In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some ...In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has developed.We are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under construction.In addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR facilities.So apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development.展开更多
The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapi...The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers.展开更多
The significance of graphene and its two-dimensional(2D)analogous inorganic layered materials especially as hexagonal boron nitride(h-BN)and molybdenum disulphide(MoS2)for“clean energy”applications became apparent o...The significance of graphene and its two-dimensional(2D)analogous inorganic layered materials especially as hexagonal boron nitride(h-BN)and molybdenum disulphide(MoS2)for“clean energy”applications became apparent over the last few years due to their extraordinary properties.In this review article we study the current progress and selected challenges in the syntheses of graphene,h-BN and MoS2 including energy storage applications as supercapacitors and batteries.Various substrates/catalysts(metals/insulator/semiconducting)have been used to obtain graphene,h-BN and MoS2 using different kinds of precursors.The most widespread methods for synthesis of graphene,h-BN and MoS2 layers are chemical vapor deposition(CVD),plasma-enhanced CVD,hydro/solvothermal methods,liquid phase exfoliation,physical methods etc.Current research has shown that graphene,h-BN and MoS2 layered materials modified with metal oxide can have an insightful influence on the performance of energy storage devices as supercapacitors and batteries.This review article also contains the discussion on the opportunities and perspectives of these materials(graphene,h-BN and MoS2)in the energy storage fields.We expect that this witen review article including recent research on energy storage will help in generating new insights for further development and practical applications of graphene,h-BN and MoS2 layers based materials.展开更多
Silver nanowires （AgNWs） have emerged as a promising nanomaterial for next generation stretchable electronics. However, until now, the fabrication of AgNW- based components has been hampered by complex and time-cons...Silver nanowires （AgNWs） have emerged as a promising nanomaterial for next generation stretchable electronics. However, until now, the fabrication of AgNW- based components has been hampered by complex and time-consuming steps. Here, we introduce a facile, fast, and one-step methodology for the fabrication of highly conductive and stretchable AgNW/polyurethane （PU） composite electrodes based on a high-intensity pulsed light （HIPL） technique. HIPL simultaneously improved wire-wire junction conductivity and wire-substrate adhesion at room temperature and in air within 50 μs, omitting the complex transfer-curing-implanting process. Owing to the localized deformation of PU at interfaces with AgNWs, embedding of the nanowires was rapidly carried out without substantial substrate damage. The resulting electrode retained a low sheet resistance （high electrical conductivity） of 〈10 Ω/sq even under 100% strain, or after 1,000 continuous stretching-relaxation cycles, with a peak strain of 60%. The fabricated electrode has found immediate application as a sensor for motion detection. Furthermore, based on our electrode, a light emitting diode （LED） driven by integrated stretchable AgNW conductors has been fabricated. In conclusion, our present fabrication approach is fast, simple, scalable, and cost- efficient, making it a good candidate for a future roll-to-roll process.展开更多
An ultrasensitive metamaterial sensor based on double-slot vertical split ring resonators(DVSRRs) is designed and numerically calculated in the terahertz frequency. This DVSRR design produces a fundament LC resonance ...An ultrasensitive metamaterial sensor based on double-slot vertical split ring resonators(DVSRRs) is designed and numerically calculated in the terahertz frequency. This DVSRR design produces a fundament LC resonance with a quality factor of about 20 when the incidence magnetic field component normal to the DVSRR array. The resonant characteristics and sensing performance of the DVSRR array design are systematically analyzed employing a contrast method among three similar vertical split ring resonator(SRRs) structures. The research results show that the elimination of bianisotropy, induced by the structural symmetry of the DVSRR design, helps to achieve LC resonance of a high quality factor. Lifting the SRRs up from the substrate sharply reduces the dielectric loss introduced by the substrate. All these factors jointly result in superior sensitivity of the DVSRR to the attributes of analytes. The maximum refractive index sensitivity is 788 GHz/RIU or 1.04 × 10~5 nm∕RIU.Also, the DVSRR sensor maintains its superior sensing performance for fabrication tolerance ranging from -4% to 4% and wide range incidence angles up to 50° under both TE and TM illuminations.展开更多
Although VEGF-B was discovered as a VEGF-A homolog a long time ago,the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups.Notwithstanding,drugs that inhibit V...Although VEGF-B was discovered as a VEGF-A homolog a long time ago,the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups.Notwithstanding,drugs that inhibit VEGF-B together with other VEGF family members are being used to treat patients with various neovascular diseases.It is therefore critical to have a better understanding of the angiogenic effect of VEGF-B and the underlying mechanisms.Using comprehensive in vitro and in vivo methods and models,we reveal here for the first time an unexpected and surprising function of VEGF-B as an endogenous inhibitor of angiogenesis by inhibiting the FGF2/FGFR1 pathway when the latter is abundantly expressed.Mechanistically,we unveil that VEGF-B binds to FGFR1,induces FGFR1/VEGFR1 complex formation,and suppresses FGF2-induced Erk activation,and inhibits FGF2-driven angiogenesis and tumor growth.Our work uncovers a previously unrecognized novel function of VEGF-B in tethering the FGF2/FGFR1 pathway.Given the anti-angiogenic nature of VEGF-B under conditions of high FGF2/FGFR1 levels,caution is warranted when modulating VEGF-B activity to treat neovascular diseases.展开更多
