This paper aims at investigating brain injury mechanisms and predicting head injuries in real world accidents. For this purpose, a 3D human head finite element model （HBM-head） was developed based on head-brain anat...This paper aims at investigating brain injury mechanisms and predicting head injuries in real world accidents. For this purpose, a 3D human head finite element model （HBM-head） was developed based on head-brain anatomy. The HBM head model was validated with two experimental tests. Then the head finite element（FE） model and a multi-body system （MBS） model were used to carry out reconstructions of real world vehicle-pedestrian accidents and brain injuries. The MBS models were used for calculating the head impact conditions in vehicle impacts. The HBM-head model was used for calculating the injury related physical parameters, such as intracranial pressure, stress, and strain. The calculated intracranial pressure and strain distribution were correlated with the injury outcomes observed from accidents. It is shown that this model can predict the intracranial biomechanical response and calculate the injury related physical parameters. The head FE model has good biofidelity and will be a valuable tool for the study of injury mechanisms and the tolerance level of the brain.展开更多
Vehicular emissions in China in 2006 and 2010 were calculated at a high spatial resolution based on the data released by the National Bureau of Statistics, by taking the emission standards into consideration. China＇s...Vehicular emissions in China in 2006 and 2010 were calculated at a high spatial resolution based on the data released by the National Bureau of Statistics, by taking the emission standards into consideration. China＇s vehicular emissions of carbon monoxide （CO）, nitrogen oxides （NOx）, volatile organic compounds （VOCs）, ammonia （NH3）, fine particulate matters （PM2.5）, inhalable particulate matters （PMlo）, black carbon （BC）, and organic carbon （OC） were 30,113.9, 4593.7, 6838.0, 20.9, 400.2, 430.5,285.6, and 105.1 Gg, respectively, in 2006 and 34,175.2, 5167.5, 7029.4, 74.0, 386.4, 417.1, 270.9, and 106.2 Gg, respectively, in 2010. CO, VOCs, and NH3 emissions were mainly from motorcycles and light-duty gasoline vehicles, whereas NOx, PMzs, PMlo, and BC emissions were mainly from rural vehicles and heavy- duty diesel trucks. OC emissions were mainly from motorcycles and heavy-duty diesel trucks. Vehicles of pre-China I （vehicular emission standard of China before phase I） and China I （vehicular emission standard of China in phase I） were the primary contributors to all of the pollutant emissions except NH3, which was mainly from China III and China IV gasoline vehicles. The total emissions of all the pollutants except NH3 changed little from 2006 to 2010. This finding can be attributed to the implementation of strict emission standards and to improvements in oil quality.展开更多
Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi...Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,respectively.Patients who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer.展开更多
This paper addresses the trajectory tracking control of a nonholonomic wheeled mobile manipulator with parameter uncertainties and disturbances. The proposed algorithm adopts a robust adaptive control strategy where p...This paper addresses the trajectory tracking control of a nonholonomic wheeled mobile manipulator with parameter uncertainties and disturbances. The proposed algorithm adopts a robust adaptive control strategy where parametric uncertainties are compensated by adaptive update techniques and the disturbances are suppressed. A kinematic controller is first designed to make the robot follow a desired end-effector and platform trajectories in task space coordinates simultaneously. Then, an adaptive control scheme is proposed, which ensures that the trajectories are accurately tracked even in the presence of external disturbances and uncertainties. The system stability and the convergence of tracking errors to zero are rigorously proven using Lyapunov theory. Simulations results are given to illustrate the effectiveness of the proposed robust adaptive control law in comparison with a sliding mode controller.展开更多
In the field of cancer therapy,inhibiting autophagy has emerged as a promising strategy.However,pharmacological disruption of autophagy can lead to the upregulation of programmed death-ligand 1(PD-L1),enabling tumor i...In the field of cancer therapy,inhibiting autophagy has emerged as a promising strategy.However,pharmacological disruption of autophagy can lead to the upregulation of programmed death-ligand 1(PD-L1),enabling tumor immune evasion.To address this issue,we developed innovative ROS-responsive cationic poly(ethylene imine)(PEI)nanogels using selenol chemistry-mediated multicomponent reaction(MCR)technology.This procedure involved simple mixing of low-molecular-weight PEI(LMW PEI),γ-selenobutylacetone(γ-SBL),and poly(ethylene glycol)methacrylate(PEGMA).Through high-throughput screening,we constructed a library of AxSeyOz nanogels and identified the optimized A1.8Se3O0.5/siPD-L1 nanogels,which exhibited a size of approximately 200 nm,excellent colloidal stability,and the most effective PD-L1 silencing efficacy.These nanogels demonstrated enhanced uptake by tumor cells,excellent oxidative degradation ability,and inhibited autophagy by alkalinizing lysosomes.The A1.8Se3O0.5/siPD-L1 nanogels significantly downregulated PD-L1 expression and increased the expression of major histocompatibility complex class I(MHC-I),resulting in robust proliferation of specific CD8+T cells and a decrease in MC38 tumor growth.As a result,the A1.8Se3O0.5/siPD-L1 nanogels inhibited tumor growth through self-inhibition of autophagy,upregulation of MHC-I,and downregulation of PD-L1.Designed with dynamic diselenide bonds,the A1.8Se3O0.5/siPD-L1 nanogels showed synergistic antitumor efficacy through self-inhibition of autophagy and prevention of immune escape.展开更多
Hydrogen sulfide(H_(2)S)is a toxic,essential gas used in various biological and physical processes and has been the subject of many targeted studies on its role as a new gas transmitter.These studies have mainly focus...Hydrogen sulfide(H_(2)S)is a toxic,essential gas used in various biological and physical processes and has been the subject of many targeted studies on its role as a new gas transmitter.These studies have mainly focused on the production and pharmacological side effects caused by H_(2)S.Therefore,effective strategies to remove H_(2)S has become a key research topic.Furthermore,the development of novel nanoplatforms has provided new tools for the targeted removal of H_(2)S.This paper was performed to review the association between H_(2)S anddisease,relatedH_(2)S inhibitory drugs,aswell as H_(2)S responsive nanoplatforms(HRNs).This review first analyzed the role of H_(2)S in multiple tissues and conditions.Second,common drugs used to eliminate H_(2)S,as well as their potential for combination with anticancer agents,were summarized.Not only the existing studies on HRNs,but also the inhibition H_(2)S combined with different therapeutic methods were both sorted out in this review.Furthermore,this review provided in-depth analysis of the potential of HRNs about treatment or detection in detail.Finally,potential challenges of HRNs were proposed.This study demonstrates the excellent potential of HRNs for biomedical applications.展开更多
