This review summarizes main research findings in soil fauna eco-geography in China in the past 30 years. The subject areas and main results were overviewed including biodiversity and eco-geological distribution of soi...This review summarizes main research findings in soil fauna eco-geography in China in the past 30 years. The subject areas and main results were overviewed including biodiversity and eco-geological distribution of soil fauna communities. Studies of ecological distributions of soil fauna and dynamic ranges in space from tropical, subtropical to temperate regions, and in categories from forest, grassland, desert, wetland, farmland to urban ecosystems, the responses and indications of soil fauna to soil environments. Effects of intensive disturbance such as fire, grazing, farming, fertilization on soil fauna include sensitive （e.g. nematode） and rare groups and community indexes. The functions of soil fauna were discussed including environmental construction, environmental purification, litter decomposition and elements cycling. Interactions between soil fauna and other biota in soil ecosystems and linking between aboveground and belowground diversity and the effects of global change on soil fauna community in China were also included. Finally, the authors pointed out common interests in soil fauna eco-geographical studies, which include application of molecule biology into soil fauna taxa; function and mechanism of soil fauna community diversity; interaction between aboveground and belowground ecosystems; effects of disturbance, pollution, biological invasion, and global change on soil fauna community and function. The review is to provide a scientific basis for promoting soil fauna eco-geographical studies in China.展开更多
Malignant ascites indicates the presence of malignant cells in the peritoneal cavity and is a grave prognostic sign. While survival in this patient population is poor, averaging about 20 wk from time of diagnosis, qua...Malignant ascites indicates the presence of malignant cells in the peritoneal cavity and is a grave prognostic sign. While survival in this patient population is poor, averaging about 20 wk from time of diagnosis, quality of life can be improved through palliative procedures. Selecting the appropriate treatment modality remains a careful process, which should take into account potential risks and benefits and the life expectancy of the patient. Traditional therapies, including paracentesis, peritoneovenous shunt placement and diuretics, are successful and effective in varying degrees. After careful review of the patient’s primary tumor origin, tumor biology, tumor stage, patient performance status and comorbidities, surgical debulking and intraperitoneal chemotherapy should be considered if the benefit of therapy outweighs the risk of operation because survival curves can be extended and palliation of symptomatic malignant ascites can be achieved in select patients. In patients with peritoneal carcinomatosis who do not qualify for surgical cytoreduction but suffer from the effects of malignant ascites, intraperitoneal chemotherapy can be safely and effectively administered via laparoscopic techniques. Short operative times, short hospital stays, low complication rates and ultimately symptomatic relief are the advantages of laparoscopically administering heated intraperitoneal chemotherapy, making it not only a valuable treatment modality but also the most successful treatment modality for achieving palliative cure of malignant ascites.展开更多
Hepatocellular cancer ranks fifth among cancers and is related to chronic viral hepatitis, alcohol abuse,steatohepatitis and liver autoimmunity. Surgical resection and orthotopic liver transplantation have curative po...Hepatocellular cancer ranks fifth among cancers and is related to chronic viral hepatitis, alcohol abuse,steatohepatitis and liver autoimmunity. Surgical resection and orthotopic liver transplantation have curative potential, but fewer than 20% of patients are suitable candidates. Interventional treatments are offered to the vast majority of patients. Radiofrequency(RFA) and microwave ablation(MWA) are among the therapeutic modalities, with similar indications which include the presence of up to three lesions, smaller than 3 cm in size, and the absence of extrahepatic disease. The therapeutic effect of both methods relies on thermal injury, but MWA uses an electromagnetic field as opposed to electrical current used in RFA. Unlike MWA, the effect of RFA is partially limited by the heat-sink effect and increased impedance of the ablated tissue. Compared with RFA, MWA attains a more predictable ablation zone, permits simultaneous treatment of multiple lesions, and achieves larger coagulation volumes in a shorter procedural time. Major complications of both methods are comparable and infrequent(approximately 2%-3%), and they include haemorrhage, infection/abscess, visceral organ injury, liver failure, and pneumothorax. RFA may incur the additional complication of skin burns. Nevertheless, there is no compelling evidence for differences in clinical outcomes, including local recurrence rates and survival.展开更多