In this study, reduction and desorption of oxides of nitrogen （NOx） were conducted using an electrical discharge plasma technique. The study was carried out using a simulated gas mixture to explore the possibility o...In this study, reduction and desorption of oxides of nitrogen （NOx） were conducted using an electrical discharge plasma technique. The study was carried out using a simulated gas mixture to explore the possibility of re-generation of used adsorbents by a nonthermal plasma desorption technique. Three different types of corona electrodes, namely, pipe, helical wire, and straight wire, were used for analyzing their effectiveness in NOx reduction/desorption. The pipe- type corona electrode exhibited a nitric oxide （NO） conversion of 50%, which is 1.5 times that of the straight-wire-type electrode at an energy density of 175 J/L. The helical-wire-type corona electrode exhibited a NOx desorption efficiency almost 4 times that of the pipe-type electrode, indicating the possibility that corona-generated species play a crucial role in desorption.展开更多
According to the conventional theory of solid solutions (the nearest neighbor atomic interaction model),ordering and spinodal decomposition/clustering are mutually exclusive processes.However,it has been found that th...According to the conventional theory of solid solutions (the nearest neighbor atomic interaction model),ordering and spinodal decomposition/clustering are mutually exclusive processes.However,it has been found that the coexistence of ordering and spinodal decomposition (COSD) occurs in a large number of alloys.This fact gave a strong challenge to the conventional theory.A statistical investigation revealed that the COSD was closely related to large atomic-siae factors.It was thus proposed that the COSD stemmed from the long-range elastic interactions due to atomic-si?E disparity.In order to verify this idea,the formulism of concentration waves was applied to calculating the elastic interactions.The results proved that long-range atomic elastic interactions promoted both ordering and spinodal decomposition.A possible application of the COSD reaction was proposed,i.e.using this reaction to fabricate high-performance "natural nano-alloys".展开更多
In this study, we propose a holographic augmented reality (AR) display with a wide viewing zone realized by using a special-designed reflective optical element. A conical holographic optical element (HOE) is used as s...In this study, we propose a holographic augmented reality (AR) display with a wide viewing zone realized by using a special-designed reflective optical element. A conical holographic optical element (HOE) is used as such a reflective optical element. This conical HOE was implemented to reconstruct a diverging spherical wave with a wide spread angle. It has a sharp wavelength selectivity by recording it as a volume hologram, enabling augmented reality (AR) representation of real and virtual 3D objects. The quality of the generated spherical wave and the spectral reflectivity of the fabricated conical HOE were investigated. An optical superimposition between real and virtual 3D objects was demonstrated, thereby enhancing the validity of our proposed method. A horizontal viewing zone of 140° and a vertical viewing zone of 30° were experimentally confirmed. The fabrication procedure for the conical HOE is presented, and the calculation method of the computer-generated hologram (CGH) based on Fermat’s principle is explained in detail.展开更多
A mode-locked thulium-doped fiber laser(TDFL) based on nonlinear polarization rotation(NPR) with different net anomalous dispersion is demonstrated. When the cavity dispersion is-1.425 ps^2, the noise-like(NL) pulse w...A mode-locked thulium-doped fiber laser(TDFL) based on nonlinear polarization rotation(NPR) with different net anomalous dispersion is demonstrated. When the cavity dispersion is-1.425 ps^2, the noise-like(NL) pulse with coherence spike width of 406 fs and pulse energy of 12.342 nJ is generated at a center wavelength of 2003.2 nm with 3 dB spectral bandwidth of 23.20 nm. In the experimental period of 400 min, the 3 dB spectral bandwidth variation, the output power fluctuation, and the central wavelength shift are less than 0.06 nm, 0.04 d B, and0.4 nm, respectively, indicating that the NPR-based TDFL operating in the NL regime holds good long-term stability.展开更多
Zr was added to Ti−Nb−Fe alloys to develop low elastic modulus and high strengthβ-Ti alloys for biomedical applications.Ingots of Ti−12Nb−2Fe−(2,4,6,8,10)Zr(at.%)were prepared by arc melting and then subjected to hom...Zr was added to Ti−Nb−Fe alloys to develop low elastic modulus and high strengthβ-Ti alloys for biomedical applications.Ingots of Ti−12Nb−2Fe−(2,4,6,8,10)Zr(at.%)were prepared by arc melting and then subjected to homogenization,cold rolling,and solution treatments.The phases and microstructures of the alloys were analyzed by optical microscopy,X-ray diffraction,and transmission electron microscopy.The mechanical properties were measured by tensile tests.The results indicate that Zr and Fe cause a remarkable solid-solution strengthening effect on the alloys;thus,all the alloys show yield and ultimate tensile strengths higher than 510 MPa and 730 MPa,respectively.Zr plays a weak role in the deformation mechanism.Further,twinning occurs in all the deformed alloys and is beneficial to both strength and plasticity.Ti−12Nb−2Fe−(8,10)Zr alloys with metastableβphases show low elastic modulus,high tensile strength,and good plasticity and are suitable candidate materials for biomedical implants.展开更多
