Disturbance specific force caused by the lever arm ef-fects in integration navigation system is investigated,Navigation errors eaused by the lever arm effects have been demonstrated under three flinght scenarios of th...Disturbance specific force caused by the lever arm ef-fects in integration navigation system is investigated,Navigation errors eaused by the lever arm effects have been demonstrated under three flinght scenarios of the air-craft.Analytical under three flight scenarios of the ari-craft.Analytical results show that disturbance specific force resulted from lever arm effects may become one of the major error sources while an aircraft undertakes the maneuvers,and mavigation errors caused by the lever arm effects accumulate rapidly with time.Therefore,a com-pensation method must be taken into account to eliminate the disturbance specific force caused by the lever arm ef-fects in integration navigation system.展开更多
Continent-continent collision is the most important driving mechanism for the occurrence of various geological processes in the continental lithosphere. How to recognize and determine continent-continent collision, es...Continent-continent collision is the most important driving mechanism for the occurrence of various geological processes in the continental lithosphere. How to recognize and determine continent-continent collision, especially its four-dimensional temporal-spatial evolution, is a subject that geological communities have long been concerned about and studied. Continent-continent collision is mainly manifested by strong underthrusting (subduction) of the underlying block along an intracontinental subduction zone and continuous obduction (thrusting propagation) of the overlying block along the intracontinental subduction zone, the occurrence of a basin-range tectonic framework in a direction perpendicular to the subduction zone and the flexure and disruption of the Moho. On the basis of numerical modeling, the authors discuss in detail the couplings between various amounts and rates of displacement caused by basin subsidence, mountain uplift and Moho updoming and downflexure during obduction (thrusting propagation) and subduction and the migration pattern of basin centers. They are probably indications or criteria for judgment or determination of continent-continent collision.展开更多
To measure the 96h-LC50 values of 32 substituted benzenes to the carp and to study the relationship between quantitative structure-activity and structural parameters of chemicals. Methods The acute toxicity values of...To measure the 96h-LC50 values of 32 substituted benzenes to the carp and to study the relationship between quantitative structure-activity and structural parameters of chemicals. Methods The acute toxicity values of 32 substituted benzenes to the carp were determined in a semistatic test. The energy of the lowest unoccupied molecular orbital, and the highest occupied molecular orbital, the dipole moment and the molecular weight of substituted benzenes were calculated by the quantum chemical method MOPAC6.0. Results The range of the toxicity of studied compounds was broad, and the most toxic compound was pentachlorophenol, while the least toxic compound was 4-methylaniline. By the stepwise regression analyses, a series of Quantitative structure-activity relationships (QSAR) equations were derived from all compounds and subclasses. The equation log1/LC50=0.759logP +2.222 (R2 (adj)=0.818) was found to fit well and the average predicted percentage error was 6.16%. Conclusion The toxicity of anilines and phenols to the carp could be modeled well by logP alone, whereas the toxicity of the halogenated benzenes and nitrobenznes not containing hydroxyl or amino group can be controlled by hydrophobic and electronic factors.展开更多
Background Epstein-Barr virus (EBV) associated malignancies with a Type Ⅱ latency gene expression pattern, such as Hodgkin’s disease, and nasopharyngeal carcinoma (NPC), frequently express the EBV antigen latent me...Background Epstein-Barr virus (EBV) associated malignancies with a Type Ⅱ latency gene expression pattern, such as Hodgkin’s disease, and nasopharyngeal carcinoma (NPC), frequently express the EBV antigen latent membrane protein 2A (LMP2A). We expected to establish a highly expressing LMP2A yeast cell strain and get the high quality LMP2A protein, which was used for detection, analysis and characterization of its antibodies in various patients’ sera of EBV associated malignancies.Methods The plasmid pPICZαA-LMP2A containing the full length of LMP2A cDNA was constructed and transformed to Pichia pastoris GS115 to express LMP2A protein. After fermentation and purification, the LMP2A protein was used as an antigen to detect anti-LMP2A antibodies (Abs) in the sera of patients with EBV-associated malignancies in enzyme linked immunosorbent assay (ELISA) or Western-blot.Results LMP2A was expressed successfully with an expected molecular weight of approximately 54 kD and Abs to LMP2A were strikingly specific to NPC. Two-thirds or more sera from NPC patients were positive for anti-LMP2A immunoglobulin G (IgG) Abs. The antibodies were absent from the sera of other EBV-associated diseases except a small fraction of the gastric carcinoma. Comparing anti-viral capsid Ags (VCA) IgA and LMP2A IgA titers in the sera from 76 NPC patients, only 55% were positive for anti-LMP2A IgA Abs while 70% were positive for anti-VCA IgA. However, we found that 3 sera negative for VCA IgA were positive for LMP2A IgA.Conclusion The results suggested the potential significance of LMP2A specific Abs for the diagnosis of EBV-associated malignancies, especially NPC.展开更多
The scheme and construction measurement of reinforcement and blocking against water for winder chamber after destroyed by mining influence have been introduced in this paper. The basic principle and advantages of bolt...The scheme and construction measurement of reinforcement and blocking against water for winder chamber after destroyed by mining influence have been introduced in this paper. The basic principle and advantages of bolting and grouting lining have been also listed. Bolting and grouting lining can increase the integrity and load-carrying capacity of supporting framework and it can assure the stability of supporting framework. It possesses not only the flexible and yielding capacity of bolting and shotcrete lining, but also the effect of rigid support such as metal support and brickwork, forming many kinds of support system, maintaining the stability of roadway together.展开更多
文摘Disturbance specific force caused by the lever arm ef-fects in integration navigation system is investigated,Navigation errors eaused by the lever arm effects have been demonstrated under three flinght scenarios of the air-craft.Analytical under three flight scenarios of the ari-craft.Analytical results show that disturbance specific force resulted from lever arm effects may become one of the major error sources while an aircraft undertakes the maneuvers,and mavigation errors caused by the lever arm effects accumulate rapidly with time.Therefore,a com-pensation method must be taken into account to eliminate the disturbance specific force caused by the lever arm ef-fects in integration navigation system.
