MicroRNA (miR)-125b has been shown to play a potential role in the development of glioma stem cells.However,the relationship between miRNA and glioma stem cells is still elusive.This study was designed to elucidate th...MicroRNA (miR)-125b has been shown to play a potential role in the development of glioma stem cells.However,the relationship between miRNA and glioma stem cells is still elusive.This study was designed to elucidate this potential relationship.We established a highly invasive glioma stem cell and progenitor (GSCP) cell line SU3.SU3 cell suspensions were injected into nude mice brains in situ,and the invasiveness of graft tumors was analyzed using hematoxylin and eosin staining as well as immunohistochemistry.Real-time polymerase chain reaction (PCR) was used to measure the expression levels of miR-125b in SU3 and other cells.In vitro,SU3 cells expressed CD133 and nestin as well as differentiation markers glial fibrillary acidic protein (GFAP) and β-tubulin III,which were consistent with the characteristics of glioma stem cells.Scratch assays indicated that the migration ability of SU3 cells was stronger than that of U251 stem cells (U251s).In vivo,SU3 cells invaded into each part of the mouse brain from the caudate nucleus in a diffuse pattern and highly expressed invasive and proliferative cell markers matrix metalloprotease 2 (MMP2),MMP9,and Ki-67.Real-time PCR results revealed that the levels of miR-125b and MMP9 were significantly higher in SU3 and SU2,also a highly invasive GSCP cell line we established before,than in U251s.High expression of miR-125b both in newly established GSCPs,SU3,and long-term cultured GSCPs,SU2 suggests that miR-125b exhibits oncogene-like behavior.This behavior should be considered in further studies of miR-125b in cancer stem cells.Furthermore,MMP9,which plays a role in cancer stem cell invasion,may be a target gene of miR-125b.展开更多
BACKGROUND Recent research suggests that although prokinetic agents,acid suppressors,and radical treatment for Helicobacter pylori infection may be effective in patients with functional dyspepsia(FD),a large proportio...BACKGROUND Recent research suggests that although prokinetic agents,acid suppressors,and radical treatment for Helicobacter pylori infection may be effective in patients with functional dyspepsia(FD),a large proportion of patients still fail to respond to these treatments or may suffer from severe adverse reactions.Many traditional Chinese medicinal herbs can regulate the status of the entire body and have special advantages in the treatment of functional diseases.The present study was designed to verify the efficacy of Biling Weitong Granules(BLWTG),a traditional Chinese medicinal herbal compound formula,in alleviating epigastric pain syndrome(EPS)in FD patients,in an attempt to provide an effective prescription for the clinical treatment of this disease.AIM To evaluate the clinical efficacy and safety of BLWTG in treating EPS in patients with FD.METHODS In this multicenter,stratified,randomized,double-blind,placebo-controlled,parallel group clinical trial,eligible patients were randomized into the BLWTG and placebo groups who were treated for 6 wk.Efficacy indicators including the severity and frequency of EPS and the time to pain resolution and safety indicators including adverse events were observed and compared.RESULTS The baseline demographic data and clinical characteristics,such as epigastric pain symptoms,pain intensity,and frequency of attacks,were matched between the two groups before randomization.After 6 wk of treatment and after the center effect was eliminated,the epigastric pain was significantly improved in 28.33%and 85.59%of the patients in the placebo and BLWTG groups,respectively(P<0.05).At 6 wk,the resolution rate of epigastric pain was 15%and 69.49%in the placebo and BLWTG groups,respectively(P<0.05).The differences of total FD clinical score between these two groups were significant(P<0.05)at 2,4,and 6 wk(P<0.05).The scores of each item and the total score in the Functional Digestive Disorders Quality of Life Questionnaire showed significant differences between the two groups at 6 wk after 展开更多
Negative air ions are natural components of the air we breathe Forests are the main continuous natural source of negative air ions （NAI）. The spatio-temporal patterns of negative air ions were explored in Shanghai, ...Negative air ions are natural components of the air we breathe Forests are the main continuous natural source of negative air ions （NAI）. The spatio-temporal patterns of negative air ions were explored in Shanghai, based on monthly monitoring in 15 parks from March 2009 to February 2010. In each park, sampling sites were selected in forests and open spaces. The annual variation in negative air ion concentrations （NAIC） showed peak values from June to October and minimum values from December to January. NAIC were highest in summer and autumn, intermediate in spring, and lowest in winter. During spring and summer, NAIC in open spaces were significantly higher in rural areas than those in suburban areas. However, there were no significant differences in NAIC at forest sites among seasons. For open spaces, total suspended particles （TSP） were the dominant determining factor of NAIC in sum- mer, and air temperature and air humidity were the dominant determining factors of NAIC in spring, which were tightly correlated with Shanghai＇s ongoing urbanization and its impacts on the environment. R is suggested that urbanization could induce variation in NAIC along the urban-rural gradient, but that may not change the temporal variation pattern. Fur- thermore, the effects of urbanization on NAIC were limited in non-vegetated or less-vegetated sites, such as open spaces, but not in well-vegetated areas, such as urban forests. Therefore, we suggest that urban greening, especially urban forest, has significant resistance to theeffect of urbanization on NAIC.展开更多
As a key component of an integrated energy system(IES),energy storage can effectively alleviate the problem of the times between energy production and consumption.Exploiting the benefits of energy storage can improve ...As a key component of an integrated energy system(IES),energy storage can effectively alleviate the problem of the times between energy production and consumption.Exploiting the benefits of energy storage can improve the competitiveness of multi-energy systems.This paper proposes a method for day-ahead operation optimization of a building-level integrated energy system(BIES)considering additional potential benefits of energy storage.Based on the characteristics of peak-shaving and valley-filling of energy storage,and further consideration of the changes in the system’s load and real-time electricity price,a model of additional potential benefits of energy storage is developed.Aiming at the lowest total operating cost,a bi-level optimal operational model for day-ahead operation of BIES is developed.A case analysis of different dispatch strategies verifies that the addition of the proposed battery scheduling strategy improves economic operation.The results demonstrate that the model can exploit energy storage’s potential,further optimize the power output of BIES and reduce the economic cost.展开更多
This prospective study was designed to examine the combined influence of insulin resistance（IR）and inflammatory biomarker levels on type 2 diabetes mellitus（T2DM）among 1,903Inner Mongolians.
