The SARS-CoV-2-caused COVID-19 pandemic has resulted in a devastating threat to human society in terms of health,economy,and lifestyle.Although the virus usually first invades and infects the lung and respiratory trac...The SARS-CoV-2-caused COVID-19 pandemic has resulted in a devastating threat to human society in terms of health,economy,and lifestyle.Although the virus usually first invades and infects the lung and respiratory track tissue,in extreme cases,almost all major organs in the body are now known to be negatively impacted often leading to severe systemic failure in some people.Unfortunately,there is currently no effective treatment for this disease.Pre-existing pathological conditions or comorbidities such as age are a major reason for premature death and increased morbidity and mortality.The immobilization due to hospitalization and bed rest and the physical inactivity due to sustained quarantine and social distancing can downregulate the ability of organs systems to resist to viral infection and increase the risk of damage to the immune,respiratory,cardiovascular,musculoskeletal systems and the brain.The cellular mechanisms and danger of this“second wave”effect of COVID-19 to the human body,along with the effects of aging,proper nutrition,and regular physical activity,are reviewed in this article.展开更多
Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain disorders.For precise localization of abnormal brain activity,a voxel-level comparison is needed.Because ...Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain disorders.For precise localization of abnormal brain activity,a voxel-level comparison is needed.Because of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1].展开更多
Performance analysis is an important tool for gymnasts and coaches to assess the techniques,strengths,and weaknesses of rhythmic gymnasts during training.To have an accurate insight about the motion and postures can h...Performance analysis is an important tool for gymnasts and coaches to assess the techniques,strengths,and weaknesses of rhythmic gymnasts during training.To have an accurate insight about the motion and postures can help the optimization of their performance and offer personalized suggestions.However,there are three primary limitations of traditional perfor-mance analysis systems applied in rhythmic gymnastics:(1)Inability to quantify anthropometric data in an imperceptible way,(2)labor-intensive nature of data labeling and analysis,and(3)lack of monitoring of all-round and multi-dimensional perspectives of the target.Thus,an advanced performance analysis system for rhythmic gymnastics is proposed in this paper,powered by intelligent fabric.The system uses intelligent fabric to detect the physiological and anthropometric data of the gymnasts.After a variety of data are collected,the analysis component is implemented by artificial intelligence techniques resulting in behavior recognition,decision-making,and other functions assisting performance improvement.A feasible solution to implementing the analysis component is the use of the hyperdimensional computing technique.In addition,four typical applications are presented to improve training performance.Powered by intelligent fabric,the proposed advanced performance analysis system exhibits the potential to promote innovative technologies for improving training and competi-tive performance,prolonging athletic careers,as well as reducing sports injuries.展开更多
Mainstream media play a crucial role in constructing the cultural memory of a city.This study used 319 short videos released by“Hi Chengdu,”a new media product of Chengdu Radio and Television,as samples.Based on the...Mainstream media play a crucial role in constructing the cultural memory of a city.This study used 319 short videos released by“Hi Chengdu,”a new media product of Chengdu Radio and Television,as samples.Based on the grounded theory,a research framework encompassing“content,technology,and discourse”was established to explore the paths through which mainstream media construct the cultural memory.Regarding content,this paper emphasized temporal and spatial contexts and urban spaces,delving deep into the themes of the cultural memory and vehicles for it.In terms of technology,this paper discussed the practice of leveraging audio/visual-mode discourse to stitch together the impressions of a city and evoke emotional resonance to create a“flow”of memory.As for discourse,this paper looked at the performance of a communication ritual to frame concepts and shape urban identity.It is essential to break free from conventional thinking and leverage local culture as the primary driving force to further boost a city’s productivity,in order to excel in cultural communication.展开更多
To the editor:Transcranial magnetic stimulation(TMS)is a non-invasive brain modulation technique.One important usage of TMS is the transient interruption of cognitive brain function(also named virtual lesion)for inves...To the editor:Transcranial magnetic stimulation(TMS)is a non-invasive brain modulation technique.One important usage of TMS is the transient interruption of cognitive brain function(also named virtual lesion)for investigating precisely where and when a specific cortical region contributes to a specific cognitive function.1 A more important usage of TMS is the treatment of brain disorders by repetitive TMS(rTMS).展开更多
Nonalcoholic fatty liver disease(NAFLD)is a prevalent medical condition with an ever-growing trend.Although multiple intracellular mechanisms are involved,endoplasmic reticulum(ER)stress has been demonstrated to play ...Nonalcoholic fatty liver disease(NAFLD)is a prevalent medical condition with an ever-growing trend.Although multiple intracellular mechanisms are involved,endoplasmic reticulum(ER)stress has been demonstrated to play a significant role in the genesis and progression.Most of the research supports the advantages of exercise for NAFLD.However,little is known about the molecular mechanism(s)that underpin the effectiveness of exercise training in NAFLD.This study aimed to identify how aerobic exercise affected hepatic ER stress in a mouse NAFLD model.In this study,the mice were fed either a standard diet(SD)or a high-fat diet(HFD)for 17 weeks.HFD mice were trained on a treadmill during the last eight weeks.All animals were tested for serum levels of biochemical assays,protein expression,and gene expression.The hematoxylin and eosin,Oil red O,and immunohistochemistry staining were also performed.The results indicated that a high-fat diet generated NAFLD,with serum lipid disruption and hepatic function impairment,and increased GRP78 and ATF6 expressions.However,aerobic training reversed the majority of these alterations.It is concluded that NAFLD appears to be associated with hepatic ER stress response,and aerobic exercise mitigates NAFLD via lowering ER stress proteins GRP78 and ATF6.展开更多
