Si-based multilayer structures are widely used in current microelectronics. During their preparation, some inhomogeneous residual stress is induced, resulting in competition between interface mismatching and surface e...Si-based multilayer structures are widely used in current microelectronics. During their preparation, some inhomogeneous residual stress is induced, resulting in competition between interface mismatching and surface energy and even leading to structure failure. This work presents a methodological study on the measurement of residual stress in a multi-layer semiconductor heterostructure. Scanning electron microscopy（SEM）, micro-Raman spectroscopy（MRS）, and transmission electron microscopy（TEM） were applied to measure the geometric parameters of the multilayer structure. The relationship between the Raman spectrum and the stress/strain on the [100] and [110] crystal orientations was determined to enable surface and crosssection residual stress analyses, respectively. Based on the Raman mapping results, the distribution of residual stress along the depth of the multi-layer heterostructure was successfully obtained.展开更多
Rechargeable aqueous Zn-ion batteries(AZIBs)are one of the most promising energy storage devices for large-scale energy storage owing to their high specific capacity,eco-friendliness,low cost and high safety.Neverthel...Rechargeable aqueous Zn-ion batteries(AZIBs)are one of the most promising energy storage devices for large-scale energy storage owing to their high specific capacity,eco-friendliness,low cost and high safety.Nevertheless,zinc metal anodes suffer from severe dendrite growth and side reactions,resulting in the inferior electrochemical performance of AZIBs.To address these problems,surface modification of zinc metal anodes is a facile and effective method to regulate the interaction between the zinc anode and an electrolyte.In this review,the current challenges and strategies for zinc metal anodes are presented.Furthermore,recent advances in surface modification strategies to improve their electrochemical performance are concluded and discussed.Finally,challenges and prospects for future development of zinc metal anodes are proposed.We hope this review will be useful for designing and fabricating highperformance AZIBs and boosting their practical applications.展开更多
A JERF36 regulation gene, a selection marker gene (NPT-II), and the foreign genes levansucrase (SacB), Vitreoscilla hemoglobin (vgb), and Binary coleopterus insect resistance (BtCry3A+OC-I) were co-transferred into Po...A JERF36 regulation gene, a selection marker gene (NPT-II), and the foreign genes levansucrase (SacB), Vitreoscilla hemoglobin (vgb), and Binary coleopterus insect resistance (BtCry3A+OC-I) were co-transferred into Populus xeuramericana 'Guariento' using biolistic bombardment; 25 kanamycin resistant plants were obtained. The results of PCR and Southern hybridization showed that the foreign genes had been integrated into the genome of P. xeuramericana 'Guariento' and 5 genes were all transferred into 7 poplar plants. The results of a BtCry3A ELISA experiment indicated that the BtCry3A gene was expressed in the 7 transgenic poplar plants, and these plants grew well on coastal saline land.展开更多
Soil degradation,characterized by declines in nutrient status and simultaneous accumulation of pesticide residues,is a major problem affecting agricultural ecosystems.Previous studies indicate that biochar application...Soil degradation,characterized by declines in nutrient status and simultaneous accumulation of pesticide residues,is a major problem affecting agricultural ecosystems.Previous studies indicate that biochar application to soil has promise as a practical method to alleviate these pressures:increasing crop yield and enhancing pesticide degradation.Here,we review the roles of biochar in both chemical and biological promotion of pesticide degradation and the potential benefits of biochar relating to the efficiency of fertilizer use,availability of nutrients,and nutrient exchange.Biochar typically has a high surface area featuring many functional groups,a high cation exchange capacity,and high stability.Major factors that impact on the nutrient retention characteristics of biochar(e.g.,feedstock,pyrolysis temperature,and application rate) are also discussed herein.Nonetheless,more studies of the long-term impacts on soil properties from biochar addition are still required before it can be possible to accurately quantify the sustainability of this approach to sequester carbon and restore soil function.展开更多
Background:Schistosomiasis is a water-borne disease caused by trematode worms belonging to genus Schistosoma,which is prevalent most of the developing world.Transmission of the disease is usually associated with multi...Background:Schistosomiasis is a water-borne disease caused by trematode worms belonging to genus Schistosoma,which is prevalent most of the developing world.Transmission of the disease is usually associated with multiple biological characteristics and social factors but also factors can play a role.Few studies have assessed the exact and interactive influence of each factor promoting schistosomiasis transmission.Methods:We used a series of different detectors(i.e.,specific detector,risk detector,ecological detector and interaction detector)to evaluate separate and interactive effects of the environmental factors on schistosomiasis prevalence.Specifically,(i)specific detector quantifies the impact of a risk factor on an observed spatial disease pattern,which were ranked statistically by a value of Power of Determinate(PD)calculation;(ii)risk detector detects high risk areas of a disease on the condition that the study area is stratified by a potential risk factor;(iii)ecological detector explores whether a risk factor is more significant than another in controlling the spatial pattern of a disease;(iv)interaction detector probes whether two risk factors when taken together weaken or enhance one another,or whether they are independent in developing a disease.Infection data of schistosomiasis based on conventional surveys were obtained at the county level from the health authorities in Anhui Province,China and used in combination with information from Chinese weather stations and internationally available environmental data.Results:The specific detector identified various factors of potential importance as follows:Proximity to Yangtze River(0.322)>Land cover(0.285)>sunshine hours(0.256)>population density(0.109)>altitude(0.090)>the normalized different vegetation index(NDVI)(0.077)>land surface temperature at daytime(LST_(day))(0.007).The risk detector indicated that areas of schistosomiasis high risk were located within a buffer distance of 50 km from Yangtze River.The ecological detector disclosed that the factors展开更多