Background Elevated fibrinogen （Fg） level is a known risk factor for ischemic stroke. There are few clinical trials on oral fibrinogen-depleting therapies for secondary ischemic stroke prevention. We aimed to assess...Background Elevated fibrinogen （Fg） level is a known risk factor for ischemic stroke. There are few clinical trials on oral fibrinogen-depleting therapies for secondary ischemic stroke prevention. We aimed to assess the effects of one-year therapy with oral lumbrokinase enteric-coated capsules on secondary ischemic stroke prevention.展开更多
Objective To explore the relationship of inflammation and endothelial dysfunction with risks to cardiovascular disease （CVD）. Methods Blood pressure, body weight, body height, waist circumference and lifestyle risk ...Objective To explore the relationship of inflammation and endothelial dysfunction with risks to cardiovascular disease （CVD）. Methods Blood pressure, body weight, body height, waist circumference and lifestyle risk factors were measured and studied among 2589 participants in Inner Mongolia of China, and biomarkers of inflammation and endothelial dysfunction including high-sensitivity C-reactive protein （hsCRP）, soluble inter-cellular adhesion molecule-1 （slCAM-1）, soluble E-selectin （sE-selectin）, and angiotensin II were investigated. Results Subjects with metabolic risk factors for CVD had higher levels of hsCRP, sE-selectin and slCAM-1 than those without such risk factors （all P〈O.05）. Levels of all biomarkers positively and significantly increased with aggregation of the metabolic risk factors among the subjects （all P for trend 〈0.001）. Data from the multivariate analysis showed that participants with high levels of hsCRP [odds ratio （OR}： 1.96, 95% confidence interval （CI）： 1.52-2.53], sE-selectin （OR： 1.35, 95% Cl： 1.05-1.72）, and angiotensin II （OR： 1.81, 95% CI＂ 1.40-2.33） were more likely to develop hypertension; participants with high levels of hsCRP （OR： 2.33, 95% CI： 1.85-2.94）, sE-selectin （OR： 1.24, 95% CI： 1.00-1.54）, and slCAM-1 （OR： 1.70, 95% CI： 1.30-2.22） were more likely to develop dyslipidemia, and those with high levels of hsCRP （OR： 2.95, 95% CI： 2.27-3.83） and slCAM-I（OR： 2.80, 95% CI： 2.06-3.80） were more likely to develop hyperglycemia. Conclusion Biomarkers of inflammation and endothelial dysfunction were separately associated with relevant metabolic risk factors for CVD. And appropriate measures should be taken to control inflammation and improve endothelial function among individuals with different metabolic risk factors for CVD.展开更多
Background Excessive daytime sleepiness （EDS） is often associated with obstructive sleep apnea hypopnea syndrome （OSAHS） and contributes to a number of comorbidities in these patients. Therefore, early detection o...Background Excessive daytime sleepiness （EDS） is often associated with obstructive sleep apnea hypopnea syndrome （OSAHS） and contributes to a number of comorbidities in these patients. Therefore, early detection of EDS is critical in disease management. We examined the association between Epworth Sleepiness Scale （ESS） and multiple sleep latency test （MSLT） and diagnostic accuracy of ESS in assessing EDS in OSAHS patients. Methods The ESS, MSLT and overnight polysomnography were administered to 107 Chinese patients to assess EDS and its correlations with polysomnographic parameters. The diagnostic accuracy of ESS in classifying EDS （mean sleep latency （MSL） 〈10 minutes） was evaluated by calculating the area under ROC curve. Results As the severity of OSAHS increased, MSL decreased with increase in ESS score. Conversely, patients with worsening EDS （shorter MSL） were characterized by advanced nocturnal hypoxaemia and sleep disruption compared to those with normal MSL, suggesting EDS is associated with more severe OSAHS. There was a negative correlation between ESS score and MSL and both moderately correlated with some polysomnographic nocturnal hypoxaemic parameters. The area under ROC curve of ESS for identifying EDS was 0.80 （95% CI： 0.71 to 0.88） and ESS score 〉12 provided the best predictive value with a sensitivity of 80% and specificity of 69%. Conclusion The ESS score moderately correlates with MSL and our ROC study supports ESS as a screening strategy for assessing EDS in OSAHS.展开更多
The unprecedented globalization of trade,travel,climate change,protectionism,and geopolitical populism,as well as pandemic health threats are no longer issues for a single nation.In the field of public health,China...The unprecedented globalization of trade,travel,climate change,protectionism,and geopolitical populism,as well as pandemic health threats are no longer issues for a single nation.In the field of public health,China's Belt and Road Initiative (BRI) offers immense opportunities for partnership and collective actions involving multiple countries to combat globalization-linked infectious and/or chronic diseases,emerging pandemics,and outbreaks of potential threats to both laboratory information management systems and health information management.The national and global health challenges have increasingly proved that economic prosperity cannot be achieved when huge knowledge and capacity gaps exist in health systems.There is thus a need for public health initiatives aimed at strengthening the health systems beyond sovereign borders to influence global geo-economics.We highlight situational insights that offer approaches and strategies for increasing public health investment and capacity development in the countries along the Belt and Road,enhancing public and global health cooperation alongside participation in disease control and elimination,promoting public health governance and data sharing for pandemic threats,and building shared values and benefits in public health through Sino-African cooperation and the BRI.Our approach also examines the values of the China's BRI in relation to public health,projections and initiatives for increasing new investment and development capacity in public health systems,and enhanced public and global health cooperation and participation toward the BRI's framework and scope.展开更多
Background：Roughly focused extracorporeal shock waves therapy （ESWT） is characterized by a wide focal area,a large therapy zone,easy positioning,and less pain during treatment.The purpose of this study was to inves...Background：Roughly focused extracorporeal shock waves therapy （ESWT） is characterized by a wide focal area,a large therapy zone,easy positioning,and less pain during treatment.The purpose of this study was to investigate the effects of roughly focused ESWT on the expression of osteoprotegerin （OPG） and bone morphogenetic protein-2 （BMP-2） in osteoporotic fractures in rats.Methods：Seventy-two female Sprague-Dawley （SD） rats,3 months old,were divided into sham-operated group （n =6） and an ovariectomized （OVX） group （n =66）.Sixty OVX SD rats were used as a model of double proximal tibial osteotomy and inner fixation.The osteotomy site in the left tibia was treated with roughly focused ESWT once at an energy density of 0.26 mJ/mm^2,60 doses/min,and 2000 pact quantities.The contralateral right tibia was left untreated and served as a control.Expression of OPG and BMP-2 in the callus of the osteoporotic fracture area was assessed using immunohistochemistry,real-time polymerase chain reaction （PCR）,and Western blotting analysis.Results：Bone mineral density （BMD） at the proximal tibia,femur,and L5 spine was significantly reduced after ovariectomy.BMD of proximal tibia was 12.9% less in the OVX group than that in the sham-operated group.Meanwhile,bilateral oophorectomy resulted in a lower trabecular bone volume fraction （BV/TV） in the proximal tibia of the sham-OVX animals.Three months after bilateral oophorectomy,BV/TV was 14.29% of baseline BV/TV in OVX legs versus 45.91% in the sham-OVX legs （P 〈 0.001）.These data showed that the SD rats became a suitable model of osteoporosis,3 months after they were OVX.Immunohistochemical analysis showed higher levels of BMP-2 and OPG expression in the treatment group than those in the control group.Compared with the contralateral controls,decreased expression of OPG and BMP-2 at 3 days after roughly focused ESWT,followed by a later increase at 7 days,was indicated by real-time PCR and Western blotting analysis.The OPG messenger RN展开更多
