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Determinants of the Ophthalmological Follow-Up of Sickle Cell Patients at the National Center of Research and Care for Sickle Cell Patients in Lome-Togo
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作者 Nidain Maneh Yawa Edebah Nagbe +5 位作者 Mawuli Ayodele Komi Santos Dadjo Amouzou Hezouwe Magnang Koffi Sylvain Kawilitetou Kokou Messan Amedome Komi Patrice Balo 《Open Journal of Ophthalmology》 2023年第4期341-351,共11页
Objectives: To assess the factors influencing the ophthalmological follow-up of sickle cell patients in Togo. Materials and Methods: The national center of research and care for sickle cell patients (CNRSD) served as ... Objectives: To assess the factors influencing the ophthalmological follow-up of sickle cell patients in Togo. Materials and Methods: The national center of research and care for sickle cell patients (CNRSD) served as study setting. It was a descriptive and analytical study by interview over a three-month period from December 01, 2020 to March 02, 2021. Was included in the study, any patient with sickle cell disease genotype SS or SC, age ≥ 17 years, regularly followed at the CNRSD and having accepted the interview by a survey sheet. Excluded were patients with sickle cell trait genotype AS or AC or with a disability that prevented them from being interviewed. Results: Two hundred and fifty (250) patients with sickle cell disease were interviewed. The mean age was 29.1 years ± 11.12 years [17 years;67 years] and the sex ratio = 0.52. Nine patients over ten (9/10) attended at least secondary school. The jobless represented 25.60% of the total population followed respectively by students and laborers in 20.40% and 16% of cases. Twenty-four percent (24%) of patients were followed up in ophthalmology department. Statistically, there was no significant relationship between level of education (p = 0.4083), occupation (p = 0.6441) and knowledge of the ocular complications of sickle cell disease. Statistically, there was a significant relationship between knowledge of the ocular complications of sickle cell disease and compliance with ophthalmological follow-up (p = 0.0009). Conclusion: The knowledge of eye disorders related to sickle cell disease by patients with sickle cell disease improves their ophthalmological follow-up. Greater awareness on eye disorders related to sickle cell disease by medical staff towards patients with sickle cell disease would improve ophthalmological follow-up. . 展开更多
关键词 Ophthalmological Follow-Up Sickle Cell Patient Ocular Complications Lome
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Restoration of the Western Himalaya: implications for metamorphic protoliths, thrust and normal faulting, and channel flow models
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作者 Michael P. Searle Ben Stephenson +1 位作者 James Walker Christian Walker 《Episodes》 SCIE 2007年第4期242-257,共16页
