In this article comparative analysis of various semi-numerical schemes has beenmade for the case of squeezing flow of an incompressible viscous fluid between two largeparallel plates having no-slip at the boundaries.T...In this article comparative analysis of various semi-numerical schemes has beenmade for the case of squeezing flow of an incompressible viscous fluid between two largeparallel plates having no-slip at the boundaries.The medium of flow contains magnetohy-drodynamic(MHD)effect and having small pores.Modeled boundary value problem is solvedanalytically using Optimal homotopy asymptotic method(OHAM),homotopy perturbationmethod(HPM),differential transform method(DTM),Daftardar Jafari method(DIM)andAdomian decomposition method(ADM).For comparison purpose,residuals of these schemeshave been found and analyzed for accuracy.Analytical study indicates that DTM and DJM arequite good in tem of accuracy near the center of domain[—1,1]but the accuracy reducesconsiderably near the start and end of the given interval.HPM and OHAM residuals indicatethat OHAM surpasses HPM in terms of accuracy in the present case.展开更多
As part of the global effort to plant billion trees,an afforestation project is launched in Pakistan in Khyber Pakhtunkhwa(KP)province to conserve existing forests and to increase area under forest cover.The present s...As part of the global effort to plant billion trees,an afforestation project is launched in Pakistan in Khyber Pakhtunkhwa(KP)province to conserve existing forests and to increase area under forest cover.The present study is designed to build a Systems'model by incorporating major activities of the Billion Tree Tsunami Afforestation Project(BTTAP)with special focus on afforestation activities to estimate the growth in forest area of KP.Availability of complete dataset was a challenge.To fix the model,the raw data taken from the project office has been utilized.Planning Commission Form 1-Phase I&II helped us with additional information.We relied on the data available for one and half period of the project as rest of the data is subject to the completion of the project.Our results show that the project target to enhance area under forest differs from the target to afforest area under the project.The system dynamics'model projection shows that the forest area of KP would be 23.59 million hectares at the end of the BTTA project,thus having an increase of 3.29%instead of 2%that has been initially proposed.However,the results show that the progress to meet the target in some afforestation classes is slow as compared to other categories.Farm forestry,plantation on communal lands and owners'plantation need special focus of the authority.Deforestation would affect 0.02 million hectares area of the project.The model under study may be used as a reference model that can be replicated to other areas where billion tree campaigns are going on.展开更多
In this paper, Differential Transform Method (DTM) is proposed for the closed form solution of linear and non-linear stiff systems. First, we apply DTM to find the series solution which can be easily converted into ex...In this paper, Differential Transform Method (DTM) is proposed for the closed form solution of linear and non-linear stiff systems. First, we apply DTM to find the series solution which can be easily converted into exact solution. The method is described and illustrated with different examples and figures are plotted accordingly. The obtained result confirm that DTM is very easy, effective and convenient.展开更多
This paper is the seventh in the Fungal Diversity Notes series,where 131 taxa accommodated in 28 families are mainly described from Rosa(Rosaceae)and a few other hosts.Novel fungal taxa are described in the present st...This paper is the seventh in the Fungal Diversity Notes series,where 131 taxa accommodated in 28 families are mainly described from Rosa(Rosaceae)and a few other hosts.Novel fungal taxa are described in the present study,including 17 new genera,93 new species,four combinations,a sexual record for a species and new host records for 16 species.Bhatiellae,Cycasicola,Dactylidina,Embarria,Hawksworthiana,Italica,Melanocucurbitaria,Melanodiplodia,Monoseptella,Uzbekistanica,Neoconiothyrium,Neopaucispora,Pararoussoella,Paraxylaria,Marjia,Sporormurispora and Xenomassariosphaeria are introduced as new ascomycete genera.We also introduce the new species Absidia jindoensis,Alternaria doliconidium,A.hampshirensis,Angustimassarina rosarum,Astragalicola vasilyevae,Backusella locustae,Bartalinia rosicola,Bhatiellae rosae,Broomella rosae,Castanediella camelliae,Coelodictyosporium rosarum,Comoclathris rosae,C.rosarum,Comoclathris rosigena,Coniochaeta baysunika,C.rosae,Cycasicola goaensis,Dactylidina shoemakeri,Dematiopleospora donetzica,D.rosicola,D.salsolae,Diaporthe rosae,D.rosicola,Endoconidioma rosaehissaricae,Epicoccum rosae,Hawksworthiana clematidicola,H.lonicerae,Italica achilleae,Keissleriella phragmiticola,K.rosacearum,K.rosae,K.rosarum,Lophiostoma rosae,Marjia tianschanica,M.uzbekistanica,Melanocucurbitaria uzbekistanica,Melanodiplodia tianschanica,Monoseptella rosae,Mucor fluvius,Muriformistrickeria rosae,Murilentithecium rosae,Neoascochyta rosicola,Neoconiothyrium rosae,Neopaucispora rosaecae,Neosetophoma rosarum,N.rosae,N.rosigena,Neostagonospora artemisiae,Ophiobolus artemisiicola,Paraconiothyrium rosae,Paraphaeosphaeria rosae,P.rosicola,Pararoussoella rosarum,Parathyridaria rosae,Paraxylaria rosacearum,Penicillium acidum,P.aquaticum,Phragmocamarosporium rosae,Pleospora rosae,P.rosae-caninae,Poaceicola agrostina,P.arundinicola,P.rosae,Populocrescentia ammophilae,P.rosae,Pseudocamarosporium pteleae,P.ulmi-minoris,Pseudocercospora rosae,Pseudopithomyces rosae,Pseudostrickeria rosae,Sclerostagonospora lathyri,S.rosa展开更多
Research Background: Atopic dermatitis (AD) is a chronic inflammatory skin condition in children that significantly impacts physical health and quality of life. Adherence to treatment regimens is crucial for effective...Research Background: Atopic dermatitis (AD) is a chronic inflammatory skin condition in children that significantly impacts physical health and quality of life. Adherence to treatment regimens is crucial for effective disease management but is often hindered by various psychosocial and socioeconomic barriers. Parental mental health issues, family dynamics, financial constraints, and limited access to specialized care contribute to inconsistent treatment adherence, exacerbating the condition. Purpose/Aim: The aim of this study is to explore the multifaceted barriers to treatment adherence in children with AD and evaluate the effectiveness of current interventions targeting these challenges. The study seeks to identify strategies that can improve adherence and health outcomes by addressing psychosocial and socioeconomic factors. Method: The method involves a comprehensive review of existing literature on the impact of psychosocial and socioeconomic factors on treatment adherence in children with AD. The study also examines various interventions designed to address these barriers, including community support programs, family-centered interventions, financial aid, integrated care models, and telehealth solutions. Results: Results indicate that psychosocial barriers, such as parental anxiety and depression, significantly hinder effective disease management. Family dynamics, including poor communication and single-parent households, complicate adherence efforts. Socioeconomic factors, such as financial constraints and limited healthcare access, further impede adherence. Interventions that address these barriers show promise in improving treatment adherence and health outcomes. Community support programs and family-centered interventions enhance parental mental health and family communication. Financial aid programs and integrated care models help mitigate economic and logistical challenges. Telehealth solutions improve access to specialized care, particularly in underserved areas. Conclusion: The study concludes that a展开更多
