Gastrointestinal stromal tumors(GISTs) are the most common mesenchymal tumors located in the alimentary tract. Its usual manifestation is gastrointestinal bleeding. However, small asymptomatic lesions are frequently d...Gastrointestinal stromal tumors(GISTs) are the most common mesenchymal tumors located in the alimentary tract. Its usual manifestation is gastrointestinal bleeding. However, small asymptomatic lesions are frequently detected as incidental finding. Characteristically, most GISTs(> 95%) are positive for the KIT protein(CD117) by IHC staining and approximately 80%-90% of GISTs carry a mutation in the c-KIT or PDGFRA genes. Mutational analysis should be performed when planning adjuvant and neoadjuvant therapy, due to its possible resistance to conventional treatment. The arise of tyrosine kinase inhibitor has supposed a revolution in GISTs treatment being useful as adjuvant, neoadjuvant or recurrence disease treatment. That is why a multidisciplinary approach to this disease is required. The correct characterization of the tumor at diagnosis(the diagnosis of recurrences and the evaluation of the response to treatment with tyrosine kinase inhibitors) is fundamental for facing these tumors and requires specialized Endoscopist, Radiologists and Nuclear Medicine Physician. Surgery is the only potentially curative treatment for suspected resectable GIST. In the case of high risk GISTs, surgery plus adjuvantImatinib-Mesylate for 3 years is the standard treatment. Neoadjuvant imatinib-mesylate should be considered to shrink the tumor in case of locally advanced primary or recurrence disease, unresectable or potentially resectable metastasic tumors, and potentially resectable disease in complex anatomic locations to decrease the related morbidity. In the case of Metastatic GIST under Neoadjuvant treatment, when there are complete response, stable disease or limited disease progression, complete cytoreductive surgery could be a therapeutic option if feasible.展开更多
BACKGROUND Among the most frequent hip fractures are trochanteric fractures,which usually occur from low-energy trauma like minor falls,especially in older people with osteoporotic bones.AIM To evaluate the treatment ...BACKGROUND Among the most frequent hip fractures are trochanteric fractures,which usually occur from low-energy trauma like minor falls,especially in older people with osteoporotic bones.AIM To evaluate the treatment efficacy of dynamic condylar screws(DCS)and proximal femoral nails(PFN)for unstable intertrochanteric fractures.METHODS To find pertinent randomized controlled trials and retrospective observational studies comparing PFN with DCS for the management of unstable femoral intertrochanteric fractures,a thorough search was carried out.For research studies published between January 1996 and April 2024,PubMed,EMBASE,Scopus,Web of Science,Cochrane Library,and Google Scholar were all searched.The complete texts of the papers were retrieved,vetted,and independently examined by two investigators.Disputes were settled by consensus,and any disagreements that persisted were arbitrated by a third author.RESULTS This study included six articles,comprising a total of 173 patients.Compared to the DCS,the PFN had a shorter operation time[mean difference(MD):-41.7 min,95%confidence interval(95%CI):-63.04 to-20.35,P=0.0001],higher success rates with closed reduction techniques[risk ratio(RR):34.05,95%CI:11.12-104.31,P<0.00001],and required less intraoperative blood transfusion(MD:-1.4 units,95%CI:-1.80 to-1.00,P<0.00001).Additionally,the PFN showed shorter fracture union time(MD:-6.92 wk,95%CI:-10.27 to-3.57,P<0.0001)and a lower incidence of reoperation(RR:0.37,95%CI:0.17-0.82,P=0.01).However,there was no discernible variation regarding hospital stay,implant-related complications,and infections.CONCLUSION Compared to DCS,PFN offers shorter operative times,reduces the blood transfusions requirements,achieves higher closed reduction success,enables faster fracture healing,and lowers reoperation incidence.展开更多
The Sendai Framework for Disaster Risk Reduction 2015–2030 recognizes the strong connection between health and disasters and promotes the concept of health resilience throughout.Several of the seven global targets st...The Sendai Framework for Disaster Risk Reduction 2015–2030 recognizes the strong connection between health and disasters and promotes the concept of health resilience throughout.Several of the seven global targets stated in the Sendai Framework are directly related to health in terms of reducing disaster mortality,the number of affected people,disaster damage to critical infrastructure,and disruption of basic services such as health facilities.The Sendai Framework also maintains close coordination with other United Nations landmark agreements relevant to health such as the Sustainable Development Goals.However,the measurement of healthrelated indicators is challenging.Issues arise,for example,in linking deaths to disasters because of the complex interplay between exposure,risk,vulnerability,and hazards.The lack of a universal classification of disasters also means that recording of health data in disasters is not standardized.Developing the guidelines to enable data onthe indicators to be collected and reported to support the Sendai targets requires detailed thinking,time,and consultation with a diverse range of stakeholders.Strong collaboration and partnership will be vital to achieving success.展开更多