The Wenchuan earthquake of 12 May 2008 is the most destructive earthquake in China in the past 30 years in terms of property damage and human losses. In order to understand the earthquake process and the geo-morpholog...The Wenchuan earthquake of 12 May 2008 is the most destructive earthquake in China in the past 30 years in terms of property damage and human losses. In order to understand the earthquake process and the geo-morphological factors affecting the seismic hazard, we simulated the strong ground mo-tion caused by the earthquake, incorporating three-dimensional (3D) earth structure, finite-fault rupture, and realistic surface topography. The simulated ground motions reveal that the fault rupture and basin structure control the overall pattern of the peak ground shaking. Large peak ground velocity (PGV) is distributed in two narrow areas: one with the largest PGV values is above the hanging wall of the fault and attributed to the locations of fault asperities and rupture directivity; the other is along the north-western margin of the Sichuan Basin and caused by both the directivity of fault rupture and the ampli-fication in the thick sediment basin. Rough topography above the rupture fault causes wave scattering, resulting in significantly larger peak ground motion on the apex of topographic relief than in the valley. Topography and scattering also reduce the wave energy in the forward direction of fault rupture but increase the PGV in other parts of the basin. These results suggest the need for a localized hazard as-sessment in places of rough topography that takes the topographic effects into account. Finally, had the earthquake started at the northeast end of the fault zone and ruptured to the southwest, Chengdu would have suffered a much stronger shaking than it experienced on 12 May, 2008.展开更多
A series of independent faulted basins developed in the present middle reaches of the Yellow River during late Cenozoic, among which the Sanmen Lake Basin is located in the east edge of the Loess Plateau, a transition...A series of independent faulted basins developed in the present middle reaches of the Yellow River during late Cenozoic, among which the Sanmen Lake Basin is located in the east edge of the Loess Plateau, a transitional zone between the second and third macromorphological step of China. The thick strata of the Sanmen Group deposited in the large basin. The Sanmen Group is a perfect place for the study on paleoenvironmental change, tectono-climatic cycles as well as the formation and evolution of the Yellow River. In this paper, the paleoenvironmental changes, regional tectonic movement and the evolutionary process of the Sanmen Lake Basin during the past 5 Ma were reconstructed based on the analysis of paleomagnetic stratigraphy, pollen, TOC and carbonate content from the Huangdigou outcrop near the Sanmenxia Reservoir, Pinglu County, Shanxi Province. The sedimentary records from the outcrop indicate that the basin was first formated by fault activity at about 5.4 MaBP, and after the strong tectonic movement at 3.6 MaBP the lake enlarged and the rainfall of summer monsoon increased. There was no great climatic transition near 2.6 MaBP, corresponding to the bottom age of loess in the Loess Plateau. After Olduvai event (about 1.77 MaBP) the Picea and Abies were presented in the sediments, which indicates a colder climate. The tectonic movement at 1.2 MaBP caused the light angular discordance between the upper and lower Sanmen Group. The sedimentary records show a cold and wet climate during the prosperous periods of loess accumulation such as L15, L9, L6. The tectonic intensification periods of the Sanmen Basin correspond with the tectonic movements in the Qinghai-Xizang Plateau chronologically. The earliest age of the outflow from the Paleo-Sanmen Lake or the partly cutting off of the Sanmenxia Gorge was about 0.41- 0.35 MaBP. The age of cutting thoroughly the Sanmenxia Gorge by the Yellow River and the disappearance of the Paleo-Sanmen Lake was about 0.15 MaBP, which symbolized the formation of the present Yellow展开更多
The role of macrophages （MФ） as the first line of host defense is well accepted. These cells play a central role in orchestrating crucial functions during schistosomal infection. Thus, understanding the functional ...The role of macrophages （MФ） as the first line of host defense is well accepted. These cells play a central role in orchestrating crucial functions during schistosomal infection. Thus, understanding the functional diversity of these cells in the process of infection as well as the mechanisms underlying these events is crucial for developing disease control strategies. In this study, we adopted a Mqb polarization recognition system. M1 macrophage was characterized by expressing CD16/32, IL-12 and iNOS. M2 macrophage was characterized by expressing CD206, IL-10 and arg-1. In vivo （mouse peritoneal macrophages of different infection stages were obtained） and in vitro （different S. japonicum antigens were used to stimulate RAW264.7） were characterized by using the above mentioned system. NCA and ACA stimulated RAW264.7 express significantly higher levels of IL-12 while significantly higher levels of IL-10 were detected after soluble egg antigen （SEA） stimulation. The results showed that dramatic changes of antigen in the microenvironment before and after egg production led to macrophage polarization. Furthermore, through TLR blocking experiments, the TLR4 signaling pathway was found to play a role in the process of macrophage polarization toward M1. Our data suggest that macrophage polarization during S. japonicum infection had significant effects on host immune responses to S. japonicum.展开更多
This paper presents the optimal design procedure of Tuned Mass Damper (TMD) for reducing vibration of an actual steel jacket offshore platform excited by random wave loading. In this study, a frequency domain is taken...This paper presents the optimal design procedure of Tuned Mass Damper (TMD) for reducing vibration of an actual steel jacket offshore platform excited by random wave loading. In this study, a frequency domain is taken. The force on the structure is determined by use of the linearized Morison equation for an input Power Spectral Density (PSD) of wave elevation. The sensitivity of optimum values of TMD to characteristic parameters of random wave spectrum is analyzed. An optimized TMD design for the modeled platform is given based on design conditions and the findings of the study.展开更多