This is a continuity of a series of taxonomic and phylogenetic papers on the fungi where materials were collected from many countries,examined and described.In addition to extensive morphological descriptions and appr...This is a continuity of a series of taxonomic and phylogenetic papers on the fungi where materials were collected from many countries,examined and described.In addition to extensive morphological descriptions and appropriate asexual and sexual connections,DNA sequence data are also analysed from concatenated datasets to infer phylogenetic relationships and substantiate systematic positions of taxa within appropriate ranks.Wherever new species or combinations are proposed,we apply an integrative approach using morphological and molecular data as well as ecological features wherever applicable.Notes on 112 fungal taxa are compiled in this paper including Biatriosporaceae and Roussoellaceae,Didysimulans gen.nov.,81 new species,18 new host records and new country records,five reference specimens,two new combinations,and three sexual and asexual morph reports.The new species are Amanita cornelii,A.emodotrygon,Angustimassarina alni,A.arezzoensis,A.italica,A.lonicerae,A.premilcurensis,Ascochyta italica,A.rosae,Austroboletus appendiculatus,Barriopsis thailandica,Berkleasmium ariense,Calophoma petasitis,Camarosporium laburnicola,C.moricola,C.grisea,C.ossea,C.paraincrustata,Colletotrichum sambucicola,Coprinopsis cerkezii,Cytospora gelida,Dacrymyces chiangraiensis,Didysimulans italica,D.mezzanensis,Entodesmium italica,Entoloma magnum,Evlachovaea indica,Exophiala italica,Favolus gracilisporus,Femsjonia monospora,Fomitopsis flabellata,F.roseoalba,Gongronella brasiliensis,Helvella crispoides,Hermatomyces chiangmaiensis,H.chromolaenae,Hysterium centramurum,Inflatispora caryotae,Inocybe brunneosquamulosa,I.luteobrunnea,I.rubrobrunnea,Keissleriella cirsii,Lepiota cylindrocystidia,L.flavocarpa,L.maerimensis,Lophiotrema guttulata,Marasmius luculentus,Morenoina calamicola,Moelleriella thanathonensis,Mucor stercorarius,Myrmecridium fluviae,Myrothecium septentrionale,Neosetophoma garethjonesii,Nigrograna cangshanensis,Nodulosphaeria guttulatum,N.multiseptata,N.sambuci,Panus subfasciatus,Paraleptosphaeria padi,Paraphaeosphaeri展开更多
Tamanu oil, derived from the nuts of Calophyllum inophyllum, has gained increasing attention for its potential in acne management due to its purported anti-inflammatory and wound-healing properties. This analysis eval...Tamanu oil, derived from the nuts of Calophyllum inophyllum, has gained increasing attention for its potential in acne management due to its purported anti-inflammatory and wound-healing properties. This analysis evaluates the efficacy of tamanu oil in acne treatment with a specific focus on its impact on inflammation and scar reduction. The novelty of this research lies in its comprehensive analysis of tamanu oil’s dual mechanism of action: reducing acne-related inflammation and promoting the healing of acne scars. Clinical trials and laboratory analyses were conducted to assess the oil’s effectiveness in diminishing erythema, swelling, and post-acne scarring compared to conventional treatments. Preliminary findings demonstrate that tamanu oil significantly reduces inflammation and accelerates wound healing, potentially offering a promising adjunct or alternative to standard acne therapies. Future research should aim to optimize formulation and application protocols, long-term effects, and comparative therapeutic efficacy with other anti-inflammatory agents. Tamanu oil offers a novel and effective approach to acne management, with potential advantages that go beyond inflammation reduction to include enhanced scar reduction, making it a subject that warrants further investigation.展开更多
Prostate cancer is a clinically heterogeneous disease, with some men having indolent disease that can safely be observed, while others have aggressive, lethal disease. Over the past decade, researchers have begun to u...Prostate cancer is a clinically heterogeneous disease, with some men having indolent disease that can safely be observed, while others have aggressive, lethal disease. Over the past decade, researchers have begun to unravel some of the genomic heterogeneity that contributes to these varying clinical phenotypes. Distinct molecular sub-classes of prostate cancer have been identified, and the uniqueness of these sub-classes has been leveraged to predict clinical outcomes, design novel biomarkers for prostate cancer diagnosis, and develop novel therapeutics. Recent work has also elucidated the temporal and spatial heterogeneity of prostate cancer, helping us understand disease pathogenesis, response to therapy, and progression. New genomic techniques have provided us with a window into the remarkable clinical and genomic heterogeneity of prostate cancer, and this new perspective will increasingly impact patient care.展开更多
Hidradenitis suppurativa (HS) is a chronic, inflammatory skin condition characterized by painful nodules, abscesses, and scarring, primarily affecting areas rich in apocrine glands. Environmental and occupational risk...Hidradenitis suppurativa (HS) is a chronic, inflammatory skin condition characterized by painful nodules, abscesses, and scarring, primarily affecting areas rich in apocrine glands. Environmental and occupational risk factors, including prolonged exposure to heat, friction, and certain chemicals, have been identified as exacerbating conditions for HS. Yet, there remains a lack of tailored recommendations for modifying work environments to alleviate these triggers. This review presents novel suggestions for work modifications to reduce HS flare-ups, such as implementing breathable, friction-reducing workwear, ergonomic adjustments to minimize pressure on affected areas, and introducing low-irritant hygiene protocols in workplaces with chemical exposure. These recommendations are grounded in emerging evidence linking specific occupational exposures to the exacerbation of HS symptoms. The novelty of this approach lies in its proactive stance, shifting from reactive management of HS symptoms to preventative environmental modifications. Future studies should explore the long-term efficacy of these modifications and investigate the potential for personalized work environment adjustments based on individual patient profiles. Targeted workplace interventions may significantly improve the quality of life for HS patients, highlighting the need for multidisciplinary collaboration between dermatologists, occupational health specialists, and employers.展开更多
Background: Cutaneous oncology encompasses a broad range of skin malignancies, including melanoma, cutaneous squamous cell carcinoma (SCC), and basal cell carcinoma (BCC), all of which pose significant global health c...Background: Cutaneous oncology encompasses a broad range of skin malignancies, including melanoma, cutaneous squamous cell carcinoma (SCC), and basal cell carcinoma (BCC), all of which pose significant global health challenges. The World Health Organization (WHO) estimates that melanoma incidence has increased by approximately 50% over the past three decades. While SCC and BCC are generally less aggressive than melanoma, they contribute significantly to the overall burden of skin cancer due to their high prevalence. Traditional treatment modalities for these malignancies, such as surgery, radiation, and chemotherapy, have shown limitations in achieving durable responses and minimizing systemic toxicity. As a result, there is an increasing need for more effective and less toxic treatment options. Immunotherapeutic strategies have emerged as a promising avenue in oncology, with the potential to revolutionize treatment approaches for cutaneous malignancies. Objectives: This literature review aims to undertake an in-depth examination of immunotherapeutic strategies for melanoma, SCC, and BCC. Specifically, the review focuses on the role of immune checkpoint inhibitors, adoptive cell therapies, and emerging immunotherapies, assessing their impact on treatment outcomes, survival rates, and patient quality of life. Methods: A literature search was conducted using databases such as PubMed, Google Scholar, and Scopus. The search terms included “cutaneous oncology”, “immunotherapy”, “immune checkpoint inhibitors”, “adoptive cell therapy”, “melanoma”, “cutaneous squamous cell carcinoma”, and “basal cell carcinoma”. Peer-reviewed articles published in the last 10 years that reported clinical outcomes from immunotherapy-based treatments for cutaneous malignancies were included. The studies were reviewed and analyzed based on their reported clinical outcomes, including survival rates, adverse events, and quality of life metrics. Results: Our review identified significant advancements in immunotherap展开更多
This comprehensive review explores the intricate dynamics between psychosocial factors and chronic wound healing processes, specifically focusing on prevalent conditions such as pressure ulcers, diabetic foot ulcers, ...This comprehensive review explores the intricate dynamics between psychosocial factors and chronic wound healing processes, specifically focusing on prevalent conditions such as pressure ulcers, diabetic foot ulcers, and venous leg ulcers. By examining the roles of psychiatric conditions, including depression, anxiety, and post-traumatic stress disorder (PTSD), this paper illuminates how these factors intricately influence wound healing dynamics, including mechanisms of pain perception and inflammatory responses. Furthermore, we evaluate the effectiveness of integrated biopsychosocial interventions, which encompass a holistic approach to wound care, thereby enhancing healing outcomes for dermatology patients. Future studies should focus on investigating the specific psychosocial determinants that significantly influence wound healing, exploring novel therapeutic strategies, and implementing personalized interventions to meet the unique needs of each patient. Such endeavors hold promise in advancing the fields of psychodermatology and wound management, fostering a deeper understanding and application of psychosocial considerations in dermatological care.展开更多