Objective Through the investigation of the pathogenicity of COL4A4 heterozygous splicing mutations and the genotype-phenotype correlation in autosomal dominant Alport syndrome(ADAS),to better understand the impact of ...Objective Through the investigation of the pathogenicity of COL4A4 heterozygous splicing mutations and the genotype-phenotype correlation in autosomal dominant Alport syndrome(ADAS),to better understand the impact of COL4A4 heterozygous splicing mutations on ADAS.Methods The study was a case series analysis.Patients from 5 ADAS families with COL4A4 heterozygous splicing mutations detected by whole exome sequencing were recruited by three hospitals.展开更多
Objective To investigate the effect of continuous positive airway pressure(CPAP)on blood pressure and blood pressure rhythm in hypertensive patients with sleep apnea syndrome.Methods Hypertensive patients with obstruc...Objective To investigate the effect of continuous positive airway pressure(CPAP)on blood pressure and blood pressure rhythm in hypertensive patients with sleep apnea syndrome.Methods Hypertensive patients with obstructive sleep apnea syndrome consecutively recruited between 2020 and 2022 were randomly divided into two groups.展开更多
Prostate cancer is one of the most common types of cancer in men. The rate of early detection of prostate cancer is low in Türkiye. Therefore, it is important to measure the level of awareness regarding prostate ...Prostate cancer is one of the most common types of cancer in men. The rate of early detection of prostate cancer is low in Türkiye. Therefore, it is important to measure the level of awareness regarding prostate cancer. In our research, we investigate the knowledge levels of prostate cancer among adult individuals in four different geographic region in Türkiye. In addition, we aimed to compare the level of awareness regarding prostate cancer and the depression and anxiety levels among the individuals. The prostate cancer awareness level survey was selected as the data collection tool. In the survey, 20 questions are asked to measure the knowledge level of the participants about prostate cancer. In addition, an evaluation of anxiety and depression was conducted by using the Hospital Anxiety and Depression Scale (HADS). Between April 2022 and December 2022, 834 participants were reached.72.9% of the participants answered the questionnaire correctly. A significant difference was found in terms of correct response rates in four different provinces located in four different regions of Türkiye (79% in Eskisehir, 75.2% in Canakkale, 73% in Ankara, and 54.4% in Maras;p < 0.05). According to the HADS scale, 240 (28.8%) individuals were found to have anxiety and 129 (15.5%) of them had depression. The knowledge level of most of the participants about prostate cancer was found to be above the average. There was a significant difference between provinces in terms of knowledge levels. A significant relationship was observed between depression and knowledge level. However, no significant difference was found for anxiety.展开更多
In this case, a young female presented with non-specific features such as fever, sore throat, headache and fatigue. She went on to develop epigastric pain, darkening of urine and jaundice, with no resolution of prior ...In this case, a young female presented with non-specific features such as fever, sore throat, headache and fatigue. She went on to develop epigastric pain, darkening of urine and jaundice, with no resolution of prior symptoms. Physical and Laboratory tests confirmed the primary diagnosis of infectious mononucleosis, however, prior history of treatment with multiple drugs led to a diagnosis of DILI as a complication. Appropriate treatment with I.V. antibiotics, hepatoprotective agents, steroids as well as discontinuation of all potential hepatotoxic agents showed significant improvement in patients’ symptoms and overall condition.展开更多
Tamarindus[Tamarindus indica L.(T.Indira)],belongs to the family Leguminosae(Fabaceae),commonly known as Tamarind tree,is one of the fruit tree species that is used as traditional medicine.The aim of this article is t...Tamarindus[Tamarindus indica L.(T.Indira)],belongs to the family Leguminosae(Fabaceae),commonly known as Tamarind tree,is one of the fruit tree species that is used as traditional medicine.The aim of this article is to review the current literatue on health related effect of T.indir.a.Literature review about this plant was conducted between 2003 and 2014 through Pubmed and Google.The keywords Tamarind,T.indica were used for search.Only the health related articles selected.Tamarind tree is found especially in the Indian subcontinent,Africa,Pakistan,Bangladesh,Nigeria and most of the tropical countries.It is preferred to be used for abdominal pain,diarrhea and dysentery,some bacterial infections and parasitic infestations,wound healing,constipation and inflammation.It is a rich source of most of the essential amino acids and phytochemicals,and hence the plant is reported to possess antidiabetic,antimicrobial,antivenomic,antioxidant,antimalarial,cardioprotective,hepatoprotective,antiasthmatic,laxative and anti-hyperlipidemir activity.T.indica has ameliorative effects on many diseases.It can also be preferred as a nutritious support for malnourished patients as it is cheap and easy to access.Those effects should be clarified with further research.展开更多