Albumin is the single most abundant protein in the human serum. Its roles in physiology and pathology are diverse. Serum albumin levels have been classically thought to reflect the nutritional status of patients. This...Albumin is the single most abundant protein in the human serum. Its roles in physiology and pathology are diverse. Serum albumin levels have been classically thought to reflect the nutritional status of patients. This concept has been challenged in the last two decades as multiple factors, such as inflammation, appeared to affect albumin levels independent of nutrition. In general, cancer patients have a high prevalence of hypoalbuminemia. As such, the role of hypoalbuminemia in patients with colorectal cancer has received significant interest. We reviewed the English literature on the prognostic value of pretreatment albumin levels in colorectal cancer. We also consolidated the evidence that led to the current understanding of hypoalbuminemia as an inflammatory marker rather than as a nutritional one among patients with colorectal cancer.展开更多
Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human dise...Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels.展开更多
With rapid economic and social development, soil contamination arising from heavy metals has become a serious problem in many parts of China. We collected a total of 445 samples （0-20 cm） at the nodes of a 2 kmx2 km...With rapid economic and social development, soil contamination arising from heavy metals has become a serious problem in many parts of China. We collected a total of 445 samples （0-20 cm） at the nodes of a 2 kmx2 km grid in surface soils of Rizhao city, and analyzed sources and risk pattern of 10 heavy metals （As, Cd, Co, Cr, Cu, Hg, Mn, Ni, Pb and Zn）. The combination of Multivariate statistics analysis and Geostatistical methods was applied to identify the sources and hazardous risk of heavy metals in soils. The result indicated that Cr, Ni, Co, Mn, Cu, and As were mainly controlled by parent materials and came from natural sources. Cd and Hg originated from anthropogenic sources. Pb and Zn, belonging to different groups in multivariate analysis, were associated with joint effect of parent materials and human inputs. Ordinary Kriging and Indicator Kriging suggested that single element and elements association from the same principal components had similar spatial distribution. Through comprehensive assessment on all elements, we also found the high risk areas were located in the populated urban areas and western study area, which could be attributed to the higher geological background in the western part and strong human interference in the eastern part.展开更多
Ocean wave propagation is slow, visible and measurable, so a wave theory can be used to approximately predict the imminnent wave force on an offshore structure based on measured, real-time wave elevation near the stru...Ocean wave propagation is slow, visible and measurable, so a wave theory can be used to approximately predict the imminnent wave force on an offshore structure based on measured, real-time wave elevation near the structure. This predictability suggests the development of a more efficient algorithm, than those that have been developed for structures under wind and seismic loads, for the active vibration control of offshore structures. The present study delveops a mutiple-step predictive optimal control (MPOC) algorithm that accounts for multiple step external loading in the determination of optimal control forces. The control efficiency of the newly developed MPOC algorithm has been Investigated under both regular (single-frequency) and irregular (multiple-frequency) wave loads, and compared with that of two other well-known optimal control algorithms: classical linear optimal control(CLOC) and instantaneous optimal control(IOC).展开更多
The productivity, product quality and competitive ability of important agricultural and horticultural plants in many regions of the world may be adversely affected by current and anticipated concentrations of ground-l...The productivity, product quality and competitive ability of important agricultural and horticultural plants in many regions of the world may be adversely affected by current and anticipated concentrations of ground-level ozone （O_3）. Exposure to elevated O_3 typically results in suppressed photosynthesis, accelerated senescence, decreased growth and lower yields. Various approaches used to evaluate O_3 effects generally concur that current yield losses range from 5% to 15% among sensitive plants. There is, however, considerable genetic variability in plant responses to O_3.展开更多
An obvious motivation of this paper is to examine the effectiveness of the lateral vibration control of a jacket type offshore platform with an AMD control device, in conjunction with H-2 control algorithm, which is a...An obvious motivation of this paper is to examine the effectiveness of the lateral vibration control of a jacket type offshore platform with an AMD control device, in conjunction with H-2 control algorithm, which is an optimal frequency domain control method based on minimization of H-2 norm of the system transfer function In this study, the offshore platform is modeled numerically by use of the finite element method, instead of a lumped mass model This structural model is later simplified to be single-degree-of-freedom (SDOF) system by extracting the first vibration mode of the structure. The corresponding 'generalized' wave force is determined based on an analytical approximation of the first mode shape function, the physical wave loading being calculated from the linearized Morison equation. This approach facilitates the filter design for the generalized force. Furthermore, the present paper also intends to make numerical comparison between H-2 active control and the corresponding passive control using a TMD with the same device parameters.展开更多