Physicians encounter significant challenges in dealing with large diaphragmatic defects in both pediatric and adult populations.Diaphragmatic hernias,such as Morgagni,Bochdalek,and Hiatus hernias,can result in congeni...Physicians encounter significant challenges in dealing with large diaphragmatic defects in both pediatric and adult populations.Diaphragmatic hernias,such as Morgagni,Bochdalek,and Hiatus hernias,can result in congenital lesions that are often undiagnosed until the appearance of symptoms(bleeding,anemia,and acid reflux).Therefore,substantial potential exists for developing tissue-engineered constructs as novel therapeutic options in clinics.Recent research indicates promising mid-term performance for both natural and synthetic materials.However,studies exploring their application in diaphragm regeneration are limited and remain in the early research stages.Additionally,further investigation is required to address the constraints in human tissue supply for clinical implementation.This article comprehensively reviews the role of biomaterials in diaphragmatic tissue repair and regeneration.It emphasizes biomaterials,including biomimetic polymers used in technological solutions.This summary will enable researchers to critically assess the capability of existing natural biomaterials as essential tissueengineered patches for clinical use.展开更多
The accuracy of the simulation of carbon and water processes largely relies on the selection of atmospheric forcing datasets when driving land surface models(LSM).Particularly in high-altitude regions,choosing appropr...The accuracy of the simulation of carbon and water processes largely relies on the selection of atmospheric forcing datasets when driving land surface models(LSM).Particularly in high-altitude regions,choosing appropriate atmospheric forcing datasets can effectively reduce uncertainties in the LSM simulations.Therefore,this study conducted four offline LSM simulations over the Tibetan Plateau(TP)using the Community Land Model version 4.5(CLM4.5)driven by four state-of-the-art atmospheric forcing datasets.The performances of CRUNCEP(CLM4.5 model default)and three other reanalysis-based atmospheric forcing datasets(i.e.ITPCAS,GSWP3 and WFDEI)in simulating the net primary productivity(NPP)and actual evapotranspiration(ET)were evaluated based on in situ and gridded reference datasets.Compared with in situ observations,simulated results exhibited determination coefficients(R2)ranging from 0.58 to 0.84 and 0.59 to 0.87 for observed NPP and ET,respectively,among which GSWP3 and ITPCAS showed superior performance.At the plateau level,CRUNCEP-based simulations displayed the largest bias compared with the reference NPP and ET.GSWP3-based simulations demonstrated the best performance when comprehensively considering both the magnitudes and change trends of TP-averaged NPP and ET.The simulated ET increase over the TP during 1982-2010 based on ITPCAS was significantly greater than in the other three simulations and reference ET,suggesting that ITPCAS may not be appropriate for studying long-term ET changes over the TP.These results suggest that GSWP3 is recommended for driving CLM4.5 in conducting long-term carbon and water processes simulations over the TP.This study contributes to enhancing the accuracy of LSM in water-carbon simulations over alpine regions.展开更多
This paper discussed the selection criteria for Ordinary Urban Heritage (OUH) in Rattanakosin, the historic center of Bangkok through the case of ordinary restaurants and everyday foods. The OUH stands for an alternat...This paper discussed the selection criteria for Ordinary Urban Heritage (OUH) in Rattanakosin, the historic center of Bangkok through the case of ordinary restaurants and everyday foods. The OUH stands for an alternative approach to heritage understanding and conservation, derived from the notion of ordinary heritage, vernacular heritage, and urban heritage emphasizing the heritages of the everydayness of ordinary people. The OUHs have co-existed and inherited through the evolution of the city but are overlooked by the official conservation process. Ordinary restaurants and everyday foods were selected by 5 criteria, 1) appeared for more than 50 years;2) created, developed, and used by ordinary people;3) found as the clusters;4) able to be adapted to the urban context;5) exist until the present day.The methodology applied to the analysis of the historical documents and Bangkok maps from 1887 to 1974, and the selection criteria developed from past research in another old commercial district of Bangkok were also reinvestigated with observational surveys. Ordinary restaurants and everyday foods are the outcomes representing the heritage of everyday life of ordinary people that are ubiquitously related to commercial activities.展开更多
Despite increased attention given to potential modifiers of temperature-mortality associations, evidence for variations between different urban landscape characteristics remains limited. It is in this context that in ...Despite increased attention given to potential modifiers of temperature-mortality associations, evidence for variations between different urban landscape characteristics remains limited. It is in this context that in this paper effect modifications of multiple urban landscape characteristics are explored under different heatwave definitions for different age groups and gender in Hong Kong, China. Daily meteorological data and heatwave-related mortality counts from 2008 to 2017 were collected from the Hong Kong Census and Statistics Department, China. A case-only design was adopted, combined with logistic regression models to examine the modification effects of five urban landscape characteristics under six heatwave definitions. Stratified analyses were conducted to investigate age- and gender-specific effect modifications. It is found that individuals living in greener areas experienced lower levels of mortality during or immediately after heatwaves. In contrast, a higher building density and nighttime land surface temperature (LST) were associated with a higher heatwave-related mortality risk. Pronounced effect modifications of these urban landscape characteristics were observed under hotter and longer heatwaves, and in older adults (age ≥ 65 years) and males. The findings provide a scientific basis for policymakers and practitioners when considering measures for coping with hotter, longer, and more frequent heatwaves in the context of global climate change.展开更多
Images are widely used by companies to advertise their products and promote awareness of their brands.The automatic synthesis of advertising images is challenging because the advertising message must be clearly convey...Images are widely used by companies to advertise their products and promote awareness of their brands.The automatic synthesis of advertising images is challenging because the advertising message must be clearly conveyed while complying with the style required for the product,brand,or target audience.In this study,we proposed a data-driven method to capture individual design attributes and the relationships between elements in advertising images with the aim of automatically synthesizing the input of elements into an advertising image according to a specified style.To achieve this multi-format advertisement design,we created a dataset containing 13280 advertising images with rich annotations that encompassed the outlines and colors of the elements,in addition to the classes and goals of the advertisements.Using our probabilistic models,users guided the style of synthesized advertisements via additional constraints(e.g.,context-based keywords).We applied our method to a variety of design tasks,and the results were evaluated in several perceptual studies,which showed that our method improved users’satisfaction by 7.1%compared to designs generated by nonprofessional students,and that more users preferred the coloring results of our designs to those generated by the color harmony model and Colormind.展开更多