The effects of the casting factors such as nozzle size to pour the melt,nozzle height,tilt of the slope and slope length,of the cooling slope on the process to make semisolid slurry were investigated.The results show ...The effects of the casting factors such as nozzle size to pour the melt,nozzle height,tilt of the slope and slope length,of the cooling slope on the process to make semisolid slurry were investigated.The results show that these factors affect the behaviors of the semisolid slurry on the cooling slope.The tilt of the slope is the factor that has major influence on the behavior of the semisolid slurry.The cooling roll is developed from the result of the research of the cooling slope.The rotating cooling roll can improve the sticking of the semisolid slurry on the substrate and it is suitable for making the semisolid slurry.展开更多
Van der Waals coupling with different stacking configurations can significantly affect the optical and electronic properties of ultrathin two-dimensional(2D)materials,which is an effective way to tune device performan...Van der Waals coupling with different stacking configurations can significantly affect the optical and electronic properties of ultrathin two-dimensional(2D)materials,which is an effective way to tune device performance.Herein,we report a salt-assisted chemical vapor deposition method for the synthesis of bilayer V-doped MoS_(2) with 2H and 3R phases,which are demonstrated by the second harmonic generation and scanning transmission electron microscopy.Notably,the mobility of the 3R phase V-doped MoS_(2) is 6.2%higher than that of the 2H phase.Through first-principles calculations,we further reveal that this particular behavior is attributed to the stronger interlayer coupling of 3R compared to the 2H stacking configuration.This research can be further generalized to other transition metal chalcogenides and will contribute to the development of electronic devices based on 2D materials in the future.展开更多
From April to July 2018,a data sample at the peak energy of the T(4 S) resonance was collected with the Belle Ⅱ detector at the SuperKEKB electron-positron collider.This is the first data sample of the Belle Ⅱ exper...From April to July 2018,a data sample at the peak energy of the T(4 S) resonance was collected with the Belle Ⅱ detector at the SuperKEKB electron-positron collider.This is the first data sample of the Belle Ⅱ experiment.Using Bhabha and digamma events,we measure the integrated luminosity of the data sample to be(496.3±0.3±3.0) pb-1,where the first uncertainty is statistical and the second is systematic.This work provides a basis for future luminosity measurements at Belle Ⅱ.展开更多
We report the charge-changing cross sections(σ_(cc))of 24 p-shell nuclides on both hydrogen and carbon at about 900A MeV,of which^(8,9)Li,^(10–12)Be,^(10,14,15)B,^(14,15,17–22)N and^(16)O on hydrogen and^(8,9)Li on...We report the charge-changing cross sections(σ_(cc))of 24 p-shell nuclides on both hydrogen and carbon at about 900A MeV,of which^(8,9)Li,^(10–12)Be,^(10,14,15)B,^(14,15,17–22)N and^(16)O on hydrogen and^(8,9)Li on carbon are for the first time.Benefiting from the data set,we found a new and robust relationship between the scaling factor of the Glauber model calculations and the separation energies of the nuclei of interest on both targets.This allows us to deduce proton radii(R_p)for the first time from the cross sections on hydrogen.Nearly identical R_p values are deduced from both target data for the neutron-rich carbon isotopes;however,the R_p from the hydrogen target is systematically smaller in the neutron-rich nitrogen isotopes.This calls for further experimental and theoretical investigations.展开更多
Mutagenesis is an important technique for microbial mutation breeding.As the source of mutations,DNA damage extent is a key indicator for the effectiveness of mutagenesis.Therefore,a rapid and easy DNA damage quantifi...Mutagenesis is an important technique for microbial mutation breeding.As the source of mutations,DNA damage extent is a key indicator for the effectiveness of mutagenesis.Therefore,a rapid and easy DNA damage quantification method is required for the comparison of mutagenesis effects and development of mutagenesis tools.Here,we used the umu-microplate test system to quantitatively compare the DNA damage strength caused by atmospheric and room-temperature plasma(ARTP)and other traditional mutagenesis methods including:ultraviolet radiation(UV),diethyl sulfate(DES)and 4-nitroquinoline-1-oxide(4-NQO).The test strain of Salmonella typhimurium TA1535/pSK1002 was used to monitor the time-course profile of b-galactosidase activity induced by DNA damage caused by different mutagenesis methods using a microplate reader.The umu-microplate test results showed that ARTP caused higher extent of DNA damage than UV and chemical mutagens,which agrees well with the result obtained by SOS-FACS-based quantification method as reported previously.This umu-microplate test is accessible for broad researchers who are lack of the expensive FACS instruments and allows the quick quantitative evaluation of DNA damage among living cells for different mutagenesis methods in the study of the microbial mutation breeding.展开更多