The Greater Himalayan Sequence (GHS) is composed of a sequence of Barrovianfacies metamorphic rocks up to kyanite or sillimanite + K-feldspar grade, migmatites, layered stromatic migmatites and leucogranite sheets.... The Greater Himalayan Sequence (GHS) is composed of a sequence of Barrovianfacies metamorphic rocks up to kyanite or sillimanite + K-feldspar grade, migmatites, layered stromatic migmatites and leucogranite sheets. These rocks were metamorphosed during the late Eocene to early Miocene, and are bounded below by a large-scale SW-vergent ductile shear zone-thrust fault (Main Central Thrust; MCT), and above by a NE-dipping low-angle normal sense shear zone and fault (Zanskar Shear Zone; ZSZ), 展开更多
关键词 变形原岩 喜玛拉雅山 断层作用 地质模型
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孟连三部曲
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作者 刘园 《中华手工》 2012年第1期15-17,共3页
"做比什么都重要",能够持续做下去,并且做出效果,才是手工助推项目真正应该努力的方向。北京东城区国子监街57号的展览大厅内,色彩清丽、做工精良的织绣物品盈盈亮相。观者很难相信,这些品质出众、时尚亮眼的产品出自云南孟连,一个傣... "做比什么都重要",能够持续做下去,并且做出效果,才是手工助推项目真正应该努力的方向。北京东城区国子监街57号的展览大厅内,色彩清丽、做工精良的织绣物品盈盈亮相。观者很难相信,这些品质出众、时尚亮眼的产品出自云南孟连,一个傣族聚居的县域。何戍中徜徉展览大厅,心里一片舒展:进行了两年多的孟连手工编织振兴项目终于告一段落。同时,这也意味着一个新的开始。 展开更多
关键词 展览大厅 手工编织 北京东城区 聚居
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EGFR Expression Is Unreliable to Decide for Cetuximab Treatment in Patients with Metastatic Colorectal Cancer: Results from “ERBITUX-OUEST”
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作者 Jean-Philippe Metges Erick Gamelin +46 位作者 Alain Volant Olivier Capitain Jean-François Ramée Jean-Luc Raoul Jean-Yves Douillard Pierre-Luc Etienne Isabelle Cumin Olivier Dupuis Roger Faroux Marie-Aude Coulon Philippe Deguiral Karine Bideau Nacr Eddine Achour Alain Gourlaouen Corinne Alleaume Annie Wdowik Laurent Miglianico Yann Touchefeu Vincent Klein Alain Penchet Ludovic Rosenfeld Daniel Martin Claire Stampfli Jean-Jacques Auger Alain Bargain Murielle Broyer-Petit Jérome Chettrit Louis-Rémi De Ybarlucea Serge Eloit Pierre Marie Girardot Nathalie Heresbach Christian Laboisse Eric Lavoine Gilles Lemasson Claire Magois Sophie Michalak Norbert Padilla Joseph Politis Frédéric Staroz Bruno Turlin Arnaud Uguen Viorel Vasiliu Véronique Verriele Fanny Marhuenda Delphine Déniel Lagadec Christian Riché Françoise Grudé 《Open Journal of Internal Medicine》 2016年第2期56-67,共13页
Purpose: Although controversial, assessment of epidermal growth factor receptor (EGFR) expression is required for the approved indications of Cetuximab in metastatic colorectal cancer (mCRC). With the objective of imp... Purpose: Although controversial, assessment of epidermal growth factor receptor (EGFR) expression is required for the approved indications of Cetuximab in metastatic colorectal cancer (mCRC). With the objective of improving patient selection, “ERBITUX-OUEST” study aimed at analyzing EGFR status in a large cohort of mCRC patients who received cetuximab without preliminary EGFR screening, and assessing the correlation between EGFR status and response to treatment retrospectively. Patients and methods: 332 patients treated with Irinotecan