Knowledge of the relationships and thus the classification of fungi,has developed rapidly with increasingly widespread use of molecular techniques,over the past 10–15 years,and continues to accelerate.Several genera ...Knowledge of the relationships and thus the classification of fungi,has developed rapidly with increasingly widespread use of molecular techniques,over the past 10–15 years,and continues to accelerate.Several genera have been found to be polyphyletic,and their generic concepts have subsequently been emended.New names have thus been introduced for species which are phylogenetically distinct from the type species of particular genera.The ending of the separate naming of morphs of the same species in 2011,has also caused changes in fungal generic names.In order to facilitate access to all important changes,it was desirable to compile these in a single document.The present article provides a list of generic names of Ascomycota(approximately 6500 accepted names published to the end of 2016),including those which are lichen-forming.Notes and summaries of the changes since the last edition of‘Ainsworth&Bisby’s Dictionary of the Fungi’in 2008 are provided.The notes include the number of accepted species,classification,type species(with location of the type material),culture availability,life-styles,distribution,and selected publications that have appeared since 2008.This work is intended to provide the foundation for updating the ascomycete component of the"Without prejudice list of generic names of Fungi"published in 2013,which will be developed into a list of protected generic names.This will be subjected to the XIXth International Botanical Congress in Shenzhen in July 2017 agreeing to a modification in the rules relating to protected lists,and scrutiny by procedures determined by the Nomenclature Committee for Fungi(NCF).The previously invalidly published generic names Barriopsis,Collophora(as Collophorina),Cryomyces,Dematiopleospora,Heterospora(as Heterosporicola),Lithophila,Palmomyces(as Palmaria)and Saxomyces are validated,as are two previously invalid family names,Bartaliniaceae and Wiesneriomycetaceae.Four species of Lalaria,which were invalidly published are transferred to Taphrina and validated as new 展开更多
Numerous new taxa and classifications of Dothideomycetes have been published following the last monograph of families of Dothideomycetes in 2013.A recent publication by Honsanan et al.in 2020 expanded information of f...Numerous new taxa and classifications of Dothideomycetes have been published following the last monograph of families of Dothideomycetes in 2013.A recent publication by Honsanan et al.in 2020 expanded information of families in Dothideo-mycetidae and Pleosporomycetidae with modern classifications.In this paper,we provide a refined updated document on orders and families incertae sedis of Dothideomycetes.Each family is provided with an updated description,notes,including figures to represent the morphology,a list of accepted genera,and economic and ecological significances.We also provide phylogenetic trees for each order.In this study,31 orders which consist 50 families are assigned as orders incertae sedis in Dothideomycetes,and 41 families are treated as families incertae sedis due to lack of molecular or morphological evidence.The new order,Catinellales,and four new families,Catinellaceae,Morenoinaceae Neobuelliellaceae and Thyrinulaceae are introduced.Seven genera(Neobuelliella,Pseudomicrothyrium,Flagellostrigula,Swinscowia,Macroconstrictolumina,Pseudobogoriella,and Schummia)are introduced.Seven new species(Acrospermum urticae,Bogoriella complexoluminata,Dothiorella ostryae,Dyfrolomyces distoseptatus,Macroconstrictolumina megalateralis,Patellaria microspora,and Pseu-domicrothyrium thailandicum)are introduced base on morphology and phylogeny,together with two new records/reports and five new collections from different families.Ninety new combinations are also provided in this paper.展开更多
Elevated expression of heat shock protein 90 （HSP90） has been found in kidneys and serum of systemic lupus erythematosus （SLE） patients and MRLIMp-FasIprIFasJpr（MRLIIpr） autoimmune mice. We investigated if inhib...Elevated expression of heat shock protein 90 （HSP90） has been found in kidneys and serum of systemic lupus erythematosus （SLE） patients and MRLIMp-FasIprIFasJpr（MRLIIpr） autoimmune mice. We investigated if inhibition of HSP90 would reduce disease in MRL/ Ipr mice. In vitro, pretreatment of mesangial cells with HSP90 inhibitor Geldanamycin prior to immune-stimulation showed reduced expression of IL-6, IL-12 and NO. In vivo, we found HSP90 expression was elevated in MRL/Ipr kidneys when compared to C57BL/6 mice and MRIJIpr mice treated with HSP90 inhibitor 17-DMAG. MRIJIpr mice treated with 17-DMAG showed decreased proteinuria and reduced serum anti-dsDNA antibody production. Glomerulonephritis and glomerular IgG and C3 were not significantly affected by administration of 17-DMAG in MRIJIpr. 17-DMAG increased CD8＋ T cells, reduced double-negative T cells, decreased the CD4/CD8 ratio and reduced follicular B cells. These studies suggest that HSP90 may play a role in regulating T-cell differentiation and activation and that HSP90 inhibition may reduce inflammation in lupus.展开更多
Title: Integrating Consistent Individualized Carbohydrate-Controlled Anti- Inflammatory Nutritional Plan (C-ICAN) in the Management of Prader-Willi Syndrome: A Case Report. Prader–Willi syndrome (PWS) is a rare genet...Title: Integrating Consistent Individualized Carbohydrate-Controlled Anti- Inflammatory Nutritional Plan (C-ICAN) in the Management of Prader-Willi Syndrome: A Case Report. Prader–Willi syndrome (PWS) is a rare genetic disorder caused by a loss of function of specific genes on chromosome 15. Patients with this disease present unique challenges in management, particularly regarding obesity and nutritional regulation as the disease symptoms change depending on the age of the patient and the phase of the disease. These challenges pose critical stressors to caregivers and their families. We present a case report of a 5-year-old Caucasian male diagnosed with PWS, exhibiting failure to thrive and uncontrolled weight gain. His caregiver was his elderly grandmother who, by her own admission, was ill-equipped to deal with the patient’s physical symptoms and his behavior in response to dietary restrictions. Through a multidisciplinary approach involving medical nutrition therapy (MNT) involving the implementation of a Consistent Individualized Carbohydrate-Controlled Anti-Inflammatory Nutritional plan (C-ICAN), growth hormone supplementation, and behavioral interventions patient markedly improved physically and emotionally.展开更多
The cosmopolitan plant genus Clematis contains many climbing species that can be found worldwide.The genus occurs in the wild and is grown commercially for horticulture.Microfungi on Clematis were collected from Belgi...The cosmopolitan plant genus Clematis contains many climbing species that can be found worldwide.The genus occurs in the wild and is grown commercially for horticulture.Microfungi on Clematis were collected from Belgium,China,Italy,Thailand and the UK.They are characterized by morphology and analyses of gene sequence data using an integrated species concept to validate identifications.The study revealed two new families,12 new genera,50 new species,26 new host records with one dimorphic character report,and ten species are transferred to other genera.The new families revealed by multigene phylogeny are Longiostiolaceae and Pseudomassarinaceae in Pleosporales(Dothideomycetes).New genera are Anthodidymella(Didymellaceae),Anthosulcatispora and Parasulcatispora(Sulcatisporaceae),Fusiformispora(Amniculicolaceae),Longispora(Phaeosphaeriaceae),Neobyssosphaeria(Melanommataceae),Neoleptosporella(Chaetosphaeriales,genera incertae sedis),Neostictis(Stictidaceae),Pseudohelminthosporium(Neomassarinaceae),Pseudomassarina(Pseudomassarinaceae),Sclerenchymomyces(Leptosphaeriaceae)and Xenoplectosphaerella(Plectosphaerellaceae).The newly described species are Alloleptosphaeria clematidis,Anthodidymella ranunculacearum,Anthosulcatispora subglobosa,Aquadictyospora clematidis,Brunneofusispora clematidis,Chaetosphaeronema clematidicola,C.clematidis,Chromolaenicola clematidis,Diaporthe clematidina,Dictyocheirospora clematidis,Distoseptispora clematidis,Floricola clematidis,Fusiformispora clematidis,Hermatomyces clematidis,Leptospora clematidis,Longispora clematidis,Massariosphaeria clematidis,Melomastia clematidis,M.fulvicomae,Neobyssosphaeria clematidis,Neoleptosporella clematidis,Neoroussoella clematidis,N.fulvicomae,Neostictis nigricans,Neovaginatispora clematidis,Parasulcatispora clematidis,Parathyridaria clematidis,P.serratifoliae,P.virginianae,Periconia verrucose,Phomatospora uniseriata,Pleopunctum clematidis,Pseudocapulatispora clematidis,Pseudocoleophoma clematidis,Pseudohelminthosporium clematidis,Pseudolophiostoma chiangraiens展开更多