Developing agents that can accurately differentiate tumors from normal healthy tissues is of utmost importance for safe cancer therapy.Active targeting has been considered as an effective technique for tumor recogniti...Developing agents that can accurately differentiate tumors from normal healthy tissues is of utmost importance for safe cancer therapy.Active targeting has been considered as an effective technique for tumor recognition.In this work,we demonstrate a folate-functionalized nanoscale covalent organic framework(FATD nCOF)highly specific to cancer cells through active targeting of their enriched folate receptors(FRs).The FATD nCOF prepared by simple post-synthetic modification of the COF surface defeats disperses well in water and exhibits a high loading capacity for various anticancer drugs.The biocompatible FATD nCOF is selectively internalized by FR-harboring cancer cells and consequently augments the efficacy of the loaded drug,Withaferin A(Wi-A),for targeted cancer cell killing.In biomolecular mechanism studies,Wi-A-loaded FATD(FATD@Wi-A)nanocomposites show remarkably a higher rate of apoptosis in FR-enriched cancer cells.Comparative analyses of FR-positive and FR-negative tumor xenografts reveal enhanced selective antitumor activity of FATD@Wi-A nanotherapeutics.Taken together,the study findings suggest that FATD nCOF holds great promise for active targeting of tumors in vivo.Our simple yet effective technology might be valuable for creating new state-of-the-art COFs for chemical and biomedical applications.展开更多
Chaotic mixing in eight different types of micro T-mixer flow has been studied experimentally and numerically. The present experimental study was performed to visualize two-liquid flows in a micro T-mixer with baffles...Chaotic mixing in eight different types of micro T-mixer flow has been studied experimentally and numerically. The present experimental study was performed to visualize two-liquid flows in a micro T-mixer with baffles. The Reynolds number, baffle height and setting angle were varied to investigate their effect on the mixing performance. Three micro T-mixer models were produced, which are several centimeters long and have a rectangular cross-section of few millimeters a side. The mixing of two-liquid was measured using the laser induced fluorescence (LIF) technique. Moreover, three-dimensional numerical simulations were conducted with the open-source CFD solver, OpenFOAM, for the same configuration as used in the experiments to investigate the detailed mechanism of the chaotic mixing. As a result, it was found that the mixing of two-liquid is greatly improved in the micro T-mixer with baffle. The baffle height and setting angle show a significant influence on the mixing performance.展开更多
Metamaterial absorbers(MAs)serve as important electromagnetic wave-absorbing devices that have captured the attention of researchers for a long term.Functioning as sensitive detectors to determine perturbations in an ...Metamaterial absorbers(MAs)serve as important electromagnetic wave-absorbing devices that have captured the attention of researchers for a long term.Functioning as sensitive detectors to determine perturbations in an ambient environment is another significant subsidiary function.Here,we theoretically propose an optimized fabrication method to implement terahertz MAs with fewer steps and also evaluate both absorption and sensing performances of such MAs realized by the new method.Simulation findings demonstrate that such MAs can basically maintain the original absorption features perfectly,including near-complete absorption at resonance as well as strong robustness to wide incident angles.Specifically,the full width at half-maximum and quality factor of the absorption resonances attenuate less than 26%and 8%with this new method,remaining in the ranges of^0.03–0.04 THz and^20–27 for two selected example MAs.More significantly,sensing capacities of this type of MA,in terms of maximum detection range(enhancing at least 9%),observable spectral modulation(increasing at least 6.3%),and refractive index sensitivity,are improved to a large extent because of more intense coupling between resonant field and matter in the case of surface-relief MAs.This stronger coupling results from exposing more spots of the resonantly high field to direct contact with an approaching analyte,which is illustrated by field profiles of the MAs at resonance in this work.Additionally,other desirable absorber features are also explored with such MAs,like functioning as building blocks to configure multiband MAs and strong robustness against fabrication errors.Such new-style terahertz MAs shown in the paper,acting as good examples,not only prove that terahertz MAs can be fabricated by the proposed time-and cost-saving route in contrast to the traditional MA fabrication process,but also can serve as novel platforms to explore other intriguing terahertz photonic effects,such as the field enhancement effect.展开更多
文摘In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has developed.We are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under construction.In addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR facilities.So apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development.
基金supported by the Program for Changjiang Scholars and Innovative Research Team in University scheme of the Ministry of Education of China(NO.IRT1111)the National Basic Research Program of China(2012CB518300)+2 种基金the National Natural Science Foundation of China(81101946)the Shanghai Pujiang Program(12PJD008)Prostate Cancer Foundation Young Investigator Award,Shanghai Municipal Health and Family Planning Commission Outstanding Young Investigator(XYQ2013077).
文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers.
基金R.K.acknowledges Japan Society for the Promotion of Science(JSPSStandard)for international postdoctoral fellowship(P18063)and this research work was supported by JSPS KAKENHI Grant No.18F18063.A.M.acknowledges the financial support from JSPS KAKENHI Grant JP-18H03841 and JSPS KAKENHI Grant JP-17K18985.R.K.and A.M.would like to thanks Toyohashi University of Technology,Toyohashi,Aichi,Japan for providing the necessarily support and facilities to complete this work.S.S.acknowledges DST-SERB,India for the national postdoctoral fellowship(NPDF File No.PDF/2017/000328).D.P.S.acknowledges with gratitude the financial support from Millennium Institute for Research in Optics(MIRO),CHILE.R.K.would like to dedicate this work to the memory of late Prof.Yoshiyuki Suda.