Objective To determine the prevalence and associations of general practice registrars’performing absolute cardio-vascular risk(ACVR)assessment(ACVRa).Design A cross-sectional study employing data(2017–2018)from the ...Objective To determine the prevalence and associations of general practice registrars’performing absolute cardio-vascular risk(ACVR)assessment(ACVRa).Design A cross-sectional study employing data(2017–2018)from the Registrar Clinical Encounters in Training project,an ongoing inception cohort study of Australian GP registrars.The outcome measure was whether an ACVRa was performed.Analyses employed univariable and multivariable regression.Analysis was conducted for all patient problems/diagnoses,then for an‘at-risk’population(specific problems/diagnoses for which ACVRa is indicated).Setting Three GP regional training organisations(RTOs)across three Australian states.Participants GP registrars training within participating RTOs.Results 1003 registrars(response rate 96.8%)recorded details of 69105 problems either with Aboriginal and/or Torres Strait patients aged 35 years and older or with non-Indigenous patients aged 45 years and older.Of these problems/diagnoses,1721(2.5%(95%CI 2.4%to 2.6%))involved an ACVRa.An ACVRa was‘plausibly indicated’in 10384 problems/diagnoses.Of these,1228(11.8%(95%CI 11.2%to 12.4%))involved ACVRa.For‘all problems/diagnoses’,on multivariable analysis female gender was associated with reduced odds of ACVRa(OR 0.61(95%CI 0.54 to 0.68)).There was some evidence for Aboriginal and/or Torres Strait Islander people being more likely to receive ACVRa(OR 1.40(95%CI 0.94 to 2.08),p=0.10).There were associations with variables related to continuity of care,with reduced odds of ACVRa:if the patient was new to the registrar(OR 0.65(95%CI 0.57 to 0.75)),new to the practice(OR 0.24(95%CI 0.15 to 0.38))or the problem was new(OR 0.68(95%CI 0.59 to 0.78));and increased odds if personal follow-up was organised(OR 1.43(95%CI 1.24 to 1.66)).For‘ACVRa indicated’problems/diagnoses,findings were similar to those for‘all problems/diagnoses’.Association with Aboriginal and/or Torres Strait Islander status,however,was significant at p<0.05(OR 1.60(95%CI 1.04 to 2.46))and association with fema展开更多
Proteins function as integral actors in essential life processes,rendering the realm of protein research a fundamental domain that possesses the potential to propel advancements in pharmaceuticals and disease investig...Proteins function as integral actors in essential life processes,rendering the realm of protein research a fundamental domain that possesses the potential to propel advancements in pharmaceuticals and disease investigation.Within the context of protein research,an imperious demand arises to uncover protein functionalities and untangle intricate mechanistic underpinnings.Due to the exorbitant costs and limited throughput inherent in experimental investigations,computational models offer a promising alternative to accelerate protein function annotation.In recent years,protein pre-training models have exhibited noteworthy advancement across multiple prediction tasks.This advancement highlights a notable prospect for effectively tackling the intricate downstream task associated with protein function prediction.In this review,we elucidate the historical evolution and research paradigms of computational methods for predicting protein function.Subsequently,we summarize the progress in protein and molecule representation as well as feature extraction techniques.Furthermore,we assess the performance of machine learning-based algorithms across various objectives in protein function prediction,thereby offering a comprehensive perspective on the progress within this field.展开更多
The sensitivity of magnetic Barkhausen noise (MBN) profile to changes in the excitation field strength and the number of turns of the detection coil was investigated in inhomogeneous material. Generally, the 0.5 mm ca...The sensitivity of magnetic Barkhausen noise (MBN) profile to changes in the excitation field strength and the number of turns of the detection coil was investigated in inhomogeneous material. Generally, the 0.5 mm case depth EN 36 steel specimen shows a double peak profile indicative of inhomogeneity through the detected depth the magnetized landscape. Various excitation field amplitudes were applied to the specimen and the induced MBN emission was analyzed for each magnetizing current. Excitation field at the lowest level induced an MBN emission of two peaks of equivalent heights. The first peak occurs at lower field than the second peak in the magnetization period. As the excitation field increased, the height of both peaks increased but the second peak increased in a higher rate than that of the first peak. Beyond certain excitation level, both peaks began to saturate and no increase in the MBN intensity was observed with increased excitation field strength. However, peak position and the number of Barkhausen events, indicated linearly as a function of the applied field strength. The experiment also establishes that the number of turns in the detection coil is important parameter which controls the height of the first peak. Low field peak height increases as the number of turn of the detection coil increases. The results indicate that the potential difference applied to the electromagnet and the sensitivity of the detection coil, determine the MBN profile characteristics.展开更多
Design intelligence,namely,artificial intelligence to solve creative problems and produce creative ideas,has improved rapidly with the new generation artificial intelligence.However,existing methods are more skillful ...Design intelligence,namely,artificial intelligence to solve creative problems and produce creative ideas,has improved rapidly with the new generation artificial intelligence.However,existing methods are more skillful in learning from data and have limitations in creating original ideas different from the training data.Crowdsourcing offers a promising method to produce creative designs by combining human inspiration and machines' computational ability.We propose a crowdsourcing intelligent design method called ‘flexible crowdsourcing design'.Design ideas produced through crowdsourcing design can be unreliable and inconsistent because they rely solely on selection among participants' submissions of ideas.In contrast,the flexible crowdsourcing design method employs a cultivation procedure that integrates the ideas from crowd participants and cultivates these ideas to improve design quality at the same time.We introduce a series of studies to show how flexible crowdsourcing design can produce original design ideas consistently.Specifically,we will describe the typical procedure of flexible crowdsourcing design,the refined crowdsourcing tasks,the factors that affect the idea development process,the method for calculating idea development potential,and two applications of the flexible crowdsourcing design method.Finally,it summarizes the design capabilities enabled by crowdsourcing intelligent design.This method enhances the performance of crowdsourcing design and supports the development of design intelligence.展开更多
