Poly lactic acid is a biodegradable, biocompatible, and non-toxic polymer, widely used in many pharmaceuticalpreparations such as controlled release formulations, parenteral preparations, surgicaltreatment application...Poly lactic acid is a biodegradable, biocompatible, and non-toxic polymer, widely used in many pharmaceuticalpreparations such as controlled release formulations, parenteral preparations, surgicaltreatment applications, and tissue engineering. In this study, we prepared lipid-polymer hybrid nanoparticlesfor topical and site targeting delivery of Norfloxacin by emulsification solvent evaporationmethod (ESE). The design of experiment (DOE) was done by using software to optimize the result, andthen a surface plot was generated to compare with the practical results. The surface morphology, particlesize, zeta potential and composition of the lipid-polymer hybrid nanoparticles were characterized bySEM, TEM, AFM, and FTIR. The thermal behavior of the lipid-polymer hybrid nanoparticles was characterizedby DSC and TGA. The prepared lipid-polymer hybrid nanoparticles of Norfloxacin exhibited anaverage particle size from 178.6 ± 3.7 nm to 220.8 ± 2.3 nm, and showed very narrow distribution withpolydispersity index ranging from 0.206 ± 0.36 to 0.383 ± 0.66. The surface charge on the lipid-polymerhybrid nanoparticles were confirmed by zeta potential, showed the value from t23.4 ± 1.5 mVto t41.5 ± 3.4 mV. An Antimicrobial study was done against Staphylococcus aureus and Pseudomonasaeruginosa, and the lipid-polymer hybrid nanoparticles showed potential activity against these two.Lipid-polymer hybrid nanoparticles of Norfloxacin showed the %cumulative drug release of 89.72% in24 h. A stability study of the optimized formulation showed the suitable condition for the storage oflipid-polymer hybrid nanoparticles was at 4 ± 2 C/60 ± 5% RH. These results illustrated high potential oflipid-polymer hybrid nanoparticles Norfloxacin for usage as a topical antibiotic drug carriers.展开更多
The present work describes a facile, one-pot three component environment friendly, green synthesis of a series of 5-（4-methoxyphenyl）-7,7-dimethyl-10-phenyl-7,8-dihydro-SH-indeno[ 1,2-b]quinoline- 9,11 （6H,10H）-di...The present work describes a facile, one-pot three component environment friendly, green synthesis of a series of 5-（4-methoxyphenyl）-7,7-dimethyl-10-phenyl-7,8-dihydro-SH-indeno[ 1,2-b]quinoline- 9,11 （6H,10H）-dione derivatives 8（a-n）. 1,3-indanedione, awl-aldehyde and enaminone was thoroughly ground in the presence of catalytic amount of p-toluene sulfonic acid （p-TSA） to give the titled compounds in good yields. All the synthesized derivatives were evaluated for their anticonvulsant activity using the maximal electroshock （MES） method with phenytoin as a standard drug along with their neurotoxicity effect. Derivatives 8b, 8e and 8k exhibited significant anticonvulsant activity （P 〈 0.001）. The neurotoxicity study clearly revealed that all the tested compounds are non-toxic at a dose of 40 mg/kg. The molecular modeling studies also predicted good binding interactions of most active molecules with the serotonin 5-HT2A receptor. Therefore, it can be safely concluded that synthesized derivatives 8（a-n） would represent useful leads for further investigation in the development of a new class of anticonvulsant agents.展开更多
Earth is a heritage of plants with an abundance of species,many of which are known among us,but many of them are still unknown for us.There are many traditional plants which have been used for medicinal purposes since...Earth is a heritage of plants with an abundance of species,many of which are known among us,but many of them are still unknown for us.There are many traditional plants which have been used for medicinal purposes since ancient times,and Nagkesar(Mesua ferrea Linn)is one of them,which is grown in many countries like India,Indochina,Nepal,Thailand,Sri Lanka and many other countries.It is used to treat diseases like bleeding piles,renal disease,dysentery,fever,and asthma,as well as bacterial and fungal infections.It is known for its medicinal properties but has also been used as an ornamental plant since ancient times.It contains active phytoconstituents like steroids,coumarins and their derivatives,terpenoids,xanthones and their derivatives,flavonoids and pyranoxanthones,which act as precursors of other ailments.The goal of this study is to summarise the all-pharmacological activities of Nagkesar as well as some novel uses of Nagkesar.A thorough bibliographic investigation was launched by examining internationally recognized scientific databases such as Cochrane library,PubMed,ScienceDirect,Web of Science,Google scholar,and several data sets from Herbalist library.We searched several clinical trial databases of the recent past year and previous systematic reviews from 1980–2022.In this review article,all probable pharmacological effects of the Nagkesar plant,as well as the active components responsible for the biological role,are discussed.Nagkesar is important in the treatment of a variety of ailments.Inflammation,bleeding piles,bronchitis,severe infection,fungal growth,diarrhea,and kidney disease are among conditions that can be treated with the Nagkesar plant.展开更多
