To improve the internal quantum efficiency(IQE)and light output power of In Ga N light-emitting diodes(LEDs),we proposed an In-composition gradient increase and decrease In Ga N quantum barrier structure.Through analy...To improve the internal quantum efficiency(IQE)and light output power of In Ga N light-emitting diodes(LEDs),we proposed an In-composition gradient increase and decrease In Ga N quantum barrier structure.Through analysis of its P-I graph,carrier concentration,and energy band diagram,the results showed that when the current was 100 m A,the In-composition gradient decrease quantum barrier(QB)structure could effectively suppress electron leakage while improving hole injection efficiency,resulting in an increase in carrier concentration in the active region and an improvement in the effective recombination rate in the quantum well(QW).As a result,the IQE and output power of the LED were effectively improved.展开更多
Background and Aims:Hepatocellular carcinoma(HCC)isa highly aggressive tumor with limited treatment options andhigh mortality.Senecavirus A(SVA)has shown potential inselectively targeting tumors while sparing healthy ...Background and Aims:Hepatocellular carcinoma(HCC)isa highly aggressive tumor with limited treatment options andhigh mortality.Senecavirus A(SVA)has shown potential inselectively targeting tumors while sparing healthy tissues.This study aimed to investigate the effects of SVA on HCCcells in vitro and in vivo and to elucidate its mechanisms ofaction.Methods:The cell counting kit-8 assay and colonyformation assay were conducted to examine cell proliferation.Flow cytometry and nuclear staining were employed toanalyze cell cycle distribution and apoptosis occurrence.Asubcutaneous tumor xenograft HCC mouse model was createdin vivo using HepG2 cells,and Ki67 expression in thetumor tissues was assessed.The terminal deoxynucleotidyltransferase dUTP nick end labeling assay and hematoxylinand eosin staining were employed to evaluate HCC apoptosisand the toxicity of SVA on mouse organs.Results:In vitro,SVA effectively suppressed the growth of tumor cells by inducingapoptosis and cell cycle arrest.However,it did nothave a notable effect on normal hepatocytes(MIHA cells).In an in vivo setting,SVA effectively suppressed the growthof HCC in a mouse model.SVA treatment resulted in a significantdecrease in Ki67 expression and an increase in apoptosisof tumor cells.No notable histopathological alterationswere observed in the organs of mice during SVA administration.Conclusions:SVA inhibits the growth of HCC cells byinducing cell cycle arrest and apoptosis.It does not causeany noticeable toxicity to vital organs.展开更多
Comprehensive Summary The EDA complex-mediated reactions involving oxime esters have been few studied.Herein,an EDA complex formed by thiophenolate anion and oxime ester is reported for photoinduced divergent synthesi...Comprehensive Summary The EDA complex-mediated reactions involving oxime esters have been few studied.Herein,an EDA complex formed by thiophenolate anion and oxime ester is reported for photoinduced divergent synthesis of thioethers,depending on different types of oxime esters.Operational simplicity,mild reaction conditions,and flexible options of leaving group demonstrate the generality and synthetic utility of this approach.Such an approach can also enable an interesting thiol-catalysis for the synthesis of phenanthridines.展开更多
In recent years,there has been a shift towards using non-fullerene electron acceptors in organic solar cells(osCs)as a replacement for fullerene derivatives.This change requires polymer donors that possess compatible ...In recent years,there has been a shift towards using non-fullerene electron acceptors in organic solar cells(osCs)as a replacement for fullerene derivatives.This change requires polymer donors that possess compatible physical properties,such as absorption range,HoMo energy level,miscibility,and crystallinity.Moreover,the high cost and poor batch-to-batch reproducibility of polymer donors also hinder future large-scale manufacturing.These emphasize the need to explore alternative types of polymer donors.The imide-functionalized building units possess several key attributes that make their polymers highly promising for non-fullerene OsCs.These attributes include ease of synthesis,strong electron-withdrawing ability,rigid and co-planar structure,and the ability to easily tune solubility through imide side chains.In this review,we summarized the synthetic routes of imide building units,and the structural evolution of imide-functionalized polymer donors by focusing on the effects of polymer structure on their physical,optoelectronic,and photovoltaic properties.We hope that this mini-review will serve as a catalyst for future research on imide-functionalized polymers toward high-performance,cost-effective,and durable organic solar cells(oscs).展开更多