Epigenetic factors, including altered microRNA （miRNA） expression, may contribute to aberrant immune cell function in systemic lupus erythematosus （SLE）. MiRNA-let-7a （let-7a） has been shown to directly alter ce...Epigenetic factors, including altered microRNA （miRNA） expression, may contribute to aberrant immune cell function in systemic lupus erythematosus （SLE）. MiRNA-let-7a （let-7a） has been shown to directly alter cell cycle progression and proinflammatory cytokine production. Due to the crucial role of let-7a in cell division and inflammation, we investigated let-7a-mediated proliferation and NFKB translocation in J774A. 1 macrophages and MES 13 mesangial cells in vitro. In immune-stimulated cells transfected with let-7a, cell proliferation was significantly increased over time. There was a significant increase in the number of immune-stimulated cells in S and G2 phases. Immune-stimulated cells overexpressing let-7a had increased nuclear translocation of NFKB. Bioinformatical analysis revealed that the E2F family, critical regulators of the G1-S transition, has potential binding sites for let-7a in their mRNA transcripts. Let-7a overexpression significantly increased the expression of the cell cycle activator E2F2 and increased retinoblastoma protein （Rb） phosphorylation in immune-stimulated cells. The cell cycle inhibitor E2F5 was significantly decreased in let-7a-transfected cells that were immune-stimulated. Bioinformatical analysis revealed E2F2 and NFKB are transcription factors predicted to regulate the let-7a promoter. We analyzed transcriptional regulation of let-7a by real-time RT-PCR using chromatin immunoprecipitation with E2F2 and NFKB antibodies. There was an increase in E2F2 and NFKB binding in DNA enriched for the let-7a promoter in immune-stimulated cells. Silencing E2F2 or NFKB significantly decreased let-7a expression and IL-6 production in immune-stimulated cells. Taken together, our results suggest that overexpression of let-7a may contribute to hyperplasia and the proinflammatory response in SLE.展开更多
Background Globally,are skincare practices and skin injuries in extremely preterm infants comparable?This study describes skin injuries,variation in skincare practices and investigates any association between them.Met...Background Globally,are skincare practices and skin injuries in extremely preterm infants comparable?This study describes skin injuries,variation in skincare practices and investigates any association between them.Methods A web-based survey was conducted between February 2019 and August 2021.Quantifying skin injuries and describing skincare practices in extremely preterm infants were the main outcomes.The association between skin injuries and skincare practices was established using binary multivariable logistic regression adjusted for regions.Results Responses from 848 neonatal intensive care units,representing all geographic regions and income status groups were received.Diaper dermatitis(331/840,39%)and medical adhesive-related skin injuries(319/838,38%)were the most common injuries.Following a local skincare guideline reduced skin injuries[medical adhesive-related injuries:adjusted odds ratios(aOR)=0.63,95%confidence interval(CI)=0.45–0.88;perineal injuries:aOR=0.66,95%CI=0.45–0.96;local skin infections:OR=0.41,95%CI=0.26–0.65;chemical burns:OR=0.46,95%CI=0.26–0.83;thermal burns:OR=0.51,95%CI=0.27–0.96].Performing skin assessments at least every four hours reduced skin injuries(abrasion:aOR=0.48,95%CI=0.33–0.67;pressure:aOR=0.51,95%CI=0.34–0.78;diaper dermatitis:aOR=0.71,95%CI=0.51–0.99;perineal:aOR=0.52,95%CI=0.36–0.75).Regional and resource settings-based variations in skin injuries and skincare practices were observed.Conclusions Skin injuries were common in extremely preterm infants.Consistency in practice and improved surveillance appears to reduce the occurrence of these injuries.Better evidence regarding optimal practices is needed to reduce skin injuries and minimize practice variations.展开更多
Epifoliar fungi are one of the significant fungal groups typically living on the surface of leaves. They are usually recordedas saprobes, obligate parasites and commensals and are widely distributed in tropical and su...Epifoliar fungi are one of the significant fungal groups typically living on the surface of leaves. They are usually recordedas saprobes, obligate parasites and commensals and are widely distributed in tropical and subtropical regions. Numerousgenera within this group remain inadequately understood, primarily attributed to limited taxonomic knowledge and insufficientmolecular data. Furthermore, the taxonomic delineation of epifoliar fungi remained uncertain, with scattered andliterature-based data often intermixed with other follicolous fungi. Herein, a comprehensive taxonomic monograph of 124genera in (32) Asterinales, (18) Capnodiales, (15) Chaetothyriales, (8) Meliolales, (8) Micropeltidales, (10) Microthyriales,(32) Parmulariales and (1) Zeloasperisporiales was provided re-describing with illustrations and line drawings. Notes onecological and economic importance of the families are also provided. Representatives type herbarium materials of Campoapulcherrima, Cycloschizon brachylaenae, Ferrarisia philippina, Hysterostomella guaranitica, Palawaniella orbiculata andPseudolembosia orbicularis of Parmulariaceae were re-examined and provided updated illustrations with descriptions. Abackbone phylogenetic tree and divergence estimation analysis for epifoliar fungi based on LSU and 5.8s ITS sequence dataare provided.展开更多
为了更好地理解互联网对青少年社会心理层面错综复杂的影响,本研究对美国青少年社交类网站使用的行为与认知进行了探讨并检验了社交性网站对于青少年的社交动机(social motivations)、人格特质(personality)、自尊(self-esteem)和社会...为了更好地理解互联网对青少年社会心理层面错综复杂的影响,本研究对美国青少年社交类网站使用的行为与认知进行了探讨并检验了社交性网站对于青少年的社交动机(social motivations)、人格特质(personality)、自尊(self-esteem)和社会孤独感(loneliness)层面的影响。本研究把社交网站的使用行为界定为以下两种:行为层面(社交网站的使用强度)和认知层面(社交网站的互动偏好)。通过对美国华盛顿州立大学的231名在校学生的网络调查研究显示,尽管社交网站的使用强度与其互动偏好呈显著的正相关联系,但他们却分别对青少年产生相异的社会心理影响:社交网站的使用强度与孤独感呈显著负相关联系,而社交网站的互动偏好却与孤独感呈显著正相关联系。研究同时发现,青少年对社交网站的使用行为和认知在他们的社交动机和人格特质方面也呈现不同的影响。研究显示,看似矛盾的两种社交动机——归属需要(need for affiliation)和排斥恐惧(fear for rejection)——都分别与社交网站的使用与互动偏好呈显著相关联系。就人格特质方面:社交网站使用强度越大的使用者就倾向呈现出外向、合群和严谨等人格特征,而社交网站互动偏好越强的人则呈现出内向、合群、神经质和开放等特征。因此,本研究揭示了对于社交性网站的影响研究需要着重考量如何测量与定义使用行为,不同的使用行为测量会显示出混杂与多样的社会心理影响。展开更多
文摘In this article comparative analysis of various semi-numerical schemes has beenmade for the case of squeezing flow of an incompressible viscous fluid between two largeparallel plates having no-slip at the boundaries.The medium of flow contains magnetohy-drodynamic(MHD)effect and having small pores.Modeled boundary value problem is solvedanalytically using Optimal homotopy asymptotic method(OHAM),homotopy perturbationmethod(HPM),differential transform method(DTM),Daftardar Jafari method(DIM)andAdomian decomposition method(ADM).For comparison purpose,residuals of these schemeshave been found and analyzed for accuracy.Analytical study indicates that DTM and DJM arequite good in tem of accuracy near the center of domain[—1,1]but the accuracy reducesconsiderably near the start and end of the given interval.HPM and OHAM residuals indicatethat OHAM surpasses HPM in terms of accuracy in the present case.
文摘As part of the global effort to plant billion trees,an afforestation project is launched in Pakistan in Khyber Pakhtunkhwa(KP)province to conserve existing forests and to increase area under forest cover.The present study is designed to build a Systems'model by incorporating major activities of the Billion Tree Tsunami Afforestation Project(BTTAP)with special focus on afforestation activities to estimate the growth in forest area of KP.Availability of complete dataset was a challenge.To fix the model,the raw data taken from the project office has been utilized.Planning Commission Form 1-Phase I&II helped us with additional information.We relied on the data available for one and half period of the project as rest of the data is subject to the completion of the project.Our results show that the project target to enhance area under forest differs from the target to afforest area under the project.The system dynamics'model projection shows that the forest area of KP would be 23.59 million hectares at the end of the BTTA project,thus having an increase of 3.29%instead of 2%that has been initially proposed.However,the results show that the progress to meet the target in some afforestation classes is slow as compared to other categories.Farm forestry,plantation on communal lands and owners'plantation need special focus of the authority.Deforestation would affect 0.02 million hectares area of the project.The model under study may be used as a reference model that can be replicated to other areas where billion tree campaigns are going on.
文摘In this paper, Differential Transform Method (DTM) is proposed for the closed form solution of linear and non-linear stiff systems. First, we apply DTM to find the series solution which can be easily converted into exact solution. The method is described and illustrated with different examples and figures are plotted accordingly. The obtained result confirm that DTM is very easy, effective and convenient.