In assessing an insect-resistant genetically engineered （IRGE） crop before its commercialization, researchers normally use so-called ＂Tier-1 assays＂ as the initial step to determine the effects of the crop on non-...In assessing an insect-resistant genetically engineered （IRGE） crop before its commercialization, researchers normally use so-called ＂Tier-1 assays＂ as the initial step to determine the effects of the crop on non-target organisms. In these tests, the insecticidal proteins （IPs） produced by the IRGEs are added to the diets of test organisms in the laboratory. Test organisms in such assays can be directly exposed to much higher concentrations of the test IPs than they would encounter in the field. The results of Tier-1 assays are thus more conservative than those generated in studies in which the organisms are exposed to the IPs by feeding on IRGE plant tissue or in the case of predators or parasites, by feeding on invertebrate prey or hosts that have fed on IRGE plant tissue. In this report, we consider three important factors that must be considered in Tier-1 assays： （i） methods for delivery of the IP to the test organisms; （ii） the need for and selection of compounds used as positive controls; and （iii） methods for monitoring the concentration, stability and bioactivity of the IP during the assay. We also analyze the existing data from Tier-1 assays regarding the toxicity of Bt Cry proteins to non-target arthropod species. The data indicate that the widely used Bt proteins have no direct toxicity to non-target organisms展开更多
Polycystic ovary syndrome(PCOS)is a complex disorder.Genome-wide association studies(GWAS)have identified several genes associated with this condition,including DENND1A.DENND1A encodes a clathrin-binding protein that ...Polycystic ovary syndrome(PCOS)is a complex disorder.Genome-wide association studies(GWAS)have identified several genes associated with this condition,including DENND1A.DENND1A encodes a clathrin-binding protein that functions as a guanine nucleotide exchange factor involved in vesicular transport.However,the specific role of DENND1A in reproductive hormone abnormalities and follicle development disorders in PCOS remain poorly understood.In this study,we investigated DENND1A expression in ovarian granulosa cells(GCs)from PCOS patients and its correlation with hormones.Our results revealed an upregulation of DENND1A expression in GCs from PCOS cases,which was positively correlated with testosterone levels.To further explore the functional implications of DENND1A,we generated a transgenic mouse model overexpressing Dennd1a(TG mice).These TG mice exhibited subfertility,irregular estrous cycles,and increased testosterone production following PMSG stimulation.Additionally,the TG mice displayed diminished responsiveness to FSH,characterized by smaller ovary size,less well-developed follicles,and abnormal expressions of FSH-priming genes.Mechanistically,we found that Dennd1a overexpression disrupted the intracellular trafficking of follicle stimulating hormone receptor(FSHR),promoting its internalization and inhibiting recycling.These findings shed light on the reproductive role of DENND1A and uncover the underlying mechanisms,thereby contributing valuable insights into the pathogenesis of PCOS and providing potential avenues for drug design in PCOS treatment.展开更多
Obesity,which can arise from genetic or environmental factors,has been shown to cause serious damages to the reproductive system.The ovary,as one of the primary regulators of female fertility,is a complex organ compri...Obesity,which can arise from genetic or environmental factors,has been shown to cause serious damages to the reproductive system.The ovary,as one of the primary regulators of female fertility,is a complex organ comprised of heterogeneous cell types that work together to maintain a normal ovarian microenvironment(OME).Despite its importance,the effect of obesity on the entire ovary remains poorly documented.In this study,we performed ovary single-cell and nanoscale spatial RNA sequencing to investigate how the OME changed under different kinds of obesity,including high-fat diet(HFD)induced obesity and Leptin ablation induced obesity(OB).Our results demonstrate that OB,but not HFD,dramatically altered the proportion of ovarian granulosa cells,theca-interstitial cells,luteal cells,and endothelial cells.Furthermore,based on the spatial dynamics of follicular development,we defined four subpopulations of granulosa cell and found that obesity drastically disrupted the differentiation of mural granulosa cells from small to large antral follicles.Functionally,HFD enhanced follicle-stimulating hormone(FSH)sensitivity and hormone conversion,while OB caused decreased sensitivity,inadequate steroid hormone conversion,and impaired follicular development.These differences can be explained by the differential expression pattern of the transcription factor Foxo1.Overall,our study provides a powerful and high-resolution resource for profiling obesity-induced OME and offers insights into the diverse effects of obesity on female reproductive disorders.展开更多
With the ever-increasing diversification of people’s interests and preferences,artwork has become one of the most popular commodities or investment goods in E-commerce,and it increasingly attracts the attention of th...With the ever-increasing diversification of people’s interests and preferences,artwork has become one of the most popular commodities or investment goods in E-commerce,and it increasingly attracts the attention of the public.Currently,many real-world or virtual artworks can be found in E-commerce,and finding a means to recommend them to appropriate users has become a significant task to alleviate the heavy burden on artwork selection decisions by users.Existing research mainly studies the problem of single-artwork recommendation while neglecting the more practical but more complex composite recommendation of artworks in E-commerce,which considerably influences the quality of experience of potential users,especially when they need to select a set of artworks instead of a single artwork.Inspired by this limitation,we put forward a novel composite recommendation approach to artworks by a user keyword-driven correlation graph search named ART_(com-rec).Through ART_(com-rec),the recommender system can output a set of artworks(e.g.,an artwork composite solution)in E-commerce by considering the keywords typed by a user to indicate his or her personalized preferences.Finally,we validate the feasibility of the ART_(com-rec) approach by a set of simulated experiments on a real-world PW dataset.展开更多
From the case study of Evening Bell Ringing at Nanping Hill,one of the West Lake Cultural Landscapes in Hangzhou,China,we investigated the soundscape of a scenic area with a profound cultural background.First,we condu...From the case study of Evening Bell Ringing at Nanping Hill,one of the West Lake Cultural Landscapes in Hangzhou,China,we investigated the soundscape of a scenic area with a profound cultural background.First,we conducted the soundscape physical index of the area in both winter and spring seasons to analyze its objective graphical expression.Second,we focused on people's reactions to the soundscape in order to obtain a subjective evaluation of each component in the soundscape and integrated environment.Then,the relationship between the objective data and the subjective evaluation was analyzed.Finally,the impacts of the natural environment,history,and cultural factors on the evaluation of the Jingci Temple soundscape were studied.It was found that natural sounds,cultural sounds,and historic sounds were widely acclaimed in people's subjective feelings,which indicated the close relationships among historical and cultural background,soundscape,and natural environment.Thus,the conclusion was made that soundscape should be consistent with the local natural environment and the historical and cultural background.展开更多