<strong>Background:</strong><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;"> Postpartum depression is the most com...<strong>Background:</strong><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;"> Postpartum depression is the most common psychological health problem among females;it begins after the birth of the child and can occur at any time during the first year of delivery. The COVID-19 pandemic is a novel virus that is highly infectious and has several negative psychological impacts on individuals globally. </span><b><span style="font-family:Verdana;">Aim:</span></b><span style="font-family:Verdana;"> Coronavirus disease 2019 (COVID-19) has been reported to increase the incidence rate of depression. We investigated the prevalence rate and associated factors of postpartum depression (PPD) among women in Jeddah, Saudi Arabia, during the COVID-19 period, thereby attempting to determine whether and how COVID-19 affected PPD. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> This is a cross-sectional study that was conducted on women at one week to six months postpartum using an online questionnaire. SPSS program was used for analyzing data. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> This study included 150 participated women;49.3% were in the age range of 25</span></span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">34 years old. There were 30.7% reported being primigravida. Regarding the level of depression, there were 60.7% reported the presence of depression;the depression was affected by some demographics of females such as the education level (P = 0.021) and other factors related to the COVID-19 pandemic such as visiting the doctor during quarantine (P = 0.049), diagnosis with depressi展开更多
By establishing a hybrid-units input-output model,this paper calculates total energy intensity coefficients and total pollution intensity coefficients of four energy sectors and 23 non-energy sectors.Meanwhile,using e...By establishing a hybrid-units input-output model,this paper calculates total energy intensity coefficients and total pollution intensity coefficients of four energy sectors and 23 non-energy sectors.Meanwhile,using export data for 2002-2006,it estimates China’s export-related energy consumption,CO<sub>2</sub> emissions and atmospheric pollution.The results reveal that the more China exports goods and services to other parts of the world,the more energy consumption, CO<sub>2</sub> emissions and atmospheric pollutants are transferred to China from outside its borders.Ihe tremendous damage of export-related pollution to China’s economy and the environment deserves serious attention.展开更多
We designed and evaluated a fluoride-based high concentration erbium/ cerium co-doped fiber amplifier. It is suitable for Metropolitan Area Networks due to faster transient, flatter (unfiltered) gain, smaller footprin...We designed and evaluated a fluoride-based high concentration erbium/ cerium co-doped fiber amplifier. It is suitable for Metropolitan Area Networks due to faster transient, flatter (unfiltered) gain, smaller footprint and gain excursion than its silica-based counterpart.展开更多
Background:Asthma is a major non-communicable disease affecting both children and adult populations,characterized by inflammation and narrowing of airways.Hydrotherapy is a naturopathy treatment modality effectively u...Background:Asthma is a major non-communicable disease affecting both children and adult populations,characterized by inflammation and narrowing of airways.Hydrotherapy is a naturopathy treatment modality effectively used to manage bronchial asthma.This case series presents the immediate effect of one such hydrotherapy treatment hot fomentation on pulmonary function in bronchial asthma.Case presentation:Three women who had chief complaints of wheezing,sneeze and breathlessness due to chronic bronchial asthma.Hot fomentation over the inter-scapular region was given to the patient for a duration of 20 minutes.Pulmonary function test was performed using Recorders&Medicine Systems Pvt Ltd.Helios 401 before and immediately after the intervention to assess the efficacy of hot fomentation.Result:When compared to baseline,the pulmonary function’s parameters,such as forced vital capacity,forced expiratory volume in the first second,forced expiratory volume in the first second/forced vital capacity ratio,forced expiratory flow(25–75%)and peak expiratory flow showed significant improvement immediately after the fomentation.Conclusion:After 20 minutes of hot fomentation,significant improvement in pulmonary function was observed.Hot fomentation over the interscapular region,could thus be used to improve clinical outcomes in the management of bronchial asthma by improving pulmonary function and relieving acute symptoms.展开更多
Objective To explore the effect of hepatocyte growth factor （HGF） and fibroblast growth factor （FGF） on preimplantation embryo development of mouse.Methods Mated mice were killed by cervical dislocation to collect...Objective To explore the effect of hepatocyte growth factor （HGF） and fibroblast growth factor （FGF） on preimplantation embryo development of mouse.Methods Mated mice were killed by cervical dislocation to collect two pronucleous （2 PN） zygotes from oviduct of pregnant 1 d NMRI mice and were cultured to the hatching blastocyst stage and the number of embryo in different stages was recorded under an invert microscope. The cleavage rates of formed 2 PN zygotes were compared with blastocyst and hatching blastocyst stage in drops of T6 medium with or without HGF or FGF （0 ng/ml, 10 ng/ml, 20 ng/ml, 50 ng/ml, 1 000 ng/ml）. Results HGF and FGF enriched embryo culture media promotea the aevetopment from 2 PN stage embryos to blastocyst. Adding 20 ng/ml of FGF or HGF to the culture medium significantly increased the percentage of 2PN embryos that developed into blastocysts （P〈0.05）, but culture of embryos in drops of T6 medium with HGF （20 ng/ml） had no improvement in in-vitro hatching.Conclusion Exogenous HGF and FGF at low concentrations promote in-vitro mouse blastocyst formation.展开更多