基金The authors extend their appreciation to the International Scientific Partnership Program ISPP at King Saud University for funding this research work through ISPP#0089.We thank the technical staff of Center of Excellence in Fungal Research,Sornram Sukpisit and Wilawan Punyaboon for their invaluable assistance.Dhanushka Wanasinghe would like to thank the Molecular Biology Experimental Center at Kunming Institute of Botany for facilities for molecular work.We are also grateful to Anuruddha Karunarathna,Binu Samarakoon and Digvijayini Bundhun for their valuable assistance.Dhanushka Wanasinghe is also thankful to Hiran Ariyawansa for his valuable suggestions.Hyang Burm Lee was supported by the Graduate Program for the Undiscovered Taxa of Korea,and the Project on Survey and Discovery of Indigenous Fungal Species of Korea funded by NIBR,and the Project on Discovery of Fungi from Freshwater and Collection of Fungarium funded by NNIBR of the Ministry of Environment(MOE),and the Cooperative Research Program for Agriculture Science and Technology Development(PJ012957)Rural Development Administration,Republic of Korea.Chayanard Phukhamsakda would like to thank Royal Golden Jubilee Ph.D.Program under Thailand Research Fund,for the award of a scholarship no.PHD/0020/2557+1 种基金Ausana Mapook is grateful to Research and Researchers for Industries(RRI)PHD57I0012R.Jeewon is grateful to University of Mauritius&Mae Fah Luang University for enabling research collaboration.K.D.Hyde thanks to National Research Council of Thailand(Mae Fah Luang University)for grants‘‘Biodiversity,phylogeny and role of fungal endophytes of Pandanaceae’’(Grant No:592010200112)and Thailand Research Fund(TRF)Grant No RSA5980068 entitled‘‘Biodiversity,phylogeny and role of fungal endophytes on above parts of Rhizophora apiculata and Nypa fruticans’’.National Research Council of Thailand(Mae Fah Luang University)grant no 60201000201 entitled‘‘Diseases of mangrove trees and maintenance of good forestry practice’’.K.D.Hyde is an Adjunc
文摘This paper is the seventh in the Fungal Diversity Notes series,where 131 taxa accommodated in 28 families are mainly described from Rosa(Rosaceae)and a few other hosts.Novel fungal taxa are described in the present study,including 17 new genera,93 new species,four combinations,a sexual record for a species and new host records for 16 species.Bhatiellae,Cycasicola,Dactylidina,Embarria,Hawksworthiana,Italica,Melanocucurbitaria,Melanodiplodia,Monoseptella,Uzbekistanica,Neoconiothyrium,Neopaucispora,Pararoussoella,Paraxylaria,Marjia,Sporormurispora and Xenomassariosphaeria are introduced as new ascomycete genera.We also introduce the new species Absidia jindoensis,Alternaria doliconidium,A.hampshirensis,Angustimassarina rosarum,Astragalicola vasilyevae,Backusella locustae,Bartalinia rosicola,Bhatiellae rosae,Broomella rosae,Castanediella camelliae,Coelodictyosporium rosarum,Comoclathris rosae,C.rosarum,Comoclathris rosigena,Coniochaeta baysunika,C.rosae,Cycasicola goaensis,Dactylidina shoemakeri,Dematiopleospora donetzica,D.rosicola,D.salsolae,Diaporthe rosae,D.rosicola,Endoconidioma rosaehissaricae,Epicoccum rosae,Hawksworthiana clematidicola,H.lonicerae,Italica achilleae,Keissleriella phragmiticola,K.rosacearum,K.rosae,K.rosarum,Lophiostoma rosae,Marjia tianschanica,M.uzbekistanica,Melanocucurbitaria uzbekistanica,Melanodiplodia tianschanica,Monoseptella rosae,Mucor fluvius,Muriformistrickeria rosae,Murilentithecium rosae,Neoascochyta rosicola,Neoconiothyrium rosae,Neopaucispora rosaecae,Neosetophoma rosarum,N.rosae,N.rosigena,Neostagonospora artemisiae,Ophiobolus artemisiicola,Paraconiothyrium rosae,Paraphaeosphaeria rosae,P.rosicola,Pararoussoella rosarum,Parathyridaria rosae,Paraxylaria rosacearum,Penicillium acidum,P.aquaticum,Phragmocamarosporium rosae,Pleospora rosae,P.rosae-caninae,Poaceicola agrostina,P.arundinicola,P.rosae,Populocrescentia ammophilae,P.rosae,Pseudocamarosporium pteleae,P.ulmi-minoris,Pseudocercospora rosae,Pseudopithomyces rosae,Pseudostrickeria rosae,Sclerostagonospora lathyri,S.rosa
文摘Research Background: Atopic dermatitis (AD) is a chronic inflammatory skin condition in children that significantly impacts physical health and quality of life. Adherence to treatment regimens is crucial for effective disease management but is often hindered by various psychosocial and socioeconomic barriers. Parental mental health issues, family dynamics, financial constraints, and limited access to specialized care contribute to inconsistent treatment adherence, exacerbating the condition. Purpose/Aim: The aim of this study is to explore the multifaceted barriers to treatment adherence in children with AD and evaluate the effectiveness of current interventions targeting these challenges. The study seeks to identify strategies that can improve adherence and health outcomes by addressing psychosocial and socioeconomic factors. Method: The method involves a comprehensive review of existing literature on the impact of psychosocial and socioeconomic factors on treatment adherence in children with AD. The study also examines various interventions designed to address these barriers, including community support programs, family-centered interventions, financial aid, integrated care models, and telehealth solutions. Results: Results indicate that psychosocial barriers, such as parental anxiety and depression, significantly hinder effective disease management. Family dynamics, including poor communication and single-parent households, complicate adherence efforts. Socioeconomic factors, such as financial constraints and limited healthcare access, further impede adherence. Interventions that address these barriers show promise in improving treatment adherence and health outcomes. Community support programs and family-centered interventions enhance parental mental health and family communication. Financial aid programs and integrated care models help mitigate economic and logistical challenges. Telehealth solutions improve access to specialized care, particularly in underserved areas. Conclusion: The study concludes that a
基金Saowaluck Tibpromma would like to thank the Molecular Biology Experimental Center at Kunming Institute of Botany for facilities for molecular work,the Mushroom Research Foundation(MRF)Chiang Rai,Thailand for the financial support of her study and Shaun Pennycook is thanked for nomenclatural advice.K.D.Hyde would like to thank the Thailand Research Fund Grant No.RSA5980068 entitled“Biodiversity,phylogeny and role of fungal endophytes on above parts of Rhizophora apiculata and Nypa fruticans”+6 种基金the Chinese Academy of Sciences,Project Number 2013T2S0030for the award of Visiting Professorship for Senior International Scientists at Kunming Institute of Botany and National Research Council of Thailand(Mae Fah Luang University)for a grants“Biodiversity,phylogeny and role of fungal endophytes of Pandanaceae”(Grant No.:592010200112)“Diseases of mangrove trees and maintenance of good forestry practice”(Grant No.:60201000201)for supporting this study.S.C.Karunarathna,P.E.Mortimer and J.C.Xu would like to thank the World Agroforestry Centre,East and Central Asia OfficeKey Laboratory for Plant Diversity and Biogeography of East Asia,Kunming Institute of Botany,Chinese Academy of Sciencethe ChineseMinistry of Science and Technology,under the 12th 5-year National Key Technology Support Program(NKTSP)2013 BAB07B06 integration and comprehensive demonstration of key technologies on Green Phosphate-mountaion Construction and the CGIAR Research Program 6:Forest,Trees and Agroforestry for partial funding.The authors would like to extend their sincere appreciation to the Deanship of Scientific Research at King Saud University for funding this research group NO(RG-1436-025)Financial support by the German Academic Exchange Service(DAAD)and the Thai Royal Golden Ph.D.Jubilee-Industry program(RGJ)for a joint TRFDAAD PPP(2012-2014)academic exchange grant to K.D.Hyde and M.Stadler,and the RGJ for a personal grant to B.Thongbai(No.Ph.D/0138/2553 in 4.S.MF/53/A.3)is gratefully acknowledged.Chayanard Phukhamsakda(PHD/0020/25
文摘This is a continuity of a series of taxonomic and phylogenetic papers on the fungi where materials were collected from many countries,examined and described.In addition to extensive morphological descriptions and appropriate asexual and sexual connections,DNA sequence data are also analysed from concatenated datasets to infer phylogenetic relationships and substantiate systematic positions of taxa within appropriate ranks.Wherever new species or combinations are proposed,we apply an integrative approach using morphological and molecular data as well as ecological features wherever applicable.Notes on 112 fungal taxa are compiled in this paper including Biatriosporaceae and Roussoellaceae,Didysimulans gen.nov.,81 new species,18 new host records and new country records,five reference specimens,two new combinations,and three sexual and asexual morph reports.The new species are Amanita cornelii,A.emodotrygon,Angustimassarina alni,A.arezzoensis,A.italica,A.lonicerae,A.premilcurensis,Ascochyta italica,A.rosae,Austroboletus appendiculatus,Barriopsis thailandica,Berkleasmium ariense,Calophoma petasitis,Camarosporium laburnicola,C.moricola,C.grisea,C.ossea,C.paraincrustata,Colletotrichum sambucicola,Coprinopsis cerkezii,Cytospora gelida,Dacrymyces chiangraiensis,Didysimulans italica,D.mezzanensis,Entodesmium italica,Entoloma magnum,Evlachovaea indica,Exophiala italica,Favolus gracilisporus,Femsjonia monospora,Fomitopsis flabellata,F.roseoalba,Gongronella brasiliensis,Helvella crispoides,Hermatomyces chiangmaiensis,H.chromolaenae,Hysterium centramurum,Inflatispora caryotae,Inocybe brunneosquamulosa,I.luteobrunnea,I.rubrobrunnea,Keissleriella cirsii,Lepiota cylindrocystidia,L.flavocarpa,L.maerimensis,Lophiotrema guttulata,Marasmius luculentus,Morenoina calamicola,Moelleriella thanathonensis,Mucor stercorarius,Myrmecridium fluviae,Myrothecium septentrionale,Neosetophoma garethjonesii,Nigrograna cangshanensis,Nodulosphaeria guttulatum,N.multiseptata,N.sambuci,Panus subfasciatus,Paraleptosphaeria padi,Paraphaeosphaeri
文摘Tamanu oil, derived from the nuts of Calophyllum inophyllum, has gained increasing attention for its potential in acne management due to its purported anti-inflammatory and wound-healing properties. This analysis evaluates the efficacy of tamanu oil in acne treatment with a specific focus on its impact on inflammation and scar reduction. The novelty of this research lies in its comprehensive analysis of tamanu oil’s dual mechanism of action: reducing acne-related inflammation and promoting the healing of acne scars. Clinical trials and laboratory analyses were conducted to assess the oil’s effectiveness in diminishing erythema, swelling, and post-acne scarring compared to conventional treatments. Preliminary findings demonstrate that tamanu oil significantly reduces inflammation and accelerates wound healing, potentially offering a promising adjunct or alternative to standard acne therapies. Future research should aim to optimize formulation and application protocols, long-term effects, and comparative therapeutic efficacy with other anti-inflammatory agents. Tamanu oil offers a novel and effective approach to acne management, with potential advantages that go beyond inflammation reduction to include enhanced scar reduction, making it a subject that warrants further investigation.