文摘The significance of graphene and its two-dimensional(2D)analogous inorganic layered materials especially as hexagonal boron nitride(h-BN)and molybdenum disulphide(MoS2)for“clean energy”applications became apparent over the last few years due to their extraordinary properties.In this review article we study the current progress and selected challenges in the syntheses of graphene,h-BN and MoS2 including energy storage applications as supercapacitors and batteries.Various substrates/catalysts(metals/insulator/semiconducting)have been used to obtain graphene,h-BN and MoS2 using different kinds of precursors.The most widespread methods for synthesis of graphene,h-BN and MoS2 layers are chemical vapor deposition(CVD),plasma-enhanced CVD,hydro/solvothermal methods,liquid phase exfoliation,physical methods etc.Current research has shown that graphene,h-BN and MoS2 layered materials modified with metal oxide can have an insightful influence on the performance of energy storage devices as supercapacitors and batteries.This review article also contains the discussion on the opportunities and perspectives of these materials(graphene,h-BN and MoS2)in the energy storage fields.We expect that this witen review article including recent research on energy storage will help in generating new insights for further development and practical applications of graphene,h-BN and MoS2 layers based materials.
文摘Silver nanowires （AgNWs） have emerged as a promising nanomaterial for next generation stretchable electronics. However, until now, the fabrication of AgNW- based components has been hampered by complex and time-consuming steps. Here, we introduce a facile, fast, and one-step methodology for the fabrication of highly conductive and stretchable AgNW/polyurethane （PU） composite electrodes based on a high-intensity pulsed light （HIPL） technique. HIPL simultaneously improved wire-wire junction conductivity and wire-substrate adhesion at room temperature and in air within 50 μs, omitting the complex transfer-curing-implanting process. Owing to the localized deformation of PU at interfaces with AgNWs, embedding of the nanowires was rapidly carried out without substantial substrate damage. The resulting electrode retained a low sheet resistance （high electrical conductivity） of 〈10 Ω/sq even under 100% strain, or after 1,000 continuous stretching-relaxation cycles, with a peak strain of 60%. The fabricated electrode has found immediate application as a sensor for motion detection. Furthermore, based on our electrode, a light emitting diode （LED） driven by integrated stretchable AgNW conductors has been fabricated. In conclusion, our present fabrication approach is fast, simple, scalable, and cost- efficient, making it a good candidate for a future roll-to-roll process.
基金National Natural Science Foundation of China(NSFC)(61327006,61620106014)
文摘An ultrasensitive metamaterial sensor based on double-slot vertical split ring resonators(DVSRRs) is designed and numerically calculated in the terahertz frequency. This DVSRR design produces a fundament LC resonance with a quality factor of about 20 when the incidence magnetic field component normal to the DVSRR array. The resonant characteristics and sensing performance of the DVSRR array design are systematically analyzed employing a contrast method among three similar vertical split ring resonator(SRRs) structures. The research results show that the elimination of bianisotropy, induced by the structural symmetry of the DVSRR design, helps to achieve LC resonance of a high quality factor. Lifting the SRRs up from the substrate sharply reduces the dielectric loss introduced by the substrate. All these factors jointly result in superior sensitivity of the DVSRR to the attributes of analytes. The maximum refractive index sensitivity is 788 GHz/RIU or 1.04 × 10~5 nm∕RIU.Also, the DVSRR sensor maintains its superior sensing performance for fabrication tolerance ranging from -4% to 4% and wide range incidence angles up to 50° under both TE and TM illuminations.
基金This study is supported by the State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,and Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science,Guangzhou 510060,P.R.Chinathe National Natural Science Foundation of China(82150710555 and 82220108016 to X.Li,81970823 to Jin Yao and 81830013 to J.O.)+4 种基金a Key Research and Development Plan of Shandong Province(2016GSF201100)the Fundamental Research Funds for the Central Universities(19ykpy151)the long-term structural Methusalem funding by the Flemish Government,Belgiumthe Deutsche Forschungsge-meinschaft(Project No.:394046768-SFB1366)the DZHK partner site Mannheim/Heidelberg to H.F.L.,an ERA PerMed 2020 JTC grant“PROGRESS”.
文摘Although VEGF-B was discovered as a VEGF-A homolog a long time ago,the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups.Notwithstanding,drugs that inhibit VEGF-B together with other VEGF family members are being used to treat patients with various neovascular diseases.It is therefore critical to have a better understanding of the angiogenic effect of VEGF-B and the underlying mechanisms.Using comprehensive in vitro and in vivo methods and models,we reveal here for the first time an unexpected and surprising function of VEGF-B as an endogenous inhibitor of angiogenesis by inhibiting the FGF2/FGFR1 pathway when the latter is abundantly expressed.Mechanistically,we unveil that VEGF-B binds to FGFR1,induces FGFR1/VEGFR1 complex formation,and suppresses FGF2-induced Erk activation,and inhibits FGF2-driven angiogenesis and tumor growth.Our work uncovers a previously unrecognized novel function of VEGF-B in tethering the FGF2/FGFR1 pathway.Given the anti-angiogenic nature of VEGF-B under conditions of high FGF2/FGFR1 levels,caution is warranted when modulating VEGF-B activity to treat neovascular diseases.