In this paper,an ultraviolet C-band laser diode lasing at 277 nm composed of B0.313Ga0.687N/B0.40Ga0.60N QW/QB heterostructure on Mg and Si-doped AlxGa1-xN layers was designed,as well as a lowest reported substitution...In this paper,an ultraviolet C-band laser diode lasing at 277 nm composed of B0.313Ga0.687N/B0.40Ga0.60N QW/QB heterostructure on Mg and Si-doped AlxGa1-xN layers was designed,as well as a lowest reported substitutional accepter and donor concentration up to NA=5.0×10^17 cm^-3 and ND=9.0×10^16 cm^-3 for deep ultraviolet lasing was achieved.The structure was assumed to be grown over bulk AIN substrate and operate under a continuous wave at room temperature.Although there is an emphasizing of the suitability for using boron nitride wide band gap in the deep ultraviolet region,there is still a shortage of investigation about the ternary BGaN in aluminum-rich AIGaN alloys.Based on the simulation,an average local gain in quantum wells of 1946 cm^-1,the maximum emitted power of 2.4 W,the threshold current of 500 mA,a slope efficiency of 1.91 W/A as well as an average DC resistance for the V-I curve of(0.336Ω)had been observed.Along with an investigation regarding different EBL,designs were included with tapered and inverse tapered structure.Therefore,it had been found a good agreement with the published results for tapered EBL design,with an overweighting for a proposed inverse tapered EBL design.展开更多
The deformation behavior of AZ31 was examined by compression and tension testes over a wide strain rate and temperature range,strain rate from 10-3 to 103 s-1,temperature from 300 to 623 K. Analysis of flow behavior a...The deformation behavior of AZ31 was examined by compression and tension testes over a wide strain rate and temperature range,strain rate from 10-3 to 103 s-1,temperature from 300 to 623 K. Analysis of flow behavior and microstructural observations indicate that in tension tests dislocation glide is the most important deformation mechanism in the test strain rate and temperature range,while in compression tests twinning deformation mechanism is important at lower temperature when the strain rate ranges from 10-3 to 10 s-1. At 103 s-1 strain rate,dislocation glide and twinning are present at the same time. At the strain rate of 2 964 s-1,adiabatic shear band can be found easily,even at the strain rate of 1 537 s-1 adiabatic shear localization zone can be found. In adiabatic shear localization zone,there are fine recrystallization grains. But in adiabatic shear band,the grains cannot be identified by optical microscopy.展开更多
Water extracts prepared from seven varieties of olive leaves native to the Mediterranean area but planted in Sichuan province, P.R. China, namely Frantoiao, Leccio, Ezhi, Picholine, Pendollino, Chenggu and Huaou 9#, w...Water extracts prepared from seven varieties of olive leaves native to the Mediterranean area but planted in Sichuan province, P.R. China, namely Frantoiao, Leccio, Ezhi, Picholine, Pendollino, Chenggu and Huaou 9#, were examined for their total phenonic and flavonoid contents, antioxidant capacity. Total phenolic and flavonoid content were measured by Folin-Ciocalteu method and a colorimetric method, respectively. ABTS＋ method and FRAP were used for examining antioxidant activity. Response surface methodology （RSM） was used for optimizing the extract condition. Under the optimum condition, the total phenolic and flavonoid content of aqueous extracts of the dry olive leaves （DOL） ranged from 40.27 to 56.58 mg gallic acid （GAE）/g DOL and 21.59 to 33.72 mg catechin （CE）/g DOL in June, 34.31 to 52.81 mg GAE/g DOL and 17.11 to 23.53 mg CE/g DOL in November. The ABTS＋ method and FRAP ranged from 0.23 to 0.35 mmol trolox （TE）/g DOL and 313.01 to 409.69 μmol Fe2＋/g DOL in June, 0.19 to 0.30 mmol TE/g DOL and 254.69 to 418.10 pmol Fe2＋/g DOL in November. Our results revealed that the total phenolic and flavonoid, or antioxidant capacity of the water extract were higher in June than November. Moreover, it was noticed that the antioxidant activity depends on the flavonoid and phenolic.展开更多
基金supported by the National Natural Science Foundation of China(No.62174148)the National Key Research and Development Program(Nos.2022YFE0112000 and 2016YFE0118400)+2 种基金the Key Program for International Joint Research of Henan Province(No.231111520300)the Ningbo Major Project of‘Science,Technology and Innovation 2025’(No.2019B10129)the Zhengzhou 1125 Innovation Project(No.ZZ2018-45)。
文摘To improve the internal quantum efficiency(IQE)and light output power of In Ga N light-emitting diodes(LEDs),we proposed an In-composition gradient increase and decrease In Ga N quantum barrier structure.Through analysis of its P-I graph,carrier concentration,and energy band diagram,the results showed that when the current was 100 m A,the In-composition gradient decrease quantum barrier(QB)structure could effectively suppress electron leakage while improving hole injection efficiency,resulting in an increase in carrier concentration in the active region and an improvement in the effective recombination rate in the quantum well(QW).As a result,the IQE and output power of the LED were effectively improved.