Previous studies have shown that Taijiquan and Qigong exercise can effectively reduce depression and anxiety in healthy and clinical populations.At present,only a few reviews have elaborated on the premise of differen...Previous studies have shown that Taijiquan and Qigong exercise can effectively reduce depression and anxiety in healthy and clinical populations.At present,only a few reviews have elaborated on the premise of different types of interventions,and there is still a lack of studies that systematically summarize the clinical evidence of patients with substance use disorders.The purpose of this meta-analysis was to assess the impact of the Taijiquan and Qigong exercise on the mood of individuals with substance use disorders(SUD);Articles were searched in Pubmed,Embase,Cochrane Library,Web of Science,and CNKI from their inception to the May 24,2021.All randomized controlled trials(RCT)using Taijiquan and Qigong intervention were included.With the Review Manager software to determine the effect(standardized mean difference,SMD),subgroup analysis was conducted to intervention type,exercise time,and exercise duration.Nine studies totaling 823 participants were included in the study.Overall results indicated that Taijiquan and Qigong exercise had significant benefits in reducing depression(SMD=-0.35,95%CI:-0.53 to-0.18,Z=4.00,p<0.01)and anxiety(SMD=-0.31,95%CI:-0.50 to-0.11,Z=3.06,p<0.01)symptoms in SUD.When depression and anxiety were examined separately,subgroup analysis demonstrated that Taijiquan intervention(SMD=0.45,95%CI:-0.71 to-0.19,Z=3.39,p<0.01)and Qigong intervention(SMD=0.28,95%CI-0.51 to-0.04,Z=2.33,p=0.02),30–60 min exercise time(SMD=0.41,95%CI:-0.61 to-0.20,Z=3.82,p<0.01)and duration of 9–12 weeks(SMD=0.57,95%CI:-1.10 to-0.04,Z=2.10,p=0.04)more than 12 weeks(SMD=0.28,95%CI:-0.50 to-0.07,Z=2.59,p=0.01)could effectively alleviate the symptoms of depression.Meanwhile,Qigong intervention(SMD=0.31,95%CI:-0.52 to-0.10,Z=2.85,p<0.01),30–60 min exercise time(SMD=0.29,95%CI:-0.53 to-0.04,Z=2.28,p=0.02),more than 60 min exercise time(SMD=0.54,95%CI:-1.06 to-0.02,Z=2.05,p=0.04),and duration of less than 9 weeks(SMD=0.35,95%CI:-0.68 to-0.02,Z=2.07,p=0.04)had positive effects on alleviating anxiety symptoms with SU展开更多
Chinese herbs have been used as dietary supplements to improve exercise performance.However,evidence-based studies for the use of Chinese herbs in sports remain scarce.Traditional Chinese therapy(TCT),a form of tradit...Chinese herbs have been used as dietary supplements to improve exercise performance.However,evidence-based studies for the use of Chinese herbs in sports remain scarce.Traditional Chinese therapy(TCT),a form of traditional Chinese non-pharmacological intervention,has remained in use for thousands of years in sports medicine.TCT is beneficial for sports injuries and in enhancing skill development,and is becoming increasingly popular among athletes,fitness enthusiasts,and individuals who regularly exercise.The therapeutic effects of TCT have been demonstrated by clinical and experimental studies,but using these modalities still is associate with potentially adverse effects.Further well-designed studies are necessary to confirm the efficacy of TCT in sports medicine.This review aims to summarize the application of TCT,discuss the issues surrounding TCT clinical research,and provide suggestions for applying traditional Chinese methods in the field of sports medicine.展开更多
To explore the appropriate exercise methods and means for astronauts in confined and small isolation conditions,a set of XunTian Tai Chi suitable for the spaceflight workforce was created,with the aim of discovering t...To explore the appropriate exercise methods and means for astronauts in confined and small isolation conditions,a set of XunTian Tai Chi suitable for the spaceflight workforce was created,with the aim of discovering the practical effects of XunTian Tai Chi and providing a scientific basis for the subsequent development of new astronaut health maintenance techniques with Chinese characteristics.Using the Controlled Ecological Life Support System(CELSS)as a research platform,we observed the changes in a crew member’s emotion regulationrelated indexes during 180 days of working and living in a confined isolation chamber through periodic interventions of the XunTian Tai Chi and conducted statistical analyses.During the 180-day cabin mission,expression suppression,cognitive reappraisal,attention index,and relaxation index were all lower than those before entering the cabin,suggesting that the crew member’s emotion regulation ability decreased during the incabin mission.A single Tai Chi exercise could cause favorable changes in the indicators,positively affecting the crew member's emotional regulation.The attention and relaxation indices of the occupants were improved significantly by both single and periodic Tai Chi exercises.After the Tai Chi exercise cycle,the results of each index showed a certain degree of effect.The 180-day ground-based simulation of Tai Chi in the confinement of a space capsule positively affects the occupant’s emotional regulation.展开更多
Melanoma accounts for one-third of all malignant skin tumors(approximately 6.8–20.0%).Globally,the incidence and mortality rates of melanoma are increasing.[1]For early-stage(I–II)melanoma,extended resection shows a...Melanoma accounts for one-third of all malignant skin tumors(approximately 6.8–20.0%).Globally,the incidence and mortality rates of melanoma are increasing.[1]For early-stage(I–II)melanoma,extended resection shows a better survival advantage.Once melanoma metastasizes,it can lead to poor prognosis.[2]Melanoma with strong immunogenicity is an excellent immunotherapy research object.[3]Immunotherapy drugs for melanoma have developed rapidly in the last 20 years.The clinical benefits of these drugs are apparent,[4,5]which provides better treatment options for most patients with melanoma.Here,we reviewed the current progress in immunotherapy for melanoma.展开更多
We studied the muscle fatigue and recovery of thirty male sprinters(aged 18–22 years)using the Frequency Analysis Method(FAM).The interferential currents(ICs)with different thresholds for sensory,motor and pain respo...We studied the muscle fatigue and recovery of thirty male sprinters(aged 18–22 years)using the Frequency Analysis Method(FAM).The interferential currents(ICs)with different thresholds for sensory,motor and pain responses,the maximal voluntary contraction(MVC),and the amplitude of the surface EMG(aEMG,sEMG)were assessed prior to and immediately after an acute explosive fatigue training session,and during one-week recovery.We found that IC increased on average from 32.38.9 mA to 37.57.5 mA in sensory response at 10 Hz immediately post training(p=0.004)but decreased at 24-hr post training(p=0.008)and returned to pre-levels thereafter.Motor and pain response patterns at 10 Hz were similar(motor:p=0.033 and 0.040;pain:p=0.022 and 0.019,respectively).The change patterns of ICs were similar to but prior to the changes of sEMG.The agreement between IC assessment and amplitude of sEMG(aEMG)/MVC ratio was good(>95%).The present study suggested that the changes in ICs were prior to the changes in both the aEMG and force during fatigue.These changes may reflect the physiological sensory change due to peripheral fatigue.FAM may be useful as an effective early detection and simple tool for monitoring muscle fatigue during training and recovery in athletes.展开更多