With the acceleration of urbanization,changes in the urban ecological environment and landscape pattern have led to a series of prominent ecological environmental problems.In order to better coordinate the balanced re...With the acceleration of urbanization,changes in the urban ecological environment and landscape pattern have led to a series of prominent ecological environmental problems.In order to better coordinate the balanced relationship between city and ecological environment,we selected land use change data to evaluate the habitat quality in Hohhot City of China,which is of great practical significance for regional urban and economic development.Thus,the integrated valuation of ecosystem services and tradeoffs(InVEST)and Cellular Automata-Markov(CA-Markov)models were used to analyze,predict,and explore the Spatiotemporal evolution path and characteristics of urban land use,and forecast the typical evolution pattern of land use in 2030.The results showed that the land use types in Hohhot City changed significantly from 2000 to 2020,and the biggest change took place in cultivated land,grassland,shrub,and artificial surface.The decrease of cultivated land area and the increase of artificial surface area were the main impact trend of land use change.The average value of habitat quality had been decreasing continuously from 2000 to 2020,and the values of habitat degradation were 0.2605,0.2494,and 0.2934 in 2000,2010,and 2020,respectively,showing a decreasing trend.The decrease of habitat quality was caused by the needs of economic development and urban construction,as well as the impact of land occupation.During this evolution,many cultivated land and urban grassland had been converted into construction land.The simulated land use changes in 2030 are basically the same as those during 2000-2020,and the habitat quality will still be declining.The regional changes are influenced by the urban rapid development and industrial layout.These results can provide decision-making reference for regional urban planning and management as well as habitat quality evaluation.展开更多
The components of the rock, the pigments, the gold foils and the adhesive of One Thousand Hand Buddha in Dazu stone sculptures, Chongqing, China, have been analyzed by X-ray diffraction (XRD), X-ray fluorescence (XRF)...The components of the rock, the pigments, the gold foils and the adhesive of One Thousand Hand Buddha in Dazu stone sculptures, Chongqing, China, have been analyzed by X-ray diffraction (XRD), X-ray fluorescence (XRF), infrared spectroscopy (IR), energy dispersive X-ray analysis (EDX) and fiber optics reflectance spectros-copy (FORS). Furthermore, the weathering and degeneration of One Thousand Hand Buddha have been discussed and the protective methods have been provided. In this work some useful information to study on conservation of stone relics is given.展开更多
Objective:This study protocol identifies the basic research route and framework of psychological and behavioral surveys among Chinese residents,aims establishing a database through a multicenter,large-sample cross-sec...Objective:This study protocol identifies the basic research route and framework of psychological and behavioral surveys among Chinese residents,aims establishing a database through a multicenter,large-sample cross-sectional survey in China to provide strong data support for research development in various fields and a more comprehensive and systematic understanding of the physical and mental health status of the public.Method:The study was conducted from June 20,2022 to August 31,2022,using stratified sampling and quota sampling methods,a total of 148 cities,202 districts and counties,390 townships/towns/sub-districts,and 780 communities/villages(excluding Hong Kong,Macao,and Taiwan)from 23 provinces,5 autonomous regions,and 4 municipalities directly under the central government in China were selected.The questionnaire was distributed one-on-one and face-to-face to the public by trained investigators,and the questionnaire included eight aspects:personal basic information,personal health status,family basic information,social environment in which they were located,psychological level scale,behavioral level scale,other scales,and attitude towards social hot issues.Data analysis will be performed after questionnaire return.Results:Data collection is ongoing.These findings will support physical and mental health research and strategy development in China and even globally,guiding policy-makers and health care organizations to reform their programs to ensure the best interests of residents and their families.展开更多
Here,we report the production of 3D-printed MoS_(2)/Ni electrodes(3D-MoS_(2)/Ni)with longterm stability and excellent performance by the selective laser melting(SLM)technique.As a cathode,the obtained 3D-MoS_(2)/Ni co...Here,we report the production of 3D-printed MoS_(2)/Ni electrodes(3D-MoS_(2)/Ni)with longterm stability and excellent performance by the selective laser melting(SLM)technique.As a cathode,the obtained 3D-MoS_(2)/Ni could maintain a degradation rate above 94.0%for forfenicol(FLO)when repeatedly used 50 times in water.We also found that the removal rate of FLO by 3D-MoS_(2)/Ni was about 12 times higher than that of 3D-printed pure Ni(3D-Ni),attributed to the improved accessibility of H^(*).In addition,the electrochemical characterization results showed that the electrochemically active surface area of the 3D-MoS_(2)/Ni electrode is about 3-fold higher than that of the 3D-Ni electrode while the electrical resistance is 4 times lower.Based on tert-butanol suppression,electron paramagnetic resonance and triple quadrupole mass spectrometer experiments,a“dual path”mechanism and possible degradation pathway for the dechlorination of FLO by 3D-MoS_(2)/Ni were proposed.Furthermore,we also investigated the impacts of the cathode potential and the initial pH of the solution on the degradation of FLO.Overall,this study reveals that the SLM 3D printing technique is a promising approach for the rapid fabrication of high-stability metal electrodes,which could have broad application in the control of water contaminants in the environmental field.展开更多
In this study,we aimed to assess the effect of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection on semenparameters.The study comprised 110 sperm volunteers who self-reported SARS-CoV-2 infection fr...In this study,we aimed to assess the effect of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection on semenparameters.The study comprised 110 sperm volunteers who self-reported SARS-CoV-2 infection from the Human Sperm Bank ofthe Center for Reproductive Medicine,Shandong University(Jinan,China).The volunteers had normal sperm concentration beforeinfection.Each volunteer provided semen samples before and after infection.We selected 90 days after infection as the cutoff point.Semen parameters within 90 days after infection of 109 volunteers(group A)were compared with semen parameters before infection.Moreover,semen parameters on or after 90 days after infection of 36 volunteers(group B)were compared with semen parameters beforeinfection.Furthermore,based on whether the volunteers had completed the three-dose SARS-CoV-2 vaccination booster,volunteersin group A and B were further divided into two subgroups separately.Semen parameters were compared before and after infection ineach subgroup.Our results showed that in this cohort population,the semen quality in volunteers with normal sperm concentrationsbefore infection decreased after SARS-CoV-2 infection within 90 days,while the semen quality returned to preinfection levels after 90days.The completion of a three-dose SARS-CoV-2 vaccination booster may exert a protective effect on semen quality after infection.展开更多
