The paper gives estimates for the finite-time ruin probability with insurance and financial risks. When the distribution of the insurance risk belongs to the class L（γ） for some γ〉0 or the subexponential distribu...The paper gives estimates for the finite-time ruin probability with insurance and financial risks. When the distribution of the insurance risk belongs to the class L（γ） for some γ〉0 or the subexponential distribution class, we abtain some asymptotic equivalent relationships for the finite-time ruin probability, respectively. When the distribution of the insurance risk belongs to the dominated varying-tailed distribution class, we obtain asymptotic upper bound and lower bound for the finite-time ruin probability, where for the asymptotic upper bound, we completely get rid of the restriction of mutual independence on insurance risks, and for the lower bound, we only need the insurance risks to have a weak positive association structure. The obtained results extend and improve some existing results.展开更多
OBJECTIVE:To monitor current production in Qi-deficient liver cells,and to study how cellular proton leakage might affect electric current production.METHODS:Cells were placed in an microbial fuel cells(MFC)anode and ...OBJECTIVE:To monitor current production in Qi-deficient liver cells,and to study how cellular proton leakage might affect electric current production.METHODS:Cells were placed in an microbial fuel cells(MFC)anode and the electric current was measured.Mitochondrial-affecting chemicals,2,4-dinitrophenol(DNP)and resveratrol(RVT),were used to induce proton leakage in cells and their effect on current production observed.MCF-7 breast cancer cells exhibited higher proton leakage relative tonormal liver cells.A mouse model for Qi-deficiency was prepared according to the Methodology of Animal Experiment in Chinese medicine.The Qi-tonics Buzhongyiqi Tang(BZYQT),which is used to treat the Qi-deficiency condition,was applied to Qi-deficient liver cells to examine how current production was altered.RESULTS:Adding either DNP or RVT to normal liver cells increased current production.MCF-7 cells that possessed high proton leakage were also found to produce higher currents than normal liver cells.Higher current production,lower cellular glucose content,and lower adenosine triphosphate(ATP)production rate were found in Qi-deficient liver cells,in which the use of DNP or RVT further increased current production.The use of BZYQT to treat Qi-deficient liver cells decreased current production,counteracted the action of DNP,and also improved cellular glucose content.CONCLUSION:High electric current production was found in liver cells with high cellular proton leakage.Positive current responses to both mitochondria-affecting chemicals,DNP and RVT,appeared to indicate proper mitochondrial function.The high proton leakage detected in Qi-deficient liver cells might have caused high energy losses,which served to explain the observed lower cellular glucose content and ATP production rate than in normal cells.These results might also explain the exhibited syndromes of low energy and fatigue in Qi-deficient patients.Proton leakage,induced by DNP or the Qi-deficient condition,was possibly caused by unusual uncoupling of oxidative phosphorylati展开更多
OBJECTIVE:To investigate how community residents in Beijing understood and used Traditional Chinese Medicine(TCM) in their medical practice.METHODS:This was a cross-sectional study conducted on 3410 community resident...OBJECTIVE:To investigate how community residents in Beijing understood and used Traditional Chinese Medicine(TCM) in their medical practice.METHODS:This was a cross-sectional study conducted on 3410 community residents from four large communities of Tongzhou district in Beijng,China.A validated, self-administered questionnaire comprised of three sections was used to gather the data.A systematic sampling procedure was applied to recruit the community residents.RESULTS:A total of 3410 participants completed the questionnaire survey.It showed that in highly educated residents, 33.4%(170) knew of the names of 3-10 Chinese herbals, 35.8%(182) knew of names of 3-10 traditional Chinese patent drug.Among all the respondent residents, 80.7%(2753)believed that TCM herbal therapy and TCM non-drug treatments were effective in disease treatment, health enhancement, 85.7%(2923) had taken traditional Chinese patent drug in their life,56.8%(1937) of residents had used herbal decoction, 40.0%(1365) had received non-drug treatment of TCM, such as acupuncture, massage, cupping, auricular acupuncture.Among the elderly residents, 11.4%(98) often used Chinese patent drug and 9.8%(85) often used herbal decoction.In addition, 70.8%(2415) of residents were willing to accept knowledge and information on TCM for health enhancement and disease prevention, such as medicated diet, medicinal tea, Tai Chi and Qi Gong, although 82.8%(2825) of residents had never used them.CONCLUSION:Chinese patent drug and herbal decoction are widely used in the communities in Beijing, and there existed a possible close correlation between high educational level and better understanding of TCM.Age and occupation also correlated with the attitude to TCM therapies.The characteristics of the residents should be considered seriously in the course of promoting the understanding and application of TCM.展开更多
Considering the inertia of individuals in real inertia of players is introduced into evolutionary prisoner＇s life, we propose a modified Fermi updating rule, where the dilemma game （PDG） on square lattices. We main...Considering the inertia of individuals in real inertia of players is introduced into evolutionary prisoner＇s life, we propose a modified Fermi updating rule, where the dilemma game （PDG） on square lattices. We mainly focus on how the inertia affects the cooperative behavior of the system. Interestingly, we find that the cooperation level has a nonmonotonic dependence on the inertia： with small inertia, cooperators will soon be invaded by defectors; with large inertia, players are unwilling to change their strategies and the cooperation level remains the same as the initial state; while a moderate inertia can induce the highest cooperation level. Moreover, effects of environmental noise and individual inertia are studied. Our work may be helpful in understanding the emergence and persistence of cooperation in nature and society.展开更多