Behavioral experiments have demonstrated that long-term physical exercise can be beneficial for learning and memory dysfunction caused by neuroinflammation in Alzheimer's disease(AD).However,the molecular mechanis...Behavioral experiments have demonstrated that long-term physical exercise can be beneficial for learning and memory dysfunction caused by neuroinflammation in Alzheimer's disease(AD).However,the molecular mechanism remains poorly understood due to a lack of sufficient pertinent biochemical evidence.We investigated the potential effect of long-term physical exercise on cognition and hippocampal gene and protein expression changes in a transgenic AD mouse model.Following twenty weeks of treadmill exercise,transgenic AD mice showed improvement in cognitive functions and downregulation of Nod-like receptor protein 3(NLRP3)(p<0.01),interleukin-1beta(IL-1β)(p<0.05),and amyloid-β1-42(Aβ1-42)(p<0.05)expression levels.In addition,we observed significant reductions of microglial activation and hippocampal neuronal damage in the exercised AD mice(p<0.01),which might be a result of the downregulation of NLRP3-mediated signaling and neuroinflammatory responses.As neuronal damage due to inflammation might be a likely cause of AD-associated cognitive dysfunction.Our results suggested that the anti-inflammatory effects of exercise training involved downregulating the expression of key inflammatory factors and might play an important role in protecting hippocampal neurons against damage during the course of AD.展开更多
Objective:We aim to investigate the effects of different exercise intensities and volumes on Phlegm-dampness constitution(PDC).Methods:The rats were fed with high-fat food and lived in 75%–85%humidity for 6 weeks to ...Objective:We aim to investigate the effects of different exercise intensities and volumes on Phlegm-dampness constitution(PDC).Methods:The rats were fed with high-fat food and lived in 75%–85%humidity for 6 weeks to establish the model of PDC.Then PDC rats were screened and intervened by varying exercise intensities for 8 weeks.Weight,constitution scores,blood and liver tissues were collected to detect the concentration of serum total cholesterol(Tch),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),homocysteine(Hcy),blood glucose(GLU),alanine transaminase(ALT)and percentage of lipid droplet area in liver tissue(PLDA).Results:The weight,Tch,TG,HDL-C,LDL-C,Hcy,GLU,and ALT of rats in moderate-intensity exercise group returned to normal.The rats with high-intensity or low-intensity exercise did not recover as well as moderate-intensity.Conclusion:Different exercise intensities and volumes have different effects on PDC,moderate-intensity exercise over an 8-week intervention is most appropriate.展开更多
Diabetes is a chronic disease characterized by hyperglycemia,of which type 2 diabetes mellitus(T2DM)accounts for about 95%[1].In addition,the prevalence of T2DM is still rising,seriously threatening human health.As th...Diabetes is a chronic disease characterized by hyperglycemia,of which type 2 diabetes mellitus(T2DM)accounts for about 95%[1].In addition,the prevalence of T2DM is still rising,seriously threatening human health.As the mechanism of T2DM is not fully understood,most of the current drugs for the treatment of T2DM focus on lowering blood glucose without solving its underlying problem.This review discusses the application of ginseng-jujube-licorice group in T2DM based on theory of traditional Chinese medicine and research of modern pharmacology,in order to provide a reference for the development of new drugs and future research.展开更多
Under the initiative of“encouraging 300 million people to participate in ice and snow sports”and the guidance of the‘Evidence-based’policy-making process,this study takes the Hierarchical Model of Leisure Constrai...Under the initiative of“encouraging 300 million people to participate in ice and snow sports”and the guidance of the‘Evidence-based’policy-making process,this study takes the Hierarchical Model of Leisure Constraints as the theoretical framework to empirically explore the constraints influencing the participation of residents in Southern China in ice and snow sports.After factor analysis,the constraint dimension of residents’participation was obtained,and the constraints of participants and non-participants were evaluated and compared by Propensity Score Matching(PSM).The results indicate that Chengdu residents have potential interest in and demand for winter sports,and the constraint dimensions are:facilities and services,companions,time,and personal feelings.The predisposition scores of the experimental group and the control group revealed that the constraints on interest,relevant knowledge and skills,and personal feelings of the participating group were significantly lower than those of the non-participating group,while the other constraints were not significant.We suggest that efforts should be made to increase the effective supply according to local conditions in order to reduce structural constraints,and the social attributes should be integrated into ice and snow sports to resolve the inter-personal constraints.展开更多
Oxidized Bacterial Cellulose （OBC）-hydroxyapatite （HAp）-gelatin （Gel） nanocomposites were prepared by a biomimetic process. HAp nanocrystals were precipitated in a mixed solution ofNa2HPO4 （pH 9.2） and Gel sol...Oxidized Bacterial Cellulose （OBC）-hydroxyapatite （HAp）-gelatin （Gel） nanocomposites were prepared by a biomimetic process. HAp nanocrystals were precipitated in a mixed solution ofNa2HPO4 （pH 9.2） and Gel solution at 37 ℃, and OBC was used to generate a three-dimensional （3D） network stent. The tensile strength of OBC-HAp-G was higher than 0.3 MPa, and the complete degradation time was approximately 90 d in Simulated Body Fluid （SBF）. Fourier transform infrared spectroscopy demonstrated that a coordinate bond had formed possibly between HAp and the cellulose hydroxyl. X-ray diffraction showed that both the oxidation of bacterial cellulose and an increase in Gel content induced the formation of tiny HAp crystallites during composite fabrication. Specific surface area and porosity measurements indicated that a low Gel concentration contributed to retention of porous structure. The Ca and P contents on the surface of materials increased initially and then decreased with an increase in Gel content, as measured by energy dispersive spectroscopy. From the thermogravimetric data, the increase in decomposition temperature suggested the formation of chemical bonds among OBC, HAp, and Gel. The above results suggest that the OBC-HAp-G0.3 composite is a potential bone scaffold material.展开更多