Cetuximab based regimen after progression on irinotecan or oxaliplatin therapy were included. EGFR status was assessed using three available immunohistochemistry (IHC) tests and in situ hybridization in case of negativity. Clinical outcomes of EGFR-positive and EGFR-non-detected (or considered as negative with at least one test) patients were compared. Results: Of the 332 samples centrally screened, 194 were classified as full-positive (i.e., EGFR-positive for all three tests), 86 as full-negative, and 52 as discordant. One third of the 131 negative samples with FDA approved test should be reclassified as positive with at least one of the two others tests. Regarding results from FDA approved test only, neither objective response rate (ORR), progression-free survival (PFS) nor overall survival (OS) differed significantly between EGFR-negative and EGFR-positive patients (P = 0.788, 0.326 and 0.888, respectively). Similarly, comparison of full-negative to other groups did not show any significant difference in terms of ORR (P = 0.507), PFS (P = 0.222) or OS (P = 0.686). Conclusion: These data strongly argue against mCRC patients selection for Cetuximab treatment based on EGFR expression as measured by currently available IHC technics. 展开更多
关键词 Metastatic Colorectal Cancer CETUXIMAB EGFR Expression
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Primary Malignant Musculosqueletal Tumors of Members in Adult in Togo
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作者 Atchi Walla Faré Gnandi-Pio +5 位作者 Piriziwè Dossim Gamal Ayouba Tchaa Towoezim Tchin Darre Anani Abalo Michel Dossim 《Open Journal of Orthopedics》 2016年第4期103-107,共5页
Purpose: Primary malignant musculosqueletal tumors in adult are rare affections group and its treatment is still a real challenge today. The aim of this work was to describe the epidemiologic and treatment aspects of ... Purpose: Primary malignant musculosqueletal tumors in adult are rare affections group and its treatment is still a real challenge today. The aim of this work was to describe the epidemiologic and treatment aspects of these tumors in the national reference center of our country. Materiel and Methods: It was a retrospective review of primary malignant musculosqueletal tumors treated in orthopedics and trauma unit of Sylvanus Olympio teaching hospital of Lomé, Togo from January 2000 to December 2014. Results: During the study period, 28 cases were selected and reviewed. There were 17 men (60.71%) and 11 women (39.29%). The average age was 32.7 years. There were 20 cases (71%) of primary malignant bone tumors (PMBT) and 8 cases (29%) of primary malignant soft tissues tumors (PMSTT). There were 6 (30%) of osteosarcoma. The tumor was located in the bones of the forearm and wrist/hand in 2 (10%) patients for each anatomical site;for the lower limb, around knee in 7 (35%) patients. Eight patients had PMSTT (28, 57%). There were three cases of rhabdomyosarcoma, 2 cases of fibrosarcoma. Tumors were located around knee in 4 cases