Drought is a worldwide natural disaster that has long affected agricultural production as well as social and economic activities. Frequent droughts have been observed in the Belt and Road area, in which much of the ag...Drought is a worldwide natural disaster that has long affected agricultural production as well as social and economic activities. Frequent droughts have been observed in the Belt and Road area, in which much of the agricultural land is concentrated in fragile ecological environment. Based on the Tropical Rainfall Measuring Mission Satellite（TRMM） 3 B43 precipitation data, we used the Precipitation Abnormity Percentage drought model to study the monthly spatio-temporal distribution of drought in south region of N50° of the Belt and Road area. It was observed that drought during winter was mainly distributed in Northeast Asia, Southeast Asia, and South Asia, while it was mainly distributed in Central Asia and West Asia during summer. The occurrence of historical droughts indicates an obvious seasonal cycle. The regional variations in drought were analyzed using the Breaks for Additive Season and Trend tool（BFAST） in six sub-regions according to the spatial distribution of six economic corridors in the Belt and Road area. The average drought conditions over the 18 years show a slight decreasing trend in Northeast Asia, West Asia, North Africa, South Asia, Central and Eastern Europe, and a slight increasing trend in Central Asia. However, it was a fluctuating pattern of first increasing and then decreasing in Southeast Asia. The results indicate that the total drought area in the Belt and Road region showed a general decreasing trend at a rate of 40,260 km^2 per year from 1998 to 2015.展开更多
The modern architectural heritage is the core carrier of city’s historical inheritance and vitality.Its value is related to the spatial and temporal evolution of the urban landscape,along with the collective memory o...The modern architectural heritage is the core carrier of city’s historical inheritance and vitality.Its value is related to the spatial and temporal evolution of the urban landscape,along with the collective memory of society and transformation in public life.The contradiction between high-speed urban construction and architectural heritage preservation has proliferated,and the problems of loss of heritage culture and fading of relics are very significant,but there is a lack of research on modern architectural heritage.This study analysed indepth the artistic archetypes and evolutionary characteristics of the architecture of Zhongshan Park in Xiamen through field research and historical data collation,adopting the theory method of architectural typology.Afterwards,we analysed the architectural typology of Zhongshan Park in Xiamen and the process of acculturation and translation with foreign cultures,explored the motives of its formation and the cultural meanings of the public space embodied in it.Based on this,we proposed a sustainable development heritage approach for the modern architectural heritage of Zhongshan Park in Xiamen.Our results indicate that modern architectural art has inherited classical Chinese historical and cultural traditions and ideological foundations.Its unique characteristics reflect the spirit of the times and result from the gradual development of Western influence.Moreover,it embodies a strong sense of national identity.These findings enrich the academic research on the cultural interaction between Chinese and Western architecture,offering valuable insights for the conservation and living heritage of modern architectural heritage in other regions.展开更多
Outdoor building stones are suffering from serious degradation.To restore internal cohesion and to alleviate the disintegration of decayed stones,consolidation treatment is necessary and significant.Up to date,no full...Outdoor building stones are suffering from serious degradation.To restore internal cohesion and to alleviate the disintegration of decayed stones,consolidation treatment is necessary and significant.Up to date,no fully satisfactory consolidation agent and its application methodology are available,mainly due to the limited penetration depth of consolidants,low compatibility,or poor durability in environmental conditions.Herein,in this study,aiming to design an effective and enduring method for the consolidation of highly porous calcareous stones,nanosilica-based consolidation treatments were tested and compared with traditional compounds(tetraethoxysilane,alkylalkoxysilane,barium hydroxide).In order to evaluate their performance and compatibility,a series of standard tests,including the Drilling Resistance Measurement System(DRMS)test,surface color measurement,vapor diffusivity measurement,and peeling test,were carried out.Besides,the penetration depth and distribution profiles of consolidants were estimated by exploiting elemental raster scanning of SEM-EDS analysis performed throughout the thickness of samples.More importantly,by employing a climatic chamber,the artificial ageing test was also conducted by simulating harsh atmospheric conditions.After accelerated ageing,the performance of all consolidants was assessed again.Results demonstrated that the application of nanosilica(<10 nm in dimension)by cellulose poultice,followed by adding tetraethoxysilane with the classical method“wet on wet”,is the best consolidation approach,in terms of in-depth consolidation efficacy,compatibility with the stone substrate,surface cohesion strength and performance durability in environmental conditions.Moreover,the treated surface is not hydrophobic,which allows further grouting and adhesion operations usually required for the restoration of historic buildings.展开更多
Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARSCo V-2)infection has swept the globe for 3 years(Zhou et al.,2020).With the nationwide relaxation of controls on the coronavirus disease 2019(COVID-19)ep...Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARSCo V-2)infection has swept the globe for 3 years(Zhou et al.,2020).With the nationwide relaxation of controls on the coronavirus disease 2019(COVID-19)epidemic since December 2022 in China,fertility and in vitro fertilization(IVF)centers are receiving increasing numbers of infected patients.展开更多
基金supported by the National Basic Research Program of China (Grant 2012CB937500)the National Natural Science Foundation of China (Grants 11422219, 11227202, 11372217, 11272232)+1 种基金the Program for New Century Excellent Talents in University (Grant NCET-13)China Scholarship Council (201308120092)
文摘Si-based multilayer structures are widely used in current microelectronics. During their preparation, some inhomogeneous residual stress is induced, resulting in competition between interface mismatching and surface energy and even leading to structure failure. This work presents a methodological study on the measurement of residual stress in a multi-layer semiconductor heterostructure. Scanning electron microscopy（SEM）, micro-Raman spectroscopy（MRS）, and transmission electron microscopy（TEM） were applied to measure the geometric parameters of the multilayer structure. The relationship between the Raman spectrum and the stress/strain on the [100] and [110] crystal orientations was determined to enable surface and crosssection residual stress analyses, respectively. Based on the Raman mapping results, the distribution of residual stress along the depth of the multi-layer heterostructure was successfully obtained.