Nuclear erythroid 2-related factor 2(Nrf2) is a central regulator of antioxidative response elements-mediated gene expression. It has a significant role in adaptive responses to oxidative stress by interacting with th...Nuclear erythroid 2-related factor 2(Nrf2) is a central regulator of antioxidative response elements-mediated gene expression. It has a significant role in adaptive responses to oxidative stress by interacting with the antioxidant response element, which induces the expression of a variety of downstream targets aimed at cytoprotection. Previous studies suggested oxidative stress and associated damage could represent a common link between different forms of diseases. Oxidative stress has been implicated in various liver diseases, including viral hepatitis, nonalcoholic fatty liver disease/steatohepatitis, alcoholic liver disease and drug-induced liver injury. Nrf2 activation is initiated by oxidative or electrophilic stress, and aids in the detoxification and elimination of potentially harmful exogenous chemicals and their metabolites. The expression of Nrf2 has been observed throughout human tissue, with high expression in detoxification organs, especially the liver. Thus, Nrf2 may serve as a major regulator of several cellular defense associated pathways by which hepatic cells combat oxidative stress. We review the relevant literature concerning the crucial role of Nrf2 and its signaling pathways against oxidative stress to protect hepatic cell from oxidative damage during development of common chronic liver diseases. We also review the use of Nrf2 as a therapeutic target to prevent and treat liver diseases.展开更多
An MIDAS-400 Customised Data Ac- quisition System was deployed to obtain current ve- locity and suspended sediment concentration profiles over the intertidal flat at Wanggang, on the Jiangsu coast (China). At the same...An MIDAS-400 Customised Data Ac- quisition System was deployed to obtain current ve- locity and suspended sediment concentration profiles over the intertidal flat at Wanggang, on the Jiangsu coast (China). At the same time, seawater tempera- ture, conductivity and pressure were measured. Us- ing a data sampling rate of 4 Hz, the high-frequency pressure signals in response to water surface fluc- tuations were recorded and subsequently trans- formed into wave parameters. The analytical results show that the apparent bed roughness length has a magnitude close to the height of sand ripples, which is much larger than the grain size diameter. The bot- tom shear stress associated with current-wave in- teraction is higher than the tidally-induced stress and intensified turbulent mixing and resuspension. Fur- thermore, several suspended sediment concentration peaks occurred during a tidal cycle, which can be related to strong turbulence near the bed caused by frontal tidal currents and the enhanced resuspension; advection and extreme weather conditions (e. g. storms and strong winds) also played an important role. Finally, large net suspended sediment fluxes were observed to present when the flood or ebb currents prolonged, i.e. the flow became quasi-unid- irectional during a tidal cycle. In general, the MIDAS- 400 is a suitable tool for high-resolution data collec- tion for the situations of combined current-wave ac- tion over intertidal flats; the data obtained can be used to analyze the processes and mechanisms of material transport.展开更多
基金National Natural Science Foundation of China, No.40871120 National Key Technology Research and De- velopment Program, No.2007BAC06B03
文摘This review summarizes main research findings in soil fauna eco-geography in China in the past 30 years. The subject areas and main results were overviewed including biodiversity and eco-geological distribution of soil fauna communities. Studies of ecological distributions of soil fauna and dynamic ranges in space from tropical, subtropical to temperate regions, and in categories from forest, grassland, desert, wetland, farmland to urban ecosystems, the responses and indications of soil fauna to soil environments. Effects of intensive disturbance such as fire, grazing, farming, fertilization on soil fauna include sensitive （e.g. nematode） and rare groups and community indexes. The functions of soil fauna were discussed including environmental construction, environmental purification, litter decomposition and elements cycling. Interactions between soil fauna and other biota in soil ecosystems and linking between aboveground and belowground diversity and the effects of global change on soil fauna community in China were also included. Finally, the authors pointed out common interests in soil fauna eco-geographical studies, which include application of molecule biology into soil fauna taxa; function and mechanism of soil fauna community diversity; interaction between aboveground and belowground ecosystems; effects of disturbance, pollution, biological invasion, and global change on soil fauna community and function. The review is to provide a scientific basis for promoting soil fauna eco-geographical studies in China.