The aerodynamic characteristics are vital for short cylindrical Terminal Sensitive Bullets(TSB)with lowaspect ratio,especially in terminal trajectory.Currently,there is little research in terms of the TSB andshort cyl...The aerodynamic characteristics are vital for short cylindrical Terminal Sensitive Bullets(TSB)with lowaspect ratio,especially in terminal trajectory.Currently,there is little research in terms of the TSB andshort cylinder with two free ends,and particularly in this trajectory,where the scanning angleβand rollangle a vary over a broad range between 0°and 180.In this work wind tunnel experiments are firstconducted to learn the effects of Reynolds number and scanning angle on aerodynamic parameters forshort cylinder with aspect ratio L/D=1.Similar to infinite cylinder,for the short cylinder with two freeends,the drag crisis phenomenon still exists in the critical regime 1.7×10^(5)≤Re≤6.8×10^(5).Then 3Dsimulations are performed to demonstrate the aerodynamic characteristics of short cylinder and TSBover a broad range of Re,L/D,a and 6.The sensitivity analysis of time step and grid are presented as well.whenβ3=0,for short cylinder,the drag crisis phenomenon was also observed in the simulation,but notas obvious as in the wind tunnel test.In some attitudes,there is an obvious Karman vortexin the wake ofshort cylinder and TSB.The correlation between time-averaged aerodynamic coefficients and L/D,Re,a&l is discussed.The vortex shedding frequency and shear layer behavior are obtained for quasi-steadyand unsteady flow.Finally,the effect of end's shape on drag reduction and vortex shedding frequency isanalyzed.展开更多
Objectives Dizziness is a common and challenging clinical presentation in general practice.Failure to determine specific aetiologies can lead to significant morbidity and mortality.We aimed to establish frequency and ...Objectives Dizziness is a common and challenging clinical presentation in general practice.Failure to determine specific aetiologies can lead to significant morbidity and mortality.We aimed to establish frequency and associations of general practitioner(GP)trainees’(registrars’)specific vertigo provisional diagnoses and their non-specific symptomatic problem formulations.Design A cross-sectional analysis of Registrar Clinical Encounters in Training(ReCEnT)cohort study data between 2010 and 2018.ReCEnT is an ongoing,prospective cohort study of registrars in general practice training in Australia.Data collection occurs once every 6 months midtraining term(for three terms)and entails recording details of 60 consecutive clinical consultations on hardcopy case report forms.The outcome factor was whether dizziness-related or vertigo-related presentations resulted in a specific vertigo provisional diagnosis versus a non-specific symptomatic problem formulation.Associations with patient,practice,registrar and consultation independent variables were assessed by univariate and multivariable logistic regression.Setting Australian general practice training programme.The training is regionalised and delivered by regional training providers(RTPs)(2010-2015)and regional training organisations(RTOs)(2016-2018)across Australia(from five states and one territory).Participants All general practice registrars enrolled with participating RTPs or RTOs undertaking GP training terms.Results 2333 registrars(96%response rate)recorded 1734 new problems related to dizziness or vertigo.Of these,546(31.5%)involved a specific vertigo diagnosis and 1188(68.5%)a non-specific symptom diagnosis.Variables associated with a non-specific symptom diagnosis on multivariable analysis were lower socioeconomic status of the practice location(OR 0.94 for each decile of disadvantage,95%CIs 0.90 to 0.98)and longer consultation duration(OR 1.02,95%CIs 1.00 to 1.04).A specific vertigo diagnosis was associated with performing a procedure(OR 0.52,95%CIs 0.27展开更多
The expression ofβ-lactamase,particularly metallo-β-lactamase(MBL)in bacteria has caused significant resistance to clinically importantβ-lactam antibiotics,including life-saving carbapenems.Antimicrobial peptides(A...The expression ofβ-lactamase,particularly metallo-β-lactamase(MBL)in bacteria has caused significant resistance to clinically importantβ-lactam antibiotics,including life-saving carbapenems.Antimicrobial peptides(AMPs)have emerged as promising therapeutic agents to combat antibiotic resistance.However,the cytotoxic AMPs has been one of the major concerns for their applications in clinical practice.Herein,we report a novel cephalosporin-caged AMP,which shows significantly reduced cytotoxicity,hemolytic activity,and antibacterial activity but turns highly active against bacteria upon specific hydrolysis by the antimicrobial resistance-causativeβ-lactamase.Further investigations demonstrate thisβ-lactamaseactivatable AMP selectively inactivates resistant bacterial pathogens over susceptible bacteria.This strategy should be applicable to other AMPs as a potential solution for the treatment of infectious diseases caused byβ-lactamase-expressing pathogenic bacteria.展开更多
Residual stress continues to be important issues in shipbuilding. This paper demonstrates how the heat affected zone that results from welding could be identified nondestructively using MBN （magnetic Barkhausen noise...Residual stress continues to be important issues in shipbuilding. This paper demonstrates how the heat affected zone that results from welding could be identified nondestructively using MBN （magnetic Barkhausen noise） technique. A stress concentration region was created by placing a weld bead on a marine steel plate used in ship construction. MBN measurements were made on the back surface of the welded plate along the weld direction and perpendicular to it in a line that crosses the weld bead. The stress distribution as deduced from the MBN measurements was found to be anisotropic in the material of the heat affected zone. The heat induced anisotropy was completely eliminated by shot peening the HAZ material as revealed by MBN intensity. It was concluded that the directional MBN measurements could be used to characterize the induced anisotropy and hence assess the thermal residual stresses distribution near a localized stresses concentration regions imposed by welding.展开更多
基金National Natural Science Foundation of China(No. 10472031).
文摘This paper aims at investigating brain injury mechanisms and predicting head injuries in real world accidents. For this purpose, a 3D human head finite element model （HBM-head） was developed based on head-brain anatomy. The HBM head model was validated with two experimental tests. Then the head finite element（FE） model and a multi-body system （MBS） model were used to carry out reconstructions of real world vehicle-pedestrian accidents and brain injuries. The MBS models were used for calculating the head impact conditions in vehicle impacts. The HBM-head model was used for calculating the injury related physical parameters, such as intracranial pressure, stress, and strain. The calculated intracranial pressure and strain distribution were correlated with the injury outcomes observed from accidents. It is shown that this model can predict the intracranial biomechanical response and calculate the injury related physical parameters. The head FE model has good biofidelity and will be a valuable tool for the study of injury mechanisms and the tolerance level of the brain.