Adolescence is an important stage for brain maturation.To investigate the effect of different exercise doses on inhibitory control in adolescents aged 12 to 14-year old,an after-school exercise program was offered 5 d...Adolescence is an important stage for brain maturation.To investigate the effect of different exercise doses on inhibitory control in adolescents aged 12 to 14-year old,an after-school exercise program was offered 5 days per week for 12 weeks during a school semester.Thirsty-four adolescents(17 boys)from the first six classes were randomly divided into low-dose exercise group(LE group,one 30-min aerobic exercise bout per day,n=16)and high-dose exercise group(HE group,two 30-min aerobic exercise bouts per day,n=18),while 23 adolescents(10 boys)in the control group(CON,zero 30-min exercise bout,n=23)were from the last two classes.All the participants in different classes received the same physical education with the same contents,duration,and intensity at class.All the participants completed flanker tests and cardiorespiratory tests before and after exercise intervention.The HE group showed more significant improvements on inhibitory control and VO_(2peak)than CON(p<0.05).Changes in physical activity(PA)were significantly correlated with changes in interference scores(Spearman rho=-0.30,p<0.05),VO_(2peak)(Spearman rho=0.31,p<0.05),and BF percentage(Spearman rho=-0.32,p<0.05).This study demonstrated that effect of exercise on inhibitory control in adolescents is dose-dependent,which highlights the need to focus on the exercise dose in daily life for improving cognition among adolescents.展开更多
Mental health problems are common during the transition from adolescence to young adulthood.Previous studies reported that rhythmic music plus aerobic exercise can have a beneficial effect on emotional state.We examin...Mental health problems are common during the transition from adolescence to young adulthood.Previous studies reported that rhythmic music plus aerobic exercise can have a beneficial effect on emotional state.We examined whether the beneficial effect differed between aerobic exercise interventions with or without rhythmic music.A sample of 94 college students who either had no depressive symptoms(n=47)or minimal depressive symptoms(n=47)underwent 30-min interventions in a randomized and counterbalanced order:rest,rhythmic music,aerobic exercise and aerobic exercise plus rhythmic music.Response time and accuracy of selective attention to positive and negative images were recorded using the spatial cueing paradigm.Participants’heart rate during all conditions and perceived exertion after each condition were measured to clarify physiological and perceptual responses,respectively.The results revealed that a multimodal intervention combining aerobic exercise and rhythmic music had a significant facilitatory effect on attentional bias to positive emotional cues in minimal depressive participants(t=-2.336,p=0.024),including less perceived exertion and higher heart rate after/during the intervention process.The single-modality intervention of aerobic exercise had significant positive effects for individuals with no depressive symptoms(t=2.510,p=0.016).The multimodal intervention was more effective than the single-modality intervention for individuals with minimal depressive symptoms,but the single-modality aerobic exercise intervention was more effective for individuals with no depressive symptoms,providing new evidence for the specificity of the intervention effect for people with different degrees of depressive symptoms.展开更多
The ability of physical activity to ameliorate cardiovascular disease and improve cardiovascular health is well accepted,but many aspects of the molecular mechanisms underlying these benefits are incompletely understo...The ability of physical activity to ameliorate cardiovascular disease and improve cardiovascular health is well accepted,but many aspects of the molecular mechanisms underlying these benefits are incompletely understood.Exercise increases the levels of reactive oxygen species(ROS)through various mechanisms.This triggers the activation of Nrf2,a redox-sensitive transcription factor activated by increases in oxidative stress.Activation of Nrf2 mitigates oxidative stress by increasing the nuclear transcription of many antioxidant genes while also mediating additional beneficial effects through the cytoprotective nature of Nrf2 signaling.Understanding the transcriptional patterns of Nrf2 caused by exercise can help in the design of pharmacological mimicry of the process in patients who are unable to exercise for various reasons.展开更多
Critical Discourse Analysis （CDA） is a new method in linguistic analysis. Usually approached from the angles of linguistics, sociology and psychology, CDA aims to uncover through analyzing linguistic forms, the rela...Critical Discourse Analysis （CDA） is a new method in linguistic analysis. Usually approached from the angles of linguistics, sociology and psychology, CDA aims to uncover through analyzing linguistic forms, the relations between language and ideology. By applying the specific methods of transitivity, transformation, modality and classification in CDA to a report on Barack Obama in The New York Times--a mainstream media in the United States, this paper aims to reveal the ideology hidden in the report, so as to raise the readers＇ awareness of perceiving unconscious ideologies in news and help them to have a deeper understanding of news and the language in news.展开更多
文摘The SARS-CoV-2-caused COVID-19 pandemic has resulted in a devastating threat to human society in terms of health,economy,and lifestyle.Although the virus usually first invades and infects the lung and respiratory track tissue,in extreme cases,almost all major organs in the body are now known to be negatively impacted often leading to severe systemic failure in some people.Unfortunately,there is currently no effective treatment for this disease.Pre-existing pathological conditions or comorbidities such as age are a major reason for premature death and increased morbidity and mortality.The immobilization due to hospitalization and bed rest and the physical inactivity due to sustained quarantine and social distancing can downregulate the ability of organs systems to resist to viral infection and increase the risk of damage to the immune,respiratory,cardiovascular,musculoskeletal systems and the brain.The cellular mechanisms and danger of this“second wave”effect of COVID-19 to the human body,along with the effects of aging,proper nutrition,and regular physical activity,are reviewed in this article.