基金the National Natural Science Foundation of China(grant 19972072)Project of the Open Laboratory of Continental Geodynamics of the Ministry of Land and Resources(grant 9812) Stat Project 305 rgrant 96—915—06—04).
文摘Continent-continent collision is the most important driving mechanism for the occurrence of various geological processes in the continental lithosphere. How to recognize and determine continent-continent collision, especially its four-dimensional temporal-spatial evolution, is a subject that geological communities have long been concerned about and studied. Continent-continent collision is mainly manifested by strong underthrusting (subduction) of the underlying block along an intracontinental subduction zone and continuous obduction (thrusting propagation) of the overlying block along the intracontinental subduction zone, the occurrence of a basin-range tectonic framework in a direction perpendicular to the subduction zone and the flexure and disruption of the Moho. On the basis of numerical modeling, the authors discuss in detail the couplings between various amounts and rates of displacement caused by basin subsidence, mountain uplift and Moho updoming and downflexure during obduction (thrusting propagation) and subduction and the migration pattern of basin centers. They are probably indications or criteria for judgment or determination of continent-continent collision.
基金This work was supported by the National "973" Great Foundation Research Item of China (2002CB412303) and theNatural Science Foundation of Jiangsu Province (BK2004118).
文摘To measure the 96h-LC50 values of 32 substituted benzenes to the carp and to study the relationship between quantitative structure-activity and structural parameters of chemicals. Methods The acute toxicity values of 32 substituted benzenes to the carp were determined in a semistatic test. The energy of the lowest unoccupied molecular orbital, and the highest occupied molecular orbital, the dipole moment and the molecular weight of substituted benzenes were calculated by the quantum chemical method MOPAC6.0. Results The range of the toxicity of studied compounds was broad, and the most toxic compound was pentachlorophenol, while the least toxic compound was 4-methylaniline. By the stepwise regression analyses, a series of Quantitative structure-activity relationships (QSAR) equations were derived from all compounds and subclasses. The equation log1/LC50=0.759logP +2.222 (R2 (adj)=0.818) was found to fit well and the average predicted percentage error was 6.16%. Conclusion The toxicity of anilines and phenols to the carp could be modeled well by logP alone, whereas the toxicity of the halogenated benzenes and nitrobenznes not containing hydroxyl or amino group can be controlled by hydrophobic and electronic factors.
文摘Background Epstein-Barr virus (EBV) associated malignancies with a Type Ⅱ latency gene expression pattern, such as Hodgkin’s disease, and nasopharyngeal carcinoma (NPC), frequently express the EBV antigen latent membrane protein 2A (LMP2A). We expected to establish a highly expressing LMP2A yeast cell strain and get the high quality LMP2A protein, which was used for detection, analysis and characterization of its antibodies in various patients’ sera of EBV associated malignancies.Methods The plasmid pPICZαA-LMP2A containing the full length of LMP2A cDNA was constructed and transformed to Pichia pastoris GS115 to express LMP2A protein. After fermentation and purification, the LMP2A protein was used as an antigen to detect anti-LMP2A antibodies (Abs) in the sera of patients with EBV-associated malignancies in enzyme linked immunosorbent assay (ELISA) or Western-blot.Results LMP2A was expressed successfully with an expected molecular weight of approximately 54 kD and Abs to LMP2A were strikingly specific to NPC. Two-thirds or more sera from NPC patients were positive for anti-LMP2A immunoglobulin G (IgG) Abs. The antibodies were absent from the sera of other EBV-associated diseases except a small fraction of the gastric carcinoma. Comparing anti-viral capsid Ags (VCA) IgA and LMP2A IgA titers in the sera from 76 NPC patients, only 55% were positive for anti-LMP2A IgA Abs while 70% were positive for anti-VCA IgA. However, we found that 3 sera negative for VCA IgA were positive for LMP2A IgA.Conclusion The results suggested the potential significance of LMP2A specific Abs for the diagnosis of EBV-associated malignancies, especially NPC.
文摘The scheme and construction measurement of reinforcement and blocking against water for winder chamber after destroyed by mining influence have been introduced in this paper. The basic principle and advantages of bolting and grouting lining have been also listed. Bolting and grouting lining can increase the integrity and load-carrying capacity of supporting framework and it can assure the stability of supporting framework. It possesses not only the flexible and yielding capacity of bolting and shotcrete lining, but also the effect of rigid support such as metal support and brickwork, forming many kinds of support system, maintaining the stability of roadway together.