Background:Tuberculosis(TB)patients in China encounter heavy financial burdens throughout the course of their treatment and it is unclear how China’s health insurance systems affect the alleviation of this burden und...Background:Tuberculosis(TB)patients in China encounter heavy financial burdens throughout the course of their treatment and it is unclear how China’s health insurance systems affect the alleviation of this burden under the integrated approach.This study aimed to measure reimbursement for TB services under the New Cooperative Medical Scheme(NCMS)in rural China and to evaluate changes in catastrophic health expenditure(CHE)caused by the reimbursement policies.Methods:Reimbursement data were obtained from routine data systems for the NCMS in Yichang(YC)and Hanzhong(HZ).1884 TB inpatients reimbursed by NCMS from 2010 to 2012 were included.Household surveys were conducted.A total of 494 TB patients under the NCMS were selected in this paper.12 Focus Group Discussions(FGDs)were held.We measured the impact of the NCMS by counterfactual analysis,which analyzed the financial burden alleviation.Equity was assessed by Concentration Index(CI),and disaggregated by project sites.Results:TB inpatients were reimbursed with an effective reimbursement rate of 57.3%.Average out-of-pocket(OOP)payments for outpatient and inpatient services after diagnosis were 1413 yuan and 430 yuan,and 3572 yuan and 3013 yuan in YC and HZ,respectively.The reimbursement level for TB outpatient care after diagnosis was very low due to a limited outpatient quota.TB patients in HZ incurred higher effective reimbursement rates,but the incidence of CHE remained higher.The reduction of CHE incidence after the NCMS showed no difference statistically(P>0.05).The severity of CHE was alleviated slightly.CIs after reimbursement were all below zero and their absolute values were higher than those before reimbursement.Conclusions:Low reimbursement for TB patients could lead to heavy financial burden.Poor TB patients incurred high rates of CHE.The NCMS was found to be a protective factor for CHE,but the impact was modest and the equity of CHE did not improve.The NCMS reimbursement policies should be improved in the future to include a more comprehensive coverage展开更多
Dear Editor,Colorectal cancer(CRC)is one of the most frequent diseases with high mortality around the world.Conventional treatments of CRC remain unsatisfactory due to the increasing recurrence rate and adverse reacti...Dear Editor,Colorectal cancer(CRC)is one of the most frequent diseases with high mortality around the world.Conventional treatments of CRC remain unsatisfactory due to the increasing recurrence rate and adverse reactions including neutropenia,drug resistance,etc.Recently,autophagy has been shown to be involved in regulating cancer development and progression by regulating apoptosis through pro-apoptosis proteins including caspases,in addition to being a potential target for cancer therapeutic intervention.1 Trifolirhizin(Supplementary Fig.S1a)is a natural flavonoid glycosides isolated from Sophora flavescens as well as a bioactive constituent of Xian-Lian-Ke-Li,a commercial traditional Chinese medicine for the cancer prevention.Numerous evidence manifested that trifolirhizin inhibited proliferative activity in melanoma B16 cell,lung cancer H23 cell,human ovarian A2780 cell,and human gastric cancer cell MKN45.2 However,its pharmacological effect and mechanism on CRC remain elusive.Herein,we evaluated the effect of trifolirhizin on autophagy and apoptosis on CRC as well as its related mechanisms,in order to provide evidence to develop a potential agent with less adverse effect in treating CRC.展开更多
Objective： To investigate the clinical efficacy of combining auricular and routine acupuncture for peripheral facial paralysis in acute stage. Methods： A total of 60 eligible cases were randomly allocated into a tre...Objective： To investigate the clinical efficacy of combining auricular and routine acupuncture for peripheral facial paralysis in acute stage. Methods： A total of 60 eligible cases were randomly allocated into a treatment group （n=30） and a control group （n=30）. Cases in treatment group received auricular and routine acupuncture, whereas cases in the control group received routine acupuncture alone. Both groups were treated for 10 d. Results： The recovery rate was 73.3% in the treatment group and 53.3% in the control group, showing a statistical difference （P〈0.05）. Conclusion： Combining auricular and routine acupuncture is effective for peripheral facial paralysis in acute stage and has a better effect than routine acupuncture.展开更多
Objective No previous studies have evaluated the association between dyslipidemia, alcohol drinking, and diabetes in an Inner Mongolian population. We aimed to evaluate the co-effects of drinking and dyslipidemia on d...Objective No previous studies have evaluated the association between dyslipidemia, alcohol drinking, and diabetes in an Inner Mongolian population. We aimed to evaluate the co-effects of drinking and dyslipidemia on diabetes incidence in this population. Methods The present study was based on 1880 participants from a population-based prospective cohort study among Inner Mongolians living in China. Participants were classified into four subgroups according to their drinking status and dyslipidemia. Multivariate logistic regression analysis and receiver operating characteristic （ROC） curves were used to evaluate the association between alcohol drinking, dyslipidemia, and diabetes. Results During the follow-up period, 203 participants were found to have developed diabetes. The multiva riable-adjusted odds ratios （95% confidence interval） for the incidence of non-dyslipidemia/drinkers, dyslipidemia/non-drinkers, and dyslipidemia/drinkers in diabetic patients were 1.40 （0.82-2.37）, 1.73 （1.17-2.55）, and 2.31 （1.38-3.87）, respectively, when compared with non-dyslipidemia/non-drinkers. The area under the ROC curve for a model containing dyslipidemia and drinking status along with conventional factors （AUC=0.746） was significantly （P=O.003） larger than the one containing only conventional factors （AUC=0.711）. Conclusion The present study showed that dyslipidemia was an independent risk factor for diabetes, and that drinkers with dyslipidemia had the highest risk of diabetes in the Mongolian population. These findings suggest that dyslipidemia and drinkin8 status may be valuable in predicting diabetes incidence.展开更多
Background:Health inequity is an important issue all around the world.The Chinese basic medical security system comprises three major insurance schemes,namely the Urban Employee Basic Medical Insurance(UEBMI),the Urba...Background:Health inequity is an important issue all around the world.The Chinese basic medical security system comprises three major insurance schemes,namely the Urban Employee Basic Medical Insurance(UEBMI),the Urban Resident Basic Medical Insurance(URBMI),and the New Cooperative Medical Scheme(NCMS).Little research has been conducted to look into the disparity in payments among the health insurance schemes in China.In this study,we aimed to evaluate the disparity in reimbursements for tuberculosis(TB)care among the abovementioned health insurance schemes.Methods:This study uses a World Health Organization(WHO)framework to analyze the disparities and equity relating to the three dimensions of health insurance:population coverage,the range of services covered,and the extent to which costs are covered.Each of the health insurance scheme’s policies were categorized and analyzed.An analysis of the claims database of all hospitalizations reimbursed from 2010 to 2012 in three counties of Yichang city(YC),which included 1506 discharges,was conducted to identify the differences in reimbursement rates and out-of-pocket(OOP)expenses among the health insurance schemes.Results:Tuberculosis patients had various inpatient expenses depending on which scheme they were covered by(TB patients covered by the NCMS have less inpatient expenses than those who were covered by the URBMI,who have less inpatient expenses than those covered by the UEBMI).We found a significant horizontal inequity of healthcare utilization among the lower socioeconomic groups.In terms of financial inequity,TB patients who earned less paid more.The NCMS provides modest financial protection,based on income.Overall,TB patients from lower socioeconomic groups were the most vulnerable.Conclusion:There are large disparities in reimbursement for TB care among the three health insurance schemes and this,in turn,hampers TB control.Reducing the gap in health outcomes between the three health insurance schemes in China should be a focus of TB care and control.Achi展开更多