文摘Malignant ascites indicates the presence of malignant cells in the peritoneal cavity and is a grave prognostic sign. While survival in this patient population is poor, averaging about 20 wk from time of diagnosis, quality of life can be improved through palliative procedures. Selecting the appropriate treatment modality remains a careful process, which should take into account potential risks and benefits and the life expectancy of the patient. Traditional therapies, including paracentesis, peritoneovenous shunt placement and diuretics, are successful and effective in varying degrees. After careful review of the patient’s primary tumor origin, tumor biology, tumor stage, patient performance status and comorbidities, surgical debulking and intraperitoneal chemotherapy should be considered if the benefit of therapy outweighs the risk of operation because survival curves can be extended and palliation of symptomatic malignant ascites can be achieved in select patients. In patients with peritoneal carcinomatosis who do not qualify for surgical cytoreduction but suffer from the effects of malignant ascites, intraperitoneal chemotherapy can be safely and effectively administered via laparoscopic techniques. Short operative times, short hospital stays, low complication rates and ultimately symptomatic relief are the advantages of laparoscopically administering heated intraperitoneal chemotherapy, making it not only a valuable treatment modality but also the most successful treatment modality for achieving palliative cure of malignant ascites.
文摘Hepatocellular cancer ranks fifth among cancers and is related to chronic viral hepatitis, alcohol abuse,steatohepatitis and liver autoimmunity. Surgical resection and orthotopic liver transplantation have curative potential, but fewer than 20% of patients are suitable candidates. Interventional treatments are offered to the vast majority of patients. Radiofrequency(RFA) and microwave ablation(MWA) are among the therapeutic modalities, with similar indications which include the presence of up to three lesions, smaller than 3 cm in size, and the absence of extrahepatic disease. The therapeutic effect of both methods relies on thermal injury, but MWA uses an electromagnetic field as opposed to electrical current used in RFA. Unlike MWA, the effect of RFA is partially limited by the heat-sink effect and increased impedance of the ablated tissue. Compared with RFA, MWA attains a more predictable ablation zone, permits simultaneous treatment of multiple lesions, and achieves larger coagulation volumes in a shorter procedural time. Major complications of both methods are comparable and infrequent(approximately 2%-3%), and they include haemorrhage, infection/abscess, visceral organ injury, liver failure, and pneumothorax. RFA may incur the additional complication of skin burns. Nevertheless, there is no compelling evidence for differences in clinical outcomes, including local recurrence rates and survival.
基金the U.S. National Science Foundation (Grant Nos. EAR 0738779 and OCE 0727919)the National Basic Research Program of China (Grant No. 2004CB418404)partially by the National Nature Science Foundation of China (Grant No. 40521002)
文摘The Wenchuan earthquake of 12 May 2008 is the most destructive earthquake in China in the past 30 years in terms of property damage and human losses. In order to understand the earthquake process and the geo-morphological factors affecting the seismic hazard, we simulated the strong ground mo-tion caused by the earthquake, incorporating three-dimensional (3D) earth structure, finite-fault rupture, and realistic surface topography. The simulated ground motions reveal that the fault rupture and basin structure control the overall pattern of the peak ground shaking. Large peak ground velocity (PGV) is distributed in two narrow areas: one with the largest PGV values is above the hanging wall of the fault and attributed to the locations of fault asperities and rupture directivity; the other is along the north-western margin of the Sichuan Basin and caused by both the directivity of fault rupture and the ampli-fication in the thick sediment basin. Rough topography above the rupture fault causes wave scattering, resulting in significantly larger peak ground motion on the apex of topographic relief than in the valley. Topography and scattering also reduce the wave energy in the forward direction of fault rupture but increase the PGV in other parts of the basin. These results suggest the need for a localized hazard as-sessment in places of rough topography that takes the topographic effects into account. Finally, had the earthquake started at the northeast end of the fault zone and ruptured to the southwest, Chengdu would have suffered a much stronger shaking than it experienced on 12 May, 2008.