and around ankle/foot in 3 cases. In the two groups of tumor, tumor resection was performed in 5 patients (17.86%) and limb amputation indicated in 23 patients (82.14%), was performed in 15 (53.57%) and 8 patients (37.78%), rejected it and left hospital against medical advice. Conclusion: Malignant musculoskeletal tumors are relatively rare in Togo. Their treatment is based on radical surgery which is often not supervised by adjuvant therapies. Ignorance, poverty of the population and embryonic state of diagnostic and treatment infrastructures are the obstacles to their care. Education and awareness must be integrated to care and fight against this group of diseases. 展开更多
关键词 Primary Bone Tumors Soft Tissue Tumors OSTEOSARCOMA RHABDOMYOSARCOMA TOGO
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微波CAE系统
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作者 CHP 《电子测量技术》 北大核心 1992年第1期46-48,45,共4页
本文介绍了最新微波CAE系统的组成及其具有的功能。对其中的设计输入,线性和非线性模,布线图生成相文件编辑等部分做了较详细的说明。通过介绍,读者可以了解到微波设计的最新发展。
关键词 微波系统 设计输入 布线图生成
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麻醉恢复室中导致镇静的阿片类药物并不能确保镇痛完善:一项病例对照研究
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作者 Claude Lentschener Patrice Tostivint +4 位作者 Paul F. White Marc E. Gentili Yves Ozier 姜旭晖(译) 李士通(校) 《麻醉与镇痛》 2008年第4期63-68,共6页
背景在麻醉恢复室(PACU)中用吗啡静脉注射治疗急性疼痛的同时也可能产生镇静作用。因此,我们设计了此项病例对照研究,以评估PACU中使用阿片类药物引起的镇静作用和手术后早期镇痛强度之间的关系。方法在PACU中每5分钟追加一次吗啡... 背景在麻醉恢复室(PACU)中用吗啡静脉注射治疗急性疼痛的同时也可能产生镇静作用。因此,我们设计了此项病例对照研究,以评估PACU中使用阿片类药物引起的镇静作用和手术后早期镇痛强度之间的关系。方法在PACU中每5分钟追加一次吗啡(静脉注射)治疗中、重度疼痛患者的疼痛(体重≤60kg每次加用2mg,体重〉60kg每次加用.3mg)。用11分的口述疼痛量表(VRS)测定疼痛强度,≥3分表示中、重度疼痛。同时用6分的Ramsay评定量表来评定镇静深度,〉3分则具有临床意义。对26例离开PACU时Ramsay评分〉3分合并VRS〉13分的患者,在手术后24小时内评估了如下几项指标:(a)在PACU中对手术后早期疼痛的记忆;(b)手术后第1晚的睡眠质量;(C)手术后第24小时的疼痛强度;(d)对手术后24小时内镇痛的满意度。对照组选用离开PACU时VRS〈3分的患者,并将每2例对照组患者分别与Ramsay评分〉3分合并VRSI〉3分的单个患者进行配对比较,对照组共有52例患者。结果Ramsay镇静评分〉3分合并VRS疼痛评分≥3分的患者,在PACU中出现中、重度疼痛的概率较高(疼痛镇静组的重度疼痛/中度疼痛/无疼痛的比例为58%/16%/26%;对照组为18%/25%/57%,P=0.006);在手术后第1晚睡眠质量较差(睡眠好/中等/差的比例为23%/23%/54%,对照组为48%/42%/10%,P=0.001);手术后第24小时的疼痛评分较高(疼痛镇静组重度疼痛/中度疼痛/无疼痛的比例为50%/42%/8%;对照组为6%/44%/50%,P〈0.0001);并且对手术后第1个24小时的镇痛满意度较低(疼痛镇静组满意/较满意/不满意的比例为50%/30%/20%,对照组为96%/2%/2%,P〈0.0001)。结论阿片类药物在PACU可引起具有临床意义的镇静,却并不能确保镇痛完善。 展开更多
关键词 病例对照研究 阿片类药物 镇静作用 镇痛强度 麻醉恢复室 RAMSAY镇静评分 静脉注射治疗 急性疼痛
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超高效液相色谱与高效液相色谱方法转换及验证 被引量:29
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作者 高青 刘颖 +3 位作者 宋彬彬 付龙 郭伟 钱忠直 《药物分析杂志》 CAS CSCD 北大核心 2016年第7期1279-1286,共8页
超高效液相色谱(UPLC)分离原理与高效液相色谱(HPLC)完全一致,但分离度更好,灵敏度更高,并且速度快,消耗溶剂少。如果实现两者方法的转换,并进行必要的验证工作,可在不变更标准的前提下合规应用UPLC技术,对药品质量进行高效精准的控制... 超高效液相色谱(UPLC)分离原理与高效液相色谱(HPLC)完全一致,但分离度更好,灵敏度更高,并且速度快,消耗溶剂少。如果实现两者方法的转换,并进行必要的验证工作,可在不变更标准的前提下合规应用UPLC技术,对药品质量进行高效精准的控制。中国药典2015年版四部关于UPLC的应用有简单说明,但是涉及与HPLC方法的转换和验证没有细节规定,使该技术推广应用受阻。本文从2种仪器的差异进行分析,阐述了方法转换时如何进行参数变更,包括色谱柱、流速、进样体积和梯度洗脱程序的转换。基于转换前方法已经经过全面验证,转换后的方法验证应主要着眼于仪器带来的差异,需验证分离度和灵敏度2个方面。本文根据转换前方法的不同情况,对方法验证细节要求进行了分析讨论,以确保方法转换后准确有效,合乎规范。 展开更多
关键词 UPLC HPLC 方法转换 色谱柱选择 方法验证 指导原则 灵敏度 分离度