This paper introduces the background,aim and objectives of the project entitled“China—the Gates Foundation Collaboration on TB Control in China”that has been underway for many years.It also summarizes the key findi...This paper introduces the background,aim and objectives of the project entitled“China—the Gates Foundation Collaboration on TB Control in China”that has been underway for many years.It also summarizes the key findings of the nine papers included in this special issue,which used data from the baseline survey of Phase II of the project.Data were collected from the survey of TB and MDR-TB patients,from designated hospitals,health insurance agencies and the routine health information systems,as well as key informant interviews and focus group discussions with relevant key stakeholders.Key issues discussed in this series of papers include the uses of TB services and anti-TB medicines and their determining factors related to socio-economic and health systems development;expenditures on TB care and the financial burden incurred on TB patients;and the impact of health insurance schemes implemented in China on financial protection.展开更多
Objective： To observe the clinical efficacy of acupuncture combined with auricular point sticking treatment for primary dysmenorrhea. Methods： Sixty-eight patients with primary dysmenorrhea were randomly divided in...Objective： To observe the clinical efficacy of acupuncture combined with auricular point sticking treatment for primary dysmenorrhea. Methods： Sixty-eight patients with primary dysmenorrhea were randomly divided into two groups, and 35 cases in the treatment group were treated by acupuncture combined with auricular point sticking, while 33 cases in the control group were only treated by acupuncture. The treatments for the patients in both groups began from one week before their menstruation and continued tiJl the menstruation came. And the efficacy was observed after treatments of three consecutive menstrual cycles. Results： The total effective rate was 94.2% in the treatment group, versus 84.8% in the control group, and the difference was statistically significant （P〈0.05）. Conclusion： Acupuncture combined with auricular point sticking treatment for primary dysmenorrhea is more effective than simple acupuncture.展开更多
BACKGROUND Acupuncture(AT)is widely used in treatment of ovulatory disorder infertility(ODI),but the safety and efficacy of AT for ODI still lack an evidence-based basis.AIM To evaluate the feasibility and effectivene...BACKGROUND Acupuncture(AT)is widely used in treatment of ovulatory disorder infertility(ODI),but the safety and efficacy of AT for ODI still lack an evidence-based basis.AIM To evaluate the feasibility and effectiveness of AT as an adjunct intervention for ODI.METHODS The Cochrane Library,Embase,PubMed,VIP,China National Knowledge Infrastructure,WanFang Data,and Chinese biomedical literature databases were searched from inception to January 20,2024.Two reviewers independently selected studies,collected data,and evaluated methodological quality through the Cochrane Risk of Bias tool.Revman 5.4 was used for meta-analysis,and the Grade system was performed to evaluate the level of evidence for the outcomes of the meta-analysis.RESULTS A total of 20 randomized controlled trials with 1677 ODI patients were included.Compared with the clomiphene citrate(CC)group,the AT plus CC group exhibited significant improvement of the pregnancy rate[relative risk(RR)=1.68,95%confidence interval(CI):1.45-1.95,P<0.00001,I^(2)=23%],ovulation rate(RR=1.34,95%CI:1.22-1.47,P<0.00001,I^(2)=32%),serum E2 level[mean difference(MD)=31.36,95%CI:21.83-40.88,P<0.00001,I^(2)=97%],thickness of endometrium(MD=1.76,95%CI:0.71-2.81,P=0.001,I^(2)=98%)and decreasing miscarriage rate(RR=0.25,95%CI:0.09-0.65,P=0.005,I^(2)=0%),serum follicle-stimulating hormone level(MD=-2.10,95%CI:-3.27 to-0.94,P=0.0004,I^(2)=99%),serum luteinizing hormone level(MD=-6.94,95%CI:-9.89 to-4.00,P<0.00001,I^(2)=100%),and serum progesterone level(MD=-1.66,95%CI:-2.98 to-0.34,P=0.01,I^(2)=96%).The AT group had a more favorable effect than CC group for improving pregnancy rate(RR=1.52,95%CI:1.33-1.73,P<0.00001,I^(2)=0%),thickness of endometrium(MD=2.48,95%CI:2.15-2.81,P<0.00001,I^(2)=0%)and reducing miscarriage rate(RR=0.23,95%CI:0.13-0.44,P<0.00001,I^(2)=0%),serum follicle-stimulating hormone level(MD=-0.55,95%CI:-0.86 to-0.24,P=0.0005,I^(2)=0%),and serum progesterone level(MD=-0.24,95%CI:-0.28 to-0.20,P<0.00001).However,the level of evidence was predominantly assessed as very展开更多
To study the impact of the COVID-19 pandemic on agricultural carbon emissions in China,the greenhouse gas emissions generated by crop and livestock production,and agricultural material and energy inputs in China from ...To study the impact of the COVID-19 pandemic on agricultural carbon emissions in China,the greenhouse gas emissions generated by crop and livestock production,and agricultural material and energy inputs in China from 2019 to 2021 were systematically calculated.It was found that from 2019 to 2021,Net greenhouse gas emissions(NGHGE)from agriculture in China had an increasing trend.Methane emissions ranked first in NGHGE,with an annual proportion exceeding 65%and an increasing annual trend.CH_(4)emissions were primarily influenced by enteric fermentation and rice production.Nitrous oxide emissions accounted for around 22%of annual NGHGE and decreased from 2019 to 2021.The main sources of N_(2)O emissions were the use of nitrogen fertilizers and manure management.Carbon dioxide emissions accounted for about 18%annually,with diesel and agricultural electricity use contributing to over 60%of CO_(2)emissions.Soil carbon sequestration represented about a 6.1%lowering of NGHGE.The combined proportion of CH4 emissions from enteric fermentation and rice production accounted for over 50%of total GHG emissions.The changes in NGHGE were mainly caused by disturbance of the livestock industry during the pandemic.展开更多
Excited-states play a crucial role in the optical absorption and luminescence of solids and hence their accurate information is highly desired. Herein, we attempt to seize the excited-states information of Mn^(4+)ions...Excited-states play a crucial role in the optical absorption and luminescence of solids and hence their accurate information is highly desired. Herein, we attempt to seize the excited-states information of Mn^(4+)ions in K_(2)SiF_(6) microcrystals via measuring and calculating their variable-temperature photoluminescence excitation(PLE) spectra. At cryogenic temperatures, an unpredicted splitting of the high-excited-state is observed. Moreover, the two-split high-excited-state levels are further revealed to primarily couple with the two hyperfine split modes of quasi-localized ν2 vibration in the distorted Mn-F_(6) octahedral configuration,whereas the coupling strengths are found to be substantially different from each other. The slightly split vibrational mode is firmly supported by the low-temperature Raman spectra. Jahn-Teller lattice distortion is believed to be responsible for the observed splitting of the electronic high-excited-state and the quasi-localized vibrational mode.展开更多
基金funded by grants from the Natural Science Foundation of China(NO.81172400,81000963)the Natural Science Foundation of Jiangsu Province(NO.BK2011341)the Natural Science Foundation of Suzhou(NO.SYS201063,SYS201161)
文摘MicroRNA (miR)-125b has been shown to play a potential role in the development of glioma stem cells.However,the relationship between miRNA and glioma stem cells is still elusive.This study was designed to elucidate this potential relationship.We established a highly invasive glioma stem cell and progenitor (GSCP) cell line SU3.SU3 cell suspensions were injected into nude mice brains in situ,and the invasiveness of graft tumors was analyzed using hematoxylin and eosin staining as well as immunohistochemistry.Real-time polymerase chain reaction (PCR) was used to measure the expression levels of miR-125b in SU3 and other cells.In vitro,SU3 cells expressed CD133 and nestin as well as differentiation markers glial fibrillary acidic protein (GFAP) and β-tubulin III,which were consistent with the characteristics of glioma stem cells.Scratch assays indicated that the migration ability of SU3 cells was stronger than that of U251 stem cells (U251s).In vivo,SU3 cells invaded into each part of the mouse brain from the caudate nucleus in a diffuse pattern and highly expressed invasive and proliferative cell markers matrix metalloprotease 2 (MMP2),MMP9,and Ki-67.Real-time PCR results revealed that the levels of miR-125b and MMP9 were significantly higher in SU3 and SU2,also a highly invasive GSCP cell line we established before,than in U251s.High expression of miR-125b both in newly established GSCPs,SU3,and long-term cultured GSCPs,SU2 suggests that miR-125b exhibits oncogene-like behavior.This behavior should be considered in further studies of miR-125b in cancer stem cells.Furthermore,MMP9,which plays a role in cancer stem cell invasion,may be a target gene of miR-125b.