Consciousness is one of the unique features of creatures,and is also the root of biological intelligence.Up to now,all machines and robots havenJt had consciousness.Then,will the artificial intelligence(AI)be consciou...Consciousness is one of the unique features of creatures,and is also the root of biological intelligence.Up to now,all machines and robots havenJt had consciousness.Then,will the artificial intelligence(AI)be conscious?Will robots have real intelligence without consciousness?The most primitive consciousness is the perception and expression of selfexistence.In order to perceive the existence of the concept of‘Ij,a creature must first have a perceivable boundary such as skin to separate‘I’from‘non-1’.For robots,to have the self-awareness,they also need to be wrapped by a similar sensory membrane.Nowadays,as intelligent tools,AI systems should also be regarded as the external extension of human intelligence.These tools are unconscious.The development of AI shows that intelligence can exist without consciousness.When human beings enter into the era of life intelligence from AI,it is not the AI became conscious,but that conscious lives will have strong AI.Therefore,it becomes more necessary to be careful on applying AI to living creatures,even to those lower-level animals with only consciousness.The subversive revolution of such application may produce more careful thinking.展开更多
OBJECTIVE:To investigating the molecular mechanism of herbal pairs in three types of Chinese medicinals:Qi-tonifying,blood activation,blood-stasis breaking in treatment of coronary heart disease(CHD).METHODS:The compo...OBJECTIVE:To investigating the molecular mechanism of herbal pairs in three types of Chinese medicinals:Qi-tonifying,blood activation,blood-stasis breaking in treatment of coronary heart disease(CHD).METHODS:The components of six herbs were searched in Chinese medicine dictionary and their target proteins were found in PubChem.CHD genes were obtained from PubMed gene database.Ingenuity Pathways Analysis was used to build the pharmacological network of three herbal pairs and CHD molecular network.The canonical pathways between each herbal pair network and CHD network was compared to decipher the molecular mechanism on three herbal pairs in treating CHD.RESULTS:The network analysis showed that there were the common signal pathways of three herbal pairs in treating CHD including hypoxia signaling in the cardiovascular system,Hypoxia-inducible factor 1-alpha signaling,glucocorticoid receptor signaling,G-Protein coupled receptor signaling and pregnane X receptor/retinoid X receptor(PXR/RXR)activation.Further to analyze cardiovascular signaling,cytokine signaling and cytokine signaling,the effective molecules for three herbal pairs in treating CHD included HIF1α and estrogen receptor 1,Qi-tonifying herbal pair included albumin and matrix metallopeptidase 2,and blood-activation herbal pair included estrogen receptor 2 and peroxisome proliferator-activated receptor-γ.CONCLUSION:Each herbal pair can affect some respective CHD-related functions and pathways,meanwhile three herbal pairs exert some mutual effects on CHD-related functions and pathways.Mutual effects of three herbal pairs may be the key components of their total molecular mechanisms and respective effects of each herbal pair may be the characteristic components of their respective molecular mechanism.展开更多
BACKGROUND Liver cancer is one of the most highly malignant cancers,characterized by easy metastasis and chemoradiotherapy resistance.Emerging evidence indicates that long noncoding RNAs(LncRNAs),including Lnc524369,a...BACKGROUND Liver cancer is one of the most highly malignant cancers,characterized by easy metastasis and chemoradiotherapy resistance.Emerging evidence indicates that long noncoding RNAs(LncRNAs),including Lnc524369,are highly involved in the initiation,progression,radioresistance,and chemoresistance of hepatocellular carcinoma(HCC).However,the function of Lnc524369 remains unclear.AIM To explore the function of Lnc524369 in HCC.METHODS To investigate the effect of Lnc524369,tissue from 41 HCC patients were analyzed using CCK8,migration,and invasion assays.Lnc524369 and YWHAZ(also named 14-3-3ζ)mRNA were detected by qPCR,and YWHAZ and RAF1 proteins were detected by western blot in liver cancer cell lines and human HCC tissues.The Cancer Cell Line Encyclopedia(CCLE)databases,STRING database,Human Protein Atlas database,and the TCGA database were used for bioinformatic analysis.RESULTS Lnc524369 was significantly upregulated in the nucleus of liver cancer cells and human HCC tissues.Overexpression of Lnc524369 was associated with the proliferation,migration,and invasion of liver cancer cells.YWHAZ and RAF1 proteins and YWHAZ mRNA were overexpressed in liver cancer,which could be attenuated by overexpression of Lnc524369.Lnc524369 and its downstream target YWHAZ and RAF1 proteins were negatively associated with overall survival time.CONCLUSION Lnc524369 might be a promising target of HCC as it can enhance liver cancer progression and decrease the overall survival time of HCC by activating the YWHAZ/RAF1 pathway.展开更多