基金supported by the Chinese Academy of Sciences Strategic Priority Research Program Grant (No.: XDB05020000)the National Natural Science Foundation of China (No. 41230642)the National key technology research and development program of the ministry of Science and technology of China (No. 2014BAC22B06)
文摘Vehicular emissions in China in 2006 and 2010 were calculated at a high spatial resolution based on the data released by the National Bureau of Statistics, by taking the emission standards into consideration. China＇s vehicular emissions of carbon monoxide （CO）, nitrogen oxides （NOx）, volatile organic compounds （VOCs）, ammonia （NH3）, fine particulate matters （PM2.5）, inhalable particulate matters （PMlo）, black carbon （BC）, and organic carbon （OC） were 30,113.9, 4593.7, 6838.0, 20.9, 400.2, 430.5,285.6, and 105.1 Gg, respectively, in 2006 and 34,175.2, 5167.5, 7029.4, 74.0, 386.4, 417.1, 270.9, and 106.2 Gg, respectively, in 2010. CO, VOCs, and NH3 emissions were mainly from motorcycles and light-duty gasoline vehicles, whereas NOx, PMzs, PMlo, and BC emissions were mainly from rural vehicles and heavy- duty diesel trucks. OC emissions were mainly from motorcycles and heavy-duty diesel trucks. Vehicles of pre-China I （vehicular emission standard of China before phase I） and China I （vehicular emission standard of China in phase I） were the primary contributors to all of the pollutant emissions except NH3, which was mainly from China III and China IV gasoline vehicles. The total emissions of all the pollutants except NH3 changed little from 2006 to 2010. This finding can be attributed to the implementation of strict emission standards and to improvements in oil quality.
基金the National Natural Science Foundation of China(92159303,81621004,81720108029,81930081,91940305,81672594,81772836,81872139,82072907,and 82003311)Guangdong Science and Technology Department(2020B1212060018 and 2020B1212030004)+8 种基金Clinical Innovation Research Program of Bioland Laboratory(2018GZR0201004)Bureau of Science and Technology of Guangzhou(20212200003)Program for Guangdong Introducing Innovative and Enterpreneurial Teams(2019BT02Y198)the Project of The Beijing Xisike Clinical Oncology Research Foundation(YRoche2019/2-0078)the Technology Development Program of Guangdong province(2021A0505030082)the Project of The Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation(2020B1212060018)Sun Yat-Sen Memorial Hospital Cultivation Project for Clinical Research(SYS-C-201805 and SYS-Q-202004)Guangzhou Science and Technology Program(202102010272)Medical Science and Technology Research Fund of Guangdong Province(A2020391)。
文摘Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,respectively.Patients who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer.
文摘This paper addresses the trajectory tracking control of a nonholonomic wheeled mobile manipulator with parameter uncertainties and disturbances. The proposed algorithm adopts a robust adaptive control strategy where parametric uncertainties are compensated by adaptive update techniques and the disturbances are suppressed. A kinematic controller is first designed to make the robot follow a desired end-effector and platform trajectories in task space coordinates simultaneously. Then, an adaptive control scheme is proposed, which ensures that the trajectories are accurately tracked even in the presence of external disturbances and uncertainties. The system stability and the convergence of tracking errors to zero are rigorously proven using Lyapunov theory. Simulations results are given to illustrate the effectiveness of the proposed robust adaptive control law in comparison with a sliding mode controller.
基金National Natural Science Foundation of China(No.21971177,82072051)Natural Science Foundation of the Jiangsu Higher Education Institution of China(No.22KJA150004)+2 种基金Priority Academic Program Development(PAPD)of Jiangsu Higher Education InstitutionsJiangsu Key Laboratory of Advanced Functional Polymers Design and Application,Soochow UniversitySuzhou Key Laboratory of Macromolecular Design and Precision Synthesis and the Program of Innovative Research Team of Soochow University.
文摘In the field of cancer therapy,inhibiting autophagy has emerged as a promising strategy.However,pharmacological disruption of autophagy can lead to the upregulation of programmed death-ligand 1(PD-L1),enabling tumor immune evasion.To address this issue,we developed innovative ROS-responsive cationic poly(ethylene imine)(PEI)nanogels using selenol chemistry-mediated multicomponent reaction(MCR)technology.This procedure involved simple mixing of low-molecular-weight PEI(LMW PEI),γ-selenobutylacetone(γ-SBL),and poly(ethylene glycol)methacrylate(PEGMA).Through high-throughput screening,we constructed a library of AxSeyOz nanogels and identified the optimized A1.8Se3O0.5/siPD-L1 nanogels,which exhibited a size of approximately 200 nm,excellent colloidal stability,and the most effective PD-L1 silencing efficacy.These nanogels demonstrated enhanced uptake by tumor cells,excellent oxidative degradation ability,and inhibited autophagy by alkalinizing lysosomes.The A1.8Se3O0.5/siPD-L1 nanogels significantly downregulated PD-L1 expression and increased the expression of major histocompatibility complex class I(MHC-I),resulting in robust proliferation of specific CD8+T cells and a decrease in MC38 tumor growth.As a result,the A1.8Se3O0.5/siPD-L1 nanogels inhibited tumor growth through self-inhibition of autophagy,upregulation of MHC-I,and downregulation of PD-L1.Designed with dynamic diselenide bonds,the A1.8Se3O0.5/siPD-L1 nanogels showed synergistic antitumor efficacy through self-inhibition of autophagy and prevention of immune escape.
基金supported by National Key Research and Development Program of China(contract No.2019YFA0904800)National Nature Science Foundation of China(32030065,31722033,92049304 to Y.Z.)+5 种基金Shanghai Sailing Program(contract No.21YF1410300)Science and Technology Commission of Shanghai Municipality(contract No.10DZ2220500)The Shanghai Committee of Science and Technology(grant No.11DZ2260600)Shanghai Frontiers Science Center of Optogenetic Techniques for CellMetabolism(Y.Z.)Research Unit of New Techniques for Live-cell Metabolic Imaging(Chinese Academy of Medical Sciences,2019-I2M-5-013 to Y.Z.)the State Key Laboratory of Bioreactor Engineering,the Fundamental Research Funds for the Central Universities.