基金National New Drug Innovation Program,No.2017ZX09304003Special Research on Modernization of Traditional Chinese Medicine in the National Key Research and Development Program in the 13th Five-Year Plan Demonstrative Research,No.2017YFC1703703.Institutional review board statement:This study was approved by the IRB of Xiyuan Hospital of China Academy of Chinese Medical Sciences(No.2016XL011).
文摘BACKGROUND Recent research suggests that although prokinetic agents,acid suppressors,and radical treatment for Helicobacter pylori infection may be effective in patients with functional dyspepsia(FD),a large proportion of patients still fail to respond to these treatments or may suffer from severe adverse reactions.Many traditional Chinese medicinal herbs can regulate the status of the entire body and have special advantages in the treatment of functional diseases.The present study was designed to verify the efficacy of Biling Weitong Granules(BLWTG),a traditional Chinese medicinal herbal compound formula,in alleviating epigastric pain syndrome(EPS)in FD patients,in an attempt to provide an effective prescription for the clinical treatment of this disease.AIM To evaluate the clinical efficacy and safety of BLWTG in treating EPS in patients with FD.METHODS In this multicenter,stratified,randomized,double-blind,placebo-controlled,parallel group clinical trial,eligible patients were randomized into the BLWTG and placebo groups who were treated for 6 wk.Efficacy indicators including the severity and frequency of EPS and the time to pain resolution and safety indicators including adverse events were observed and compared.RESULTS The baseline demographic data and clinical characteristics,such as epigastric pain symptoms,pain intensity,and frequency of attacks,were matched between the two groups before randomization.After 6 wk of treatment and after the center effect was eliminated,the epigastric pain was significantly improved in 28.33%and 85.59%of the patients in the placebo and BLWTG groups,respectively(P<0.05).At 6 wk,the resolution rate of epigastric pain was 15%and 69.49%in the placebo and BLWTG groups,respectively(P<0.05).The differences of total FD clinical score between these two groups were significant(P<0.05)at 2,4,and 6 wk(P<0.05).The scores of each item and the total score in the Functional Digestive Disorders Quality of Life Questionnaire showed significant differences between the two groups at 6 wk after
基金supported by the National Natural Science Foundation of China(No.40971041)
文摘Negative air ions are natural components of the air we breathe Forests are the main continuous natural source of negative air ions （NAI）. The spatio-temporal patterns of negative air ions were explored in Shanghai, based on monthly monitoring in 15 parks from March 2009 to February 2010. In each park, sampling sites were selected in forests and open spaces. The annual variation in negative air ion concentrations （NAIC） showed peak values from June to October and minimum values from December to January. NAIC were highest in summer and autumn, intermediate in spring, and lowest in winter. During spring and summer, NAIC in open spaces were significantly higher in rural areas than those in suburban areas. However, there were no significant differences in NAIC at forest sites among seasons. For open spaces, total suspended particles （TSP） were the dominant determining factor of NAIC in sum- mer, and air temperature and air humidity were the dominant determining factors of NAIC in spring, which were tightly correlated with Shanghai＇s ongoing urbanization and its impacts on the environment. R is suggested that urbanization could induce variation in NAIC along the urban-rural gradient, but that may not change the temporal variation pattern. Fur- thermore, the effects of urbanization on NAIC were limited in non-vegetated or less-vegetated sites, such as open spaces, but not in well-vegetated areas, such as urban forests. Therefore, we suggest that urban greening, especially urban forest, has significant resistance to theeffect of urbanization on NAIC.
基金Supported by National Nature Science Foundation of China under Grant 51907024.
文摘As a key component of an integrated energy system(IES),energy storage can effectively alleviate the problem of the times between energy production and consumption.Exploiting the benefits of energy storage can improve the competitiveness of multi-energy systems.This paper proposes a method for day-ahead operation optimization of a building-level integrated energy system(BIES)considering additional potential benefits of energy storage.Based on the characteristics of peak-shaving and valley-filling of energy storage,and further consideration of the changes in the system’s load and real-time electricity price,a model of additional potential benefits of energy storage is developed.Aiming at the lowest total operating cost,a bi-level optimal operational model for day-ahead operation of BIES is developed.A case analysis of different dispatch strategies verifies that the addition of the proposed battery scheduling strategy improves economic operation.The results demonstrate that the model can exploit energy storage’s potential,further optimize the power output of BIES and reduce the economic cost.
基金supported by the National Natural Science Foundation of China[Grant No.81773509][Grant No.81102190]
文摘This prospective study was designed to examine the combined influence of insulin resistance（IR）and inflammatory biomarker levels on type 2 diabetes mellitus（T2DM）among 1,903Inner Mongolians.
文摘Background Elevated fibrinogen （Fg） level is a known risk factor for ischemic stroke. There are few clinical trials on oral fibrinogen-depleting therapies for secondary ischemic stroke prevention. We aimed to assess the effects of one-year therapy with oral lumbrokinase enteric-coated capsules on secondary ischemic stroke prevention.