Objective To explore the effect of peimine on excision repair cross-complementation 1(ERCC1)m RNA and lung resistant protein(LRP)expressions in A549/cisplatin(DDP)multidrug resistance(MDR)cell line.Methods Lung cancer...Objective To explore the effect of peimine on excision repair cross-complementation 1(ERCC1)m RNA and lung resistant protein(LRP)expressions in A549/cisplatin(DDP)multidrug resistance(MDR)cell line.Methods Lung cancer A549/DDP cells were cultured in vitro.Cells at logarithmic growth phase were divided展开更多
BACKGROUND Identification of the morphology of the genial tubercles (GTs) is valuable for different dental applications. The morphological pattern of the GTs is still controversial, and therefore, the study of its mor...BACKGROUND Identification of the morphology of the genial tubercles (GTs) is valuable for different dental applications. The morphological pattern of the GTs is still controversial, and therefore, the study of its morphology using cone beam computed tomography (CBCT) plays a valuable role in resolving the controversy. AIM To assess the morphological pattern, dimensions and position of the GTs using CBCT among a selected Saudi population. METHODS CBCT records of 155 Saudi subjects (49 female and 106 male) were used to assess the pattern and size of the GTs and to determine the distance from the apices of the lower central incisors to the superior border of the incisors (I-SGT) and the distance from the inferior border of the GTs to the menton (IGT-M). RESULTS The results of this study showed that the most common morphological pattern was of two superior GTs and a rough impression below them (36.8%), followed by two superior GTs and a median ridge representing fused inferior GTs below them (22.6%) and a single median eminence or projection (20%). The classically described pattern, of two superior and two inferior GTs placed one above the other, was found in only 14.2% of cases, while 6.4% of the studied cases had no GTs. The mean width and height were 6.23 ± 1.93 mm and 6.67 ± 3.04 mm, respectively, while the mean I-SGT and IGT-M measurements were 8.26 ± 2.7 mm and 8.13 ± 3.07 mm, respectively. CONCLUSION The GTs are a controversial anatomical landmark with wide variation in their morphological pattern. The most common pattern among the studied Saudi sample was of two superior GTs and a rough impression below them, and there were no significant differences between males and females.展开更多
Objective To investigate the role of leptin-p38 mitogen-activated protein kinase(MAPK)pathway in high glucose(HG)-induced injury in H9c2 cardiac cells.Methods H9c2 cardiac cells were treated with HG to establish a mod...Objective To investigate the role of leptin-p38 mitogen-activated protein kinase(MAPK)pathway in high glucose(HG)-induced injury in H9c2 cardiac cells.Methods H9c2 cardiac cells were treated with HG to establish a model of cellular injury induced by HG.Cell viability was tested by cell counter kit 8(CCK-8).The intracellular level of reactive oxygen species(ROS)展开更多
Background: Frozen section (FS) has a valuable role in the diagnosis of ovarian tumors. It is considered a pivotal point in guiding the surgical therapy, particularly in premenopausal women. In postmenopausal women, i...Background: Frozen section (FS) has a valuable role in the diagnosis of ovarian tumors. It is considered a pivotal point in guiding the surgical therapy, particularly in premenopausal women. In postmenopausal women, it may be required as well to avoid unnecessary surgical staging in benign ovarian tumors. Aim: This study aims to evaluate the accuracy of intraoperative frozen section in ovarian neoplasms in postmenopausal women. Materials and Methods: A retrospective analysis was done for intraoperative FS for suspected ovarian neoplasms. The study was conducted in Oncology Center, Mansoura University from March 2008 to December 2014. The frozen and paraffin section reports were compared, and overall accuracy, sensitivity, specificity, positive and negative predictive values were determined. Results: The study included 105 patients and the overall accuracy of FS in determining malignancy was 81.7%. The sensitivity for malignant tumors was 75.32% with specificity of 100%. For benign tumors, the sensitivity and specificity were 100% and 93%, respectively. Borderline tumors had the lowest sensitivity of 100% with specificity of 95.19%. Conclusion: The present study concurs that frozen section is an accurate test for diagnosis of benign and malignant tumors in postmenopausal women thus determining the extent of surgery done for them. On the other hand, accuracy rates for borderline tumors are low.展开更多
Objective To analyze the differences in the clinical characteristics,endoscopy,pathology and therapy between the patients with new onset ulcerative colitis(UC)in the elderly versus youth and middle-aged patients.Metho...Objective To analyze the differences in the clinical characteristics,endoscopy,pathology and therapy between the patients with new onset ulcerative colitis(UC)in the elderly versus youth and middle-aged patients.Methods A review analysis was carried out in the 178hospitalized patients with UC in Third Hospital of Peking University from 1994 to 2010.The patients were divided into two groups according to the age of onset:UC onset at age of 60 years and older were enrolled in展开更多