基金supported by the National Key Research and Development Program of China(2020YFB1713500)the Chinese 02 Special Fund(2017ZX02408003)+2 种基金the Open Fund of National Joint Engineering Research Center for abrasion control and molding of metal materials(HKDNM201807)the Student Research Training Plan of Henan University of Science and Technology(2020026)the National Undergraduate Innovation and Entrepreneurship Training Program(202010464031,202110464005)。
文摘Rechargeable aqueous Zn-ion batteries(AZIBs)are one of the most promising energy storage devices for large-scale energy storage owing to their high specific capacity,eco-friendliness,low cost and high safety.Nevertheless,zinc metal anodes suffer from severe dendrite growth and side reactions,resulting in the inferior electrochemical performance of AZIBs.To address these problems,surface modification of zinc metal anodes is a facile and effective method to regulate the interaction between the zinc anode and an electrolyte.In this review,the current challenges and strategies for zinc metal anodes are presented.Furthermore,recent advances in surface modification strategies to improve their electrochemical performance are concluded and discussed.Finally,challenges and prospects for future development of zinc metal anodes are proposed.We hope this review will be useful for designing and fabricating highperformance AZIBs and boosting their practical applications.
文摘A JERF36 regulation gene, a selection marker gene (NPT-II), and the foreign genes levansucrase (SacB), Vitreoscilla hemoglobin (vgb), and Binary coleopterus insect resistance (BtCry3A+OC-I) were co-transferred into Populus xeuramericana 'Guariento' using biolistic bombardment; 25 kanamycin resistant plants were obtained. The results of PCR and Southern hybridization showed that the foreign genes had been integrated into the genome of P. xeuramericana 'Guariento' and 5 genes were all transferred into 7 poplar plants. The results of a BtCry3A ELISA experiment indicated that the BtCry3A gene was expressed in the 7 transgenic poplar plants, and these plants grew well on coastal saline land.
基金financially supported by the National Natural Science Foundation and Innovation Group of China(Nos.41271332 and 51521006)
文摘Soil degradation,characterized by declines in nutrient status and simultaneous accumulation of pesticide residues,is a major problem affecting agricultural ecosystems.Previous studies indicate that biochar application to soil has promise as a practical method to alleviate these pressures:increasing crop yield and enhancing pesticide degradation.Here,we review the roles of biochar in both chemical and biological promotion of pesticide degradation and the potential benefits of biochar relating to the efficiency of fertilizer use,availability of nutrients,and nutrient exchange.Biochar typically has a high surface area featuring many functional groups,a high cation exchange capacity,and high stability.Major factors that impact on the nutrient retention characteristics of biochar(e.g.,feedstock,pyrolysis temperature,and application rate) are also discussed herein.Nonetheless,more studies of the long-term impacts on soil properties from biochar addition are still required before it can be possible to accurately quantify the sustainability of this approach to sequester carbon and restore soil function.
基金This research was supported by the National Natural Science Foundation of China(81673239)the National Science Fund for Distinguished Young Scholars(No.81325017)+1 种基金Chang Jiang Scholars Program(No.T2014089)the Fourth Round of Three-Year Public Health Action Plan of Shanghai,China(15GWZK0202,15GWZK0101).
文摘Background:Schistosomiasis is a water-borne disease caused by trematode worms belonging to genus Schistosoma,which is prevalent most of the developing world.Transmission of the disease is usually associated with multiple biological characteristics and social factors but also factors can play a role.Few studies have assessed the exact and interactive influence of each factor promoting schistosomiasis transmission.Methods:We used a series of different detectors(i.e.,specific detector,risk detector,ecological detector and interaction detector)to evaluate separate and interactive effects of the environmental factors on schistosomiasis prevalence.Specifically,(i)specific detector quantifies the impact of a risk factor on an observed spatial disease pattern,which were ranked statistically by a value of Power of Determinate(PD)calculation;(ii)risk detector detects high risk areas of a disease on the condition that the study area is stratified by a potential risk factor;(iii)ecological detector explores whether a risk factor is more significant than another in controlling the spatial pattern of a disease;(iv)interaction detector probes whether two risk factors when taken together weaken or enhance one another,or whether they are independent in developing a disease.Infection data of schistosomiasis based on conventional surveys were obtained at the county level from the health authorities in Anhui Province,China and used in combination with information from Chinese weather stations and internationally available environmental data.Results:The specific detector identified various factors of potential importance as follows:Proximity to Yangtze River(0.322)>Land cover(0.285)>sunshine hours(0.256)>population density(0.109)>altitude(0.090)>the normalized different vegetation index(NDVI)(0.077)>land surface temperature at daytime(LST_(day))(0.007).The risk detector indicated that areas of schistosomiasis high risk were located within a buffer distance of 50 km from Yangtze River.The ecological detector disclosed that the factors
文摘In assessing an insect-resistant genetically engineered （IRGE） crop before its commercialization, researchers normally use so-called ＂Tier-1 assays＂ as the initial step to determine the effects of the crop on non-target organisms. In these tests, the insecticidal proteins （IPs） produced by the IRGEs are added to the diets of test organisms in the laboratory. Test organisms in such assays can be directly exposed to much higher concentrations of the test IPs than they would encounter in the field. The results of Tier-1 assays are thus more conservative than those generated in studies in which the organisms are exposed to the IPs by feeding on IRGE plant tissue or in the case of predators or parasites, by feeding on invertebrate prey or hosts that have fed on IRGE plant tissue. In this report, we consider three important factors that must be considered in Tier-1 assays： （i） methods for delivery of the IP to the test organisms; （ii） the need for and selection of compounds used as positive controls; and （iii） methods for monitoring the concentration, stability and bioactivity of the IP during the assay. We also analyze the existing data from Tier-1 assays regarding the toxicity of Bt Cry proteins to non-target arthropod species. The data indicate that the widely used Bt proteins have no direct toxicity to non-target organisms
基金supported by the National Key Research and Development Program of China(2021YFC2700400)the Basic Science Center Program(31988101)+2 种基金the National Natural Science Foundation of China(82071606,31871509,82201800,82071610)the Shandong Provincial Key Research and Development Program(2020ZLYS02)Ferring Institute of Reproductive Medicine(FIRMA180310).