基金This work was supported by the Fund for Key Projects of Chinese Academy of Sciences (Grant No. KZ951-A 1-402-04-02) the Fund for National Key Projects (Grant No. G1998040800).
文摘A series of independent faulted basins developed in the present middle reaches of the Yellow River during late Cenozoic, among which the Sanmen Lake Basin is located in the east edge of the Loess Plateau, a transitional zone between the second and third macromorphological step of China. The thick strata of the Sanmen Group deposited in the large basin. The Sanmen Group is a perfect place for the study on paleoenvironmental change, tectono-climatic cycles as well as the formation and evolution of the Yellow River. In this paper, the paleoenvironmental changes, regional tectonic movement and the evolutionary process of the Sanmen Lake Basin during the past 5 Ma were reconstructed based on the analysis of paleomagnetic stratigraphy, pollen, TOC and carbonate content from the Huangdigou outcrop near the Sanmenxia Reservoir, Pinglu County, Shanxi Province. The sedimentary records from the outcrop indicate that the basin was first formated by fault activity at about 5.4 MaBP, and after the strong tectonic movement at 3.6 MaBP the lake enlarged and the rainfall of summer monsoon increased. There was no great climatic transition near 2.6 MaBP, corresponding to the bottom age of loess in the Loess Plateau. After Olduvai event (about 1.77 MaBP) the Picea and Abies were presented in the sediments, which indicates a colder climate. The tectonic movement at 1.2 MaBP caused the light angular discordance between the upper and lower Sanmen Group. The sedimentary records show a cold and wet climate during the prosperous periods of loess accumulation such as L15, L9, L6. The tectonic intensification periods of the Sanmen Basin correspond with the tectonic movements in the Qinghai-Xizang Plateau chronologically. The earliest age of the outflow from the Paleo-Sanmen Lake or the partly cutting off of the Sanmenxia Gorge was about 0.41- 0.35 MaBP. The age of cutting thoroughly the Sanmenxia Gorge by the Yellow River and the disappearance of the Paleo-Sanmen Lake was about 0.15 MaBP, which symbolized the formation of the present Yellow
文摘The role of macrophages （MФ） as the first line of host defense is well accepted. These cells play a central role in orchestrating crucial functions during schistosomal infection. Thus, understanding the functional diversity of these cells in the process of infection as well as the mechanisms underlying these events is crucial for developing disease control strategies. In this study, we adopted a Mqb polarization recognition system. M1 macrophage was characterized by expressing CD16/32, IL-12 and iNOS. M2 macrophage was characterized by expressing CD206, IL-10 and arg-1. In vivo （mouse peritoneal macrophages of different infection stages were obtained） and in vitro （different S. japonicum antigens were used to stimulate RAW264.7） were characterized by using the above mentioned system. NCA and ACA stimulated RAW264.7 express significantly higher levels of IL-12 while significantly higher levels of IL-10 were detected after soluble egg antigen （SEA） stimulation. The results showed that dramatic changes of antigen in the microenvironment before and after egg production led to macrophage polarization. Furthermore, through TLR blocking experiments, the TLR4 signaling pathway was found to play a role in the process of macrophage polarization toward M1. Our data suggest that macrophage polarization during S. japonicum infection had significant effects on host immune responses to S. japonicum.
基金National Natural Foundation of China.(Grant No.69572015)
文摘This paper presents the optimal design procedure of Tuned Mass Damper (TMD) for reducing vibration of an actual steel jacket offshore platform excited by random wave loading. In this study, a frequency domain is taken. The force on the structure is determined by use of the linearized Morison equation for an input Power Spectral Density (PSD) of wave elevation. The sensitivity of optimum values of TMD to characteristic parameters of random wave spectrum is analyzed. An optimized TMD design for the modeled platform is given based on design conditions and the findings of the study.