Native of Australia,Thaumastocoris peregrinus(Eucalyptus bronze bug)is a Eucalyptus insect pest which was firstly detected in Brazil in June 2008.Some studies have shown favorable areas for T.peregrinus population out...Native of Australia,Thaumastocoris peregrinus(Eucalyptus bronze bug)is a Eucalyptus insect pest which was firstly detected in Brazil in June 2008.Some studies have shown favorable areas for T.peregrinus population outbreaks in Brazil,based on georeferenced-crossing information using geographical information system(GIS).Despite that,it is crucial to both enhance the precision of methods used on georeferenced crossings and update information,in order to enable greater precision toward the identification of propitious areas for the occurrence of the insect.The objective of this study was to identify areas with favorable conditions to occurrence of Thaumastocoris peregrinus in Brazil,in at least one month in the year,based on national information of this insect-pest.Favorable conditions to the occurrence of the insect,the average climatic data from weather stations(2009-2018)and Eucalyptus crop areas in 2018 were considered.This information was used in GIS to obtain a zoning map indicating the favorable areas to the insect in at least one month in the year.The georeferenced-crossing technique used considered both spatial interpolation by Cokriging methods and by Inverse Distance Weighted(IDW).Results indicated the presence of propitious outbreaks for T.peregrinus occurring in differentiated months in the Southern,Southeastern,Midwestern and Northeastern geographic regions of the country,with lowest monthly aptitude noticed for the Northern region.Different sequential periods of favorability for occurrences from very high to medium intensities were identified.展开更多
文摘Gastrointestinal stromal tumors(GISTs) are the most common mesenchymal tumors located in the alimentary tract. Its usual manifestation is gastrointestinal bleeding. However, small asymptomatic lesions are frequently detected as incidental finding. Characteristically, most GISTs(> 95%) are positive for the KIT protein(CD117) by IHC staining and approximately 80%-90% of GISTs carry a mutation in the c-KIT or PDGFRA genes. Mutational analysis should be performed when planning adjuvant and neoadjuvant therapy, due to its possible resistance to conventional treatment. The arise of tyrosine kinase inhibitor has supposed a revolution in GISTs treatment being useful as adjuvant, neoadjuvant or recurrence disease treatment. That is why a multidisciplinary approach to this disease is required. The correct characterization of the tumor at diagnosis(the diagnosis of recurrences and the evaluation of the response to treatment with tyrosine kinase inhibitors) is fundamental for facing these tumors and requires specialized Endoscopist, Radiologists and Nuclear Medicine Physician. Surgery is the only potentially curative treatment for suspected resectable GIST. In the case of high risk GISTs, surgery plus adjuvantImatinib-Mesylate for 3 years is the standard treatment. Neoadjuvant imatinib-mesylate should be considered to shrink the tumor in case of locally advanced primary or recurrence disease, unresectable or potentially resectable metastasic tumors, and potentially resectable disease in complex anatomic locations to decrease the related morbidity. In the case of Metastatic GIST under Neoadjuvant treatment, when there are complete response, stable disease or limited disease progression, complete cytoreductive surgery could be a therapeutic option if feasible.
文摘BACKGROUND Among the most frequent hip fractures are trochanteric fractures,which usually occur from low-energy trauma like minor falls,especially in older people with osteoporotic bones.AIM To evaluate the treatment efficacy of dynamic condylar screws(DCS)and proximal femoral nails(PFN)for unstable intertrochanteric fractures.METHODS To find pertinent randomized controlled trials and retrospective observational studies comparing PFN with DCS for the management of unstable femoral intertrochanteric fractures,a thorough search was carried out.For research studies published between January 1996 and April 2024,PubMed,EMBASE,Scopus,Web of Science,Cochrane Library,and Google Scholar were all searched.The complete texts of the papers were retrieved,vetted,and independently examined by two investigators.Disputes were settled by consensus,and any disagreements that persisted were arbitrated by a third author.RESULTS This study included six articles,comprising a total of 173 patients.Compared to the DCS,the PFN had a shorter operation time[mean difference(MD):-41.7 min,95%confidence interval(95%CI):-63.04 to-20.35,P=0.0001],higher success rates with closed reduction techniques[risk ratio(RR):34.05,95%CI:11.12-104.31,P<0.00001],and required less intraoperative blood transfusion(MD:-1.4 units,95%CI:-1.80 to-1.00,P<0.00001).Additionally,the PFN showed shorter fracture union time(MD:-6.92 wk,95%CI:-10.27 to-3.57,P<0.0001)and a lower incidence of reoperation(RR:0.37,95%CI:0.17-0.82,P=0.01).However,there was no discernible variation regarding hospital stay,implant-related complications,and infections.CONCLUSION Compared to DCS,PFN offers shorter operative times,reduces the blood transfusions requirements,achieves higher closed reduction success,enables faster fracture healing,and lowers reoperation incidence.