Objective:In this research,we tried to explore how short-term mindfulness(STM)intervention affects adoles-cents’anxiety,depression,and negative and positive emotion during the COVID-19 pandemic.Design:10 classes were...Objective:In this research,we tried to explore how short-term mindfulness(STM)intervention affects adoles-cents’anxiety,depression,and negative and positive emotion during the COVID-19 pandemic.Design:10 classes were divided into experiment groups(5 classes;n=238)and control(5 classes;n=244)randomly.Hospital Anxi-ety and Depression Scale(HADS)and Positive and Negative Affect Schedule(PANAS)were used to measure par-ticipants’dependent variables.In the experiment group,we conducted STM practice interventions every morning in theirfirst class from March to November 2020.No interventions were conducted in the control group.Methods:Paired-sample t-tests were used to identify if a significant difference exists between every time point of the experimental and control groups.Repeated ANOVA and Growth Mixture Model(GMM)were used to analyze the tendency of positive and negative emotions,anxiety,and depression in the experimental group.Results and Conclusions:(1)With the intervention of STM,there was a significant decrease in negative emotions and an increase in positive emotions in the experimental group,whereas there were non-significant differences in the control group.(2)To explore the heterogeneity trajectories of dependent variables,we built a GMM and found there were two latent growth classes in the trajectories.(3)The results of the models showed their trajec-tories were downward,which meant that the levels of anxiety,depression,and negative emotions of participants decreased during the STM training period.Nonetheless,the score of positive affect showed upward in three loops of intervention,which indicated that the level of the participants’positive affect increased through the STM inter-vention.(4)This research indicated that STM should be given increasing consideration to enhance mental health during the worldwide outbreak of COVID-19.展开更多
With the objective to evaluate the bonding efficacy of a new self-adhesive resin cement（RelyX Unicem, 3M ESPE） to enamel and dentin using a shear bonding strengths test with or without acid etching pretreatment, fla...With the objective to evaluate the bonding efficacy of a new self-adhesive resin cement（RelyX Unicem, 3M ESPE） to enamel and dentin using a shear bonding strengths test with or without acid etching pretreatment, flat buccal dentin surface and mesial/distal enamel surface were made using a high-speed diamond bur. Copper rings were luted using Rely X Unicem（RU; 3M ESPE）, Panavia F（PF; Kuraray） or Vitique（VI; DMG）. For RU, the shear bonding strengths using GL（Gluma Etch, Heraeus） acid etching pretreatment were also tested. The teeth were placed into copper rings（inner diameter： 16 mm, height： 4mm） and embedded in methylmethacrylate resin. The specimens were stored for 24 h in distilled water at 37 ℃ prior to shear bonding strengths testing. In addition, bond failures were examined by optical microscope and categorized as 4 models such as different adhesive, cohesive, or mixed. Shear bonding strengths were calculated by dividing the maximum debonding force over the cross sectional area of each specimen. The Kruskal-Wallis test was used to determine pairwise statistical differences（P 〈 0.05） in SBS between the experimental groups. For dentin bonding strength, statistical analysis showed that there was no significant difference among RU（12.84 MPa）, PF（14.93 MPa） and VI（11.03 MP）; and the bonding strengths of them were higher than RU with acid etching pretreatment（9.12 MP）. When bonded to enamel, PF（17.99 MP） and VI（17.58 MP） scored significantly higher than RU efficacy.The use of self-adhesive cement Rely X Unicem can obtain the bonding strengths to dentin similar to traditional resin cements. Phosphoric acid etching can improve the bonding strengths of the selfadhesive resin cement to enamel, but was negative for dentin.展开更多
Acute pancreatitis is an inflammation initially localized in the pancreas,which may be accompanied with severe complications such as multi-organ failure,gastrointestinal hemorrhage and malnutrition.One in ten severe c...Acute pancreatitis is an inflammation initially localized in the pancreas,which may be accompanied with severe complications such as multi-organ failure,gastrointestinal hemorrhage and malnutrition.One in ten severe cases of acute pancreatitis develops systemic inflammatory response syndrome.Despite treatment,acute pancreatitis can be a life-threatening disease as its mortality rate amounts to 5%-10%in general,and up to 35%in cases of severe course.[1]Over the years,the role of oxidative stress展开更多
AIM: To investigate proteomic changes in spinal cord and dorsal root ganglia (DRG) of rats with trinitrobenzene sulfonic acid (TNBS)-induced colitis. METHODS: The colonic myeloperoxidase (MPO) activity and tumor necro...AIM: To investigate proteomic changes in spinal cord and dorsal root ganglia (DRG) of rats with trinitrobenzene sulfonic acid (TNBS)-induced colitis. METHODS: The colonic myeloperoxidase (MPO) activity and tumor necrosis factor-(TNF- ) level were determined. A two-dimensional electrophoresis (2-DE)-based proteomic technique was used to profile the global protein expression changes in the DRG and spinal cord of the rats with acute colitis induced by intracolonic injection of TNBS. RESULTS: TNBS group showed significantly elevated colonic MPO activity and increased TNF-level. The proteins derived from lumbosacral enlargement of the spinal cord and DRG were resolved by 2-DE; and 26 and 19 proteins that displayed significantly different expression levels in the DRG and spinal cord were identified respectively. Altered proteins were found to be involved in a number of biological functions, such as inflammation/immunity, cell signaling, redox regulation, sulfate transport and cellular metabolism. The over-expression of the protein similar to potassium channel tetramerisation domain containing protein 12 (Kctd 12) and low expression of proteasome subunit type-1 (psma) were validated by Western blotting analysis. CONCLUSION: TNBS-induced colitis has a profound impact on protein profiling in the nervous system. This result helps understand the neurological pathogenesis of inflammatory bowel disease.展开更多