文摘Prostate cancer is a clinically heterogeneous disease, with some men having indolent disease that can safely be observed, while others have aggressive, lethal disease. Over the past decade, researchers have begun to unravel some of the genomic heterogeneity that contributes to these varying clinical phenotypes. Distinct molecular sub-classes of prostate cancer have been identified, and the uniqueness of these sub-classes has been leveraged to predict clinical outcomes, design novel biomarkers for prostate cancer diagnosis, and develop novel therapeutics. Recent work has also elucidated the temporal and spatial heterogeneity of prostate cancer, helping us understand disease pathogenesis, response to therapy, and progression. New genomic techniques have provided us with a window into the remarkable clinical and genomic heterogeneity of prostate cancer, and this new perspective will increasingly impact patient care.
文摘Hidradenitis suppurativa (HS) is a chronic, inflammatory skin condition characterized by painful nodules, abscesses, and scarring, primarily affecting areas rich in apocrine glands. Environmental and occupational risk factors, including prolonged exposure to heat, friction, and certain chemicals, have been identified as exacerbating conditions for HS. Yet, there remains a lack of tailored recommendations for modifying work environments to alleviate these triggers. This review presents novel suggestions for work modifications to reduce HS flare-ups, such as implementing breathable, friction-reducing workwear, ergonomic adjustments to minimize pressure on affected areas, and introducing low-irritant hygiene protocols in workplaces with chemical exposure. These recommendations are grounded in emerging evidence linking specific occupational exposures to the exacerbation of HS symptoms. The novelty of this approach lies in its proactive stance, shifting from reactive management of HS symptoms to preventative environmental modifications. Future studies should explore the long-term efficacy of these modifications and investigate the potential for personalized work environment adjustments based on individual patient profiles. Targeted workplace interventions may significantly improve the quality of life for HS patients, highlighting the need for multidisciplinary collaboration between dermatologists, occupational health specialists, and employers.
文摘Background: Cutaneous oncology encompasses a broad range of skin malignancies, including melanoma, cutaneous squamous cell carcinoma (SCC), and basal cell carcinoma (BCC), all of which pose significant global health challenges. The World Health Organization (WHO) estimates that melanoma incidence has increased by approximately 50% over the past three decades. While SCC and BCC are generally less aggressive than melanoma, they contribute significantly to the overall burden of skin cancer due to their high prevalence. Traditional treatment modalities for these malignancies, such as surgery, radiation, and chemotherapy, have shown limitations in achieving durable responses and minimizing systemic toxicity. As a result, there is an increasing need for more effective and less toxic treatment options. Immunotherapeutic strategies have emerged as a promising avenue in oncology, with the potential to revolutionize treatment approaches for cutaneous malignancies. Objectives: This literature review aims to undertake an in-depth examination of immunotherapeutic strategies for melanoma, SCC, and BCC. Specifically, the review focuses on the role of immune checkpoint inhibitors, adoptive cell therapies, and emerging immunotherapies, assessing their impact on treatment outcomes, survival rates, and patient quality of life. Methods: A literature search was conducted using databases such as PubMed, Google Scholar, and Scopus. The search terms included “cutaneous oncology”, “immunotherapy”, “immune checkpoint inhibitors”, “adoptive cell therapy”, “melanoma”, “cutaneous squamous cell carcinoma”, and “basal cell carcinoma”. Peer-reviewed articles published in the last 10 years that reported clinical outcomes from immunotherapy-based treatments for cutaneous malignancies were included. The studies were reviewed and analyzed based on their reported clinical outcomes, including survival rates, adverse events, and quality of life metrics. Results: Our review identified significant advancements in immunotherap
文摘This comprehensive review explores the intricate dynamics between psychosocial factors and chronic wound healing processes, specifically focusing on prevalent conditions such as pressure ulcers, diabetic foot ulcers, and venous leg ulcers. By examining the roles of psychiatric conditions, including depression, anxiety, and post-traumatic stress disorder (PTSD), this paper illuminates how these factors intricately influence wound healing dynamics, including mechanisms of pain perception and inflammatory responses. Furthermore, we evaluate the effectiveness of integrated biopsychosocial interventions, which encompass a holistic approach to wound care, thereby enhancing healing outcomes for dermatology patients. Future studies should focus on investigating the specific psychosocial determinants that significantly influence wound healing, exploring novel therapeutic strategies, and implementing personalized interventions to meet the unique needs of each patient. Such endeavors hold promise in advancing the fields of psychodermatology and wound management, fostering a deeper understanding and application of psychosocial considerations in dermatological care.
基金Acknowledgements Nalin Wijayawardene would like to thank Lechat Christian,Yuanpin Xiao,Danushka Sandaruwan,Paul Mungai,Huang Zhang,Ishani Goonasekara,Chada Norphanphoun,Ishara Manawasingha,Rajesh Jeewon,Thilini Chethana and Hasini Ekanayaka for their assistances and suggestions.We would like to thank Mark Stadler for his help to check names in Xylariales.Nalin Wijayawardene and Pedro Crous thank Ulrike Damm for her comments and suggestions for validating several names.K.D.Hyde thanks The Chinese Academy of Sciences,for the award of Visiting Professorship for Senior International Scientists at Kunming Institute of Botany.K.D.Hyde and Monika C.Dayarathne would like to thank the Thailand Research Fund(TRF)grant no RSA5980068 entitled Biodiversity,phylogeny and role of fungal endophytes on above parts of Rhizophora apiculata and Nypa fruticans,National Research Council of Thailand(NRCT)entitled Diseases of mangrove trees and maintenance of good forestry practice(Grant number:60201000201)Mae Fah Luang University grant"Biodiversity,phylogeny and role of fungal endophytes of Pandanaceae"(Grant number:592010200112)+3 种基金Hugo Madrid was funded by Comisio´n Nacional de Investigacio´n Cientı´fica y Tecnolo´gica(CONICYT)Fondo Nacional de Desarrollo Cientı´fico y Tecnolo´gico(FONDECYT),Chile,project no.11140562."Rafael F.Castan˜eda-Ruiz is grateful to the Organizacio´n Superior de Direccio´n Empresarial,Grupo Agrı´cola,(OSDE)from the Cuban Ministry of Agriculture and"Programa de Salud Animal y Vegetal",project P131LH003033.Dong Qin Dai would like to thank the Key Laboratory of Yunnan Province Universities of the Diversity and Ecological Adaptive Evolution for Animals and plants on Yun-Gui Plateau for the support.Ka-Lai Pang thanks Ministry of Science and Technology,Taiwan for financial support(105-2621-B-019-002-)Guo Zhu Zhao was funded by the National Natural Science Foundation of China(No.31570019)Mingkwan Doilom acknowledges the Royal Golden Jubilee Ph.D.Program(PHD./0072/2553 in 4.S.M.F./53/A.2.K.Tanaka would