文摘In this study, reduction and desorption of oxides of nitrogen （NOx） were conducted using an electrical discharge plasma technique. The study was carried out using a simulated gas mixture to explore the possibility of re-generation of used adsorbents by a nonthermal plasma desorption technique. Three different types of corona electrodes, namely, pipe, helical wire, and straight wire, were used for analyzing their effectiveness in NOx reduction/desorption. The pipe- type corona electrode exhibited a nitric oxide （NO） conversion of 50%, which is 1.5 times that of the straight-wire-type electrode at an energy density of 175 J/L. The helical-wire-type corona electrode exhibited a NOx desorption efficiency almost 4 times that of the pipe-type electrode, indicating the possibility that corona-generated species play a crucial role in desorption.
基金Project supported by the National Natural Science Foundation of China.
文摘According to the conventional theory of solid solutions (the nearest neighbor atomic interaction model),ordering and spinodal decomposition/clustering are mutually exclusive processes.However,it has been found that the coexistence of ordering and spinodal decomposition (COSD) occurs in a large number of alloys.This fact gave a strong challenge to the conventional theory.A statistical investigation revealed that the COSD was closely related to large atomic-siae factors.It was thus proposed that the COSD stemmed from the long-range elastic interactions due to atomic-si?E disparity.In order to verify this idea,the formulism of concentration waves was applied to calculating the elastic interactions.The results proved that long-range atomic elastic interactions promoted both ordering and spinodal decomposition.A possible application of the COSD reaction was proposed,i.e.using this reaction to fabricate high-performance "natural nano-alloys".
文摘In this study, we propose a holographic augmented reality (AR) display with a wide viewing zone realized by using a special-designed reflective optical element. A conical holographic optical element (HOE) is used as such a reflective optical element. This conical HOE was implemented to reconstruct a diverging spherical wave with a wide spread angle. It has a sharp wavelength selectivity by recording it as a volume hologram, enabling augmented reality (AR) representation of real and virtual 3D objects. The quality of the generated spherical wave and the spectral reflectivity of the fabricated conical HOE were investigated. An optical superimposition between real and virtual 3D objects was demonstrated, thereby enhancing the validity of our proposed method. A horizontal viewing zone of 140° and a vertical viewing zone of 30° were experimentally confirmed. The fabrication procedure for the conical HOE is presented, and the calculation method of the computer-generated hologram (CGH) based on Fermat’s principle is explained in detail.
基金Fundamental Research Funds for the Central Universities(2016YJS034)
文摘A mode-locked thulium-doped fiber laser(TDFL) based on nonlinear polarization rotation(NPR) with different net anomalous dispersion is demonstrated. When the cavity dispersion is-1.425 ps^2, the noise-like(NL) pulse with coherence spike width of 406 fs and pulse energy of 12.342 nJ is generated at a center wavelength of 2003.2 nm with 3 dB spectral bandwidth of 23.20 nm. In the experimental period of 400 min, the 3 dB spectral bandwidth variation, the output power fluctuation, and the central wavelength shift are less than 0.06 nm, 0.04 d B, and0.4 nm, respectively, indicating that the NPR-based TDFL operating in the NL regime holds good long-term stability.
基金the Natural Science Foundation of Shanghai,China(No.15ZR1428400)Shanghai Engineering Research Center of High-Performance Medical Device Materials,China(No.20DZ2255500)the Project of Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development,Tohoku University,sponsored by Ministry,Education,Culture,Sports,Science and Technology,Japan,and the Grant-in Aid for Scientific Research(C)(No.20K05139)from JSPS(Japan Society for the Promotion of Science),Tokyo,Japan.
文摘Zr was added to Ti−Nb−Fe alloys to develop low elastic modulus and high strengthβ-Ti alloys for biomedical applications.Ingots of Ti−12Nb−2Fe−(2,4,6,8,10)Zr(at.%)were prepared by arc melting and then subjected to homogenization,cold rolling,and solution treatments.The phases and microstructures of the alloys were analyzed by optical microscopy,X-ray diffraction,and transmission electron microscopy.The mechanical properties were measured by tensile tests.The results indicate that Zr and Fe cause a remarkable solid-solution strengthening effect on the alloys;thus,all the alloys show yield and ultimate tensile strengths higher than 510 MPa and 730 MPa,respectively.Zr plays a weak role in the deformation mechanism.Further,twinning occurs in all the deformed alloys and is beneficial to both strength and plasticity.Ti−12Nb−2Fe−(8,10)Zr alloys with metastableβphases show low elastic modulus,high tensile strength,and good plasticity and are suitable candidate materials for biomedical implants.
文摘The effects of the casting factors such as nozzle size to pour the melt,nozzle height,tilt of the slope and slope length,of the cooling slope on the process to make semisolid slurry were investigated.The results show that these factors affect the behaviors of the semisolid slurry on the cooling slope.The tilt of the slope is the factor that has major influence on the behavior of the semisolid slurry.The cooling roll is developed from the result of the research of the cooling slope.The rotating cooling roll can improve the sticking of the semisolid slurry on the substrate and it is suitable for making the semisolid slurry.