文摘The Sendai Framework for Disaster Risk Reduction 2015–2030 recognizes the strong connection between health and disasters and promotes the concept of health resilience throughout.Several of the seven global targets stated in the Sendai Framework are directly related to health in terms of reducing disaster mortality,the number of affected people,disaster damage to critical infrastructure,and disruption of basic services such as health facilities.The Sendai Framework also maintains close coordination with other United Nations landmark agreements relevant to health such as the Sustainable Development Goals.However,the measurement of healthrelated indicators is challenging.Issues arise,for example,in linking deaths to disasters because of the complex interplay between exposure,risk,vulnerability,and hazards.The lack of a universal classification of disasters also means that recording of health data in disasters is not standardized.Developing the guidelines to enable data onthe indicators to be collected and reported to support the Sendai targets requires detailed thinking,time,and consultation with a diverse range of stakeholders.Strong collaboration and partnership will be vital to achieving success.
文摘Objective Through the investigation of the pathogenicity of COL4A4 heterozygous splicing mutations and the genotype-phenotype correlation in autosomal dominant Alport syndrome(ADAS),to better understand the impact of COL4A4 heterozygous splicing mutations on ADAS.Methods The study was a case series analysis.Patients from 5 ADAS families with COL4A4 heterozygous splicing mutations detected by whole exome sequencing were recruited by three hospitals.
文摘Objective To investigate the effect of continuous positive airway pressure(CPAP)on blood pressure and blood pressure rhythm in hypertensive patients with sleep apnea syndrome.Methods Hypertensive patients with obstructive sleep apnea syndrome consecutively recruited between 2020 and 2022 were randomly divided into two groups.
文摘Prostate cancer is one of the most common types of cancer in men. The rate of early detection of prostate cancer is low in Türkiye. Therefore, it is important to measure the level of awareness regarding prostate cancer. In our research, we investigate the knowledge levels of prostate cancer among adult individuals in four different geographic region in Türkiye. In addition, we aimed to compare the level of awareness regarding prostate cancer and the depression and anxiety levels among the individuals. The prostate cancer awareness level survey was selected as the data collection tool. In the survey, 20 questions are asked to measure the knowledge level of the participants about prostate cancer. In addition, an evaluation of anxiety and depression was conducted by using the Hospital Anxiety and Depression Scale (HADS). Between April 2022 and December 2022, 834 participants were reached.72.9% of the participants answered the questionnaire correctly. A significant difference was found in terms of correct response rates in four different provinces located in four different regions of Türkiye (79% in Eskisehir, 75.2% in Canakkale, 73% in Ankara, and 54.4% in Maras;p < 0.05). According to the HADS scale, 240 (28.8%) individuals were found to have anxiety and 129 (15.5%) of them had depression. The knowledge level of most of the participants about prostate cancer was found to be above the average. There was a significant difference between provinces in terms of knowledge levels. A significant relationship was observed between depression and knowledge level. However, no significant difference was found for anxiety.
文摘In this case, a young female presented with non-specific features such as fever, sore throat, headache and fatigue. She went on to develop epigastric pain, darkening of urine and jaundice, with no resolution of prior symptoms. Physical and Laboratory tests confirmed the primary diagnosis of infectious mononucleosis, however, prior history of treatment with multiple drugs led to a diagnosis of DILI as a complication. Appropriate treatment with I.V. antibiotics, hepatoprotective agents, steroids as well as discontinuation of all potential hepatotoxic agents showed significant improvement in patients’ symptoms and overall condition.
文摘Tamarindus[Tamarindus indica L.(T.Indira)],belongs to the family Leguminosae(Fabaceae),commonly known as Tamarind tree,is one of the fruit tree species that is used as traditional medicine.The aim of this article is to review the current literatue on health related effect of T.indir.a.Literature review about this plant was conducted between 2003 and 2014 through Pubmed and Google.The keywords Tamarind,T.indica were used for search.Only the health related articles selected.Tamarind tree is found especially in the Indian subcontinent,Africa,Pakistan,Bangladesh,Nigeria and most of the tropical countries.It is preferred to be used for abdominal pain,diarrhea and dysentery,some bacterial infections and parasitic infestations,wound healing,constipation and inflammation.It is a rich source of most of the essential amino acids and phytochemicals,and hence the plant is reported to possess antidiabetic,antimicrobial,antivenomic,antioxidant,antimalarial,cardioprotective,hepatoprotective,antiasthmatic,laxative and anti-hyperlipidemir activity.T.indica has ameliorative effects on many diseases.It can also be preferred as a nutritious support for malnourished patients as it is cheap and easy to access.Those effects should be clarified with further research.