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Impaired T-cell differentiation in diabetic foot ulceration 被引量:6
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作者 João Moura João Rodrigues +3 位作者 Marta Gonçalves Cláudia Amaral Margarida Lima Eugénia Carvalho 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2017年第9期758-769,共12页
Foot ulceration is one of the most debilitating complications associated with diabetes,but its cause remains poorly understood.Several studies have been undertaken to understand healing kinetics or find possible thera... Foot ulceration is one of the most debilitating complications associated with diabetes,but its cause remains poorly understood.Several studies have been undertaken to understand healing kinetics or find possible therapies to enhance healing.However,few studies have been directed at understanding the immunological alterations that could influence wound healing in diabetes.In this study,we analysed the T-cell receptor(TCR)repertoire diversity in TCR-αβ^(+)T cells.We also analysed the distribution and phenotype of T cells obtained from the peripheral blood of healthy controls and diabetic individuals with or without foot ulcers.Our results showed that diabetic individuals,especially those with foot ulcers,have a significantly lower naive T-cell number and a poorer TCR-Vβrepertoire diversity.We also showed that the reduced TCR-Vβrepertoire diversity in diabetic individuals was mainly owing to the accumulation of effector T cells,the major source of tumour necrosis factor-αproduction,which was even more pronounced in patients with acute foot ulceration.Moreover,the expression of several inflammatory chemokine receptors was significantly reduced in diabetic patients.In conclusion,effector T-cell accumulation and TCR repertoire diversity reduction appear to precede the development of foot ulcers.This finding may open new immunological therapeutic possibilities and provide a new prognostic tool in diabetic wound care. 展开更多
关键词 DIABETES T-CELLS T-cell repertoire diversity wound healing
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UPLC与HPLC法测定阿托伐他汀钙及其制剂中的有关物质 被引量:5
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作者 周怡 高青 +5 位作者 尚悦 付龙 刘颖 宋彬彬 郭伟 钱忠直 《药物分析杂志》 CAS CSCD 北大核心 2018年第4期720-727,共8页
目的:建立测定阿托伐他汀钙有关物质及含量的超高效液相色谱法(UPLC)和高效液相色谱法(HPLC),并对方法及测定结果进行比较。方法:UPLC法,采用Acquity BEH Shield RP18色谱柱(150 mm×2.1 mm,1.7μm),流速0.4 mL·min^(-1);HPLC... 目的:建立测定阿托伐他汀钙有关物质及含量的超高效液相色谱法(UPLC)和高效液相色谱法(HPLC),并对方法及测定结果进行比较。方法:UPLC法,采用Acquity BEH Shield RP18色谱柱(150 mm×2.1 mm,1.7μm),流速0.4 mL·min^(-1);HPLC法,采用Symetry Shield RP18色谱柱(250 mm×4.6 mm,5μm),流速1.5 mL·min^(-1)。两方法均以20 mmol·L^(-1)醋酸铵溶液(用冰醋酸调节pH为4.0)为流动相A,乙腈-四氢呋喃(95∶5)为流动相B,梯度洗脱,检测波长254 nm,柱温35℃。结果:UPLC法和HPLC法测定有关物质在一定范围内均呈现良好线性,r>0.999,加样回收率、精密度和样品测定结果基本无差异;UPLC检测下限略低于HPLC检测下限,主峰与非对映异构体(杂质B)分离度优于HPLC法,UPLC法测定时间为17 min,HPLC法为50 min,UPLC法溶剂使用量减少12倍。用建立的UPLC和HPLC方法对阿托伐他汀钙5个企业10批样品,阿托伐他汀钙片剂4个企业14批样品以及阿托伐他汀钙胶囊1个企业6批样品进行有关物质检查,结果无显著差异。结论:UPLC和HPLC 2种方法准确性、精密度、线性等验证试验结果以及样品测定结果基本一致;UPLC法测定阿托伐他汀钙有关物质和含量快速、灵敏度高,分离度好,更环保。 展开更多
