
文摘Studies were performed in 20 patients with breast cancer, who received 26 cycles of high-dose cisplatin (100 mg/m2, IV. drip). In twenty-five cycles of them urinary Alb, IgG and NAG showed abnormal values. The patients were divided into low-nephrotoxicity and high-nephrotoxicity groups by the degree of renal dysfunction. Thirty-five percent of the patients exhibited high-nephrotoxicity. These patients had significantly higher plasma and/ or urinary Pt peak levels during cisplatin (CP) infusion than did low-nephrotoxicity. 70 - 80% of the patients developed significant nephrotoxicity when urinary Pt peak level rose up to 40 fig/ml or plasma Pt peak level >4 μg/ml. It is quite important to reduce nephrotoxicity that urinary Pt level is controlled below 40 μg/ml and plasma Pt level <4 μg/ml. It is suggested that urine output should be maintained over 300 ml/hr during 2 hours before and after the end of infusion and >100 ml/hr during 3 days after the infusion. That may keep the nephrotoxicity of CP in less serious degree and easy to recover.
基金supported by the National Natural Science Foundation of China under Grant No.62001004the Key Provincial Natural Science Research Projects of Colleges and Universities in Anhui Province under Grant No.KJ2019A0768+2 种基金the Key Research and Development Program of Anhui Province under Grant No.202104A07020017the Research Project Reserve of Anhui Jianzhu University under Grant No.2020XMK04the Natural Science Foundation of the Anhui Higher Education Institutions of China,No.KJ2019A0789.
文摘As a current popular method,intelligent detection of cracks is of great significance to road safety,so deep learning has gradually attracted attention in the field of crack image detection.The nonlinear structure,low contrast and discontinuity of cracks bring great challenges to existing crack detection methods based on deep learning.Therefore,an end-to-end deep convolutional neural network(AttentionCrack)is proposed for automatic crack detection to overcome the inaccuracy of boundary location between crack and non-crack pixels.The AttentionCrack network is built on U-Net based encoder-decoder architecture,and an attention mechanism is incorporated into the multi-scale convolutional feature to enhance the recognition of crack region.Additionally,a dilated convolution module is introduced in the encoder-decoder architecture to reduce the loss of crack detail due to the pooling operation in the encoder network.Furthermore,since up-sampling will lead to the loss of crack boundary information in the decoder network,a depthwise separable residual module is proposed to capture the boundary information of pavement crack.The AttentionCrack net on public pavement crack image datasets named CrackSegNet and Crack500 is trained and tested,the results demonstrate that the AttentionCrack achieves F1 score over 0.70 on the CrackSegNet and 0.71 on the Crack500 in average and outperforms the current state-of-the-art methods.
基金supported by the Project-Oriented Hundred Talents Programme (O7CX031003)the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-YW-R-131, KSCX2-EW-J-8)a grant from the National Science Fund for Distinguished Young Scholars(81088001) to Raymond Chan
文摘The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011.
文摘Double-copy retroviral vector containing human factor Ⅸ cDNA driven by human cytomegalovirus enhancer-promoter was constructed. The vector was introduced into the amphotropic packaging cell line PA317. The recombinant virus produced in PA317 was used to transduce skin fibroblasts from a hemophilia B patient. The infected cells produced high levels of biologically active human factor Ⅸ at a rate of 3420 ng/10~6 cells/24 h. These cells were embedded in a collagen matrix and implanted into the peritoneal cavity or subcutaneous space of mice. It was demonstrated that human factor Ⅸ was produced by the implants for at least 12 days in vivo, reaching a peak of 105 ng/ml plasma. Over 90% of the protein was functionally active. This technique has the potential to be developed into a new approach for gene therapy for hemophilia B.
基金supported by one-line budget(5501703),provide from the School of Life Sciences,The Chinese University of Hong Kong。
文摘Background:To understand the dietary composition of the highly aerial swift(Apodidae),ecologists conventionally depend on the morphological identification of prey items from food boluses or stomach contents,but these techniques are often invasive,require expertise in identification,and often cannot produce accurate identifications at the species level.Methods:DNA barcoding was used to analyse the dietary composition of House Swifts(Apus nipalensis)in Hong Kong,China.Faecal samples from five different colonial nest sites were collected between 2019 and 2020.We used universal primers to amplify a region of the cytochrome C oxidase gene from prey DNA in the faecal samples for identification purposes.Results:Ten different orders and 44 families from three different classes of Arthropoda were identified in the collected faecal samples.Hymenoptera,Hemiptera and Diptera were the most prevalent groups of prey found in the samples.Differences in the dietary composition of House Swifts during the breeding(April to September)and nonbreeding(October to March)season were also found.Hymenoptera,particularly ants(Formicidae),were predominant in the diet during the breeding season,whereas Diptera and Hemiptera were predominant during the non-breeding season.Conclusion:The prey groups identified in this study were similar to those identified in a previous study of the diet of House Swift,which also suggests a possible role of House Swifts in reducing the numbers of local insect pests.This study demonstrates the usefulness of applying molecular tools for the dietary analysis of aerial feeders.Conserving local forested areas may be crucial for the maintenance of House Swift population.
文摘Peak oil theory is a theory concerning long-term oil reserves and the rate of oil production. Peak oil refers to the maximum rate of the production of oil or gas in any area under consideration. Its inevitability is analyzed from three aspects. The factors that influence peak oil and their mechanisms are discussed. These include the amount of resources, the discovery maturity of resources, the depletion rate of reserves and the demand for oil. The advance in the study of peak oil in China is divided into three stages. The main characteristics, main researchers, forecast results and research methods are described in each stage. The progress of the study of peak oil in China is summarized and the present problems are analyzed. Finally three development trends of peak oil study in China are presented.