文摘Polycystic ovary syndrome(PCOS)is a complex disorder.Genome-wide association studies(GWAS)have identified several genes associated with this condition,including DENND1A.DENND1A encodes a clathrin-binding protein that functions as a guanine nucleotide exchange factor involved in vesicular transport.However,the specific role of DENND1A in reproductive hormone abnormalities and follicle development disorders in PCOS remain poorly understood.In this study,we investigated DENND1A expression in ovarian granulosa cells(GCs)from PCOS patients and its correlation with hormones.Our results revealed an upregulation of DENND1A expression in GCs from PCOS cases,which was positively correlated with testosterone levels.To further explore the functional implications of DENND1A,we generated a transgenic mouse model overexpressing Dennd1a(TG mice).These TG mice exhibited subfertility,irregular estrous cycles,and increased testosterone production following PMSG stimulation.Additionally,the TG mice displayed diminished responsiveness to FSH,characterized by smaller ovary size,less well-developed follicles,and abnormal expressions of FSH-priming genes.Mechanistically,we found that Dennd1a overexpression disrupted the intracellular trafficking of follicle stimulating hormone receptor(FSHR),promoting its internalization and inhibiting recycling.These findings shed light on the reproductive role of DENND1A and uncover the underlying mechanisms,thereby contributing valuable insights into the pathogenesis of PCOS and providing potential avenues for drug design in PCOS treatment.
基金This work was supported by the National Key Research and Development Program of China(2021YFC2700400,2018YFC1004303)the National Natural Science Foundation of China(31988101,82201798,82192874,82071606,82101707)+3 种基金CAMS Innovation Fund for Medical Sciences(2021-I2M-5-001)Shandong Provincial Key Research and Development Program(2020ZLYS02)the Taishan Scholars Program of Shandong Province(ts20190988)the Fundamental Research Funds of Shandong University.
文摘Obesity,which can arise from genetic or environmental factors,has been shown to cause serious damages to the reproductive system.The ovary,as one of the primary regulators of female fertility,is a complex organ comprised of heterogeneous cell types that work together to maintain a normal ovarian microenvironment(OME).Despite its importance,the effect of obesity on the entire ovary remains poorly documented.In this study,we performed ovary single-cell and nanoscale spatial RNA sequencing to investigate how the OME changed under different kinds of obesity,including high-fat diet(HFD)induced obesity and Leptin ablation induced obesity(OB).Our results demonstrate that OB,but not HFD,dramatically altered the proportion of ovarian granulosa cells,theca-interstitial cells,luteal cells,and endothelial cells.Furthermore,based on the spatial dynamics of follicular development,we defined four subpopulations of granulosa cell and found that obesity drastically disrupted the differentiation of mural granulosa cells from small to large antral follicles.Functionally,HFD enhanced follicle-stimulating hormone(FSH)sensitivity and hormone conversion,while OB caused decreased sensitivity,inadequate steroid hormone conversion,and impaired follicular development.These differences can be explained by the differential expression pattern of the transcription factor Foxo1.Overall,our study provides a powerful and high-resolution resource for profiling obesity-induced OME and offers insights into the diverse effects of obesity on female reproductive disorders.
文摘With the ever-increasing diversification of people’s interests and preferences,artwork has become one of the most popular commodities or investment goods in E-commerce,and it increasingly attracts the attention of the public.Currently,many real-world or virtual artworks can be found in E-commerce,and finding a means to recommend them to appropriate users has become a significant task to alleviate the heavy burden on artwork selection decisions by users.Existing research mainly studies the problem of single-artwork recommendation while neglecting the more practical but more complex composite recommendation of artworks in E-commerce,which considerably influences the quality of experience of potential users,especially when they need to select a set of artworks instead of a single artwork.Inspired by this limitation,we put forward a novel composite recommendation approach to artworks by a user keyword-driven correlation graph search named ART_(com-rec).Through ART_(com-rec),the recommender system can output a set of artworks(e.g.,an artwork composite solution)in E-commerce by considering the keywords typed by a user to indicate his or her personalized preferences.Finally,we validate the feasibility of the ART_(com-rec) approach by a set of simulated experiments on a real-world PW dataset.
基金Project supported by the National Natural Science Foundation of China (No. 51078325)the State Key Lab of Subtropical Building Science,South China University of Technology,China
文摘From the case study of Evening Bell Ringing at Nanping Hill,one of the West Lake Cultural Landscapes in Hangzhou,China,we investigated the soundscape of a scenic area with a profound cultural background.First,we conducted the soundscape physical index of the area in both winter and spring seasons to analyze its objective graphical expression.Second,we focused on people's reactions to the soundscape in order to obtain a subjective evaluation of each component in the soundscape and integrated environment.Then,the relationship between the objective data and the subjective evaluation was analyzed.Finally,the impacts of the natural environment,history,and cultural factors on the evaluation of the Jingci Temple soundscape were studied.It was found that natural sounds,cultural sounds,and historic sounds were widely acclaimed in people's subjective feelings,which indicated the close relationships among historical and cultural background,soundscape,and natural environment.Thus,the conclusion was made that soundscape should be consistent with the local natural environment and the historical and cultural background.