关键词 有关物质 阿托伐他汀钙 降血脂药 超高效液相色谱 高效液相色谱 梯度洗脱 方法验证 方法转换 方法比较
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2010年上海世博会健康遗产评估指标体系的构建思考 被引量:4
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作者 袁东 Gauden Galea +3 位作者 俞晓静 陈依 宋彦 吴凡 《环境与职业医学》 CAS 北大核心 2009年第3期219-222,共4页
2010年上海世博会的筹办是社会各方面多年总动员和巨额投资的结果,估计期间将有约7000万人次的参观者来上海光临这一盛会,这无疑将给主办城市的环境、卫生等基础设施带来巨大压力,也是对城市卫生服务提出的新挑战。2008年北京奥运会中... 2010年上海世博会的筹办是社会各方面多年总动员和巨额投资的结果,估计期间将有约7000万人次的参观者来上海光临这一盛会,这无疑将给主办城市的环境、卫生等基础设施带来巨大压力,也是对城市卫生服务提出的新挑战。2008年北京奥运会中首次引入了奥运健康遗产的概念,并建立了一套包含56个指标的奥运健康影响评估指标体系,有效地促进了政府对卫生事业的关注。借鉴北京奥运健康遗产概念,突出上海世博特点,建立一套世博健康遗产评估指标体系,可有效观察上海世博会在健康和公共卫生领域的长期影响,进一步延伸和拓展奥运健康遗产概念,充分发挥大型国际活动的健康促进功能,以期对今后大型国际活动的举办有一定的参考和促进作用。 展开更多
关键词 上海2010年世博会 北京奥运会 健康遗产 评估指标体系
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银杏叶提取物中掺伪标志物槐角苷检查方法的研究 被引量:3
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作者 刘颖 宋彬彬 +2 位作者 付龙 高青 钱忠直 《中国药品标准》 CAS 2016年第4期257-263,共7页
目的:对银杏叶提取物中疑似掺伪的标志物槐角苷检出方法进行研究。方法:超高效液相色谱柱为ACQUITY UPLC BEH Shield RP18(2.1mm×100mm,1.7μm);高效液相色谱柱为Shield RP18(4.6mm×250mm,5μm);流动相以乙腈为... 目的:对银杏叶提取物中疑似掺伪的标志物槐角苷检出方法进行研究。方法:超高效液相色谱柱为ACQUITY UPLC BEH Shield RP18(2.1mm×100mm,1.7μm);高效液相色谱柱为Shield RP18(4.6mm×250mm,5μm);流动相以乙腈为流动相A,0.1%磷酸溶液为流动相B,梯度洗脱;柱温30℃;检测波长260nm。结果:高效液相色谱在2.2~43.9ng范围内呈良好的线性关系(r=1.000),加样回收率为101.5%,其RSD为2.1%;超高效液相色谱在0.40~6.5ng范围内呈良好的线性关系(r=0.9999),加样回收率为104.0%,其RSD为1.6%。结论:所建方法前处理简便易行,采用超高效液相色谱法测定迅速,节能环保,适合于应急快速检验;采用高效液相色谱法通用性好,适合常规检验;两种方法均有很好的重复性,可作为银杏叶提取物中槐角苷的补充检验方法。 展开更多
关键词 银杏叶提取物 槐角苷 超高效液相色谱 高效液相色谱 光电二极管阵列检测器
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SFC和UPLC方法用于丹参饮片中多成分研究 被引量:3
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作者 张光华 付龙 +4 位作者 王京辉 宋彬彬 郭伟 张琳培 钱忠直 《药物分析杂志》 CAS CSCD 北大核心 2020年第5期940-947,共8页
目的:建立SFC-PDA法同时检测丹参饮片中4个脂溶性丹参酮类成分,以及UPLC法同时测定丹参饮片中3个水溶性丹酚酸类成分,以7个成分的测定结果综合评价丹参饮片的质量。方法:采用SFC-PDA法,使用Viridis■HSS SB C18100A(3.0 mm×100 mm,... 目的:建立SFC-PDA法同时检测丹参饮片中4个脂溶性丹参酮类成分,以及UPLC法同时测定丹参饮片中3个水溶性丹酚酸类成分,以7个成分的测定结果综合评价丹参饮片的质量。方法:采用SFC-PDA法,使用Viridis■HSS SB C18100A(3.0 mm×100 mm,1.8μm)色谱柱,以二氧化碳(A)-[正庚烷-异丙醇(8∶2)(B)]为流动相,梯度洗脱,流速1.5 mL·min^-1,柱温45℃,背压13.8 MPa;采用UPLC-PDA法,使用BEH Shield RP(2.1 mm×100 mm,1.7μm)色谱柱,以乙腈(A)-0.1%磷酸溶液(B)为流动相,梯度洗脱,流速0.4 mL·min^-1,柱温30℃。结果:在建立的色谱条件下,丹参饮片中7个主要成分在各自的液相系统中分离完全,线性良好,精密度、重复性、稳定性及回收率实验结果均符合含量测定要求,同时还比较了用HPLC和SFC 2种方法测定脂溶性成分时的仪器灵敏度,结果为一个数量级。结论:SFC方法快速简便、结果准确,在节省溶剂、减少环境污染的方面具有独特优势,同时采用UPLC方法测定水溶性成分,2种方法可用于丹参饮片的质量分析,同时大大降低检测成本。 展开更多
关键词 超临界流体色谱 超高效液相色谱 含量测定 丹参饮片 丹参酮类成分 丹酚酸类成分
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PROBING A STOCHASTIC EPIDEMIC HEPATITIS C VIRUS MODEL WITH A CHRONICALLY INFECTED TREATED POPULATION 被引量:2
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作者 S.P.RAJASEKAR M.PITCHAIMANI Quanxin ZHU 《Acta Mathematica Scientia》 SCIE CSCD 2022年第5期2087-2112,共26页
