Apoptosis is a key process for tissue homeostasis and renewal. Its dysregulation is implicated in most human diseases, from cancer to neurodegeneration. Apoptosis is triggered by stimuli that damage the internal struc...Apoptosis is a key process for tissue homeostasis and renewal. Its dysregulation is implicated in most human diseases, from cancer to neurodegeneration. Apoptosis is triggered by stimuli that damage the internal structures of the cell, or by specialized ＂death＂ receptors on its surface. In certain cell types, Bid, a ＂BH3-only＂ member of the Bcl-2 family of death regulators integrates these two pathways at the mitochondrial level. Despite years of intense research,展开更多
文摘Apoptosis is a key process for tissue homeostasis and renewal. Its dysregulation is implicated in most human diseases, from cancer to neurodegeneration. Apoptosis is triggered by stimuli that damage the internal structures of the cell, or by specialized ＂death＂ receptors on its surface. In certain cell types, Bid, a ＂BH3-only＂ member of the Bcl-2 family of death regulators integrates these two pathways at the mitochondrial level. Despite years of intense research,
