Background:This study aimed to determine the effect of different carbohydrate(CHO)doses on exercise capacity in patients with McArdle disease—the paradigm of“exercise intolerance”,characterized by complete muscle g...Background:This study aimed to determine the effect of different carbohydrate(CHO)doses on exercise capacity in patients with McArdle disease—the paradigm of“exercise intolerance”,characterized by complete muscle glycogen unavailability—and to determine whether higher exogenous glucose levels affect metabolic responses at the McArdle muscle cell(in vitro)level.Methods:Patients with McArdle disease(n=8)and healthy controls(n=9)underwent a 12-min submaximal cycling constant-load bout followed by a maximal ramp test 15 min after ingesting a non-caloric placebo.In a randomized,double-blinded,cross-over design,patients repeated the tests after consuming either 75 g or 150 g of CHO(glucose:fructose=2:1).Cardiorespiratory,biochemical,perceptual,and electromyographic(EMG)variables were assessed.Additionally,glucose uptake and lactate appearance were studied in vitro in wild-type and McArdle mouse myotubes cultured with increasing glucose concentrations(0.35,1.00,4.50,and 10.00 g/L).Results:Compared with controls,patients showed the“classical”second-wind phenomenon(after prior disproportionate tachycardia,myalgia,and excess electromyographic activity during submaximal exercise,all p<0.05)and an impaired endurance exercise capacity(-51%ventilatory threshold and55%peak power output,both p<0.001).Regardless of the CHO dose(p<0.05 for both doses compared with the placebo),CHO intake increased blood glucose and lactate levels,decreased fat oxidation rates,and attenuated the second wind in the patients.However,only the higher dose increased ventilatory threshold(+27%,p=0.010)and peak power output(+18%,p=0.007).In vitro analyses revealed no differences in lactate levels across glucose concentrations in wild-type myotubes,whereas a doseresponse effect was observed in McArdle myotubes.Conclusion:CHO intake exerts beneficial effects on exercise capacity in McArdle disease,a condition associated with total muscle glycogen unavailability.Some of these benefits are dose dependent.展开更多
Computing,serving as the cornerstone of information processing,plays a pivotal role in the digital service era.The"network"and"computing,"responsible for information transmission and processing res...Computing,serving as the cornerstone of information processing,plays a pivotal role in the digital service era.The"network"and"computing,"responsible for information transmission and processing respectively,traditionally belong to different stakeholders and have evolved separately.However,the recent trend toward the coordination and integration of computing and networks has garnered significant attention from both industry and academia.Concepts such as"computility network"and"computing force network"have emerged,and the International Telecommunication Union-Telecommunication Standardization(ITU-T)has initiated efforts to develop standards for the coordination of networking and computing(CNC),focusing on the architecture and framework.展开更多
This paper is concerned with the distributed resilient fusion filtering(DRFF)problem for a class of time-varying multi-sensor nonlinear stochastic systems(MNSSs)with random sensor delays(RSDs).The phenomenon of the RS...This paper is concerned with the distributed resilient fusion filtering(DRFF)problem for a class of time-varying multi-sensor nonlinear stochastic systems(MNSSs)with random sensor delays(RSDs).The phenomenon of the RSDs is modeled by a set of random variables with certain statistical features.In addition,the nonlinear function is handled via Taylor expansion in order to deal with the nonlinear fusion filtering problem.The aim of the addressed issue is to propose a DRFF scheme for MNSSs such that,for both RSDs and estimator gain perturbations,certain upper bounds of estimation error covariance(EEC)are given and locally minimized at every sample time.In the light of the obtained local filters,a new DRFF algorithm is developed via the matrix-weighted fusion method.Furthermore,a sufficient condition is presented,which can guarantee that the local upper bound of the EEC is bounded.Finally,a numerical example is provided,which can show the usefulness of the developed DRFF approach.展开更多