基金supported by the National Natural Science Foundation of China (Grant Nos.30471484 and 30972531)Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘Objective To explore the relationship of inflammation and endothelial dysfunction with risks to cardiovascular disease （CVD）. Methods Blood pressure, body weight, body height, waist circumference and lifestyle risk factors were measured and studied among 2589 participants in Inner Mongolia of China, and biomarkers of inflammation and endothelial dysfunction including high-sensitivity C-reactive protein （hsCRP）, soluble inter-cellular adhesion molecule-1 （slCAM-1）, soluble E-selectin （sE-selectin）, and angiotensin II were investigated. Results Subjects with metabolic risk factors for CVD had higher levels of hsCRP, sE-selectin and slCAM-1 than those without such risk factors （all P〈O.05）. Levels of all biomarkers positively and significantly increased with aggregation of the metabolic risk factors among the subjects （all P for trend 〈0.001）. Data from the multivariate analysis showed that participants with high levels of hsCRP [odds ratio （OR}： 1.96, 95% confidence interval （CI）： 1.52-2.53], sE-selectin （OR： 1.35, 95% Cl： 1.05-1.72）, and angiotensin II （OR： 1.81, 95% CI＂ 1.40-2.33） were more likely to develop hypertension; participants with high levels of hsCRP （OR： 2.33, 95% CI： 1.85-2.94）, sE-selectin （OR： 1.24, 95% CI： 1.00-1.54）, and slCAM-1 （OR： 1.70, 95% CI： 1.30-2.22） were more likely to develop dyslipidemia, and those with high levels of hsCRP （OR： 2.95, 95% CI： 2.27-3.83） and slCAM-I（OR： 2.80, 95% CI： 2.06-3.80） were more likely to develop hyperglycemia. Conclusion Biomarkers of inflammation and endothelial dysfunction were separately associated with relevant metabolic risk factors for CVD. And appropriate measures should be taken to control inflammation and improve endothelial function among individuals with different metabolic risk factors for CVD.
基金This study was supported by grants fi-om the National Natural Science Foundation of China （NSFC） （No. 81170070, No. 81270147）, and from the Scientific Research Foundation of the Chinese Ministry of Health （No. W2012w4）.
文摘Background Excessive daytime sleepiness （EDS） is often associated with obstructive sleep apnea hypopnea syndrome （OSAHS） and contributes to a number of comorbidities in these patients. Therefore, early detection of EDS is critical in disease management. We examined the association between Epworth Sleepiness Scale （ESS） and multiple sleep latency test （MSLT） and diagnostic accuracy of ESS in assessing EDS in OSAHS patients. Methods The ESS, MSLT and overnight polysomnography were administered to 107 Chinese patients to assess EDS and its correlations with polysomnographic parameters. The diagnostic accuracy of ESS in classifying EDS （mean sleep latency （MSL） 〈10 minutes） was evaluated by calculating the area under ROC curve. Results As the severity of OSAHS increased, MSL decreased with increase in ESS score. Conversely, patients with worsening EDS （shorter MSL） were characterized by advanced nocturnal hypoxaemia and sleep disruption compared to those with normal MSL, suggesting EDS is associated with more severe OSAHS. There was a negative correlation between ESS score and MSL and both moderately correlated with some polysomnographic nocturnal hypoxaemic parameters. The area under ROC curve of ESS for identifying EDS was 0.80 （95% CI： 0.71 to 0.88） and ESS score 〉12 provided the best predictive value with a sensitivity of 80% and specificity of 69%. Conclusion The ESS score moderately correlates with MSL and our ROC study supports ESS as a screening strategy for assessing EDS in OSAHS.
文摘The unprecedented globalization of trade,travel,climate change,protectionism,and geopolitical populism,as well as pandemic health threats are no longer issues for a single nation.In the field of public health,China's Belt and Road Initiative (BRI) offers immense opportunities for partnership and collective actions involving multiple countries to combat globalization-linked infectious and/or chronic diseases,emerging pandemics,and outbreaks of potential threats to both laboratory information management systems and health information management.The national and global health challenges have increasingly proved that economic prosperity cannot be achieved when huge knowledge and capacity gaps exist in health systems.There is thus a need for public health initiatives aimed at strengthening the health systems beyond sovereign borders to influence global geo-economics.We highlight situational insights that offer approaches and strategies for increasing public health investment and capacity development in the countries along the Belt and Road,enhancing public and global health cooperation alongside participation in disease control and elimination,promoting public health governance and data sharing for pandemic threats,and building shared values and benefits in public health through Sino-African cooperation and the BRI.Our approach also examines the values of the China's BRI in relation to public health,projections and initiatives for increasing new investment and development capacity in public health systems,and enhanced public and global health cooperation and participation toward the BRI's framework and scope.
基金This work was supported by grants from the National Nature Science Foundation of China （No. 81071501） and the Shanghai Committee of Science and Technology, China （No. 09411966500）.
文摘Background：Roughly focused extracorporeal shock waves therapy （ESWT） is characterized by a wide focal area,a large therapy zone,easy positioning,and less pain during treatment.The purpose of this study was to investigate the effects of roughly focused ESWT on the expression of osteoprotegerin （OPG） and bone morphogenetic protein-2 （BMP-2） in osteoporotic fractures in rats.Methods：Seventy-two female Sprague-Dawley （SD） rats,3 months old,were divided into sham-operated group （n =6） and an ovariectomized （OVX） group （n =66）.Sixty OVX SD rats were used as a model of double proximal tibial osteotomy and inner fixation.The osteotomy site in the left tibia was treated with roughly focused ESWT once at an energy density of 0.26 mJ/mm^2,60 doses/min,and 2000 pact quantities.The contralateral right tibia was left untreated and served as a control.Expression of OPG and BMP-2 in the callus of the osteoporotic fracture area was assessed using immunohistochemistry,real-time polymerase chain reaction （PCR）,and Western blotting analysis.Results：Bone mineral density （BMD） at the proximal tibia,femur,and L5 spine was significantly reduced after ovariectomy.BMD of proximal tibia was 12.9% less in the OVX group than that in the sham-operated group.Meanwhile,bilateral oophorectomy resulted in a lower trabecular bone volume fraction （BV/TV） in the proximal tibia of the sham-OVX animals.Three months after bilateral oophorectomy,BV/TV was 14.29% of baseline BV/TV in OVX legs versus 45.91% in the sham-OVX legs （P 〈 0.001）.These data showed that the SD rats became a suitable model of osteoporosis,3 months after they were OVX.Immunohistochemical analysis showed higher levels of BMP-2 and OPG expression in the treatment group than those in the control group.Compared with the contralateral controls,decreased expression of OPG and BMP-2 at 3 days after roughly focused ESWT,followed by a later increase at 7 days,was indicated by real-time PCR and Western blotting analysis.The OPG messenger RN
基金supported by the project“Research on Economic Risk of Major Diseases and the Protection Effect Model of Rural Residents in the Central and Western Regions of China”(Grant No.71203068)the“Study on the Dynamic Optimization of Catastrophic Health Insurance Reimbursement Modes and the Scale of Fund Expenditure in the Perspective of UHC”(Grant No.71573095)supported by the National Natural Science Foundation of China.