基金the National Natural Science Foundation of China(81520108016,81661148045,and 31471084 to Yu-Feng Zang81671774 and 81630031 to Chao-Gan Yan+11 种基金81571228 to Tao Wu61571047 to Xia Wu81701664 to Jian Wang,81471654 to Biao Huang81701671 to Wei-Guo Liu82001898 to Xi-Ze Jia81771820,81371519 and 81571654 to Wei Luo)Henry G Leong Endowed Professorship in Neurology to Shu-Leong Ho and Shirley YY Pang,BRC for Mental Health at South London and Maudsley NHS Foundation Trust and by the Sackler Institute to Grainne McAlonan,NIH(2R01AG006457 to Fay B.Horak1RC4NS073008-01 and P50NS062684 to Tara Madhyastha)NINDS Intramural Research Program to Mark HallettStart-up Funds for Leading Talents at Beijing Normal UniversityNational Basic Science Data Center‘‘Chinese Data-sharing Warehouse for In-vivo Imaging Brain”(NBSDC-DB-15)to Xi-Nian ZuoGrant NU20-04-00294 of the Agency for Health Research,Czech Republic to Lenka Krajcovicova and Irena Rektorova。
文摘Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain disorders.For precise localization of abnormal brain activity,a voxel-level comparison is needed.Because of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1].
文摘Performance analysis is an important tool for gymnasts and coaches to assess the techniques,strengths,and weaknesses of rhythmic gymnasts during training.To have an accurate insight about the motion and postures can help the optimization of their performance and offer personalized suggestions.However,there are three primary limitations of traditional perfor-mance analysis systems applied in rhythmic gymnastics:(1)Inability to quantify anthropometric data in an imperceptible way,(2)labor-intensive nature of data labeling and analysis,and(3)lack of monitoring of all-round and multi-dimensional perspectives of the target.Thus,an advanced performance analysis system for rhythmic gymnastics is proposed in this paper,powered by intelligent fabric.The system uses intelligent fabric to detect the physiological and anthropometric data of the gymnasts.After a variety of data are collected,the analysis component is implemented by artificial intelligence techniques resulting in behavior recognition,decision-making,and other functions assisting performance improvement.A feasible solution to implementing the analysis component is the use of the hyperdimensional computing technique.In addition,four typical applications are presented to improve training performance.Powered by intelligent fabric,the proposed advanced performance analysis system exhibits the potential to promote innovative technologies for improving training and competi-tive performance,prolonging athletic careers,as well as reducing sports injuries.
文摘Mainstream media play a crucial role in constructing the cultural memory of a city.This study used 319 short videos released by“Hi Chengdu,”a new media product of Chengdu Radio and Television,as samples.Based on the grounded theory,a research framework encompassing“content,technology,and discourse”was established to explore the paths through which mainstream media construct the cultural memory.Regarding content,this paper emphasized temporal and spatial contexts and urban spaces,delving deep into the themes of the cultural memory and vehicles for it.In terms of technology,this paper discussed the practice of leveraging audio/visual-mode discourse to stitch together the impressions of a city and evoke emotional resonance to create a“flow”of memory.As for discourse,this paper looked at the performance of a communication ritual to frame concepts and shape urban identity.It is essential to break free from conventional thinking and leverage local culture as the primary driving force to further boost a city’s productivity,in order to excel in cultural communication.
基金Ministry Key Project(JW0890006)Key Realm R&D Program of Guangdong Province(2019B030335001)+1 种基金Department of Science and Technology of Sichuan Province(2022NSFSC0808)Key Medical Discipline of Hangzhou,The Cultivation Project of the Province-leveled Preponderant Characteristic Discipline of Hangzhou Normal University(18JYXK046,20JYXK004).
文摘To the editor:Transcranial magnetic stimulation(TMS)is a non-invasive brain modulation technique.One important usage of TMS is the transient interruption of cognitive brain function(also named virtual lesion)for investigating precisely where and when a specific cortical region contributes to a specific cognitive function.1 A more important usage of TMS is the treatment of brain disorders by repetitive TMS(rTMS).
基金This work was provided by the National Natural Science Foundation of China(No.31900846)the Science and Technology Program of Sichuan,China(No.2020YFS0436).We would like to thank Jiaqian Wang,Yalong Li and Changjun Jiang who assisted in performing daily training of the mice over the course of the study.
文摘Nonalcoholic fatty liver disease(NAFLD)is a prevalent medical condition with an ever-growing trend.Although multiple intracellular mechanisms are involved,endoplasmic reticulum(ER)stress has been demonstrated to play a significant role in the genesis and progression.Most of the research supports the advantages of exercise for NAFLD.However,little is known about the molecular mechanism(s)that underpin the effectiveness of exercise training in NAFLD.This study aimed to identify how aerobic exercise affected hepatic ER stress in a mouse NAFLD model.In this study,the mice were fed either a standard diet(SD)or a high-fat diet(HFD)for 17 weeks.HFD mice were trained on a treadmill during the last eight weeks.All animals were tested for serum levels of biochemical assays,protein expression,and gene expression.The hematoxylin and eosin,Oil red O,and immunohistochemistry staining were also performed.The results indicated that a high-fat diet generated NAFLD,with serum lipid disruption and hepatic function impairment,and increased GRP78 and ATF6 expressions.However,aerobic training reversed the majority of these alterations.It is concluded that NAFLD appears to be associated with hepatic ER stress response,and aerobic exercise mitigates NAFLD via lowering ER stress proteins GRP78 and ATF6.