基金financially supported by the National Natural Science Foundation of China (Nos.62174013 and92265111)the Funding Program of Beijing Institute of Technology (Nos.3180012212214 and 3180023012204)。
文摘Van der Waals coupling with different stacking configurations can significantly affect the optical and electronic properties of ultrathin two-dimensional(2D)materials,which is an effective way to tune device performance.Herein,we report a salt-assisted chemical vapor deposition method for the synthesis of bilayer V-doped MoS_(2) with 2H and 3R phases,which are demonstrated by the second harmonic generation and scanning transmission electron microscopy.Notably,the mobility of the 3R phase V-doped MoS_(2) is 6.2%higher than that of the 2H phase.Through first-principles calculations,we further reveal that this particular behavior is attributed to the stronger interlayer coupling of 3R compared to the 2H stacking configuration.This research can be further generalized to other transition metal chalcogenides and will contribute to the development of electronic devices based on 2D materials in the future.
基金supported by the following funding sources:Science Committee of the Republic of Armenia Grant No.18T-1C180Australian Research Council and research grant Nos.DP180102629,DP170102389,DP170102204,DP150103061,FT130100303,and FT130100018+22 种基金Austrian Federal Ministry of Education,Science and Research,and Austrian Science Fund No.P 31361-N36Natural Sciences and Engineering Research Council of Canada,Compute Canada and CANARIEChinese Academy of Sciences and research grant No.QYZDJ-SSW-SLH011National Natural Science Foundation of China and research grant Nos.11521505,11575017,11675166,11761141009,11705209,and 11975076LiaoNing Revitalization Talents Program under contract No.XLYC1807135Shanghai Municipal Science and Technology Committee under contract No.19ZR1403000Shanghai Pujiang Program under Grant No.18PJ1401000the CAS Center for Excellence in Particle Physics(CCEPP)the Ministry of Education,Youth and Sports of the Czech Republic under Contract No.LTT17020Charles University grants SVV260448 and GAUK 404316European Research Council,7th Framework PIEF-GA-2013-622527Horizon 2020 Marie Sklodowska-Curie grant agreement No.700525’NIOBE,’Horizon 2020 Marie Sklodowska-Curie RISE project JENNIFER grant agreement No.644294Horizon 2020 ERC-Advanced Grant No.267104NewAve No.638528(European grants)L’Institut National de Physique Nucléaire et de Physique des Particules(IN2P3)du CNRS(France),BMBF,DFG,HGF,MPG and AvH Foundation(Germany)Department of Atomic Energy and Department of Science and Technology(India)Israel Science Foundation grant No.2476/17United States-Israel Binational Science Foundation grant No.2016113Istituto Nazionale di Fisica Nucleare and the research grants BELLE2Japan Society for the Promotion of Science,Grant-in-Aid for Scientific Research grant Nos.16H03968,16H03993,16H06492,16K05323,17H01133,17H05405,18K03621,18H03710,18H05226,19H00682,26220706,and 26400255the National Institute of Informatics,and Science Information NETwork 5(SINET5)the Ministry of Education,Culture,Sports,Science,an
文摘From April to July 2018,a data sample at the peak energy of the T(4 S) resonance was collected with the Belle Ⅱ detector at the SuperKEKB electron-positron collider.This is the first data sample of the Belle Ⅱ experiment.Using Bhabha and digamma events,we measure the integrated luminosity of the data sample to be(496.3±0.3±3.0) pb-1,where the first uncertainty is statistical and the second is systematic.This work provides a basis for future luminosity measurements at Belle Ⅱ.
基金supported by the National Natural Science Foundation of China(12325506,11961141004)the“111 center”(B20065)+1 种基金the NSERC,Canada,the Faculty Research Scheme at IIT(ISM)Dhanbad(FRS(154)/2021–2022/Physics)the support of the Chinese government and Beihang University under the Thousand Talent program。
文摘We report the charge-changing cross sections(σ_(cc))of 24 p-shell nuclides on both hydrogen and carbon at about 900A MeV,of which^(8,9)Li,^(10–12)Be,^(10,14,15)B,^(14,15,17–22)N and^(16)O on hydrogen and^(8,9)Li on carbon are for the first time.Benefiting from the data set,we found a new and robust relationship between the scaling factor of the Glauber model calculations and the separation energies of the nuclei of interest on both targets.This allows us to deduce proton radii(R_p)for the first time from the cross sections on hydrogen.Nearly identical R_p values are deduced from both target data for the neutron-rich carbon isotopes;however,the R_p from the hydrogen target is systematically smaller in the neutron-rich nitrogen isotopes.This calls for further experimental and theoretical investigations.
基金National Key Research and Development Project of China(2016YFD0102106)National Key Scientific Instrument and Equipment Project of National Natural Science Foundation of China(21627812).