The hepatitis C virus is hitherto a tremendous threat to human beings,but many researchers have analyzed mathematical models for hepatitis C virus transmission dynamics only in the deterministic case.Stochasticity pla... The hepatitis C virus is hitherto a tremendous threat to human beings,but many researchers have analyzed mathematical models for hepatitis C virus transmission dynamics only in the deterministic case.Stochasticity plays an immense role in pathology and epidemiology.Hence,the main theme of this article is to investigate a stochastic epidemic hepatitis C virus model with five states of epidemiological classification:susceptible,acutely infected,chronically infected,recovered or removed and chronically infected,and treated.The stochastic hepatitis C virus model in epidemiology is established based on the environmental influence on individuals,is manifested by stochastic perturbations,and is proportional to each state.We assert that the stochastic HCV model has a unique global positive solution and attains sufficient conditions for the extinction of the hepatotropic RNA virus.Furthermore,by constructing a suitable Lyapunov function,we obtain sufficient conditions for the existence of an ergodic stationary distribution of the solutions to the stochastic HCV model.Moreover,this article confirms that using numerical simulations,the six parameters of the stochastic HCV model can have a high impact over the disease transmission dynamics,specifically the disease transmission rate,the rate of chronically infected population,the rate of progression to chronic infection,the treatment failure rate of chronically infected population,the recovery rate from chronic infection and the treatment rate of the chronically infected population.Eventually,numerical simulations validate the effectiveness of our theoretical conclusions. 展开更多
关键词 infeted chroniclly infeted treated hepatitis Cextinction stationary distributior
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静电放电的危害与防护(1) 被引量:2
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《现代仪器使用与维修》 1996年第5期36-37,共2页
1、静电放电的危害 在电子仪器的生产、维修和校准中,静电放电的危害是不容忽视的。但是仍有些人不大相信静电放电会使元器件损坏,其原因是要判断或检查静电放电引起的失效比较困难,而且有些元器件受到静电损伤后,当时并不坏而经过一段... 1、静电放电的危害 在电子仪器的生产、维修和校准中,静电放电的危害是不容忽视的。但是仍有些人不大相信静电放电会使元器件损坏,其原因是要判断或检查静电放电引起的失效比较困难,而且有些元器件受到静电损伤后,当时并不坏而经过一段时间后才出现损坏,表现为性能下降或击穿。其严重性不容忽视。 工作人员自身带的静电会直接造成元器件损坏的后果。人身带静电甚至高达5000V以上。 展开更多
关键词 电子仪器 静电防电 故障 维修
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Epidemiological and Diagnostic Aspects of Childhood Proptosis in Lome (Togo) from 2010 to 2020
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作者 Nidain Maneh Mawuli Ayodele Komi Santos +5 位作者 Koffi Sylvain Kawilitetou Dadjo Amouzou Kossi Dzidzinyo Kokou Vonor Didier Koffi Ayena Patrice Komi Balo 《Open Journal of Ophthalmology》 2023年第4期333-340,共8页