基金This research was funded by Sichuan Social Science Fund,grant number SC21ZW003.
文摘Previous studies have shown that Taijiquan and Qigong exercise can effectively reduce depression and anxiety in healthy and clinical populations.At present,only a few reviews have elaborated on the premise of different types of interventions,and there is still a lack of studies that systematically summarize the clinical evidence of patients with substance use disorders.The purpose of this meta-analysis was to assess the impact of the Taijiquan and Qigong exercise on the mood of individuals with substance use disorders(SUD);Articles were searched in Pubmed,Embase,Cochrane Library,Web of Science,and CNKI from their inception to the May 24,2021.All randomized controlled trials(RCT)using Taijiquan and Qigong intervention were included.With the Review Manager software to determine the effect(standardized mean difference,SMD),subgroup analysis was conducted to intervention type,exercise time,and exercise duration.Nine studies totaling 823 participants were included in the study.Overall results indicated that Taijiquan and Qigong exercise had significant benefits in reducing depression(SMD=-0.35,95%CI:-0.53 to-0.18,Z=4.00,p<0.01)and anxiety(SMD=-0.31,95%CI:-0.50 to-0.11,Z=3.06,p<0.01)symptoms in SUD.When depression and anxiety were examined separately,subgroup analysis demonstrated that Taijiquan intervention(SMD=0.45,95%CI:-0.71 to-0.19,Z=3.39,p<0.01)and Qigong intervention(SMD=0.28,95%CI-0.51 to-0.04,Z=2.33,p=0.02),30–60 min exercise time(SMD=0.41,95%CI:-0.61 to-0.20,Z=3.82,p<0.01)and duration of 9–12 weeks(SMD=0.57,95%CI:-1.10 to-0.04,Z=2.10,p=0.04)more than 12 weeks(SMD=0.28,95%CI:-0.50 to-0.07,Z=2.59,p=0.01)could effectively alleviate the symptoms of depression.Meanwhile,Qigong intervention(SMD=0.31,95%CI:-0.52 to-0.10,Z=2.85,p<0.01),30–60 min exercise time(SMD=0.29,95%CI:-0.53 to-0.04,Z=2.28,p=0.02),more than 60 min exercise time(SMD=0.54,95%CI:-1.06 to-0.02,Z=2.05,p=0.04),and duration of less than 9 weeks(SMD=0.35,95%CI:-0.68 to-0.02,Z=2.07,p=0.04)had positive effects on alleviating anxiety symptoms with SU
基金supported by the National Key R&D Programme of the Ministry of Science and Technology of China(2019YFF0301704)the National Natural Science Foundation of China(81704190,82074576)+1 种基金Sichuan Science and Technology Project(2019YFS0526)the Key Laboratory of Sports Medicine of Sichuan Province.
文摘Chinese herbs have been used as dietary supplements to improve exercise performance.However,evidence-based studies for the use of Chinese herbs in sports remain scarce.Traditional Chinese therapy(TCT),a form of traditional Chinese non-pharmacological intervention,has remained in use for thousands of years in sports medicine.TCT is beneficial for sports injuries and in enhancing skill development,and is becoming increasingly popular among athletes,fitness enthusiasts,and individuals who regularly exercise.The therapeutic effects of TCT have been demonstrated by clinical and experimental studies,but using these modalities still is associate with potentially adverse effects.Further well-designed studies are necessary to confirm the efficacy of TCT in sports medicine.This review aims to summarize the application of TCT,discuss the issues surrounding TCT clinical research,and provide suggestions for applying traditional Chinese methods in the field of sports medicine.
基金The study was approved by the ethics committee of the China Astronaut Training Center,and all investigators were aware of the study and gave their consent for publication.The Ethics Committee of the Astronaut Center of China(NO.ACC201508)reviewed this study.
文摘To explore the appropriate exercise methods and means for astronauts in confined and small isolation conditions,a set of XunTian Tai Chi suitable for the spaceflight workforce was created,with the aim of discovering the practical effects of XunTian Tai Chi and providing a scientific basis for the subsequent development of new astronaut health maintenance techniques with Chinese characteristics.Using the Controlled Ecological Life Support System(CELSS)as a research platform,we observed the changes in a crew member’s emotion regulationrelated indexes during 180 days of working and living in a confined isolation chamber through periodic interventions of the XunTian Tai Chi and conducted statistical analyses.During the 180-day cabin mission,expression suppression,cognitive reappraisal,attention index,and relaxation index were all lower than those before entering the cabin,suggesting that the crew member’s emotion regulation ability decreased during the incabin mission.A single Tai Chi exercise could cause favorable changes in the indicators,positively affecting the crew member's emotional regulation.The attention and relaxation indices of the occupants were improved significantly by both single and periodic Tai Chi exercises.After the Tai Chi exercise cycle,the results of each index showed a certain degree of effect.The 180-day ground-based simulation of Tai Chi in the confinement of a space capsule positively affects the occupant’s emotional regulation.
基金1·3·5 project for disciplines of excellence,West China Hospital,Sichuan University(Nos.ZYPY20001 and ZYPY20002)
文摘Melanoma accounts for one-third of all malignant skin tumors(approximately 6.8–20.0%).Globally,the incidence and mortality rates of melanoma are increasing.[1]For early-stage(I–II)melanoma,extended resection shows a better survival advantage.Once melanoma metastasizes,it can lead to poor prognosis.[2]Melanoma with strong immunogenicity is an excellent immunotherapy research object.[3]Immunotherapy drugs for melanoma have developed rapidly in the last 20 years.The clinical benefits of these drugs are apparent,[4,5]which provides better treatment options for most patients with melanoma.Here,we reviewed the current progress in immunotherapy for melanoma.