In this paper we examine two classes of correlated aggregate claims distributions, with univariate claim counts and multivariate claim sizes. Firstly, we extend the results of Hesselager [ASTIN Bulletin, 24： 19-32（1...In this paper we examine two classes of correlated aggregate claims distributions, with univariate claim counts and multivariate claim sizes. Firstly, we extend the results of Hesselager [ASTIN Bulletin, 24： 19-32（1994）] and Wang ＆ Sobrero＇s [ASTIN Bulletin, 24：161-166 （1994）] concerning recursions for compound distributions to a multivariate situation where each claim event generates a random vector. Then we give a multivariate continuous version of recursive algorithm for calculating a family of compound distribution. Especially, to some extent, we obtain a continuous version of the corresponding results in Sundt [ASTIN Bulletin, 29：29-45 （1999）] and Ambagaspitiya [Insurance： Mathematics and Economics, 24：301-308 （1999）]. Finally, we give an example and show how to use the algorithm for aggregate claim distribution of first class to compute recursively the compound distribution.展开更多
We investigate how the geographical structure of a complex network affects its network topology, synchronization and the average spatial length of edges. The geographical structure means that the connecting probabilit...We investigate how the geographical structure of a complex network affects its network topology, synchronization and the average spatial length of edges. The geographical structure means that the connecting probability of two nodes is related to the spatial distance of the two nodes. Our simulation results show that the geographical structure changes the network topology. The synchronization tendency is enhanced and the average spatial length of edges is enlarged when the node can randomly connect to the further one. Analytic results support our understanding of the phenomena.展开更多
An approximate solution of the refinement equation was given by its mask, and the approximate sampling theorem for bivariate continuous function was proved by applying the approximate solution . The approximate sampli...An approximate solution of the refinement equation was given by its mask, and the approximate sampling theorem for bivariate continuous function was proved by applying the approximate solution . The approximate sampling function defined uniquely by the mask of the refinement equation is the approximate solution of the equation , a piece-wise linear function , and posseses an explicit computation formula . Therefore the mask of the refinement equation is selected according to one' s requirement, so that one may controll the decay speed of the approximate sampling function .展开更多
Value at Risk (VaR) is a basic and very useful tool in measuring market risks. Numerous VaR models have been proposed in literature. Therefore, it is of great interest to evaluate the efficiency of these models, and t...Value at Risk (VaR) is a basic and very useful tool in measuring market risks. Numerous VaR models have been proposed in literature. Therefore, it is of great interest to evaluate the efficiency of these models, and to select the most appropriate one. In this paper, we shall propose to use the empirical likelihood approach to evaluate these models. Simulation results and real life examples show that the empirical likelihood method is more powerful and more robust than some of the asymptotic method available in literature.展开更多
The properties of the spontaneous emission from a three-level atom with an external driving field in a photonic crystal are studied.The population in the two upper levels displays complete decay or oscillatory behavio...The properties of the spontaneous emission from a three-level atom with an external driving field in a photonic crystal are studied.The population in the two upper levels displays complete decay or oscillatory behavior,depending on the initial atomic state and the relative position of the two upper levels from the forbidden gap The intensity and the phase of the external field can also affect spontaneous emission from the atom.展开更多
Background:Since the outbreak of COVID-19 caused adults suffer from mental disorders,it would be an essen-tial for psychologist to help individuals overcome mental disorders.Objective:This study aim to explore whether...Background:Since the outbreak of COVID-19 caused adults suffer from mental disorders,it would be an essen-tial for psychologist to help individuals overcome mental disorders.Objective:This study aim to explore whether the intervention of mindfulness is an efficient method to enhance adolescents’emotional intelligence(EI)and psychological capital(PC)to provide a theoretical basis and future directions for both targeted crisis intervention and psychological trauma recovery plans.Design:This research was designed as randomized controlled trial and total of 798 students were evaluated statistically.Methods:We used paired-sample t-tests and repeated measures ANOVA to compare every factor defined above by time and group.Then,we used Mplus to build LGCM to examine the trajectory of changes in EI and PC in the experimental group.Results and Conclusions:(1)The EI and PC scores had significantly different time points in the experimental group but not in the control group.(2)EI and PC tended to increase with intervention,and there were significant individual differences in the initial level and development speed.(3)Individuals’EI could promote the growth of PC.This research indicated that mindfulness should be given increasing consideration to enhance mental health during the worldwide outbreak of COVID-19.展开更多
基金Supported by the National Natural Science Foundation of China (No.10671139)
文摘The paper gives estimates for the finite-time ruin probability with insurance and financial risks. When the distribution of the insurance risk belongs to the class L（γ） for some γ〉0 or the subexponential distribution class, we abtain some asymptotic equivalent relationships for the finite-time ruin probability, respectively. When the distribution of the insurance risk belongs to the dominated varying-tailed distribution class, we obtain asymptotic upper bound and lower bound for the finite-time ruin probability, where for the asymptotic upper bound, we completely get rid of the restriction of mutual independence on insurance risks, and for the lower bound, we only need the insurance risks to have a weak positive association structure. The obtained results extend and improve some existing results.
