In recent years, the paradigm of real-world study （RWS） has been at the forefront oI climcal research worldwide, particularly in the field of traditional Chinese medicine. In this paper, basic features and nature of...In recent years, the paradigm of real-world study （RWS） has been at the forefront oI climcal research worldwide, particularly in the field of traditional Chinese medicine. In this paper, basic features and nature of real- world clinical studies are discussed, and ethical issues in different stages of RWS are raised and reviewed. Moreover, some preliminary solutions to these issues, such as protecting subjects during the process of RWS and performing ethical review, are presented based on recent practices and basic ethical rules to improve the scientific validity and ethical level of RWS.展开更多
Internet addiction is associated with an increased risk of suicidal behavior and can lead to brain dysfunction among adolescents.However,whether brain dysfunction occurs in adolescents with Internet addiction who atte...Internet addiction is associated with an increased risk of suicidal behavior and can lead to brain dysfunction among adolescents.However,whether brain dysfunction occurs in adolescents with Internet addiction who attempt suicide remains unknown.This observational cross-sectional study enrolled 41 young Internet addicts,aged from 15 to 20 years,from the Department of Psychiatry,the First Affiliated Hospital of Chongqing Medical University,China from January to May 2018.The participants included 21 individuals who attempted suicide and 20 individuals with Internet addiction without a suicidal attempt history.Brain images in the resting state were obtained by a 3.0 T magnetic resonance imaging scanner.The results showed that activity in the gyrus frontalis inferior of the right pars triangularis and the right pars opercularis was significantly increased in the suicidal attempt group compared with the non-suicidal attempt group.In the resting state,the prefrontal lobe of adolescents who had attempted suicide because of Internet addiction exhibited functional abnormalities,which may provide a new basis for studying suicide pathogenesis in Internet addicts.The study was authorized by the Ethics Committee of Chongqing Medical University,China(approval No.2017 Scientific Research Ethics(2017-157))on December 11,2017.展开更多
Silyl enol ethers are often obtained when the lithium enolates are trapped with chlorosilanes.Herein,we report a general method for the regio-and diasteroselective C-silylation of enolate enabled by theβ-boronyl grou...Silyl enol ethers are often obtained when the lithium enolates are trapped with chlorosilanes.Herein,we report a general method for the regio-and diasteroselective C-silylation of enolate enabled by theβ-boronyl group.The formation of five-membered chelation intermediate is key to the C-selective silylation and anti-selectivity.The operationally simple protocol provides a general and predictable access to theα-silylated esters.The synthetic versatility of the boron-silicon bifunctional products was demonstrated by down-stream transformations.展开更多
文摘In recent years, the paradigm of real-world study （RWS） has been at the forefront oI climcal research worldwide, particularly in the field of traditional Chinese medicine. In this paper, basic features and nature of real- world clinical studies are discussed, and ethical issues in different stages of RWS are raised and reviewed. Moreover, some preliminary solutions to these issues, such as protecting subjects during the process of RWS and performing ethical review, are presented based on recent practices and basic ethical rules to improve the scientific validity and ethical level of RWS.
基金supported by a grant from Chongqing Science and Technology Commission of China,Nos.CSTC2018jxj1130009,cstc2019 jscx-msxmX0279(both to YH)the Traditional Chinese Medicine Scientific Research Fund from Chongqing Health Committee of China,No.2019ZY023315(to YH)
文摘Internet addiction is associated with an increased risk of suicidal behavior and can lead to brain dysfunction among adolescents.However,whether brain dysfunction occurs in adolescents with Internet addiction who attempt suicide remains unknown.This observational cross-sectional study enrolled 41 young Internet addicts,aged from 15 to 20 years,from the Department of Psychiatry,the First Affiliated Hospital of Chongqing Medical University,China from January to May 2018.The participants included 21 individuals who attempted suicide and 20 individuals with Internet addiction without a suicidal attempt history.Brain images in the resting state were obtained by a 3.0 T magnetic resonance imaging scanner.The results showed that activity in the gyrus frontalis inferior of the right pars triangularis and the right pars opercularis was significantly increased in the suicidal attempt group compared with the non-suicidal attempt group.In the resting state,the prefrontal lobe of adolescents who had attempted suicide because of Internet addiction exhibited functional abnormalities,which may provide a new basis for studying suicide pathogenesis in Internet addicts.The study was authorized by the Ethics Committee of Chongqing Medical University,China(approval No.2017 Scientific Research Ethics(2017-157))on December 11,2017.
基金Financial support was provided by the National Natural Science Foundation of China(Nos.22001210 and 21971202)the Natural Science Basic Research Plan of Shaanxi Province(2020JC-08)。
文摘Silyl enol ethers are often obtained when the lithium enolates are trapped with chlorosilanes.Herein,we report a general method for the regio-and diasteroselective C-silylation of enolate enabled by theβ-boronyl group.The formation of five-membered chelation intermediate is key to the C-selective silylation and anti-selectivity.The operationally simple protocol provides a general and predictable access to theα-silylated esters.The synthetic versatility of the boron-silicon bifunctional products was demonstrated by down-stream transformations.