基金The authors thank anonymous reviewers and editors for their helpful comments on improving the quality of this manuscript.
文摘With the acceleration of urbanization,changes in the urban ecological environment and landscape pattern have led to a series of prominent ecological environmental problems.In order to better coordinate the balanced relationship between city and ecological environment,we selected land use change data to evaluate the habitat quality in Hohhot City of China,which is of great practical significance for regional urban and economic development.Thus,the integrated valuation of ecosystem services and tradeoffs(InVEST)and Cellular Automata-Markov(CA-Markov)models were used to analyze,predict,and explore the Spatiotemporal evolution path and characteristics of urban land use,and forecast the typical evolution pattern of land use in 2030.The results showed that the land use types in Hohhot City changed significantly from 2000 to 2020,and the biggest change took place in cultivated land,grassland,shrub,and artificial surface.The decrease of cultivated land area and the increase of artificial surface area were the main impact trend of land use change.The average value of habitat quality had been decreasing continuously from 2000 to 2020,and the values of habitat degradation were 0.2605,0.2494,and 0.2934 in 2000,2010,and 2020,respectively,showing a decreasing trend.The decrease of habitat quality was caused by the needs of economic development and urban construction,as well as the impact of land occupation.During this evolution,many cultivated land and urban grassland had been converted into construction land.The simulated land use changes in 2030 are basically the same as those during 2000-2020,and the habitat quality will still be declining.The regional changes are influenced by the urban rapid development and industrial layout.These results can provide decision-making reference for regional urban planning and management as well as habitat quality evaluation.
基金Project supported by the Natural Science Foundation of Shaanxi Province (No. 2001H12).
文摘The components of the rock, the pigments, the gold foils and the adhesive of One Thousand Hand Buddha in Dazu stone sculptures, Chongqing, China, have been analyzed by X-ray diffraction (XRD), X-ray fluorescence (XRF), infrared spectroscopy (IR), energy dispersive X-ray analysis (EDX) and fiber optics reflectance spectros-copy (FORS). Furthermore, the weathering and degeneration of One Thousand Hand Buddha have been discussed and the protective methods have been provided. In this work some useful information to study on conservation of stone relics is given.
文摘Objective:This study protocol identifies the basic research route and framework of psychological and behavioral surveys among Chinese residents,aims establishing a database through a multicenter,large-sample cross-sectional survey in China to provide strong data support for research development in various fields and a more comprehensive and systematic understanding of the physical and mental health status of the public.Method:The study was conducted from June 20,2022 to August 31,2022,using stratified sampling and quota sampling methods,a total of 148 cities,202 districts and counties,390 townships/towns/sub-districts,and 780 communities/villages(excluding Hong Kong,Macao,and Taiwan)from 23 provinces,5 autonomous regions,and 4 municipalities directly under the central government in China were selected.The questionnaire was distributed one-on-one and face-to-face to the public by trained investigators,and the questionnaire included eight aspects:personal basic information,personal health status,family basic information,social environment in which they were located,psychological level scale,behavioral level scale,other scales,and attitude towards social hot issues.Data analysis will be performed after questionnaire return.Results:Data collection is ongoing.These findings will support physical and mental health research and strategy development in China and even globally,guiding policy-makers and health care organizations to reform their programs to ensure the best interests of residents and their families.
基金supported by the Guangdong Province Youth Innovative Talents Project in Higher Education (No.2018KQNCX257)the Guangdong Province Enterprise Science and Technology Commissioner Project (No.GDKTP2021048000)+4 种基金the Key-Area Research and Development Program of Guangdong Province (No.2020B090923002)the Guangdong-Dongguan Joint Fund (No.2019B151530005)the Guangdong Basic and Applied Basic Research Foundation (No.2019A1515110497)the National Natural Science Foundation of China (No.41907292)the National Natural Science Foundation of China (No.21876130)。
文摘Here,we report the production of 3D-printed MoS_(2)/Ni electrodes(3D-MoS_(2)/Ni)with longterm stability and excellent performance by the selective laser melting(SLM)technique.As a cathode,the obtained 3D-MoS_(2)/Ni could maintain a degradation rate above 94.0%for forfenicol(FLO)when repeatedly used 50 times in water.We also found that the removal rate of FLO by 3D-MoS_(2)/Ni was about 12 times higher than that of 3D-printed pure Ni(3D-Ni),attributed to the improved accessibility of H^(*).In addition,the electrochemical characterization results showed that the electrochemically active surface area of the 3D-MoS_(2)/Ni electrode is about 3-fold higher than that of the 3D-Ni electrode while the electrical resistance is 4 times lower.Based on tert-butanol suppression,electron paramagnetic resonance and triple quadrupole mass spectrometer experiments,a“dual path”mechanism and possible degradation pathway for the dechlorination of FLO by 3D-MoS_(2)/Ni were proposed.Furthermore,we also investigated the impacts of the cathode potential and the initial pH of the solution on the degradation of FLO.Overall,this study reveals that the SLM 3D printing technique is a promising approach for the rapid fabrication of high-stability metal electrodes,which could have broad application in the control of water contaminants in the environmental field.
基金supported by the National Key Research and Development Program of China(No.2022YFC2703200 and No.2021YFC2700600).
文摘In this study,we aimed to assess the effect of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection on semenparameters.The study comprised 110 sperm volunteers who self-reported SARS-CoV-2 infection from the Human Sperm Bank ofthe Center for Reproductive Medicine,Shandong University(Jinan,China).The volunteers had normal sperm concentration beforeinfection.Each volunteer provided semen samples before and after infection.We selected 90 days after infection as the cutoff point.Semen parameters within 90 days after infection of 109 volunteers(group A)were compared with semen parameters before infection.Moreover,semen parameters on or after 90 days after infection of 36 volunteers(group B)were compared with semen parameters beforeinfection.Furthermore,based on whether the volunteers had completed the three-dose SARS-CoV-2 vaccination booster,volunteersin group A and B were further divided into two subgroups separately.Semen parameters were compared before and after infection ineach subgroup.Our results showed that in this cohort population,the semen quality in volunteers with normal sperm concentrationsbefore infection decreased after SARS-CoV-2 infection within 90 days,while the semen quality returned to preinfection levels after 90days.The completion of a three-dose SARS-CoV-2 vaccination booster may exert a protective effect on semen quality after infection.