文摘Background:Tuberculosis(TB)patients in China encounter heavy financial burdens throughout the course of their treatment and it is unclear how China’s health insurance systems affect the alleviation of this burden under the integrated approach.This study aimed to measure reimbursement for TB services under the New Cooperative Medical Scheme(NCMS)in rural China and to evaluate changes in catastrophic health expenditure(CHE)caused by the reimbursement policies.Methods:Reimbursement data were obtained from routine data systems for the NCMS in Yichang(YC)and Hanzhong(HZ).1884 TB inpatients reimbursed by NCMS from 2010 to 2012 were included.Household surveys were conducted.A total of 494 TB patients under the NCMS were selected in this paper.12 Focus Group Discussions(FGDs)were held.We measured the impact of the NCMS by counterfactual analysis,which analyzed the financial burden alleviation.Equity was assessed by Concentration Index(CI),and disaggregated by project sites.Results:TB inpatients were reimbursed with an effective reimbursement rate of 57.3%.Average out-of-pocket(OOP)payments for outpatient and inpatient services after diagnosis were 1413 yuan and 430 yuan,and 3572 yuan and 3013 yuan in YC and HZ,respectively.The reimbursement level for TB outpatient care after diagnosis was very low due to a limited outpatient quota.TB patients in HZ incurred higher effective reimbursement rates,but the incidence of CHE remained higher.The reduction of CHE incidence after the NCMS showed no difference statistically(P>0.05).The severity of CHE was alleviated slightly.CIs after reimbursement were all below zero and their absolute values were higher than those before reimbursement.Conclusions:Low reimbursement for TB patients could lead to heavy financial burden.Poor TB patients incurred high rates of CHE.The NCMS was found to be a protective factor for CHE,but the impact was modest and the equity of CHE did not improve.The NCMS reimbursement policies should be improved in the future to include a more comprehensive coverage
基金supported by the National Natural Science Foundation of China(81930117,81673559,81973523)National Key Research and Development Project(2017YFC1700602)funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘Dear Editor,Colorectal cancer(CRC)is one of the most frequent diseases with high mortality around the world.Conventional treatments of CRC remain unsatisfactory due to the increasing recurrence rate and adverse reactions including neutropenia,drug resistance,etc.Recently,autophagy has been shown to be involved in regulating cancer development and progression by regulating apoptosis through pro-apoptosis proteins including caspases,in addition to being a potential target for cancer therapeutic intervention.1 Trifolirhizin(Supplementary Fig.S1a)is a natural flavonoid glycosides isolated from Sophora flavescens as well as a bioactive constituent of Xian-Lian-Ke-Li,a commercial traditional Chinese medicine for the cancer prevention.Numerous evidence manifested that trifolirhizin inhibited proliferative activity in melanoma B16 cell,lung cancer H23 cell,human ovarian A2780 cell,and human gastric cancer cell MKN45.2 However,its pharmacological effect and mechanism on CRC remain elusive.Herein,we evaluated the effect of trifolirhizin on autophagy and apoptosis on CRC as well as its related mechanisms,in order to provide evidence to develop a potential agent with less adverse effect in treating CRC.
文摘Objective： To investigate the clinical efficacy of combining auricular and routine acupuncture for peripheral facial paralysis in acute stage. Methods： A total of 60 eligible cases were randomly allocated into a treatment group （n=30） and a control group （n=30）. Cases in treatment group received auricular and routine acupuncture, whereas cases in the control group received routine acupuncture alone. Both groups were treated for 10 d. Results： The recovery rate was 73.3% in the treatment group and 53.3% in the control group, showing a statistical difference （P〈0.05）. Conclusion： Combining auricular and routine acupuncture is effective for peripheral facial paralysis in acute stage and has a better effect than routine acupuncture.
基金supported by Youth Found of the National Natural Science Foundation of China[Grant No.81102190]partially supported by a Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions,China
文摘Objective No previous studies have evaluated the association between dyslipidemia, alcohol drinking, and diabetes in an Inner Mongolian population. We aimed to evaluate the co-effects of drinking and dyslipidemia on diabetes incidence in this population. Methods The present study was based on 1880 participants from a population-based prospective cohort study among Inner Mongolians living in China. Participants were classified into four subgroups according to their drinking status and dyslipidemia. Multivariate logistic regression analysis and receiver operating characteristic （ROC） curves were used to evaluate the association between alcohol drinking, dyslipidemia, and diabetes. Results During the follow-up period, 203 participants were found to have developed diabetes. The multiva riable-adjusted odds ratios （95% confidence interval） for the incidence of non-dyslipidemia/drinkers, dyslipidemia/non-drinkers, and dyslipidemia/drinkers in diabetic patients were 1.40 （0.82-2.37）, 1.73 （1.17-2.55）, and 2.31 （1.38-3.87）, respectively, when compared with non-dyslipidemia/non-drinkers. The area under the ROC curve for a model containing dyslipidemia and drinking status along with conventional factors （AUC=0.746） was significantly （P=O.003） larger than the one containing only conventional factors （AUC=0.711）. Conclusion The present study showed that dyslipidemia was an independent risk factor for diabetes, and that drinkers with dyslipidemia had the highest risk of diabetes in the Mongolian population. These findings suggest that dyslipidemia and drinkin8 status may be valuable in predicting diabetes incidence.
基金supported by the project“Research on Economic Risk of Major Diseases and the Protection Effect Model of Rural Residents in the Central and Western Regions of China”(grant no.71203068)the“Study on the Dynamic Optimization of Catastrophic Health Insurance Reimbursement Modes and the Scale of Fund Expenditure in the Perspective of UHC”(grant no.71573095)both supported by the National Natural Science Foundation of China.
文摘Background:Health inequity is an important issue all around the world.The Chinese basic medical security system comprises three major insurance schemes,namely the Urban Employee Basic Medical Insurance(UEBMI),the Urban Resident Basic Medical Insurance(URBMI),and the New Cooperative Medical Scheme(NCMS).Little research has been conducted to look into the disparity in payments among the health insurance schemes in China.In this study,we aimed to evaluate the disparity in reimbursements for tuberculosis(TB)care among the abovementioned health insurance schemes.Methods:This study uses a World Health Organization(WHO)framework to analyze the disparities and equity relating to the three dimensions of health insurance:population coverage,the range of services covered,and the extent to which costs are covered.Each of the health insurance scheme’s policies were categorized and analyzed.An analysis of the claims database of all hospitalizations reimbursed from 2010 to 2012 in three counties of Yichang city(YC),which included 1506 discharges,was conducted to identify the differences in reimbursement rates and out-of-pocket(OOP)expenses among the health insurance schemes.Results:Tuberculosis patients had various inpatient expenses depending on which scheme they were covered by(TB patients covered by the NCMS have less inpatient expenses than those who were covered by the URBMI,who have less inpatient expenses than those covered by the UEBMI).We found a significant horizontal inequity of healthcare utilization among the lower socioeconomic groups.In terms of financial inequity,TB patients who earned less paid more.The NCMS provides modest financial protection,based on income.Overall,TB patients from lower socioeconomic groups were the most vulnerable.Conclusion:There are large disparities in reimbursement for TB care among the three health insurance schemes and this,in turn,hampers TB control.Reducing the gap in health outcomes between the three health insurance schemes in China should be a focus of TB care and control.Achi
基金The study based on which this paper was written is part of the program entitled“China National Health and Family Planning Commission and the Gates Foundation TB Project”-a collaboration between the Government of China and the Melinda and Bill Gates Foundation(Grant No.51914)implemented by the China Center of Disease Control and Prevention(CDC).