文摘<strong>Background:</strong><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;"> Postpartum depression is the most common psychological health problem among females;it begins after the birth of the child and can occur at any time during the first year of delivery. The COVID-19 pandemic is a novel virus that is highly infectious and has several negative psychological impacts on individuals globally. </span><b><span style="font-family:Verdana;">Aim:</span></b><span style="font-family:Verdana;"> Coronavirus disease 2019 (COVID-19) has been reported to increase the incidence rate of depression. We investigated the prevalence rate and associated factors of postpartum depression (PPD) among women in Jeddah, Saudi Arabia, during the COVID-19 period, thereby attempting to determine whether and how COVID-19 affected PPD. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> This is a cross-sectional study that was conducted on women at one week to six months postpartum using an online questionnaire. SPSS program was used for analyzing data. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> This study included 150 participated women;49.3% were in the age range of 25</span></span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">34 years old. There were 30.7% reported being primigravida. Regarding the level of depression, there were 60.7% reported the presence of depression;the depression was affected by some demographics of females such as the education level (P = 0.021) and other factors related to the COVID-19 pandemic such as visiting the doctor during quarantine (P = 0.049), diagnosis with depressi
文摘By establishing a hybrid-units input-output model,this paper calculates total energy intensity coefficients and total pollution intensity coefficients of four energy sectors and 23 non-energy sectors.Meanwhile,using export data for 2002-2006,it estimates China’s export-related energy consumption,CO<sub>2</sub> emissions and atmospheric pollution.The results reveal that the more China exports goods and services to other parts of the world,the more energy consumption, CO<sub>2</sub> emissions and atmospheric pollutants are transferred to China from outside its borders.Ihe tremendous damage of export-related pollution to China’s economy and the environment deserves serious attention.
文摘We designed and evaluated a fluoride-based high concentration erbium/ cerium co-doped fiber amplifier. It is suitable for Metropolitan Area Networks due to faster transient, flatter (unfiltered) gain, smaller footprint and gain excursion than its silica-based counterpart.
文摘Background:Asthma is a major non-communicable disease affecting both children and adult populations,characterized by inflammation and narrowing of airways.Hydrotherapy is a naturopathy treatment modality effectively used to manage bronchial asthma.This case series presents the immediate effect of one such hydrotherapy treatment hot fomentation on pulmonary function in bronchial asthma.Case presentation:Three women who had chief complaints of wheezing,sneeze and breathlessness due to chronic bronchial asthma.Hot fomentation over the inter-scapular region was given to the patient for a duration of 20 minutes.Pulmonary function test was performed using Recorders&Medicine Systems Pvt Ltd.Helios 401 before and immediately after the intervention to assess the efficacy of hot fomentation.Result:When compared to baseline,the pulmonary function’s parameters,such as forced vital capacity,forced expiratory volume in the first second,forced expiratory volume in the first second/forced vital capacity ratio,forced expiratory flow(25–75%)and peak expiratory flow showed significant improvement immediately after the fomentation.Conclusion:After 20 minutes of hot fomentation,significant improvement in pulmonary function was observed.Hot fomentation over the interscapular region,could thus be used to improve clinical outcomes in the management of bronchial asthma by improving pulmonary function and relieving acute symptoms.
文摘Objective To explore the effect of hepatocyte growth factor （HGF） and fibroblast growth factor （FGF） on preimplantation embryo development of mouse.Methods Mated mice were killed by cervical dislocation to collect two pronucleous （2 PN） zygotes from oviduct of pregnant 1 d NMRI mice and were cultured to the hatching blastocyst stage and the number of embryo in different stages was recorded under an invert microscope. The cleavage rates of formed 2 PN zygotes were compared with blastocyst and hatching blastocyst stage in drops of T6 medium with or without HGF or FGF （0 ng/ml, 10 ng/ml, 20 ng/ml, 50 ng/ml, 1 000 ng/ml）. Results HGF and FGF enriched embryo culture media promotea the aevetopment from 2 PN stage embryos to blastocyst. Adding 20 ng/ml of FGF or HGF to the culture medium significantly increased the percentage of 2PN embryos that developed into blastocysts （P〈0.05）, but culture of embryos in drops of T6 medium with HGF （20 ng/ml） had no improvement in in-vitro hatching.Conclusion Exogenous HGF and FGF at low concentrations promote in-vitro mouse blastocyst formation.