基金funded by the Natural Science Foundation of China(NSFC)through Grant No.82102383the Sichuan Science and Technology Program through Grant No.2022JDRC0047+3 种基金the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences through Grant No.2021-I2M-1-060the Central Government-Directed Special Funds for Local Science and Technology Development Project through Grant No.2021ZYD0085QinChuangyuan recruited high-level innovation and entrepreneurship talents project of Science and Technology Department of Shanxi Province(QCYRCXM-2022-56)Additionally,they have received funding for a medical research project from the Xi’an Science and Technology Bureau(22YXYJ0120).
文摘Background and Aims:Hepatocellular carcinoma(HCC)isa highly aggressive tumor with limited treatment options andhigh mortality.Senecavirus A(SVA)has shown potential inselectively targeting tumors while sparing healthy tissues.This study aimed to investigate the effects of SVA on HCCcells in vitro and in vivo and to elucidate its mechanisms ofaction.Methods:The cell counting kit-8 assay and colonyformation assay were conducted to examine cell proliferation.Flow cytometry and nuclear staining were employed toanalyze cell cycle distribution and apoptosis occurrence.Asubcutaneous tumor xenograft HCC mouse model was createdin vivo using HepG2 cells,and Ki67 expression in thetumor tissues was assessed.The terminal deoxynucleotidyltransferase dUTP nick end labeling assay and hematoxylinand eosin staining were employed to evaluate HCC apoptosisand the toxicity of SVA on mouse organs.Results:In vitro,SVA effectively suppressed the growth of tumor cells by inducingapoptosis and cell cycle arrest.However,it did nothave a notable effect on normal hepatocytes(MIHA cells).In an in vivo setting,SVA effectively suppressed the growthof HCC in a mouse model.SVA treatment resulted in a significantdecrease in Ki67 expression and an increase in apoptosisof tumor cells.No notable histopathological alterationswere observed in the organs of mice during SVA administration.Conclusions:SVA inhibits the growth of HCC cells byinducing cell cycle arrest and apoptosis.It does not causeany noticeable toxicity to vital organs.
基金support from the National Natural Science Foundation of China(22171177)the Guangdong-Hong Kong Joint Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province(2023B1212120011)+3 种基金the Guangdong Basic and Applied Basic Research Foundation(2023A1515110791)the Chemistry and Chemical Engineering Guangdong Laboratory(2312002)the Guangdong Major Project of Basic and Applied Basic Research(2019B030302009)the Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme 2019(GDUPS2019).
文摘Comprehensive Summary The EDA complex-mediated reactions involving oxime esters have been few studied.Herein,an EDA complex formed by thiophenolate anion and oxime ester is reported for photoinduced divergent synthesis of thioethers,depending on different types of oxime esters.Operational simplicity,mild reaction conditions,and flexible options of leaving group demonstrate the generality and synthetic utility of this approach.Such an approach can also enable an interesting thiol-catalysis for the synthesis of phenanthridines.
基金supported by the National Natural Science Foundation of China(22179076)the Natural Science Foundation of Guangdong Province(2022A1515011803,2023B1212120011)the Department of Education of Guangdong Province(2021KCXTD032).