文摘This paper introduces the background,aim and objectives of the project entitled“China—the Gates Foundation Collaboration on TB Control in China”that has been underway for many years.It also summarizes the key findings of the nine papers included in this special issue,which used data from the baseline survey of Phase II of the project.Data were collected from the survey of TB and MDR-TB patients,from designated hospitals,health insurance agencies and the routine health information systems,as well as key informant interviews and focus group discussions with relevant key stakeholders.Key issues discussed in this series of papers include the uses of TB services and anti-TB medicines and their determining factors related to socio-economic and health systems development;expenditures on TB care and the financial burden incurred on TB patients;and the impact of health insurance schemes implemented in China on financial protection.
文摘Objective： To observe the clinical efficacy of acupuncture combined with auricular point sticking treatment for primary dysmenorrhea. Methods： Sixty-eight patients with primary dysmenorrhea were randomly divided into two groups, and 35 cases in the treatment group were treated by acupuncture combined with auricular point sticking, while 33 cases in the control group were only treated by acupuncture. The treatments for the patients in both groups began from one week before their menstruation and continued tiJl the menstruation came. And the efficacy was observed after treatments of three consecutive menstrual cycles. Results： The total effective rate was 94.2% in the treatment group, versus 84.8% in the control group, and the difference was statistically significant （P〈0.05）. Conclusion： Acupuncture combined with auricular point sticking treatment for primary dysmenorrhea is more effective than simple acupuncture.
基金Supported by Kunshan Chinese Medicine Science and Technology Development Fund,No.KZYY2212.
文摘BACKGROUND Acupuncture(AT)is widely used in treatment of ovulatory disorder infertility(ODI),but the safety and efficacy of AT for ODI still lack an evidence-based basis.AIM To evaluate the feasibility and effectiveness of AT as an adjunct intervention for ODI.METHODS The Cochrane Library,Embase,PubMed,VIP,China National Knowledge Infrastructure,WanFang Data,and Chinese biomedical literature databases were searched from inception to January 20,2024.Two reviewers independently selected studies,collected data,and evaluated methodological quality through the Cochrane Risk of Bias tool.Revman 5.4 was used for meta-analysis,and the Grade system was performed to evaluate the level of evidence for the outcomes of the meta-analysis.RESULTS A total of 20 randomized controlled trials with 1677 ODI patients were included.Compared with the clomiphene citrate(CC)group,the AT plus CC group exhibited significant improvement of the pregnancy rate[relative risk(RR)=1.68,95%confidence interval(CI):1.45-1.95,P<0.00001,I^(2)=23%],ovulation rate(RR=1.34,95%CI:1.22-1.47,P<0.00001,I^(2)=32%),serum E2 level[mean difference(MD)=31.36,95%CI:21.83-40.88,P<0.00001,I^(2)=97%],thickness of endometrium(MD=1.76,95%CI:0.71-2.81,P=0.001,I^(2)=98%)and decreasing miscarriage rate(RR=0.25,95%CI:0.09-0.65,P=0.005,I^(2)=0%),serum follicle-stimulating hormone level(MD=-2.10,95%CI:-3.27 to-0.94,P=0.0004,I^(2)=99%),serum luteinizing hormone level(MD=-6.94,95%CI:-9.89 to-4.00,P<0.00001,I^(2)=100%),and serum progesterone level(MD=-1.66,95%CI:-2.98 to-0.34,P=0.01,I^(2)=96%).The AT group had a more favorable effect than CC group for improving pregnancy rate(RR=1.52,95%CI:1.33-1.73,P<0.00001,I^(2)=0%),thickness of endometrium(MD=2.48,95%CI:2.15-2.81,P<0.00001,I^(2)=0%)and reducing miscarriage rate(RR=0.23,95%CI:0.13-0.44,P<0.00001,I^(2)=0%),serum follicle-stimulating hormone level(MD=-0.55,95%CI:-0.86 to-0.24,P=0.0005,I^(2)=0%),and serum progesterone level(MD=-0.24,95%CI:-0.28 to-0.20,P<0.00001).However,the level of evidence was predominantly assessed as very
基金sponsored by the Kunshan Municipal Government Research Funding(23KKSGR023).
文摘To study the impact of the COVID-19 pandemic on agricultural carbon emissions in China,the greenhouse gas emissions generated by crop and livestock production,and agricultural material and energy inputs in China from 2019 to 2021 were systematically calculated.It was found that from 2019 to 2021,Net greenhouse gas emissions(NGHGE)from agriculture in China had an increasing trend.Methane emissions ranked first in NGHGE,with an annual proportion exceeding 65%and an increasing annual trend.CH_(4)emissions were primarily influenced by enteric fermentation and rice production.Nitrous oxide emissions accounted for around 22%of annual NGHGE and decreased from 2019 to 2021.The main sources of N_(2)O emissions were the use of nitrogen fertilizers and manure management.Carbon dioxide emissions accounted for about 18%annually,with diesel and agricultural electricity use contributing to over 60%of CO_(2)emissions.Soil carbon sequestration represented about a 6.1%lowering of NGHGE.The combined proportion of CH4 emissions from enteric fermentation and rice production accounted for over 50%of total GHG emissions.The changes in NGHGE were mainly caused by disturbance of the livestock industry during the pandemic.
基金supported by the National Natural Science Foundation of China (Grant Nos. 12074324, and 11374247)the Science, Technology, and Innovation Commission of Shenzhen Municipality (Grant Nos. JCJY20180508163404043, and JCYJ20170818141709893)。
文摘Excited-states play a crucial role in the optical absorption and luminescence of solids and hence their accurate information is highly desired. Herein, we attempt to seize the excited-states information of Mn^(4+)ions in K_(2)SiF_(6) microcrystals via measuring and calculating their variable-temperature photoluminescence excitation(PLE) spectra. At cryogenic temperatures, an unpredicted splitting of the high-excited-state is observed. Moreover, the two-split high-excited-state levels are further revealed to primarily couple with the two hyperfine split modes of quasi-localized ν2 vibration in the distorted Mn-F_(6) octahedral configuration,whereas the coupling strengths are found to be substantially different from each other. The slightly split vibrational mode is firmly supported by the low-temperature Raman spectra. Jahn-Teller lattice distortion is believed to be responsible for the observed splitting of the electronic high-excited-state and the quasi-localized vibrational mode.