文摘Knowledge of the relationships and thus the classification of fungi,has developed rapidly with increasingly widespread use of molecular techniques,over the past 10–15 years,and continues to accelerate.Several genera have been found to be polyphyletic,and their generic concepts have subsequently been emended.New names have thus been introduced for species which are phylogenetically distinct from the type species of particular genera.The ending of the separate naming of morphs of the same species in 2011,has also caused changes in fungal generic names.In order to facilitate access to all important changes,it was desirable to compile these in a single document.The present article provides a list of generic names of Ascomycota(approximately 6500 accepted names published to the end of 2016),including those which are lichen-forming.Notes and summaries of the changes since the last edition of‘Ainsworth&Bisby’s Dictionary of the Fungi’in 2008 are provided.The notes include the number of accepted species,classification,type species(with location of the type material),culture availability,life-styles,distribution,and selected publications that have appeared since 2008.This work is intended to provide the foundation for updating the ascomycete component of the"Without prejudice list of generic names of Fungi"published in 2013,which will be developed into a list of protected generic names.This will be subjected to the XIXth International Botanical Congress in Shenzhen in July 2017 agreeing to a modification in the rules relating to protected lists,and scrutiny by procedures determined by the Nomenclature Committee for Fungi(NCF).The previously invalidly published generic names Barriopsis,Collophora(as Collophorina),Cryomyces,Dematiopleospora,Heterospora(as Heterosporicola),Lithophila,Palmomyces(as Palmaria)and Saxomyces are validated,as are two previously invalid family names,Bartaliniaceae and Wiesneriomycetaceae.Four species of Lalaria,which were invalidly published are transferred to Taphrina and validated as new
基金National Natural Science Foundation of China for supporting the project Biodiversity,Taxonomy,Phylogeny,Evolution and Phytogeography of phytopathogens in Dothideomycetes from Southern China(Grant No.31950410548)for funding this research.Ning Xie would like to thank Project of DEGP(2019KTSCX150)+15 种基金.Kevin D Hyde thanks the Thailand Research Fund for the grant RDG6130001 entitled“Impact of climate change on fungal diversity and biogeography in the Greater Mekong Subregion”.Rungtiwa Phookamsak thanks CAS President’s International Fellowship Initiative(PIFI)for young staff(Grant No.Y9215811Q1)the Yunnan Provincial Department of Human Resources and Social Security(Grant No.Y836181261)National Science Foundation of China(NSFC)project code 31850410489(Grant No.Y81I982211)for financial supportDhanushka Wanasinghe would like to thank CAS President’s International Fellowship Initiative(PIFI)for funding his postdoctoral research(number 2019PC0008)the 64th batch of China Postdoctoral Science Foundation(Grant No.Y913083271).Vemuri V.Sarma would like to thank SERB,Department of Science and Technology,Government of India,for funding a project(SERB/SB/SO/PS/18/2014 dt.19.5.2015)Ministry of Earth Sciences(MOES),Govt.of India for funding a project(Sanction order:MOES/36/OO1S/Extra/40/2014/PC-IV dt.14.01.2015)the Department of Biotechnology,Pondicherry University for facilitiesthe National Research Council of Thailand(projects no.61215320013 and No.61215320023)the Thailand Research Fund(project no.TRG6180001)Plant Genetic Conservation Project under the Royal Initiation of Her Royal High-ness Princess Maha Chakri Sirindhorn-Mae Fah Luang University.Alan JL Phillips acknowledges the support from UIDB/04046/2020 and UIDP/04046/2020 Centre grants from FCT,Portugal(to Bio-ISI).Saowaluck Tibpromma would like to thank the International Postdoctoral Exchange Fellowship Program(number Y9180822S1)CAS President’s International Fellowship Initiative(PIFI)(number 2020PC0009)the National Natural Science Foundation of China
文摘Numerous new taxa and classifications of Dothideomycetes have been published following the last monograph of families of Dothideomycetes in 2013.A recent publication by Honsanan et al.in 2020 expanded information of families in Dothideo-mycetidae and Pleosporomycetidae with modern classifications.In this paper,we provide a refined updated document on orders and families incertae sedis of Dothideomycetes.Each family is provided with an updated description,notes,including figures to represent the morphology,a list of accepted genera,and economic and ecological significances.We also provide phylogenetic trees for each order.In this study,31 orders which consist 50 families are assigned as orders incertae sedis in Dothideomycetes,and 41 families are treated as families incertae sedis due to lack of molecular or morphological evidence.The new order,Catinellales,and four new families,Catinellaceae,Morenoinaceae Neobuelliellaceae and Thyrinulaceae are introduced.Seven genera(Neobuelliella,Pseudomicrothyrium,Flagellostrigula,Swinscowia,Macroconstrictolumina,Pseudobogoriella,and Schummia)are introduced.Seven new species(Acrospermum urticae,Bogoriella complexoluminata,Dothiorella ostryae,Dyfrolomyces distoseptatus,Macroconstrictolumina megalateralis,Patellaria microspora,and Pseu-domicrothyrium thailandicum)are introduced base on morphology and phylogeny,together with two new records/reports and five new collections from different families.Ninety new combinations are also provided in this paper.
文摘Elevated expression of heat shock protein 90 （HSP90） has been found in kidneys and serum of systemic lupus erythematosus （SLE） patients and MRLIMp-FasIprIFasJpr（MRLIIpr） autoimmune mice. We investigated if inhibition of HSP90 would reduce disease in MRL/ Ipr mice. In vitro, pretreatment of mesangial cells with HSP90 inhibitor Geldanamycin prior to immune-stimulation showed reduced expression of IL-6, IL-12 and NO. In vivo, we found HSP90 expression was elevated in MRL/Ipr kidneys when compared to C57BL/6 mice and MRIJIpr mice treated with HSP90 inhibitor 17-DMAG. MRIJIpr mice treated with 17-DMAG showed decreased proteinuria and reduced serum anti-dsDNA antibody production. Glomerulonephritis and glomerular IgG and C3 were not significantly affected by administration of 17-DMAG in MRIJIpr. 17-DMAG increased CD8＋ T cells, reduced double-negative T cells, decreased the CD4/CD8 ratio and reduced follicular B cells. These studies suggest that HSP90 may play a role in regulating T-cell differentiation and activation and that HSP90 inhibition may reduce inflammation in lupus.
文摘Title: Integrating Consistent Individualized Carbohydrate-Controlled Anti- Inflammatory Nutritional Plan (C-ICAN) in the Management of Prader-Willi Syndrome: A Case Report. Prader–Willi syndrome (PWS) is a rare genetic disorder caused by a loss of function of specific genes on chromosome 15. Patients with this disease present unique challenges in management, particularly regarding obesity and nutritional regulation as the disease symptoms change depending on the age of the patient and the phase of the disease. These challenges pose critical stressors to caregivers and their families. We present a case report of a 5-year-old Caucasian male diagnosed with PWS, exhibiting failure to thrive and uncontrolled weight gain. His caregiver was his elderly grandmother who, by her own admission, was ill-equipped to deal with the patient’s physical symptoms and his behavior in response to dietary restrictions. Through a multidisciplinary approach involving medical nutrition therapy (MNT) involving the implementation of a Consistent Individualized Carbohydrate-Controlled Anti-Inflammatory Nutritional plan (C-ICAN), growth hormone supplementation, and behavioral interventions patient markedly improved physically and emotionally.