文摘Objective To explore the effect of peimine on excision repair cross-complementation 1(ERCC1)m RNA and lung resistant protein(LRP)expressions in A549/cisplatin(DDP)multidrug resistance(MDR)cell line.Methods Lung cancer A549/DDP cells were cultured in vitro.Cells at logarithmic growth phase were divided
文摘BACKGROUND Identification of the morphology of the genial tubercles (GTs) is valuable for different dental applications. The morphological pattern of the GTs is still controversial, and therefore, the study of its morphology using cone beam computed tomography (CBCT) plays a valuable role in resolving the controversy. AIM To assess the morphological pattern, dimensions and position of the GTs using CBCT among a selected Saudi population. METHODS CBCT records of 155 Saudi subjects (49 female and 106 male) were used to assess the pattern and size of the GTs and to determine the distance from the apices of the lower central incisors to the superior border of the incisors (I-SGT) and the distance from the inferior border of the GTs to the menton (IGT-M). RESULTS The results of this study showed that the most common morphological pattern was of two superior GTs and a rough impression below them (36.8%), followed by two superior GTs and a median ridge representing fused inferior GTs below them (22.6%) and a single median eminence or projection (20%). The classically described pattern, of two superior and two inferior GTs placed one above the other, was found in only 14.2% of cases, while 6.4% of the studied cases had no GTs. The mean width and height were 6.23 ± 1.93 mm and 6.67 ± 3.04 mm, respectively, while the mean I-SGT and IGT-M measurements were 8.26 ± 2.7 mm and 8.13 ± 3.07 mm, respectively. CONCLUSION The GTs are a controversial anatomical landmark with wide variation in their morphological pattern. The most common pattern among the studied Saudi sample was of two superior GTs and a rough impression below them, and there were no significant differences between males and females.
文摘Objective To investigate the role of leptin-p38 mitogen-activated protein kinase(MAPK)pathway in high glucose(HG)-induced injury in H9c2 cardiac cells.Methods H9c2 cardiac cells were treated with HG to establish a model of cellular injury induced by HG.Cell viability was tested by cell counter kit 8(CCK-8).The intracellular level of reactive oxygen species(ROS)
文摘Background: Frozen section (FS) has a valuable role in the diagnosis of ovarian tumors. It is considered a pivotal point in guiding the surgical therapy, particularly in premenopausal women. In postmenopausal women, it may be required as well to avoid unnecessary surgical staging in benign ovarian tumors. Aim: This study aims to evaluate the accuracy of intraoperative frozen section in ovarian neoplasms in postmenopausal women. Materials and Methods: A retrospective analysis was done for intraoperative FS for suspected ovarian neoplasms. The study was conducted in Oncology Center, Mansoura University from March 2008 to December 2014. The frozen and paraffin section reports were compared, and overall accuracy, sensitivity, specificity, positive and negative predictive values were determined. Results: The study included 105 patients and the overall accuracy of FS in determining malignancy was 81.7%. The sensitivity for malignant tumors was 75.32% with specificity of 100%. For benign tumors, the sensitivity and specificity were 100% and 93%, respectively. Borderline tumors had the lowest sensitivity of 100% with specificity of 95.19%. Conclusion: The present study concurs that frozen section is an accurate test for diagnosis of benign and malignant tumors in postmenopausal women thus determining the extent of surgery done for them. On the other hand, accuracy rates for borderline tumors are low.
文摘Objective To analyze the differences in the clinical characteristics,endoscopy,pathology and therapy between the patients with new onset ulcerative colitis(UC)in the elderly versus youth and middle-aged patients.Methods A review analysis was carried out in the 178hospitalized patients with UC in Third Hospital of Peking University from 1994 to 2010.The patients were divided into two groups according to the age of onset:UC onset at age of 60 years and older were enrolled in
文摘Native of Australia,Thaumastocoris peregrinus(Eucalyptus bronze bug)is a Eucalyptus insect pest which was firstly detected in Brazil in June 2008.Some studies have shown favorable areas for T.peregrinus population outbreaks in Brazil,based on georeferenced-crossing information using geographical information system(GIS).Despite that,it is crucial to both enhance the precision of methods used on georeferenced crossings and update information,in order to enable greater precision toward the identification of propitious areas for the occurrence of the insect.The objective of this study was to identify areas with favorable conditions to occurrence of Thaumastocoris peregrinus in Brazil,in at least one month in the year,based on national information of this insect-pest.Favorable conditions to the occurrence of the insect,the average climatic data from weather stations(2009-2018)and Eucalyptus crop areas in 2018 were considered.This information was used in GIS to obtain a zoning map indicating the favorable areas to the insect in at least one month in the year.The georeferenced-crossing technique used considered both spatial interpolation by Cokriging methods and by Inverse Distance Weighted(IDW).Results indicated the presence of propitious outbreaks for T.peregrinus occurring in differentiated months in the Southern,Southeastern,Midwestern and Northeastern geographic regions of the country,with lowest monthly aptitude noticed for the Northern region.Different sequential periods of favorability for occurrences from very high to medium intensities were identified.