文摘In recent years,there has been a shift towards using non-fullerene electron acceptors in organic solar cells(osCs)as a replacement for fullerene derivatives.This change requires polymer donors that possess compatible physical properties,such as absorption range,HoMo energy level,miscibility,and crystallinity.Moreover,the high cost and poor batch-to-batch reproducibility of polymer donors also hinder future large-scale manufacturing.These emphasize the need to explore alternative types of polymer donors.The imide-functionalized building units possess several key attributes that make their polymers highly promising for non-fullerene OsCs.These attributes include ease of synthesis,strong electron-withdrawing ability,rigid and co-planar structure,and the ability to easily tune solubility through imide side chains.In this review,we summarized the synthetic routes of imide building units,and the structural evolution of imide-functionalized polymer donors by focusing on the effects of polymer structure on their physical,optoelectronic,and photovoltaic properties.We hope that this mini-review will serve as a catalyst for future research on imide-functionalized polymers toward high-performance,cost-effective,and durable organic solar cells(oscs).
基金National Key Research and Development Program (Nos. NKRDP 2016YFE0118400)the Key project of Science and Technology of Henan Province (No. 172102410062)+1 种基金National Natural Science Foundation of China (No. 61176008)National Natural Science Foundation of China Henan Provincial Joint Fund Key Project (No. U1604263)
文摘In this paper,an ultraviolet C-band laser diode lasing at 277 nm composed of B0.313Ga0.687N/B0.40Ga0.60N QW/QB heterostructure on Mg and Si-doped AlxGa1-xN layers was designed,as well as a lowest reported substitutional accepter and donor concentration up to NA=5.0×10^17 cm^-3 and ND=9.0×10^16 cm^-3 for deep ultraviolet lasing was achieved.The structure was assumed to be grown over bulk AIN substrate and operate under a continuous wave at room temperature.Although there is an emphasizing of the suitability for using boron nitride wide band gap in the deep ultraviolet region,there is still a shortage of investigation about the ternary BGaN in aluminum-rich AIGaN alloys.Based on the simulation,an average local gain in quantum wells of 1946 cm^-1,the maximum emitted power of 2.4 W,the threshold current of 500 mA,a slope efficiency of 1.91 W/A as well as an average DC resistance for the V-I curve of(0.336Ω)had been observed.Along with an investigation regarding different EBL,designs were included with tapered and inverse tapered structure.Therefore,it had been found a good agreement with the published results for tapered EBL design,with an overweighting for a proposed inverse tapered EBL design.
文摘The deformation behavior of AZ31 was examined by compression and tension testes over a wide strain rate and temperature range,strain rate from 10-3 to 103 s-1,temperature from 300 to 623 K. Analysis of flow behavior and microstructural observations indicate that in tension tests dislocation glide is the most important deformation mechanism in the test strain rate and temperature range,while in compression tests twinning deformation mechanism is important at lower temperature when the strain rate ranges from 10-3 to 10 s-1. At 103 s-1 strain rate,dislocation glide and twinning are present at the same time. At the strain rate of 2 964 s-1,adiabatic shear band can be found easily,even at the strain rate of 1 537 s-1 adiabatic shear localization zone can be found. In adiabatic shear localization zone,there are fine recrystallization grains. But in adiabatic shear band,the grains cannot be identified by optical microscopy.
文摘Water extracts prepared from seven varieties of olive leaves native to the Mediterranean area but planted in Sichuan province, P.R. China, namely Frantoiao, Leccio, Ezhi, Picholine, Pendollino, Chenggu and Huaou 9#, were examined for their total phenonic and flavonoid contents, antioxidant capacity. Total phenolic and flavonoid content were measured by Folin-Ciocalteu method and a colorimetric method, respectively. ABTS＋ method and FRAP were used for examining antioxidant activity. Response surface methodology （RSM） was used for optimizing the extract condition. Under the optimum condition, the total phenolic and flavonoid content of aqueous extracts of the dry olive leaves （DOL） ranged from 40.27 to 56.58 mg gallic acid （GAE）/g DOL and 21.59 to 33.72 mg catechin （CE）/g DOL in June, 34.31 to 52.81 mg GAE/g DOL and 17.11 to 23.53 mg CE/g DOL in November. The ABTS＋ method and FRAP ranged from 0.23 to 0.35 mmol trolox （TE）/g DOL and 313.01 to 409.69 μmol Fe2＋/g DOL in June, 0.19 to 0.30 mmol TE/g DOL and 254.69 to 418.10 pmol Fe2＋/g DOL in November. Our results revealed that the total phenolic and flavonoid, or antioxidant capacity of the water extract were higher in June than November. Moreover, it was noticed that the antioxidant activity depends on the flavonoid and phenolic.