文摘Hydrogen sulfide(H_(2)S)is a toxic,essential gas used in various biological and physical processes and has been the subject of many targeted studies on its role as a new gas transmitter.These studies have mainly focused on the production and pharmacological side effects caused by H_(2)S.Therefore,effective strategies to remove H_(2)S has become a key research topic.Furthermore,the development of novel nanoplatforms has provided new tools for the targeted removal of H_(2)S.This paper was performed to review the association between H_(2)S anddisease,relatedH_(2)S inhibitory drugs,aswell as H_(2)S responsive nanoplatforms(HRNs).This review first analyzed the role of H_(2)S in multiple tissues and conditions.Second,common drugs used to eliminate H_(2)S,as well as their potential for combination with anticancer agents,were summarized.Not only the existing studies on HRNs,but also the inhibition H_(2)S combined with different therapeutic methods were both sorted out in this review.Furthermore,this review provided in-depth analysis of the potential of HRNs about treatment or detection in detail.Finally,potential challenges of HRNs were proposed.This study demonstrates the excellent potential of HRNs for biomedical applications.
文摘Physicians encounter significant challenges in dealing with large diaphragmatic defects in both pediatric and adult populations.Diaphragmatic hernias,such as Morgagni,Bochdalek,and Hiatus hernias,can result in congenital lesions that are often undiagnosed until the appearance of symptoms(bleeding,anemia,and acid reflux).Therefore,substantial potential exists for developing tissue-engineered constructs as novel therapeutic options in clinics.Recent research indicates promising mid-term performance for both natural and synthetic materials.However,studies exploring their application in diaphragm regeneration are limited and remain in the early research stages.Additionally,further investigation is required to address the constraints in human tissue supply for clinical implementation.This article comprehensively reviews the role of biomaterials in diaphragmatic tissue repair and regeneration.It emphasizes biomaterials,including biomimetic polymers used in technological solutions.This summary will enable researchers to critically assess the capability of existing natural biomaterials as essential tissueengineered patches for clinical use.
基金supported by the National Key Research and Development Program of China(2022YFC3201702)the National Natural Science Foundation of China(42201146,U2240226)+1 种基金the Science and Technology Project of Sichuan Province(2022NSFSC1001)Fundamental Research Funds for The Central Universities(YJ2021133).
文摘The accuracy of the simulation of carbon and water processes largely relies on the selection of atmospheric forcing datasets when driving land surface models(LSM).Particularly in high-altitude regions,choosing appropriate atmospheric forcing datasets can effectively reduce uncertainties in the LSM simulations.Therefore,this study conducted four offline LSM simulations over the Tibetan Plateau(TP)using the Community Land Model version 4.5(CLM4.5)driven by four state-of-the-art atmospheric forcing datasets.The performances of CRUNCEP(CLM4.5 model default)and three other reanalysis-based atmospheric forcing datasets(i.e.ITPCAS,GSWP3 and WFDEI)in simulating the net primary productivity(NPP)and actual evapotranspiration(ET)were evaluated based on in situ and gridded reference datasets.Compared with in situ observations,simulated results exhibited determination coefficients(R2)ranging from 0.58 to 0.84 and 0.59 to 0.87 for observed NPP and ET,respectively,among which GSWP3 and ITPCAS showed superior performance.At the plateau level,CRUNCEP-based simulations displayed the largest bias compared with the reference NPP and ET.GSWP3-based simulations demonstrated the best performance when comprehensively considering both the magnitudes and change trends of TP-averaged NPP and ET.The simulated ET increase over the TP during 1982-2010 based on ITPCAS was significantly greater than in the other three simulations and reference ET,suggesting that ITPCAS may not be appropriate for studying long-term ET changes over the TP.These results suggest that GSWP3 is recommended for driving CLM4.5 in conducting long-term carbon and water processes simulations over the TP.This study contributes to enhancing the accuracy of LSM in water-carbon simulations over alpine regions.
文摘This paper discussed the selection criteria for Ordinary Urban Heritage (OUH) in Rattanakosin, the historic center of Bangkok through the case of ordinary restaurants and everyday foods. The OUH stands for an alternative approach to heritage understanding and conservation, derived from the notion of ordinary heritage, vernacular heritage, and urban heritage emphasizing the heritages of the everydayness of ordinary people. The OUHs have co-existed and inherited through the evolution of the city but are overlooked by the official conservation process. Ordinary restaurants and everyday foods were selected by 5 criteria, 1) appeared for more than 50 years;2) created, developed, and used by ordinary people;3) found as the clusters;4) able to be adapted to the urban context;5) exist until the present day.The methodology applied to the analysis of the historical documents and Bangkok maps from 1887 to 1974, and the selection criteria developed from past research in another old commercial district of Bangkok were also reinvestigated with observational surveys. Ordinary restaurants and everyday foods are the outcomes representing the heritage of everyday life of ordinary people that are ubiquitously related to commercial activities.
基金supported by the National Natural Science Foundation of China(Nos.42007421 and 42001013)the General Research Project Fund of Hong Kong Research Grants Council(Hong Kong,China)(No.11207520)+2 种基金the Key Program Special Fund(China)(No.KSF-E-43)the Research Development Fund(China)(No.RDF-19-02-13)of XJTLUthe Zhejiang Provincial Natural Science Foundation of China(No.Y23D050006).
文摘Despite increased attention given to potential modifiers of temperature-mortality associations, evidence for variations between different urban landscape characteristics remains limited. It is in this context that in this paper effect modifications of multiple urban landscape characteristics are explored under different heatwave definitions for different age groups and gender in Hong Kong, China. Daily meteorological data and heatwave-related mortality counts from 2008 to 2017 were collected from the Hong Kong Census and Statistics Department, China. A case-only design was adopted, combined with logistic regression models to examine the modification effects of five urban landscape characteristics under six heatwave definitions. Stratified analyses were conducted to investigate age- and gender-specific effect modifications. It is found that individuals living in greener areas experienced lower levels of mortality during or immediately after heatwaves. In contrast, a higher building density and nighttime land surface temperature (LST) were associated with a higher heatwave-related mortality risk. Pronounced effect modifications of these urban landscape characteristics were observed under hotter and longer heatwaves, and in older adults (age ≥ 65 years) and males. The findings provide a scientific basis for policymakers and practitioners when considering measures for coping with hotter, longer, and more frequent heatwaves in the context of global climate change.