基金The study was funded by National Key Research and Development Program(2018YFF0300904,2019YFF0301700)from Ministry of Science and Technology of the People's Republic of China.
文摘We studied the muscle fatigue and recovery of thirty male sprinters(aged 18–22 years)using the Frequency Analysis Method(FAM).The interferential currents(ICs)with different thresholds for sensory,motor and pain responses,the maximal voluntary contraction(MVC),and the amplitude of the surface EMG(aEMG,sEMG)were assessed prior to and immediately after an acute explosive fatigue training session,and during one-week recovery.We found that IC increased on average from 32.38.9 mA to 37.57.5 mA in sensory response at 10 Hz immediately post training(p=0.004)but decreased at 24-hr post training(p=0.008)and returned to pre-levels thereafter.Motor and pain response patterns at 10 Hz were similar(motor:p=0.033 and 0.040;pain:p=0.022 and 0.019,respectively).The change patterns of ICs were similar to but prior to the changes of sEMG.The agreement between IC assessment and amplitude of sEMG(aEMG)/MVC ratio was good(>95%).The present study suggested that the changes in ICs were prior to the changes in both the aEMG and force during fatigue.These changes may reflect the physiological sensory change due to peripheral fatigue.FAM may be useful as an effective early detection and simple tool for monitoring muscle fatigue during training and recovery in athletes.
基金the Sports Medicine Key Laboratory of Sichuan Province/Sports Medicine Key Laboratory of State Sport General Administration(Grant No.2023-A015)the Innovative Project of Sports Medicine and Health Institute/Zheng Huaixian Bone and Trauma Research Institute(Grant No.CX21A02)the"14th Five Year Plan"Scientific Research and Innovation Team of Chengdu Sport University(Grant No.23CXTD02).
文摘Behavioral experiments have demonstrated that long-term physical exercise can be beneficial for learning and memory dysfunction caused by neuroinflammation in Alzheimer's disease(AD).However,the molecular mechanism remains poorly understood due to a lack of sufficient pertinent biochemical evidence.We investigated the potential effect of long-term physical exercise on cognition and hippocampal gene and protein expression changes in a transgenic AD mouse model.Following twenty weeks of treadmill exercise,transgenic AD mice showed improvement in cognitive functions and downregulation of Nod-like receptor protein 3(NLRP3)(p<0.01),interleukin-1beta(IL-1β)(p<0.05),and amyloid-β1-42(Aβ1-42)(p<0.05)expression levels.In addition,we observed significant reductions of microglial activation and hippocampal neuronal damage in the exercised AD mice(p<0.01),which might be a result of the downregulation of NLRP3-mediated signaling and neuroinflammatory responses.As neuronal damage due to inflammation might be a likely cause of AD-associated cognitive dysfunction.Our results suggested that the anti-inflammatory effects of exercise training involved downregulating the expression of key inflammatory factors and might play an important role in protecting hippocampal neurons against damage during the course of AD.
文摘Objective:We aim to investigate the effects of different exercise intensities and volumes on Phlegm-dampness constitution(PDC).Methods:The rats were fed with high-fat food and lived in 75%–85%humidity for 6 weeks to establish the model of PDC.Then PDC rats were screened and intervened by varying exercise intensities for 8 weeks.Weight,constitution scores,blood and liver tissues were collected to detect the concentration of serum total cholesterol(Tch),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),homocysteine(Hcy),blood glucose(GLU),alanine transaminase(ALT)and percentage of lipid droplet area in liver tissue(PLDA).Results:The weight,Tch,TG,HDL-C,LDL-C,Hcy,GLU,and ALT of rats in moderate-intensity exercise group returned to normal.The rats with high-intensity or low-intensity exercise did not recover as well as moderate-intensity.Conclusion:Different exercise intensities and volumes have different effects on PDC,moderate-intensity exercise over an 8-week intervention is most appropriate.
基金supported by the Sichuan Famous Chinese Medicine Studio Construction Project.
文摘Diabetes is a chronic disease characterized by hyperglycemia,of which type 2 diabetes mellitus(T2DM)accounts for about 95%[1].In addition,the prevalence of T2DM is still rising,seriously threatening human health.As the mechanism of T2DM is not fully understood,most of the current drugs for the treatment of T2DM focus on lowering blood glucose without solving its underlying problem.This review discusses the application of ginseng-jujube-licorice group in T2DM based on theory of traditional Chinese medicine and research of modern pharmacology,in order to provide a reference for the development of new drugs and future research.
基金The National Social Science Foundation of China(17CTY014).
文摘Under the initiative of“encouraging 300 million people to participate in ice and snow sports”and the guidance of the‘Evidence-based’policy-making process,this study takes the Hierarchical Model of Leisure Constraints as the theoretical framework to empirically explore the constraints influencing the participation of residents in Southern China in ice and snow sports.After factor analysis,the constraint dimension of residents’participation was obtained,and the constraints of participants and non-participants were evaluated and compared by Propensity Score Matching(PSM).The results indicate that Chengdu residents have potential interest in and demand for winter sports,and the constraint dimensions are:facilities and services,companions,time,and personal feelings.The predisposition scores of the experimental group and the control group revealed that the constraints on interest,relevant knowledge and skills,and personal feelings of the participating group were significantly lower than those of the non-participating group,while the other constraints were not significant.We suggest that efforts should be made to increase the effective supply according to local conditions in order to reduce structural constraints,and the social attributes should be integrated into ice and snow sports to resolve the inter-personal constraints.