文摘Mutagenesis is an important technique for microbial mutation breeding.As the source of mutations,DNA damage extent is a key indicator for the effectiveness of mutagenesis.Therefore,a rapid and easy DNA damage quantification method is required for the comparison of mutagenesis effects and development of mutagenesis tools.Here,we used the umu-microplate test system to quantitatively compare the DNA damage strength caused by atmospheric and room-temperature plasma(ARTP)and other traditional mutagenesis methods including:ultraviolet radiation(UV),diethyl sulfate(DES)and 4-nitroquinoline-1-oxide(4-NQO).The test strain of Salmonella typhimurium TA1535/pSK1002 was used to monitor the time-course profile of b-galactosidase activity induced by DNA damage caused by different mutagenesis methods using a microplate reader.The umu-microplate test results showed that ARTP caused higher extent of DNA damage than UV and chemical mutagens,which agrees well with the result obtained by SOS-FACS-based quantification method as reported previously.This umu-microplate test is accessible for broad researchers who are lack of the expensive FACS instruments and allows the quick quantitative evaluation of DNA damage among living cells for different mutagenesis methods in the study of the microbial mutation breeding.
基金the Japan Society for the Promotion of Science(JSPS)KAKENHI Grant-in-Aid for Early-Career Scientists(No.21K14508)Takeda Science Foundation+4 种基金Advanced Technology Institute Research Grants 2021Senri Life Science FoundationMurata Science Foundation,JST CREST Grant(No.JPMJCR21B3)grants from AIST(Japan)and the Department of Biotechnology(Govt.of India)under the DAILAB and DAICENTER projectsthe National Key Research and Development Program of China(No.2022YFF0710705).
文摘Developing agents that can accurately differentiate tumors from normal healthy tissues is of utmost importance for safe cancer therapy.Active targeting has been considered as an effective technique for tumor recognition.In this work,we demonstrate a folate-functionalized nanoscale covalent organic framework(FATD nCOF)highly specific to cancer cells through active targeting of their enriched folate receptors(FRs).The FATD nCOF prepared by simple post-synthetic modification of the COF surface defeats disperses well in water and exhibits a high loading capacity for various anticancer drugs.The biocompatible FATD nCOF is selectively internalized by FR-harboring cancer cells and consequently augments the efficacy of the loaded drug,Withaferin A(Wi-A),for targeted cancer cell killing.In biomolecular mechanism studies,Wi-A-loaded FATD(FATD@Wi-A)nanocomposites show remarkably a higher rate of apoptosis in FR-enriched cancer cells.Comparative analyses of FR-positive and FR-negative tumor xenografts reveal enhanced selective antitumor activity of FATD@Wi-A nanotherapeutics.Taken together,the study findings suggest that FATD nCOF holds great promise for active targeting of tumors in vivo.Our simple yet effective technology might be valuable for creating new state-of-the-art COFs for chemical and biomedical applications.
文摘Chaotic mixing in eight different types of micro T-mixer flow has been studied experimentally and numerically. The present experimental study was performed to visualize two-liquid flows in a micro T-mixer with baffles. The Reynolds number, baffle height and setting angle were varied to investigate their effect on the mixing performance. Three micro T-mixer models were produced, which are several centimeters long and have a rectangular cross-section of few millimeters a side. The mixing of two-liquid was measured using the laser induced fluorescence (LIF) technique. Moreover, three-dimensional numerical simulations were conducted with the open-source CFD solver, OpenFOAM, for the same configuration as used in the experiments to investigate the detailed mechanism of the chaotic mixing. As a result, it was found that the mixing of two-liquid is greatly improved in the micro T-mixer with baffle. The baffle height and setting angle show a significant influence on the mixing performance.
基金National Natural Science Foundation of China(61620106014,61827818,61805010)Natural Science Foundation of Beijing Municipality(4192048)。
文摘Metamaterial absorbers(MAs)serve as important electromagnetic wave-absorbing devices that have captured the attention of researchers for a long term.Functioning as sensitive detectors to determine perturbations in an ambient environment is another significant subsidiary function.Here,we theoretically propose an optimized fabrication method to implement terahertz MAs with fewer steps and also evaluate both absorption and sensing performances of such MAs realized by the new method.Simulation findings demonstrate that such MAs can basically maintain the original absorption features perfectly,including near-complete absorption at resonance as well as strong robustness to wide incident angles.Specifically,the full width at half-maximum and quality factor of the absorption resonances attenuate less than 26%and 8%with this new method,remaining in the ranges of^0.03–0.04 THz and^20–27 for two selected example MAs.More significantly,sensing capacities of this type of MA,in terms of maximum detection range(enhancing at least 9%),observable spectral modulation(increasing at least 6.3%),and refractive index sensitivity,are improved to a large extent because of more intense coupling between resonant field and matter in the case of surface-relief MAs.This stronger coupling results from exposing more spots of the resonantly high field to direct contact with an approaching analyte,which is illustrated by field profiles of the MAs at resonance in this work.Additionally,other desirable absorber features are also explored with such MAs,like functioning as building blocks to configure multiband MAs and strong robustness against fabrication errors.Such new-style terahertz MAs shown in the paper,acting as good examples,not only prove that terahertz MAs can be fabricated by the proposed time-and cost-saving route in contrast to the traditional MA fabrication process,but also can serve as novel platforms to explore other intriguing terahertz photonic effects,such as the field enhancement effect.