基金Supported by College Research Grant of Beijing Normal University-Hong Kong Baptist University United International College(To Investigate the Effect of Chinese Medicine on Proton Leakage of Cells and its Potential Therapeutic Applications,No.R201406)
文摘OBJECTIVE:To monitor current production in Qi-deficient liver cells,and to study how cellular proton leakage might affect electric current production.METHODS:Cells were placed in an microbial fuel cells(MFC)anode and the electric current was measured.Mitochondrial-affecting chemicals,2,4-dinitrophenol(DNP)and resveratrol(RVT),were used to induce proton leakage in cells and their effect on current production observed.MCF-7 breast cancer cells exhibited higher proton leakage relative tonormal liver cells.A mouse model for Qi-deficiency was prepared according to the Methodology of Animal Experiment in Chinese medicine.The Qi-tonics Buzhongyiqi Tang(BZYQT),which is used to treat the Qi-deficiency condition,was applied to Qi-deficient liver cells to examine how current production was altered.RESULTS:Adding either DNP or RVT to normal liver cells increased current production.MCF-7 cells that possessed high proton leakage were also found to produce higher currents than normal liver cells.Higher current production,lower cellular glucose content,and lower adenosine triphosphate(ATP)production rate were found in Qi-deficient liver cells,in which the use of DNP or RVT further increased current production.The use of BZYQT to treat Qi-deficient liver cells decreased current production,counteracted the action of DNP,and also improved cellular glucose content.CONCLUSION:High electric current production was found in liver cells with high cellular proton leakage.Positive current responses to both mitochondria-affecting chemicals,DNP and RVT,appeared to indicate proper mitochondrial function.The high proton leakage detected in Qi-deficient liver cells might have caused high energy losses,which served to explain the observed lower cellular glucose content and ATP production rate than in normal cells.These results might also explain the exhibited syndromes of low energy and fatigue in Qi-deficient patients.Proton leakage,induced by DNP or the Qi-deficient condition,was possibly caused by unusual uncoupling of oxidative phosphorylati
基金Supported by the Beijing Municipal Science&Technology Commission(Popularized the Technologies of Chinese Medicine for Prevention and Treatment of Hypertension,Diabetes Mellitus,and Cerebrovascular Diseases in Communities,No.Z121100000312006)Tradition Chinese Medicine National Professional Project 2012(Management Pattern of Preventing and Treating Chronic Diseases using Chinese Medicine in Communities,No.201207012)
文摘OBJECTIVE:To investigate how community residents in Beijing understood and used Traditional Chinese Medicine(TCM) in their medical practice.METHODS:This was a cross-sectional study conducted on 3410 community residents from four large communities of Tongzhou district in Beijng,China.A validated, self-administered questionnaire comprised of three sections was used to gather the data.A systematic sampling procedure was applied to recruit the community residents.RESULTS:A total of 3410 participants completed the questionnaire survey.It showed that in highly educated residents, 33.4%(170) knew of the names of 3-10 Chinese herbals, 35.8%(182) knew of names of 3-10 traditional Chinese patent drug.Among all the respondent residents, 80.7%(2753)believed that TCM herbal therapy and TCM non-drug treatments were effective in disease treatment, health enhancement, 85.7%(2923) had taken traditional Chinese patent drug in their life,56.8%(1937) of residents had used herbal decoction, 40.0%(1365) had received non-drug treatment of TCM, such as acupuncture, massage, cupping, auricular acupuncture.Among the elderly residents, 11.4%(98) often used Chinese patent drug and 9.8%(85) often used herbal decoction.In addition, 70.8%(2415) of residents were willing to accept knowledge and information on TCM for health enhancement and disease prevention, such as medicated diet, medicinal tea, Tai Chi and Qi Gong, although 82.8%(2825) of residents had never used them.CONCLUSION:Chinese patent drug and herbal decoction are widely used in the communities in Beijing, and there existed a possible close correlation between high educational level and better understanding of TCM.Age and occupation also correlated with the attitude to TCM therapies.The characteristics of the residents should be considered seriously in the course of promoting the understanding and application of TCM.
基金Supported by the National Basic Research Program of China under Grant No.2011CB707004the Foundation for Innovative Research Groups of the NNSFC under Grant No.60921001+1 种基金the National Key Technologies R&D Program of China under Grant No.2011BAH24B02the State Science and Technology Support Program under Grant No.2012BAG04B01
文摘Considering the inertia of individuals in real inertia of players is introduced into evolutionary prisoner＇s life, we propose a modified Fermi updating rule, where the dilemma game （PDG） on square lattices. We mainly focus on how the inertia affects the cooperative behavior of the system. Interestingly, we find that the cooperation level has a nonmonotonic dependence on the inertia： with small inertia, cooperators will soon be invaded by defectors; with large inertia, players are unwilling to change their strategies and the cooperation level remains the same as the initial state; while a moderate inertia can induce the highest cooperation level. Moreover, effects of environmental noise and individual inertia are studied. Our work may be helpful in understanding the emergence and persistence of cooperation in nature and society.
文摘Consciousness is one of the unique features of creatures,and is also the root of biological intelligence.Up to now,all machines and robots havenJt had consciousness.Then,will the artificial intelligence(AI)be conscious?Will robots have real intelligence without consciousness?The most primitive consciousness is the perception and expression of selfexistence.In order to perceive the existence of the concept of‘Ij,a creature must first have a perceivable boundary such as skin to separate‘I’from‘non-1’.For robots,to have the self-awareness,they also need to be wrapped by a similar sensory membrane.Nowadays,as intelligent tools,AI systems should also be regarded as the external extension of human intelligence.These tools are unconscious.The development of AI shows that intelligence can exist without consciousness.When human beings enter into the era of life intelligence from AI,it is not the AI became conscious,but that conscious lives will have strong AI.Therefore,it becomes more necessary to be careful on applying AI to living creatures,even to those lower-level animals with only consciousness.The subversive revolution of such application may produce more careful thinking.