基金Construction Project of China Knowledge Center for Engineering Sciences and Technology(CKCEST-2017-3-1)Cultivate Project of Institute of Geographic Sciences and Natural Resources Research,Chinese Academy of Science(TSYJS03)National University of Mongolia(P2017-2396)
文摘Drought is a worldwide natural disaster that has long affected agricultural production as well as social and economic activities. Frequent droughts have been observed in the Belt and Road area, in which much of the agricultural land is concentrated in fragile ecological environment. Based on the Tropical Rainfall Measuring Mission Satellite（TRMM） 3 B43 precipitation data, we used the Precipitation Abnormity Percentage drought model to study the monthly spatio-temporal distribution of drought in south region of N50° of the Belt and Road area. It was observed that drought during winter was mainly distributed in Northeast Asia, Southeast Asia, and South Asia, while it was mainly distributed in Central Asia and West Asia during summer. The occurrence of historical droughts indicates an obvious seasonal cycle. The regional variations in drought were analyzed using the Breaks for Additive Season and Trend tool（BFAST） in six sub-regions according to the spatial distribution of six economic corridors in the Belt and Road area. The average drought conditions over the 18 years show a slight decreasing trend in Northeast Asia, West Asia, North Africa, South Asia, Central and Eastern Europe, and a slight increasing trend in Central Asia. However, it was a fluctuating pattern of first increasing and then decreasing in Southeast Asia. The results indicate that the total drought area in the Belt and Road region showed a general decreasing trend at a rate of 40,260 km^2 per year from 1998 to 2015.
基金This research was funded by the National Natural Science Foundation of China(Grant No.52278073).
文摘The modern architectural heritage is the core carrier of city’s historical inheritance and vitality.Its value is related to the spatial and temporal evolution of the urban landscape,along with the collective memory of society and transformation in public life.The contradiction between high-speed urban construction and architectural heritage preservation has proliferated,and the problems of loss of heritage culture and fading of relics are very significant,but there is a lack of research on modern architectural heritage.This study analysed indepth the artistic archetypes and evolutionary characteristics of the architecture of Zhongshan Park in Xiamen through field research and historical data collation,adopting the theory method of architectural typology.Afterwards,we analysed the architectural typology of Zhongshan Park in Xiamen and the process of acculturation and translation with foreign cultures,explored the motives of its formation and the cultural meanings of the public space embodied in it.Based on this,we proposed a sustainable development heritage approach for the modern architectural heritage of Zhongshan Park in Xiamen.Our results indicate that modern architectural art has inherited classical Chinese historical and cultural traditions and ideological foundations.Its unique characteristics reflect the spirit of the times and result from the gradual development of Western influence.Moreover,it embodies a strong sense of national identity.These findings enrich the academic research on the cultural interaction between Chinese and Western architecture,offering valuable insights for the conservation and living heritage of modern architectural heritage in other regions.
基金supported by Provincia Veneta dell’Ordine dei Carmelitani Scalzi through the Special allocation grant(CNR-IGG Prot.N.0001882)the National Natural Science Foundation of China(Grant No.52202028)“the Belt and Road”Innovation Talent Exchange Program for Foreign Experts(Grant No.DL2021183001L)。
文摘Outdoor building stones are suffering from serious degradation.To restore internal cohesion and to alleviate the disintegration of decayed stones,consolidation treatment is necessary and significant.Up to date,no fully satisfactory consolidation agent and its application methodology are available,mainly due to the limited penetration depth of consolidants,low compatibility,or poor durability in environmental conditions.Herein,in this study,aiming to design an effective and enduring method for the consolidation of highly porous calcareous stones,nanosilica-based consolidation treatments were tested and compared with traditional compounds(tetraethoxysilane,alkylalkoxysilane,barium hydroxide).In order to evaluate their performance and compatibility,a series of standard tests,including the Drilling Resistance Measurement System(DRMS)test,surface color measurement,vapor diffusivity measurement,and peeling test,were carried out.Besides,the penetration depth and distribution profiles of consolidants were estimated by exploiting elemental raster scanning of SEM-EDS analysis performed throughout the thickness of samples.More importantly,by employing a climatic chamber,the artificial ageing test was also conducted by simulating harsh atmospheric conditions.After accelerated ageing,the performance of all consolidants was assessed again.Results demonstrated that the application of nanosilica(<10 nm in dimension)by cellulose poultice,followed by adding tetraethoxysilane with the classical method“wet on wet”,is the best consolidation approach,in terms of in-depth consolidation efficacy,compatibility with the stone substrate,surface cohesion strength and performance durability in environmental conditions.Moreover,the treated surface is not hydrophobic,which allows further grouting and adhesion operations usually required for the restoration of historic buildings.
基金supported by the National Natural Science Foundation of China(31988101,82192874,82130046)the National Key Research and Development Program of China(2021YFC2700400)+3 种基金CAMS Innovation Fund for Medical Sciences(2021-I2M-5-001)Shandong Provincial Key Research and Development Program(2020ZLYS02)Taishan Scholars Program of Shandong Province(ts20190988,tsqn201909194)Innovative research team of high-level local universities in Shanghai(SHSMU-ZLCX20210200,SHSMUZLCX20210201)。
文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARSCo V-2)infection has swept the globe for 3 years(Zhou et al.,2020).With the nationwide relaxation of controls on the coronavirus disease 2019(COVID-19)epidemic since December 2022 in China,fertility and in vitro fertilization(IVF)centers are receiving increasing numbers of infected patients.