基金Project supported by the National Science and Technology Innovation 2030 Major Project of the Ministry of Science and Technology of China(No.2018AAA0100700)the National Natural Science Foundation of China(No.61672451)+2 种基金the Provincial Key Research and Development Plan of Zhejiang Province,China(No.2019C03137)the China Postdoctoral Science Foundation(No.2018M630658)the Alibaba-Zhejiang University Joint Institute of Frontier Technologies。
文摘Images are widely used by companies to advertise their products and promote awareness of their brands.The automatic synthesis of advertising images is challenging because the advertising message must be clearly conveyed while complying with the style required for the product,brand,or target audience.In this study,we proposed a data-driven method to capture individual design attributes and the relationships between elements in advertising images with the aim of automatically synthesizing the input of elements into an advertising image according to a specified style.To achieve this multi-format advertisement design,we created a dataset containing 13280 advertising images with rich annotations that encompassed the outlines and colors of the elements,in addition to the classes and goals of the advertisements.Using our probabilistic models,users guided the style of synthesized advertisements via additional constraints(e.g.,context-based keywords).We applied our method to a variety of design tasks,and the results were evaluated in several perceptual studies,which showed that our method improved users’satisfaction by 7.1%compared to designs generated by nonprofessional students,and that more users preferred the coloring results of our designs to those generated by the color harmony model and Colormind.
基金The ReCEnT project was funded from 2016 to 2019 by an Australian Department of Health-commissioned research grantsupported by the GP Synergy Regional Training Organisation.
文摘Objective To determine the prevalence and associations of general practice registrars’performing absolute cardio-vascular risk(ACVR)assessment(ACVRa).Design A cross-sectional study employing data(2017–2018)from the Registrar Clinical Encounters in Training project,an ongoing inception cohort study of Australian GP registrars.The outcome measure was whether an ACVRa was performed.Analyses employed univariable and multivariable regression.Analysis was conducted for all patient problems/diagnoses,then for an‘at-risk’population(specific problems/diagnoses for which ACVRa is indicated).Setting Three GP regional training organisations(RTOs)across three Australian states.Participants GP registrars training within participating RTOs.Results 1003 registrars(response rate 96.8%)recorded details of 69105 problems either with Aboriginal and/or Torres Strait patients aged 35 years and older or with non-Indigenous patients aged 45 years and older.Of these problems/diagnoses,1721(2.5%(95%CI 2.4%to 2.6%))involved an ACVRa.An ACVRa was‘plausibly indicated’in 10384 problems/diagnoses.Of these,1228(11.8%(95%CI 11.2%to 12.4%))involved ACVRa.For‘all problems/diagnoses’,on multivariable analysis female gender was associated with reduced odds of ACVRa(OR 0.61(95%CI 0.54 to 0.68)).There was some evidence for Aboriginal and/or Torres Strait Islander people being more likely to receive ACVRa(OR 1.40(95%CI 0.94 to 2.08),p=0.10).There were associations with variables related to continuity of care,with reduced odds of ACVRa:if the patient was new to the registrar(OR 0.65(95%CI 0.57 to 0.75)),new to the practice(OR 0.24(95%CI 0.15 to 0.38))or the problem was new(OR 0.68(95%CI 0.59 to 0.78));and increased odds if personal follow-up was organised(OR 1.43(95%CI 1.24 to 1.66)).For‘ACVRa indicated’problems/diagnoses,findings were similar to those for‘all problems/diagnoses’.Association with Aboriginal and/or Torres Strait Islander status,however,was significant at p<0.05(OR 1.60(95%CI 1.04 to 2.46))and association with fema
基金supported in part by the National Natural Science Foundation of China(22033001)the National Key R&D Program of China(2022YFA1303700)the Chinese Academy of Medical Sciences(2021-I2M-5-014).
文摘Proteins function as integral actors in essential life processes,rendering the realm of protein research a fundamental domain that possesses the potential to propel advancements in pharmaceuticals and disease investigation.Within the context of protein research,an imperious demand arises to uncover protein functionalities and untangle intricate mechanistic underpinnings.Due to the exorbitant costs and limited throughput inherent in experimental investigations,computational models offer a promising alternative to accelerate protein function annotation.In recent years,protein pre-training models have exhibited noteworthy advancement across multiple prediction tasks.This advancement highlights a notable prospect for effectively tackling the intricate downstream task associated with protein function prediction.In this review,we elucidate the historical evolution and research paradigms of computational methods for predicting protein function.Subsequently,we summarize the progress in protein and molecule representation as well as feature extraction techniques.Furthermore,we assess the performance of machine learning-based algorithms across various objectives in protein function prediction,thereby offering a comprehensive perspective on the progress within this field.
文摘The sensitivity of magnetic Barkhausen noise (MBN) profile to changes in the excitation field strength and the number of turns of the detection coil was investigated in inhomogeneous material. Generally, the 0.5 mm case depth EN 36 steel specimen shows a double peak profile indicative of inhomogeneity through the detected depth the magnetized landscape. Various excitation field amplitudes were applied to the specimen and the induced MBN emission was analyzed for each magnetizing current. Excitation field at the lowest level induced an MBN emission of two peaks of equivalent heights. The first peak occurs at lower field than the second peak in the magnetization period. As the excitation field increased, the height of both peaks increased but the second peak increased in a higher rate than that of the first peak. Beyond certain excitation level, both peaks began to saturate and no increase in the MBN intensity was observed with increased excitation field strength. However, peak position and the number of Barkhausen events, indicated linearly as a function of the applied field strength. The experiment also establishes that the number of turns in the detection coil is important parameter which controls the height of the first peak. Low field peak height increases as the number of turn of the detection coil increases. The results indicate that the potential difference applied to the electromagnet and the sensitivity of the detection coil, determine the MBN profile characteristics.
基金supported by the National Natural Science Foundation of China(No.61672451)the National Basic Research Program(973)of China(No.2015CB352503)the Alibaba-Zhejiang University Joint Institute of Frontier Technologies
文摘Design intelligence,namely,artificial intelligence to solve creative problems and produce creative ideas,has improved rapidly with the new generation artificial intelligence.However,existing methods are more skillful in learning from data and have limitations in creating original ideas different from the training data.Crowdsourcing offers a promising method to produce creative designs by combining human inspiration and machines' computational ability.We propose a crowdsourcing intelligent design method called ‘flexible crowdsourcing design'.Design ideas produced through crowdsourcing design can be unreliable and inconsistent because they rely solely on selection among participants' submissions of ideas.In contrast,the flexible crowdsourcing design method employs a cultivation procedure that integrates the ideas from crowd participants and cultivates these ideas to improve design quality at the same time.We introduce a series of studies to show how flexible crowdsourcing design can produce original design ideas consistently.Specifically,we will describe the typical procedure of flexible crowdsourcing design,the refined crowdsourcing tasks,the factors that affect the idea development process,the method for calculating idea development potential,and two applications of the flexible crowdsourcing design method.Finally,it summarizes the design capabilities enabled by crowdsourcing intelligent design.This method enhances the performance of crowdsourcing design and supports the development of design intelligence.