文摘Albumin is the single most abundant protein in the human serum. Its roles in physiology and pathology are diverse. Serum albumin levels have been classically thought to reflect the nutritional status of patients. This concept has been challenged in the last two decades as multiple factors, such as inflammation, appeared to affect albumin levels independent of nutrition. In general, cancer patients have a high prevalence of hypoalbuminemia. As such, the role of hypoalbuminemia in patients with colorectal cancer has received significant interest. We reviewed the English literature on the prognostic value of pretreatment albumin levels in colorectal cancer. We also consolidated the evidence that led to the current understanding of hypoalbuminemia as an inflammatory marker rather than as a nutritional one among patients with colorectal cancer.
基金supported by the National Natural Science Foundation of China(31871380,32000500,32070730,32170756,32170804,81330008,81671377,81725010,81725010,81872874,81921006,81922027,81971312,81991512,82030041,82103167,82122024,82125009,82125011,82130044,91749126,91949101,91949207,92049302)the National Key Research and Development Program of China(2017YFA0506400,2018YFA0800200,2018YFA0800700,2018YFA0900200,2018YFC2000100,2018YFC2000400,2018YFE-0203700,20192ACB70002,2019YFA0802202,2020YFA0113400,2020YFA0803401,2020YFA0804000,2020YFC2002800,2020YFC-2002900,2021ZD0202401)+11 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16010100,XDA16010603,XDA16020400,XDB29020000,XDB39000000,XDB39000000,XDB39030300)the China Association for Science and Technology(2021QNRC001)the Beijing Municipal Science and Technology Commission(Z200022)the Natural Science Foundation of Shanghai(21JC1406400)the Key Programs of the Jiangxi ProvinceChina(20192ACB70002)the“Shu Guang”Project supported by the Shanghai Municipal Education Commission and Shanghai Education Development Foundation(19SG18)the Shanghai Sailing Program(22YF1434300)the Research Project of Joint Laboratory of University of Science and Technology of China and Anhui Mental Health Center(2019LH03)the Fundamental Research Funds for the Central Universities(WK2070210004)the Young Elite Scientists Sponsorship Program by China Association for Science and Technology(YESS20210002)the Youth Innovation Promotion Association of Chinese Academy of Sciences(2022083)。
文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels.
基金China State-Sponsored Postgraduate Study Abroad Program,No.201306190053National Natural Science Foundation of China,No.41101079+1 种基金The Program B for Outstanding PhD Candidate of Nanjing University,No.2014001B008The Program for Graduate Student’s Research Innovation of Jiangsu Province,No.CXLX13-051
文摘With rapid economic and social development, soil contamination arising from heavy metals has become a serious problem in many parts of China. We collected a total of 445 samples （0-20 cm） at the nodes of a 2 kmx2 km grid in surface soils of Rizhao city, and analyzed sources and risk pattern of 10 heavy metals （As, Cd, Co, Cr, Cu, Hg, Mn, Ni, Pb and Zn）. The combination of Multivariate statistics analysis and Geostatistical methods was applied to identify the sources and hazardous risk of heavy metals in soils. The result indicated that Cr, Ni, Co, Mn, Cu, and As were mainly controlled by parent materials and came from natural sources. Cd and Hg originated from anthropogenic sources. Pb and Zn, belonging to different groups in multivariate analysis, were associated with joint effect of parent materials and human inputs. Ordinary Kriging and Indicator Kriging suggested that single element and elements association from the same principal components had similar spatial distribution. Through comprehensive assessment on all elements, we also found the high risk areas were located in the populated urban areas and western study area, which could be attributed to the higher geological background in the western part and strong human interference in the eastern part.
基金National Science Foundation of U.S.A.under grant CMS-9503533
文摘Ocean wave propagation is slow, visible and measurable, so a wave theory can be used to approximately predict the imminnent wave force on an offshore structure based on measured, real-time wave elevation near the structure. This predictability suggests the development of a more efficient algorithm, than those that have been developed for structures under wind and seismic loads, for the active vibration control of offshore structures. The present study delveops a mutiple-step predictive optimal control (MPOC) algorithm that accounts for multiple step external loading in the determination of optimal control forces. The control efficiency of the newly developed MPOC algorithm has been Investigated under both regular (single-frequency) and irregular (multiple-frequency) wave loads, and compared with that of two other well-known optimal control algorithms: classical linear optimal control(CLOC) and instantaneous optimal control(IOC).