基金Chayanard Phukhamsakda would like to thank the Royal Golden Jubilee PhD Program under Thailand Research Fund(RGJ)and the German Academic Exchange Service(DAAD)for a joint TRF-DAAD(PPP 2017-2018)academic exchange Grant to K.D.Hyde and M.Stadler and the RGJ for a personal grant to C.Phukhamsakda(The scholarship no.PHD/0020/2557 to study towards a PhD).Dr.Shaun Pennycook is thanked for checking and suggesting Latin names of the new taxa.Dr.Olivier Raspé,Dr.Rajesh Jeewon,Sirinapa Konta,Milan Samarakoon,Indunil C.Senanayake,Dr.Sinang Hongsanan,Chuan-Gen Lin,Qiu-Ju Shang and Pranami D.Abeywickrama are thanked for their valuable suggestions on the phylogenetic analysis and for sequencing.Mr.Martin van de Bult,Cyrille Gerstmans,Prof.Hong-Yan Su,Tian Qing,Dr.Zong-Long Luo are gratefully acknowledged for sample collection guidance in China and Thailand.Kevin D.Hyde thanks the future of specialist fungi in a changing climate:baseline data for generalist and specialist fungi associated with ants,Rhododendron species and Dracaena species(Grant No:DBG6080013)Impact of climate change on fungal diversity and biogeography in the Greater Mekong Subregion(Grant No:RDG6130001)+5 种基金Alan J.L.Phillips acknowledges the support from UID/MULTI/04046/2019 Research Unit grant from FCT,Portugal to BioISI.E.B.Gareth Jones is supported under the Distinguished Scientist Fellowship Program(DSFP),King Saud University,Kingdom of Saudi Arabia.D.N.Wanasinghe would like to thank the CAS President’s International Fellowship Initiative(PIFI)for funding his postdoctoral research(Number 2019PC0008)the National Science Foundation of China and the Chinese Academy of Sciences for financial support under the following Grants:41761144055,41771063 and Y4ZK111B01Wanasinghe also thanks the 64th batch of China Postdoctoral Science Foundation(Grant No.:Y913083271)Saowaluck Tibpromma would like to thanks the International Postdoctoral Exchange Fellowship Program(Number Y9180822S1)CAS President’s International Fellowship Initiative(PIFI)(Number 2020PC0009)Chi
文摘The cosmopolitan plant genus Clematis contains many climbing species that can be found worldwide.The genus occurs in the wild and is grown commercially for horticulture.Microfungi on Clematis were collected from Belgium,China,Italy,Thailand and the UK.They are characterized by morphology and analyses of gene sequence data using an integrated species concept to validate identifications.The study revealed two new families,12 new genera,50 new species,26 new host records with one dimorphic character report,and ten species are transferred to other genera.The new families revealed by multigene phylogeny are Longiostiolaceae and Pseudomassarinaceae in Pleosporales(Dothideomycetes).New genera are Anthodidymella(Didymellaceae),Anthosulcatispora and Parasulcatispora(Sulcatisporaceae),Fusiformispora(Amniculicolaceae),Longispora(Phaeosphaeriaceae),Neobyssosphaeria(Melanommataceae),Neoleptosporella(Chaetosphaeriales,genera incertae sedis),Neostictis(Stictidaceae),Pseudohelminthosporium(Neomassarinaceae),Pseudomassarina(Pseudomassarinaceae),Sclerenchymomyces(Leptosphaeriaceae)and Xenoplectosphaerella(Plectosphaerellaceae).The newly described species are Alloleptosphaeria clematidis,Anthodidymella ranunculacearum,Anthosulcatispora subglobosa,Aquadictyospora clematidis,Brunneofusispora clematidis,Chaetosphaeronema clematidicola,C.clematidis,Chromolaenicola clematidis,Diaporthe clematidina,Dictyocheirospora clematidis,Distoseptispora clematidis,Floricola clematidis,Fusiformispora clematidis,Hermatomyces clematidis,Leptospora clematidis,Longispora clematidis,Massariosphaeria clematidis,Melomastia clematidis,M.fulvicomae,Neobyssosphaeria clematidis,Neoleptosporella clematidis,Neoroussoella clematidis,N.fulvicomae,Neostictis nigricans,Neovaginatispora clematidis,Parasulcatispora clematidis,Parathyridaria clematidis,P.serratifoliae,P.virginianae,Periconia verrucose,Phomatospora uniseriata,Pleopunctum clematidis,Pseudocapulatispora clematidis,Pseudocoleophoma clematidis,Pseudohelminthosporium clematidis,Pseudolophiostoma chiangraiens
文摘Epigenetic factors, including altered microRNA （miRNA） expression, may contribute to aberrant immune cell function in systemic lupus erythematosus （SLE）. MiRNA-let-7a （let-7a） has been shown to directly alter cell cycle progression and proinflammatory cytokine production. Due to the crucial role of let-7a in cell division and inflammation, we investigated let-7a-mediated proliferation and NFKB translocation in J774A. 1 macrophages and MES 13 mesangial cells in vitro. In immune-stimulated cells transfected with let-7a, cell proliferation was significantly increased over time. There was a significant increase in the number of immune-stimulated cells in S and G2 phases. Immune-stimulated cells overexpressing let-7a had increased nuclear translocation of NFKB. Bioinformatical analysis revealed that the E2F family, critical regulators of the G1-S transition, has potential binding sites for let-7a in their mRNA transcripts. Let-7a overexpression significantly increased the expression of the cell cycle activator E2F2 and increased retinoblastoma protein （Rb） phosphorylation in immune-stimulated cells. The cell cycle inhibitor E2F5 was significantly decreased in let-7a-transfected cells that were immune-stimulated. Bioinformatical analysis revealed E2F2 and NFKB are transcription factors predicted to regulate the let-7a promoter. We analyzed transcriptional regulation of let-7a by real-time RT-PCR using chromatin immunoprecipitation with E2F2 and NFKB antibodies. There was an increase in E2F2 and NFKB binding in DNA enriched for the let-7a promoter in immune-stimulated cells. Silencing E2F2 or NFKB significantly decreased let-7a expression and IL-6 production in immune-stimulated cells. Taken together, our results suggest that overexpression of let-7a may contribute to hyperplasia and the proinflammatory response in SLE.
文摘Background Globally,are skincare practices and skin injuries in extremely preterm infants comparable?This study describes skin injuries,variation in skincare practices and investigates any association between them.Methods A web-based survey was conducted between February 2019 and August 2021.Quantifying skin injuries and describing skincare practices in extremely preterm infants were the main outcomes.The association between skin injuries and skincare practices was established using binary multivariable logistic regression adjusted for regions.Results Responses from 848 neonatal intensive care units,representing all geographic regions and income status groups were received.Diaper dermatitis(331/840,39%)and medical adhesive-related skin injuries(319/838,38%)were the most common injuries.Following a local skincare guideline reduced skin injuries[medical adhesive-related injuries:adjusted odds ratios(aOR)=0.63,95%confidence interval(CI)=0.45–0.88;perineal injuries:aOR=0.66,95%CI=0.45–0.96;local skin infections:OR=0.41,95%CI=0.26–0.65;chemical burns:OR=0.46,95%CI=0.26–0.83;thermal burns:OR=0.51,95%CI=0.27–0.96].Performing skin assessments at least every four hours reduced skin injuries(abrasion:aOR=0.48,95%CI=0.33–0.67;pressure:aOR=0.51,95%CI=0.34–0.78;diaper dermatitis:aOR=0.71,95%CI=0.51–0.99;perineal:aOR=0.52,95%CI=0.36–0.75).Regional and resource settings-based variations in skin injuries and skincare practices were observed.Conclusions Skin injuries were common in extremely preterm infants.Consistency in practice and improved surveillance appears to reduce the occurrence of these injuries.Better evidence regarding optimal practices is needed to reduce skin injuries and minimize practice variations.
基金Thailand Research Fund(Grant no.RDG6130001)Thailand Science Research and Innovation(Grant no.DBG6280009).
文摘Epifoliar fungi are one of the significant fungal groups typically living on the surface of leaves. They are usually recordedas saprobes, obligate parasites and commensals and are widely distributed in tropical and subtropical regions. Numerousgenera within this group remain inadequately understood, primarily attributed to limited taxonomic knowledge and insufficientmolecular data. Furthermore, the taxonomic delineation of epifoliar fungi remained uncertain, with scattered andliterature-based data often intermixed with other follicolous fungi. Herein, a comprehensive taxonomic monograph of 124genera in (32) Asterinales, (18) Capnodiales, (15) Chaetothyriales, (8) Meliolales, (8) Micropeltidales, (10) Microthyriales,(32) Parmulariales and (1) Zeloasperisporiales was provided re-describing with illustrations and line drawings. Notes onecological and economic importance of the families are also provided. Representatives type herbarium materials of Campoapulcherrima, Cycloschizon brachylaenae, Ferrarisia philippina, Hysterostomella guaranitica, Palawaniella orbiculata andPseudolembosia orbicularis of Parmulariaceae were re-examined and provided updated illustrations with descriptions. Abackbone phylogenetic tree and divergence estimation analysis for epifoliar fungi based on LSU and 5.8s ITS sequence dataare provided.
文摘为了更好地理解互联网对青少年社会心理层面错综复杂的影响,本研究对美国青少年社交类网站使用的行为与认知进行了探讨并检验了社交性网站对于青少年的社交动机(social motivations)、人格特质(personality)、自尊(self-esteem)和社会孤独感(loneliness)层面的影响。本研究把社交网站的使用行为界定为以下两种:行为层面(社交网站的使用强度)和认知层面(社交网站的互动偏好)。通过对美国华盛顿州立大学的231名在校学生的网络调查研究显示,尽管社交网站的使用强度与其互动偏好呈显著的正相关联系,但他们却分别对青少年产生相异的社会心理影响:社交网站的使用强度与孤独感呈显著负相关联系,而社交网站的互动偏好却与孤独感呈显著正相关联系。研究同时发现,青少年对社交网站的使用行为和认知在他们的社交动机和人格特质方面也呈现不同的影响。研究显示,看似矛盾的两种社交动机——归属需要(need for affiliation)和排斥恐惧(fear for rejection)——都分别与社交网站的使用与互动偏好呈显著相关联系。就人格特质方面:社交网站使用强度越大的使用者就倾向呈现出外向、合群和严谨等人格特征,而社交网站互动偏好越强的人则呈现出内向、合群、神经质和开放等特征。因此,本研究揭示了对于社交性网站的影响研究需要着重考量如何测量与定义使用行为,不同的使用行为测量会显示出混杂与多样的社会心理影响。