基金Supported by National Natural Science Foundation of China:The Molecular Mechanism Research of YiQi Huoxue Fang Postponing Vascular Endothelial Cell Senescence by SIRT1-autophagy Pathway(No.81503448)Self-Project Foundation from China Acadamy of Chinese Medical Sciences:the Mechanism Study of YiQi Huoxue Herbs Delaying the Vascular Aging(No.ZZ2013002)+1 种基金the Intervention Effects of the Extracts of Panax,Notoginseng and Rhizoma Ligustici Wallichii through Sirt1-autophagy pathway in endothelial cell senescence(No.ZZ2015011)Beijing Science and Technology Plan:Study on Traditional Chinese Herbal Medicine System Evaluation and Service(No.Z141102003414021)
文摘OBJECTIVE:To investigating the molecular mechanism of herbal pairs in three types of Chinese medicinals:Qi-tonifying,blood activation,blood-stasis breaking in treatment of coronary heart disease(CHD).METHODS:The components of six herbs were searched in Chinese medicine dictionary and their target proteins were found in PubChem.CHD genes were obtained from PubMed gene database.Ingenuity Pathways Analysis was used to build the pharmacological network of three herbal pairs and CHD molecular network.The canonical pathways between each herbal pair network and CHD network was compared to decipher the molecular mechanism on three herbal pairs in treating CHD.RESULTS:The network analysis showed that there were the common signal pathways of three herbal pairs in treating CHD including hypoxia signaling in the cardiovascular system,Hypoxia-inducible factor 1-alpha signaling,glucocorticoid receptor signaling,G-Protein coupled receptor signaling and pregnane X receptor/retinoid X receptor(PXR/RXR)activation.Further to analyze cardiovascular signaling,cytokine signaling and cytokine signaling,the effective molecules for three herbal pairs in treating CHD included HIF1α and estrogen receptor 1,Qi-tonifying herbal pair included albumin and matrix metallopeptidase 2,and blood-activation herbal pair included estrogen receptor 2 and peroxisome proliferator-activated receptor-γ.CONCLUSION:Each herbal pair can affect some respective CHD-related functions and pathways,meanwhile three herbal pairs exert some mutual effects on CHD-related functions and pathways.Mutual effects of three herbal pairs may be the key components of their total molecular mechanisms and respective effects of each herbal pair may be the characteristic components of their respective molecular mechanism.
基金the Medical and Health Science and Technology Project of Zhejiang Province(No.2021KY043)Chinese Foundation for Hepatitis Prevention and Control-TianQing Liver Disease Research Fund Subject(No.TQGB2020168).
文摘BACKGROUND Liver cancer is one of the most highly malignant cancers,characterized by easy metastasis and chemoradiotherapy resistance.Emerging evidence indicates that long noncoding RNAs(LncRNAs),including Lnc524369,are highly involved in the initiation,progression,radioresistance,and chemoresistance of hepatocellular carcinoma(HCC).However,the function of Lnc524369 remains unclear.AIM To explore the function of Lnc524369 in HCC.METHODS To investigate the effect of Lnc524369,tissue from 41 HCC patients were analyzed using CCK8,migration,and invasion assays.Lnc524369 and YWHAZ(also named 14-3-3ζ)mRNA were detected by qPCR,and YWHAZ and RAF1 proteins were detected by western blot in liver cancer cell lines and human HCC tissues.The Cancer Cell Line Encyclopedia(CCLE)databases,STRING database,Human Protein Atlas database,and the TCGA database were used for bioinformatic analysis.RESULTS Lnc524369 was significantly upregulated in the nucleus of liver cancer cells and human HCC tissues.Overexpression of Lnc524369 was associated with the proliferation,migration,and invasion of liver cancer cells.YWHAZ and RAF1 proteins and YWHAZ mRNA were overexpressed in liver cancer,which could be attenuated by overexpression of Lnc524369.Lnc524369 and its downstream target YWHAZ and RAF1 proteins were negatively associated with overall survival time.CONCLUSION Lnc524369 might be a promising target of HCC as it can enhance liver cancer progression and decrease the overall survival time of HCC by activating the YWHAZ/RAF1 pathway.
基金Regional Science Fund Project of Northwest Normal University,Grant No.31660281.
文摘Objective:In this research,we tried to explore how short-term mindfulness(STM)intervention affects adoles-cents’anxiety,depression,and negative and positive emotion during the COVID-19 pandemic.Design:10 classes were divided into experiment groups(5 classes;n=238)and control(5 classes;n=244)randomly.Hospital Anxi-ety and Depression Scale(HADS)and Positive and Negative Affect Schedule(PANAS)were used to measure par-ticipants’dependent variables.In the experiment group,we conducted STM practice interventions every morning in theirfirst class from March to November 2020.No interventions were conducted in the control group.Methods:Paired-sample t-tests were used to identify if a significant difference exists between every time point of the experimental and control groups.Repeated ANOVA and Growth Mixture Model(GMM)were used to analyze the tendency of positive and negative emotions,anxiety,and depression in the experimental group.Results and Conclusions:(1)With the intervention of STM,there was a significant decrease in negative emotions and an increase in positive emotions in the experimental group,whereas there were non-significant differences in the control group.(2)To explore the heterogeneity trajectories of dependent variables,we built a GMM and found there were two latent growth classes in the trajectories.(3)The results of the models showed their trajec-tories were downward,which meant that the levels of anxiety,depression,and negative emotions of participants decreased during the STM training period.Nonetheless,the score of positive affect showed upward in three loops of intervention,which indicated that the level of the participants’positive affect increased through the STM inter-vention.(4)This research indicated that STM should be given increasing consideration to enhance mental health during the worldwide outbreak of COVID-19.