文摘The productivity, product quality and competitive ability of important agricultural and horticultural plants in many regions of the world may be adversely affected by current and anticipated concentrations of ground-level ozone （O_3）. Exposure to elevated O_3 typically results in suppressed photosynthesis, accelerated senescence, decreased growth and lower yields. Various approaches used to evaluate O_3 effects generally concur that current yield losses range from 5% to 15% among sensitive plants. There is, however, considerable genetic variability in plant responses to O_3.
基金This work was partly supported by the Japan Society for the Promotion of Science (JSPS) for RONPAKU program by Foundation for University Key Teacher by the Ministry of Education of China
文摘An obvious motivation of this paper is to examine the effectiveness of the lateral vibration control of a jacket type offshore platform with an AMD control device, in conjunction with H-2 control algorithm, which is an optimal frequency domain control method based on minimization of H-2 norm of the system transfer function In this study, the offshore platform is modeled numerically by use of the finite element method, instead of a lumped mass model This structural model is later simplified to be single-degree-of-freedom (SDOF) system by extracting the first vibration mode of the structure. The corresponding 'generalized' wave force is determined based on an analytical approximation of the first mode shape function, the physical wave loading being calculated from the linearized Morison equation. This approach facilitates the filter design for the generalized force. Furthermore, the present paper also intends to make numerical comparison between H-2 active control and the corresponding passive control using a TMD with the same device parameters.
基金Supported by The Scientific Research Projects from the Development and Reform Commission of Hunan Province,China,No.2011(1318),No.2012(1493)and No.2013(1132)
文摘Nuclear erythroid 2-related factor 2(Nrf2) is a central regulator of antioxidative response elements-mediated gene expression. It has a significant role in adaptive responses to oxidative stress by interacting with the antioxidant response element, which induces the expression of a variety of downstream targets aimed at cytoprotection. Previous studies suggested oxidative stress and associated damage could represent a common link between different forms of diseases. Oxidative stress has been implicated in various liver diseases, including viral hepatitis, nonalcoholic fatty liver disease/steatohepatitis, alcoholic liver disease and drug-induced liver injury. Nrf2 activation is initiated by oxidative or electrophilic stress, and aids in the detoxification and elimination of potentially harmful exogenous chemicals and their metabolites. The expression of Nrf2 has been observed throughout human tissue, with high expression in detoxification organs, especially the liver. Thus, Nrf2 may serve as a major regulator of several cellular defense associated pathways by which hepatic cells combat oxidative stress. We review the relevant literature concerning the crucial role of Nrf2 and its signaling pathways against oxidative stress to protect hepatic cell from oxidative damage during development of common chronic liver diseases. We also review the use of Nrf2 as a therapeutic target to prevent and treat liver diseases.
基金supported by the National Natural Science Foundation of China(Grant Nos.40576040,40231010 and 40206006).
文摘An MIDAS-400 Customised Data Ac- quisition System was deployed to obtain current ve- locity and suspended sediment concentration profiles over the intertidal flat at Wanggang, on the Jiangsu coast (China). At the same time, seawater tempera- ture, conductivity and pressure were measured. Us- ing a data sampling rate of 4 Hz, the high-frequency pressure signals in response to water surface fluc- tuations were recorded and subsequently trans- formed into wave parameters. The analytical results show that the apparent bed roughness length has a magnitude close to the height of sand ripples, which is much larger than the grain size diameter. The bot- tom shear stress associated with current-wave in- teraction is higher than the tidally-induced stress and intensified turbulent mixing and resuspension. Fur- thermore, several suspended sediment concentration peaks occurred during a tidal cycle, which can be related to strong turbulence near the bed caused by frontal tidal currents and the enhanced resuspension; advection and extreme weather conditions (e. g. storms and strong winds) also played an important role. Finally, large net suspended sediment fluxes were observed to present when the flood or ebb currents prolonged, i.e. the flow became quasi-unid- irectional during a tidal cycle. In general, the MIDAS- 400 is a suitable tool for high-resolution data collec- tion for the situations of combined current-wave ac- tion over intertidal flats; the data obtained can be used to analyze the processes and mechanisms of material transport.