Forested areas are extremely vulnerable to disasters leading to environmental destruction.Forest Fire is one among them which requires immediate attention.There are lot of works done by authors where Wireless Sensors ...Forested areas are extremely vulnerable to disasters leading to environmental destruction.Forest Fire is one among them which requires immediate attention.There are lot of works done by authors where Wireless Sensors and IoT have been used for forest fire monitoring.So,towards monitoring the forest fire and managing the energy efficiently in IoT,Energy Efficient Routing Protocol for Low power lossy networks(E-RPL)was developed.There were challenges about the scalability of the network resulting in a large end-to-end delay and less packet delivery which led to the development of Aggregator-based Energy Efficient RPL with Data Compression(CAAERPL).Though CAA-ERPL proved effective in terms of reduced packet delivery,less energy consumption,and increased packet delivery ratio for varying number of nodes,there is still challenge in the selection of aggregator which is based purely on probability percentage of nodes.There has been research work where fuzzy logic been employed for Mobile Ad-hoc Routing,RPL routing and cluster head selection in Wireless Sensor.There has been no work where fuzzy logic is employed for aggregator selection in Energy Efficient RPL.So accordingly,we here have proposed Fuzzy Based Aggregator selection in Energy-efficient RPL for region thereby forming DODAG for communicating to Fog/Edge.We here have developed fuzzy inference rules for selecting the aggregator based on strength which takes residual power,Node degree,and Expected Transmission Count(ETX)as input metrics.The Fuzzy Aggregator Energy Efficient RPL(FA-ERPL)based on fuzzy inference rules were analysed against E-RPL in terms of scalability(First and Half Node die),Energy Consumption,and aggregator node energy deviation.From the analysis,it was found that FA-ERPL performed better than E-RPL.These were simulated using MATLAB and results.展开更多
Genetic algorithm (GA) is one of the alternative approaches for solving the shortest path routing problem. In previous work, we have developed a coarse-grained parallel GA-based shortest path routing algorithm. With p...Genetic algorithm (GA) is one of the alternative approaches for solving the shortest path routing problem. In previous work, we have developed a coarse-grained parallel GA-based shortest path routing algorithm. With parallel GA, there is a GA operator called migration, where a chromosome is taken from one sub-population to replace a chromosome in another sub-population. Which chromosome to be taken and replaced is subjected to the migration strategy used. There are four different migration strategies that can be employed: best replace worst, best replace random, random replace worst, and random replace random. In this paper, we are going to evaluate the effect of different migration strategies on the parallel GA-based routing algorithm that has been developed in the previous work. Theoretically, the migration strategy best replace worst should perform better than the other strategies. However, result from simulation shows that even though the migration strategy best replace worst performs better most of the time, there are situations when one of the other strategies can perform just as well, or sometimes better.展开更多
基金supported by a Sara Borrell postdoctoral contract granted by Instituto de Salud Carlos III(CD21/00138).PLV,DB-G and AL are funded by the Spanish Ministry of Economy and Competitiveness and Fondos Feder(Alejandro Lucia,Grant No.PI18/00139)TP is funded by the Spanish Ministry of Economy and Competitiveness and Fondos Feder(Tomas Pinos,Grant No.PI22/00201).
文摘Background:This study aimed to determine the effect of different carbohydrate(CHO)doses on exercise capacity in patients with McArdle disease—the paradigm of“exercise intolerance”,characterized by complete muscle glycogen unavailability—and to determine whether higher exogenous glucose levels affect metabolic responses at the McArdle muscle cell(in vitro)level.Methods:Patients with McArdle disease(n=8)and healthy controls(n=9)underwent a 12-min submaximal cycling constant-load bout followed by a maximal ramp test 15 min after ingesting a non-caloric placebo.In a randomized,double-blinded,cross-over design,patients repeated the tests after consuming either 75 g or 150 g of CHO(glucose:fructose=2:1).Cardiorespiratory,biochemical,perceptual,and electromyographic(EMG)variables were assessed.Additionally,glucose uptake and lactate appearance were studied in vitro in wild-type and McArdle mouse myotubes cultured with increasing glucose concentrations(0.35,1.00,4.50,and 10.00 g/L).Results:Compared with controls,patients showed the“classical”second-wind phenomenon(after prior disproportionate tachycardia,myalgia,and excess electromyographic activity during submaximal exercise,all p<0.05)and an impaired endurance exercise capacity(-51%ventilatory threshold and55%peak power output,both p<0.001).Regardless of the CHO dose(p<0.05 for both doses compared with the placebo),CHO intake increased blood glucose and lactate levels,decreased fat oxidation rates,and attenuated the second wind in the patients.However,only the higher dose increased ventilatory threshold(+27%,p=0.010)and peak power output(+18%,p=0.007).In vitro analyses revealed no differences in lactate levels across glucose concentrations in wild-type myotubes,whereas a doseresponse effect was observed in McArdle myotubes.Conclusion:CHO intake exerts beneficial effects on exercise capacity in McArdle disease,a condition associated with total muscle glycogen unavailability.Some of these benefits are dose dependent.