文摘Oxidized Bacterial Cellulose （OBC）-hydroxyapatite （HAp）-gelatin （Gel） nanocomposites were prepared by a biomimetic process. HAp nanocrystals were precipitated in a mixed solution ofNa2HPO4 （pH 9.2） and Gel solution at 37 ℃, and OBC was used to generate a three-dimensional （3D） network stent. The tensile strength of OBC-HAp-G was higher than 0.3 MPa, and the complete degradation time was approximately 90 d in Simulated Body Fluid （SBF）. Fourier transform infrared spectroscopy demonstrated that a coordinate bond had formed possibly between HAp and the cellulose hydroxyl. X-ray diffraction showed that both the oxidation of bacterial cellulose and an increase in Gel content induced the formation of tiny HAp crystallites during composite fabrication. Specific surface area and porosity measurements indicated that a low Gel concentration contributed to retention of porous structure. The Ca and P contents on the surface of materials increased initially and then decreased with an increase in Gel content, as measured by energy dispersive spectroscopy. From the thermogravimetric data, the increase in decomposition temperature suggested the formation of chemical bonds among OBC, HAp, and Gel. The above results suggest that the OBC-HAp-G0.3 composite is a potential bone scaffold material.
基金supported by National Key Research and Development Program Major Prevention and Control Research on Chronic Noncommunicable Diseases(2016YFC1300202).
文摘Adolescence is an important stage for brain maturation.To investigate the effect of different exercise doses on inhibitory control in adolescents aged 12 to 14-year old,an after-school exercise program was offered 5 days per week for 12 weeks during a school semester.Thirsty-four adolescents(17 boys)from the first six classes were randomly divided into low-dose exercise group(LE group,one 30-min aerobic exercise bout per day,n=16)and high-dose exercise group(HE group,two 30-min aerobic exercise bouts per day,n=18),while 23 adolescents(10 boys)in the control group(CON,zero 30-min exercise bout,n=23)were from the last two classes.All the participants in different classes received the same physical education with the same contents,duration,and intensity at class.All the participants completed flanker tests and cardiorespiratory tests before and after exercise intervention.The HE group showed more significant improvements on inhibitory control and VO_(2peak)than CON(p<0.05).Changes in physical activity(PA)were significantly correlated with changes in interference scores(Spearman rho=-0.30,p<0.05),VO_(2peak)(Spearman rho=0.31,p<0.05),and BF percentage(Spearman rho=-0.32,p<0.05).This study demonstrated that effect of exercise on inhibitory control in adolescents is dose-dependent,which highlights the need to focus on the exercise dose in daily life for improving cognition among adolescents.
基金This work was supported by the Social Science Planning Project of Jiangxi Province(China)“Evidence-based Practical Research on the Exercise Promotion of College Students’Emotional Health in the Context of Healthy China”[grant number 19TY16]2021-2022 Innovation Project of the Institute of Sports Medicine and Health Science/Institute of Zheng Huaixian Bone Injury,Chengdu Sport University(China)[grant number CX21B01]+1 种基金Basic Education Research Project of the Department of Education,Jiangxi Province(China)[grant number SZUSYTY2019-991]to Ping YangNational Key Research and Development Program(China)[grant number 2019YFF0301704]to Benxiang He.
文摘Mental health problems are common during the transition from adolescence to young adulthood.Previous studies reported that rhythmic music plus aerobic exercise can have a beneficial effect on emotional state.We examined whether the beneficial effect differed between aerobic exercise interventions with or without rhythmic music.A sample of 94 college students who either had no depressive symptoms(n=47)or minimal depressive symptoms(n=47)underwent 30-min interventions in a randomized and counterbalanced order:rest,rhythmic music,aerobic exercise and aerobic exercise plus rhythmic music.Response time and accuracy of selective attention to positive and negative images were recorded using the spatial cueing paradigm.Participants’heart rate during all conditions and perceived exertion after each condition were measured to clarify physiological and perceptual responses,respectively.The results revealed that a multimodal intervention combining aerobic exercise and rhythmic music had a significant facilitatory effect on attentional bias to positive emotional cues in minimal depressive participants(t=-2.336,p=0.024),including less perceived exertion and higher heart rate after/during the intervention process.The single-modality intervention of aerobic exercise had significant positive effects for individuals with no depressive symptoms(t=2.510,p=0.016).The multimodal intervention was more effective than the single-modality intervention for individuals with minimal depressive symptoms,but the single-modality aerobic exercise intervention was more effective for individuals with no depressive symptoms,providing new evidence for the specificity of the intervention effect for people with different degrees of depressive symptoms.
文摘The ability of physical activity to ameliorate cardiovascular disease and improve cardiovascular health is well accepted,but many aspects of the molecular mechanisms underlying these benefits are incompletely understood.Exercise increases the levels of reactive oxygen species(ROS)through various mechanisms.This triggers the activation of Nrf2,a redox-sensitive transcription factor activated by increases in oxidative stress.Activation of Nrf2 mitigates oxidative stress by increasing the nuclear transcription of many antioxidant genes while also mediating additional beneficial effects through the cytoprotective nature of Nrf2 signaling.Understanding the transcriptional patterns of Nrf2 caused by exercise can help in the design of pharmacological mimicry of the process in patients who are unable to exercise for various reasons.
文摘Critical Discourse Analysis （CDA） is a new method in linguistic analysis. Usually approached from the angles of linguistics, sociology and psychology, CDA aims to uncover through analyzing linguistic forms, the relations between language and ideology. By applying the specific methods of transitivity, transformation, modality and classification in CDA to a report on Barack Obama in The New York Times--a mainstream media in the United States, this paper aims to reveal the ideology hidden in the report, so as to raise the readers＇ awareness of perceiving unconscious ideologies in news and help them to have a deeper understanding of news and the language in news.