基金Funded by the National Natural Science Foundation of China(51473130)the International Cooperation Funding of Hubei Province(No.2012IHA0120)
文摘With the objective to evaluate the bonding efficacy of a new self-adhesive resin cement（RelyX Unicem, 3M ESPE） to enamel and dentin using a shear bonding strengths test with or without acid etching pretreatment, flat buccal dentin surface and mesial/distal enamel surface were made using a high-speed diamond bur. Copper rings were luted using Rely X Unicem（RU; 3M ESPE）, Panavia F（PF; Kuraray） or Vitique（VI; DMG）. For RU, the shear bonding strengths using GL（Gluma Etch, Heraeus） acid etching pretreatment were also tested. The teeth were placed into copper rings（inner diameter： 16 mm, height： 4mm） and embedded in methylmethacrylate resin. The specimens were stored for 24 h in distilled water at 37 ℃ prior to shear bonding strengths testing. In addition, bond failures were examined by optical microscope and categorized as 4 models such as different adhesive, cohesive, or mixed. Shear bonding strengths were calculated by dividing the maximum debonding force over the cross sectional area of each specimen. The Kruskal-Wallis test was used to determine pairwise statistical differences（P 〈 0.05） in SBS between the experimental groups. For dentin bonding strength, statistical analysis showed that there was no significant difference among RU（12.84 MPa）, PF（14.93 MPa） and VI（11.03 MP）; and the bonding strengths of them were higher than RU with acid etching pretreatment（9.12 MP）. When bonded to enamel, PF（17.99 MP） and VI（17.58 MP） scored significantly higher than RU efficacy.The use of self-adhesive cement Rely X Unicem can obtain the bonding strengths to dentin similar to traditional resin cements. Phosphoric acid etching can improve the bonding strengths of the selfadhesive resin cement to enamel, but was negative for dentin.
文摘Acute pancreatitis is an inflammation initially localized in the pancreas,which may be accompanied with severe complications such as multi-organ failure,gastrointestinal hemorrhage and malnutrition.One in ten severe cases of acute pancreatitis develops systemic inflammatory response syndrome.Despite treatment,acute pancreatitis can be a life-threatening disease as its mortality rate amounts to 5%-10%in general,and up to 35%in cases of severe course.[1]Over the years,the role of oxidative stress
基金Supported by The Research Grants Council of Hong Kong,RGC-HKBU2/07CThe Hong Kong Jockey Club Institute of Chinese Medicine, JCICM4-07
文摘AIM: To investigate proteomic changes in spinal cord and dorsal root ganglia (DRG) of rats with trinitrobenzene sulfonic acid (TNBS)-induced colitis. METHODS: The colonic myeloperoxidase (MPO) activity and tumor necrosis factor-(TNF- ) level were determined. A two-dimensional electrophoresis (2-DE)-based proteomic technique was used to profile the global protein expression changes in the DRG and spinal cord of the rats with acute colitis induced by intracolonic injection of TNBS. RESULTS: TNBS group showed significantly elevated colonic MPO activity and increased TNF-level. The proteins derived from lumbosacral enlargement of the spinal cord and DRG were resolved by 2-DE; and 26 and 19 proteins that displayed significantly different expression levels in the DRG and spinal cord were identified respectively. Altered proteins were found to be involved in a number of biological functions, such as inflammation/immunity, cell signaling, redox regulation, sulfate transport and cellular metabolism. The over-expression of the protein similar to potassium channel tetramerisation domain containing protein 12 (Kctd 12) and low expression of proteasome subunit type-1 (psma) were validated by Western blotting analysis. CONCLUSION: TNBS-induced colitis has a profound impact on protein profiling in the nervous system. This result helps understand the neurological pathogenesis of inflammatory bowel disease.
基金supported by a grant the from National Natural Science Foundation of China(10671072)the Doctoral Program Foundation of the Ministry of Education of China(20060269016)+1 种基金the National Basic Research Program of China(973 Program,2007CB814904)the Research Grants Council of the Hong Kong Special Administrative Region,China(Project No:HKU 7139/01H,7323/01M,7054/04P and 7060/04P).
文摘In this paper we examine two classes of correlated aggregate claims distributions, with univariate claim counts and multivariate claim sizes. Firstly, we extend the results of Hesselager [ASTIN Bulletin, 24： 19-32（1994）] and Wang ＆ Sobrero＇s [ASTIN Bulletin, 24：161-166 （1994）] concerning recursions for compound distributions to a multivariate situation where each claim event generates a random vector. Then we give a multivariate continuous version of recursive algorithm for calculating a family of compound distribution. Especially, to some extent, we obtain a continuous version of the corresponding results in Sundt [ASTIN Bulletin, 29：29-45 （1999）] and Ambagaspitiya [Insurance： Mathematics and Economics, 24：301-308 （1999）]. Finally, we give an example and show how to use the algorithm for aggregate claim distribution of first class to compute recursively the compound distribution.