基金The authors would like to acknowledge the financial supports from the National Natural Science Foundation of China(Grant No.11372136)the Special fund for basic scientific research of Central University(Grant No.30916011306)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(Grant No.KYCX17_0386).
文摘The aerodynamic characteristics are vital for short cylindrical Terminal Sensitive Bullets(TSB)with lowaspect ratio,especially in terminal trajectory.Currently,there is little research in terms of the TSB andshort cylinder with two free ends,and particularly in this trajectory,where the scanning angleβand rollangle a vary over a broad range between 0°and 180.In this work wind tunnel experiments are firstconducted to learn the effects of Reynolds number and scanning angle on aerodynamic parameters forshort cylinder with aspect ratio L/D=1.Similar to infinite cylinder,for the short cylinder with two freeends,the drag crisis phenomenon still exists in the critical regime 1.7×10^(5)≤Re≤6.8×10^(5).Then 3Dsimulations are performed to demonstrate the aerodynamic characteristics of short cylinder and TSBover a broad range of Re,L/D,a and 6.The sensitivity analysis of time step and grid are presented as well.whenβ3=0,for short cylinder,the drag crisis phenomenon was also observed in the simulation,but notas obvious as in the wind tunnel test.In some attitudes,there is an obvious Karman vortexin the wake ofshort cylinder and TSB.The correlation between time-averaged aerodynamic coefficients and L/D,Re,a&l is discussed.The vortex shedding frequency and shear layer behavior are obtained for quasi-steadyand unsteady flow.Finally,the effect of end's shape on drag reduction and vortex shedding frequency isanalyzed.
基金The Registrar Clinical Encounters in Training(ReCEnT)project was funded from 2010 to 2015 by the participating educational organisations:General Practice Training Valley to Coast,the Victorian Metropolitan Alliance,General Practice Training Tasmania,Adelaide to Outback GP Training Program and Tropical Medical Training,all of which were funded by the Australian Department of Health(DoH).From 2016 to 2019,ReCEnT was funded by a DoH commissioned research grant(no award/grant number)and supported by GP Synergy RTO.From 2019,ReCEnT is conducted by GP Synergy in collaboration with Eastern Victoria GP Training and General Practice Training Tasmania.GP Synergy,Eastern Victoria GP Training and General Practice Training Tasmania are funded by the DoH.JL was supported by a GP Synergy Medical Student Scholarship.
文摘Objectives Dizziness is a common and challenging clinical presentation in general practice.Failure to determine specific aetiologies can lead to significant morbidity and mortality.We aimed to establish frequency and associations of general practitioner(GP)trainees’(registrars’)specific vertigo provisional diagnoses and their non-specific symptomatic problem formulations.Design A cross-sectional analysis of Registrar Clinical Encounters in Training(ReCEnT)cohort study data between 2010 and 2018.ReCEnT is an ongoing,prospective cohort study of registrars in general practice training in Australia.Data collection occurs once every 6 months midtraining term(for three terms)and entails recording details of 60 consecutive clinical consultations on hardcopy case report forms.The outcome factor was whether dizziness-related or vertigo-related presentations resulted in a specific vertigo provisional diagnosis versus a non-specific symptomatic problem formulation.Associations with patient,practice,registrar and consultation independent variables were assessed by univariate and multivariable logistic regression.Setting Australian general practice training programme.The training is regionalised and delivered by regional training providers(RTPs)(2010-2015)and regional training organisations(RTOs)(2016-2018)across Australia(from five states and one territory).Participants All general practice registrars enrolled with participating RTPs or RTOs undertaking GP training terms.Results 2333 registrars(96%response rate)recorded 1734 new problems related to dizziness or vertigo.Of these,546(31.5%)involved a specific vertigo diagnosis and 1188(68.5%)a non-specific symptom diagnosis.Variables associated with a non-specific symptom diagnosis on multivariable analysis were lower socioeconomic status of the practice location(OR 0.94 for each decile of disadvantage,95%CIs 0.90 to 0.98)and longer consultation duration(OR 1.02,95%CIs 1.00 to 1.04).A specific vertigo diagnosis was associated with performing a procedure(OR 0.52,95%CIs 0.27
基金financial support from the NSFC-BRICS(No.81861148020,H.Xie)the Fundamental Research Funds for the Central Universities(H.Xie)+1 种基金the Research Program of State Key Laboratory of Bioreactor Engineering(H.Xie)DST-BRICS multilateral cooperation project(DST/IMRCD/BRICS/PilotCall2/MBLI/2018(G))。
文摘The expression ofβ-lactamase,particularly metallo-β-lactamase(MBL)in bacteria has caused significant resistance to clinically importantβ-lactam antibiotics,including life-saving carbapenems.Antimicrobial peptides(AMPs)have emerged as promising therapeutic agents to combat antibiotic resistance.However,the cytotoxic AMPs has been one of the major concerns for their applications in clinical practice.Herein,we report a novel cephalosporin-caged AMP,which shows significantly reduced cytotoxicity,hemolytic activity,and antibacterial activity but turns highly active against bacteria upon specific hydrolysis by the antimicrobial resistance-causativeβ-lactamase.Further investigations demonstrate thisβ-lactamaseactivatable AMP selectively inactivates resistant bacterial pathogens over susceptible bacteria.This strategy should be applicable to other AMPs as a potential solution for the treatment of infectious diseases caused byβ-lactamase-expressing pathogenic bacteria.
文摘Residual stress continues to be important issues in shipbuilding. This paper demonstrates how the heat affected zone that results from welding could be identified nondestructively using MBN （magnetic Barkhausen noise） technique. A stress concentration region was created by placing a weld bead on a marine steel plate used in ship construction. MBN measurements were made on the back surface of the welded plate along the weld direction and perpendicular to it in a line that crosses the weld bead. The stress distribution as deduced from the MBN measurements was found to be anisotropic in the material of the heat affected zone. The heat induced anisotropy was completely eliminated by shot peening the HAZ material as revealed by MBN intensity. It was concluded that the directional MBN measurements could be used to characterize the induced anisotropy and hence assess the thermal residual stresses distribution near a localized stresses concentration regions imposed by welding.