文摘Computing,serving as the cornerstone of information processing,plays a pivotal role in the digital service era.The"network"and"computing,"responsible for information transmission and processing respectively,traditionally belong to different stakeholders and have evolved separately.However,the recent trend toward the coordination and integration of computing and networks has garnered significant attention from both industry and academia.Concepts such as"computility network"and"computing force network"have emerged,and the International Telecommunication Union-Telecommunication Standardization(ITU-T)has initiated efforts to develop standards for the coordination of networking and computing(CNC),focusing on the architecture and framework.
基金This work was supported in part by the National Natural Science Foundation of China under Grant Nos.12171124,61873058,and 61673141the Natural Science Foundation of Heilongjiang Province of China under Grant No.ZD2022F003+1 种基金the Key Foundation of Educational Science Planning in Heilongjiang Province of China under Grant No.GJB1422069the Alexander von Humboldt Foundation of Germany。
文摘This paper is concerned with the distributed resilient fusion filtering(DRFF)problem for a class of time-varying multi-sensor nonlinear stochastic systems(MNSSs)with random sensor delays(RSDs).The phenomenon of the RSDs is modeled by a set of random variables with certain statistical features.In addition,the nonlinear function is handled via Taylor expansion in order to deal with the nonlinear fusion filtering problem.The aim of the addressed issue is to propose a DRFF scheme for MNSSs such that,for both RSDs and estimator gain perturbations,certain upper bounds of estimation error covariance(EEC)are given and locally minimized at every sample time.In the light of the obtained local filters,a new DRFF algorithm is developed via the matrix-weighted fusion method.Furthermore,a sufficient condition is presented,which can guarantee that the local upper bound of the EEC is bounded.Finally,a numerical example is provided,which can show the usefulness of the developed DRFF approach.
基金This work is partially funded by FCT/MCTES through national funds and,when applicable,co-funded EU funds under the Project UIDB/50008/2020Ministry of Science and Higher Education of the Russian Federation,Grant 08-08by the Brazilian National Council for Scientific and Technological Development-CNPq,via Grant No.313036/2020-9.
文摘Forested areas are extremely vulnerable to disasters leading to environmental destruction.Forest Fire is one among them which requires immediate attention.There are lot of works done by authors where Wireless Sensors and IoT have been used for forest fire monitoring.So,towards monitoring the forest fire and managing the energy efficiently in IoT,Energy Efficient Routing Protocol for Low power lossy networks(E-RPL)was developed.There were challenges about the scalability of the network resulting in a large end-to-end delay and less packet delivery which led to the development of Aggregator-based Energy Efficient RPL with Data Compression(CAAERPL).Though CAA-ERPL proved effective in terms of reduced packet delivery,less energy consumption,and increased packet delivery ratio for varying number of nodes,there is still challenge in the selection of aggregator which is based purely on probability percentage of nodes.There has been research work where fuzzy logic been employed for Mobile Ad-hoc Routing,RPL routing and cluster head selection in Wireless Sensor.There has been no work where fuzzy logic is employed for aggregator selection in Energy Efficient RPL.So accordingly,we here have proposed Fuzzy Based Aggregator selection in Energy-efficient RPL for region thereby forming DODAG for communicating to Fog/Edge.We here have developed fuzzy inference rules for selecting the aggregator based on strength which takes residual power,Node degree,and Expected Transmission Count(ETX)as input metrics.The Fuzzy Aggregator Energy Efficient RPL(FA-ERPL)based on fuzzy inference rules were analysed against E-RPL in terms of scalability(First and Half Node die),Energy Consumption,and aggregator node energy deviation.From the analysis,it was found that FA-ERPL performed better than E-RPL.These were simulated using MATLAB and results.
文摘Genetic algorithm (GA) is one of the alternative approaches for solving the shortest path routing problem. In previous work, we have developed a coarse-grained parallel GA-based shortest path routing algorithm. With parallel GA, there is a GA operator called migration, where a chromosome is taken from one sub-population to replace a chromosome in another sub-population. Which chromosome to be taken and replaced is subjected to the migration strategy used. There are four different migration strategies that can be employed: best replace worst, best replace random, random replace worst, and random replace random. In this paper, we are going to evaluate the effect of different migration strategies on the parallel GA-based routing algorithm that has been developed in the previous work. Theoretically, the migration strategy best replace worst should perform better than the other strategies. However, result from simulation shows that even though the migration strategy best replace worst performs better most of the time, there are situations when one of the other strategies can perform just as well, or sometimes better.