基金Supported by the National Natural Science Foundation of China under Grant No 49894190, and the Knowledge Innovation Project of Chinese Academy of Sciences under Grant No KZCXI-SW-18.
文摘We investigate how the geographical structure of a complex network affects its network topology, synchronization and the average spatial length of edges. The geographical structure means that the connecting probability of two nodes is related to the spatial distance of the two nodes. Our simulation results show that the geographical structure changes the network topology. The synchronization tendency is enhanced and the average spatial length of edges is enlarged when the node can randomly connect to the further one. Analytic results support our understanding of the phenomena.
基金the NSF of Henan Province (984051900)the NSF of Henan Education Committee (98110015)the Excellent Teacher Foundation of High School in Henan Province
文摘An approximate solution of the refinement equation was given by its mask, and the approximate sampling theorem for bivariate continuous function was proved by applying the approximate solution . The approximate sampling function defined uniquely by the mask of the refinement equation is the approximate solution of the equation , a piece-wise linear function , and posseses an explicit computation formula . Therefore the mask of the refinement equation is selected according to one' s requirement, so that one may controll the decay speed of the approximate sampling function .
基金supported by Guangdong Natural Science Foundation (Grant No.2008276)a grant from the Research Grants Council of Hong Kong,China
文摘Value at Risk (VaR) is a basic and very useful tool in measuring market risks. Numerous VaR models have been proposed in literature. Therefore, it is of great interest to evaluate the efficiency of these models, and to select the most appropriate one. In this paper, we shall propose to use the empirical likelihood approach to evaluate these models. Simulation results and real life examples show that the empirical likelihood method is more powerful and more robust than some of the asymptotic method available in literature.
基金Supported in part by the Shanghai Educational Council and FRG from Hong Kong Baptist University.
文摘The properties of the spontaneous emission from a three-level atom with an external driving field in a photonic crystal are studied.The population in the two upper levels displays complete decay or oscillatory behavior,depending on the initial atomic state and the relative position of the two upper levels from the forbidden gap The intensity and the phase of the external field can also affect spontaneous emission from the atom.
基金funded by the Regional Science Fund Project of Northwest Normal University,Grant No.31660281.
文摘Background:Since the outbreak of COVID-19 caused adults suffer from mental disorders,it would be an essen-tial for psychologist to help individuals overcome mental disorders.Objective:This study aim to explore whether the intervention of mindfulness is an efficient method to enhance adolescents’emotional intelligence(EI)and psychological capital(PC)to provide a theoretical basis and future directions for both targeted crisis intervention and psychological trauma recovery plans.Design:This research was designed as randomized controlled trial and total of 798 students were evaluated statistically.Methods:We used paired-sample t-tests and repeated measures ANOVA to compare every factor defined above by time and group.Then,we used Mplus to build LGCM to examine the trajectory of changes in EI and PC in the experimental group.Results and Conclusions:(1)The EI and PC scores had significantly different time points in the experimental group but not in the control group.(2)EI and PC tended to increase with intervention,and there were significant individual differences in the initial level and development speed.(3)Individuals’EI could promote the growth of PC.This research indicated that mindfulness should be given increasing consideration to enhance mental health during the worldwide outbreak of COVID-19.
基金partially supported by Hong Kong Baptist University Faculty Research Grant(FRG)CategoryⅡ[Grant No.FRG2/17-18/076]Hong Kong Baptist University Research Committee’s Startup Grant for New Academics
文摘在世界语言和汉语方言类型学研究中,前人对擦音的种类和擦音系统的特点进行了广泛探索。就辅音的部位对立而言,有研究显示不同部位辅音之间的音系对立,在不同元音环境中的表现可能有所不同。本文考察清擦音的类型,检验前人对擦音类型的结论,同时探索汉语方言中清擦音在[_i]和[_a]两个元音环境中的部位对立,以及不同清擦音和这两个元音的组合情况。本研究以《方言》杂志1979—2020年之间发表的描写汉语方言语音系统的文章为材料,考察了不同方言区共201种方言的清擦音。本研究的主要结果包括以下几点:(1)就清擦音的出现频率而言,汉语方言中最常见的依次为[f s x],分别出现在70%以上的方言中,其次为[x hs],基本验证了前人对汉语方言清擦音类型的总结。(2)就清擦音系统而言,本研究所涉及的201种方言中,平均每种有4.11个清擦音,具体到每个方言有2—6个清擦音不等。(3)清擦音数相同的系统,所包括的擦音组合差别很大,丰富多样;5个擦音的系统以[f-s-φ-s-x]最常见,4个擦音的系统以[f-s-φ-x]最常见,3个擦音的系统以[f-s-h]较为常见;2个擦音的系统以[s-h]较为常见。(4)就清擦音的部位对立而言,如果汉语方言中被描写为[φia]的音节可以在音系上视作相当于[φa],那么元音[_a]环境中存在部位对立的情况(例如[fa-sa-φa])基本多于相应的元音[_i]环境中存在部位对立的情况(例如[fi-si-φi]),这与前人类型学研究发现的元音[_i]有避免辅音部位对立的倾向相符。(5)就清擦音和[_i]或[_a]之间的组合而言,[φʃ]和[_i]组合的情况多于和[_a]组合的情况,而[f ssx h]都是和[_a]的组合多于和[_i]的组合。