Background: Although proptosis is rare, it is nevertheless the main sign of orbital disease. Its discovery usually indicates a serious eye disease especially in children. Objective: To determine epidemiological and di... Background: Although proptosis is rare, it is nevertheless the main sign of orbital disease. Its discovery usually indicates a serious eye disease especially in children. Objective: To determine epidemiological and diagnostic aspects of childhood proptosis in Lome (Togo). Methods: Retrospective cross-sectional study conducted from June 2010 to May 2020, which is 10 years, in the ophthalmology department of CHU-campus of Lome. Files of patients between the age of 0 and 15 who presented a proptosis during the study period were taken into account in the study. Patients with a false proptosis or incomplete records during the study period were not taken into account in the study. Results: The study considered 42 children with an age average of 7.63 years ± 4.96 [4 days;15 years] and a sex-ratio of 1.33. The frequency of proptosis was 0.5% with an average progression of 383.7 days before the first consultation. The proptosis was unilateral in 80.95% of cases. The orbito-cerebral CT scan was done in 47.62% of cases. The proptosis in these patients was predominantly of grade 3 in 45% of cases. The tumor pathologies were at the forefront in 35.71%, dominated by retinoblastoma, and followed by infectious and inflammatory diseases in 14.29%. Conclusion: Childhood proptosis is rare and often indicative of infectious and tumor pathologies in our context. Its diagnosis is delayed, which shows the importance of an early and effective diagnosis. . 展开更多
关键词 Childhood Proptosis TUMORS INFECTIONS Lome
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仪器使用中的静电防护问题 被引量:1
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《现代仪器使用与维修》 1996年第6期27-29,共3页
1.前言 在现代化仪器中大量地使用了高性能元器件,使仪器的各项性能有了惊奇的提高。但是在生产、使用以及维修和校准过程中不可避免地遇到了静电防护问题。本文就这个问题提出一些见解以供读者参考。
关键词 仪器仪表 静电防护 应用
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VXIbus:测试系统的标准结构
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《电子测量技术》 北大核心 1994年第2期30-34,共5页
1.前言 1987年HP等五家电子仪器公司共同宣布,他们共同支持VXIbus新标准。VX-Ibus是一个开放结构。各公司的仪器设备可在同一个机箱中工作。此后很快形成了VX-Ibus的国际集团,制定了VXIbus的技术规范,阐述了适用于VXIbus的机械的,电的... 1.前言 1987年HP等五家电子仪器公司共同宣布,他们共同支持VXIbus新标准。VX-Ibus是一个开放结构。各公司的仪器设备可在同一个机箱中工作。此后很快形成了VX-Ibus的国际集团,制定了VXIbus的技术规范,阐述了适用于VXIbus的机械的,电的和通信接口的技术标准。已有50多家公司生产出上百种VXIbus的产品,其中有机箱。 展开更多
关键词 UXI总线 测试 标准 结构 VXIBUS
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未来的电磁干扰仪器及测试方法
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作者 张兰秀 《电子测量技术》 北大核心 1992年第2期23-27,共5页
电磁兼容(EMC)产品的设计包括三个阶段,首先是硬件设计,其次是产品的预兼容估算,最后是兼容性测试。在每个阶段中都要尽可能采取有效措施来缩短产品生产时间和降低成本。产品之间的电磁兼容性,在设计阶段就必须重点考虑。精确的预兼容... 电磁兼容(EMC)产品的设计包括三个阶段,首先是硬件设计,其次是产品的预兼容估算,最后是兼容性测试。在每个阶段中都要尽可能采取有效措施来缩短产品生产时间和降低成本。产品之间的电磁兼容性,在设计阶段就必须重点考虑。精确的预兼容估算、先进的测试手段和快速的测试仪器,是缩短产品设计周期,降低成本的有效措施。现今商用产品辐射损耗的开放场地测试方法,势必被屏蔽室中自动测试所取代。 展开更多
关键词 电磁干扰仪器 测试
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在维修仪器中如何保管静电敏感器件
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《现代仪器使用与维修》 1997年第1期30-32,共3页
1.前言 在现代化仪器中大量使用了对静电放电敏感的器件和组件。在维修过程中不可避免地要拆装那些装有静电放电敏感器件的印刷电路板。特别是在移动这些印刷电路板时更应采取防静电措施。例如用静电屏蔽袋包装。静电屏蔽袋的保护效果... 1.前言 在现代化仪器中大量使用了对静电放电敏感的器件和组件。在维修过程中不可避免地要拆装那些装有静电放电敏感器件的印刷电路板。特别是在移动这些印刷电路板时更应采取防静电措施。例如用静电屏蔽袋包装。静电屏蔽袋的保护效果是由表面导电率决定的。 展开更多
关键词 仪器仪表 静电敏感器件 维修 故障
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