文摘Poly lactic acid is a biodegradable, biocompatible, and non-toxic polymer, widely used in many pharmaceuticalpreparations such as controlled release formulations, parenteral preparations, surgicaltreatment applications, and tissue engineering. In this study, we prepared lipid-polymer hybrid nanoparticlesfor topical and site targeting delivery of Norfloxacin by emulsification solvent evaporationmethod (ESE). The design of experiment (DOE) was done by using software to optimize the result, andthen a surface plot was generated to compare with the practical results. The surface morphology, particlesize, zeta potential and composition of the lipid-polymer hybrid nanoparticles were characterized bySEM, TEM, AFM, and FTIR. The thermal behavior of the lipid-polymer hybrid nanoparticles was characterizedby DSC and TGA. The prepared lipid-polymer hybrid nanoparticles of Norfloxacin exhibited anaverage particle size from 178.6 ± 3.7 nm to 220.8 ± 2.3 nm, and showed very narrow distribution withpolydispersity index ranging from 0.206 ± 0.36 to 0.383 ± 0.66. The surface charge on the lipid-polymerhybrid nanoparticles were confirmed by zeta potential, showed the value from t23.4 ± 1.5 mVto t41.5 ± 3.4 mV. An Antimicrobial study was done against Staphylococcus aureus and Pseudomonasaeruginosa, and the lipid-polymer hybrid nanoparticles showed potential activity against these two.Lipid-polymer hybrid nanoparticles of Norfloxacin showed the %cumulative drug release of 89.72% in24 h. A stability study of the optimized formulation showed the suitable condition for the storage oflipid-polymer hybrid nanoparticles was at 4 ± 2 C/60 ± 5% RH. These results illustrated high potential oflipid-polymer hybrid nanoparticles Norfloxacin for usage as a topical antibiotic drug carriers.
文摘The present work describes a facile, one-pot three component environment friendly, green synthesis of a series of 5-（4-methoxyphenyl）-7,7-dimethyl-10-phenyl-7,8-dihydro-SH-indeno[ 1,2-b]quinoline- 9,11 （6H,10H）-dione derivatives 8（a-n）. 1,3-indanedione, awl-aldehyde and enaminone was thoroughly ground in the presence of catalytic amount of p-toluene sulfonic acid （p-TSA） to give the titled compounds in good yields. All the synthesized derivatives were evaluated for their anticonvulsant activity using the maximal electroshock （MES） method with phenytoin as a standard drug along with their neurotoxicity effect. Derivatives 8b, 8e and 8k exhibited significant anticonvulsant activity （P 〈 0.001）. The neurotoxicity study clearly revealed that all the tested compounds are non-toxic at a dose of 40 mg/kg. The molecular modeling studies also predicted good binding interactions of most active molecules with the serotonin 5-HT2A receptor. Therefore, it can be safely concluded that synthesized derivatives 8（a-n） would represent useful leads for further investigation in the development of a new class of anticonvulsant agents.
文摘Earth is a heritage of plants with an abundance of species,many of which are known among us,but many of them are still unknown for us.There are many traditional plants which have been used for medicinal purposes since ancient times,and Nagkesar(Mesua ferrea Linn)is one of them,which is grown in many countries like India,Indochina,Nepal,Thailand,Sri Lanka and many other countries.It is used to treat diseases like bleeding piles,renal disease,dysentery,fever,and asthma,as well as bacterial and fungal infections.It is known for its medicinal properties but has also been used as an ornamental plant since ancient times.It contains active phytoconstituents like steroids,coumarins and their derivatives,terpenoids,xanthones and their derivatives,flavonoids and pyranoxanthones,which act as precursors of other ailments.The goal of this study is to summarise the all-pharmacological activities of Nagkesar as well as some novel uses of Nagkesar.A thorough bibliographic investigation was launched by examining internationally recognized scientific databases such as Cochrane library,PubMed,ScienceDirect,Web of Science,Google scholar,and several data sets from Herbalist library.We searched several clinical trial databases of the recent past year and previous systematic reviews from 1980–2022.In this review article,all probable pharmacological effects of the Nagkesar plant,as well as the active components responsible for the biological role,are discussed.Nagkesar is important in the treatment of a variety of ailments.Inflammation,bleeding piles,bronchitis,severe infection,fungal growth,diarrhea,and kidney disease are among conditions that can be treated with the Nagkesar plant.
