Male infertility has become a problem worldwide,and recent research has emphasized the development of more effective therapy options.Among natural compounds,rutin has been widely studied for its potential to treat dys...Male infertility has become a problem worldwide,and recent research has emphasized the development of more effective therapy options.Among natural compounds,rutin has been widely studied for its potential to treat dysfunction related to male infertility,including a reduction in sperm quality,spermatogenesis disruption and structural disruption in the testis.A thorough review of scientific literature published in several databases,including Google Scholar,PubMed/MEDLINE and Scopus,was used to synthesize the present state of research on the role of rutin in male reproductive health.Rutin has been shown to possess antiapoptotic,antioxidant and anti-inflammatory activities,among others,which are crucial in the management of male infertility.Numerous investigations have shown that rutin protects against male infertility and have explored the underlying mechanisms involved.The present review,therefore,assesses the therapeutic mechanisms involved in male infertility treatment using rutin.Rutin was able to mitigate the induced oxidative stress,apoptosis,inflammation,and related physiological processes that can cause testicular dysfunction.展开更多
Introduction: COVID-19 vaccine uptake and acceptance have been a major global concern due to the prevalent misinformation and disinformation that has characterized the vaccine rollout worldwide. This study aimed to as...Introduction: COVID-19 vaccine uptake and acceptance have been a major global concern due to the prevalent misinformation and disinformation that has characterized the vaccine rollout worldwide. This study aimed to assess COVID-19 vaccine uptake and acceptance, and associated factors among selected community members in two states in southwestern Nigeria. Method: We conducted a cross-sectional study using a multistage sampling technique. Fifty catchment settlements of 10 health facilities in each of Oyo and Ogun States targeted for a COVID-19 infection prevention and control intervention were randomly selected. Four households were targeted per settlement. All households that refused access were replaced, to ensure a minimum of four households randomly selected per settlement. The primary household decision-maker was interviewed in each household. Information elicited included respondents’ sociodemographic characteristics, health history, knowledge, risk and benefit perception about the COVID-19 vaccine, vaccine uptake, and willingness to be vaccinated. The study was conducted from July–August 2021. Data were analyzed using SPSS IBM version 23. Result: Four hundred household decision-makers were surveyed in Oyo and Ogun states, after replacement. The mean age of the respondents was 43.0 ± 11.0 years. The majority, 346 (86.5%) had heard about COVID-19 vaccination, but only 47 (13.6%) had received a COVID-19 vaccination. Of the 299 respondents who reported not receiving a COVID-19 vaccination, 166 (55.5%) were willing to be vaccinated. In univariate analysis, respondents who were female had tertiary education, perceived that COVID-19 vaccines are free and accessible, perceived that COVID-19 vaccines have minimal side effects, and perceived higher benefits of COVID-19 vaccination had higher odds of being vaccinated. In contrast, younger respondents, respondents with higher knowledge scores on COVID-19 preventive measures, and with chronic illness had lower likelihoods of being vaccinated. In multivariate analy展开更多
Based on the inheritance and development of Zhuang medicine culture from the perspective of a comprehensive well-off society,traditional Chinese medicine is a treasure of Chinese civilization.The inheritance,innovatio...Based on the inheritance and development of Zhuang medicine culture from the perspective of a comprehensive well-off society,traditional Chinese medicine is a treasure of Chinese civilization.The inheritance,innovation,and development of traditional Chinese medicine are crucial to the cause of socialism with Chinese characteristics in the new era.By engaging young people,reducing the aging of the medical team,and understanding the views and suggestions of various groups on Zhuang medicine culture,questionnaire surveys,field interviews,literature searches,and other methods were employed to gather and analyze public opinions and suggestions on Zhuang medicine.Additionally,online consultations were conducted to assess the popularity of Zhuang medicine and identify existing problems.Based on these findings,recommendations and strategies for improvement were formulated.Furthermore,the design of an online consultation app is proposed to enhance the role and effectiveness of Zhuang medicine’s inheritance and development.展开更多
Background:Increasing number of people globally gives in to indiscriminate consumption of excess alcohol as a coping mechanism to relieve any form of physical or psychological stress.Previously,ethnomedicinal use of Z...Background:Increasing number of people globally gives in to indiscriminate consumption of excess alcohol as a coping mechanism to relieve any form of physical or psychological stress.Previously,ethnomedicinal use of Zingiber officinale Roscoe(Ginger)have been shown to exhibit broad range of pharmacological benefits but no data has reported the phytotherapeutic treatment of Zingiber officinale methanol extract(MEZO)on alcohol-use disorder(AUD)and post-traumatic stress disorder(PTSD)-induced oxidative and inflammatory stress relevant to disruption of kidney functions in animal model.Objective:To investigate the protective effect of MEZO on kidney-oxidative and inflammatory biomarkers in sub-chronic alcohol exacerbation of PTSD symptoms in mice.Methods:Male Swiss mice were administered 30%ethanol for two weeks and thereafter introduced to single pro-longed stress to induce AUD and PTSD respectively prior to post-treatment with MEZO and vitamin C.Markers of oxidative stress,inflammatory cytokines,kidney functions,HPA-axis signaling molecules,vasodilator substance,and histopathology of the kidney were evaluated.Results:Sub-chronic alcohol intoxication heightened PTSD-induced oxido-inflammatory stress,altered the kidney function indices and HPA-axis,and reduced nitric oxide production,which were ameliorated by the phytother-apeutic treatment with MEZO.Furthermore,severe degeneration and atrophy of renal tubules were observed.Meanwhile,MEZO interventions strongly abated all these effects.Conclusions:Herein,the study shows that phytotherapeutic treatment with MEZO prevents the damaging effects of co-exposure to sub-chronic alcohol intoxication and PTSD.展开更多
Objective:To identify the knowledge and awareness level of human mpox viral infection among healthcare workers in southwestern Nigeria.Methods:A cross-sectional study was conducted in Ekiti State,southwest Nigeria amo...Objective:To identify the knowledge and awareness level of human mpox viral infection among healthcare workers in southwestern Nigeria.Methods:A cross-sectional study was conducted in Ekiti State,southwest Nigeria among 316 healthcare workers that were selected through a systematic random sampling.Data were collected with the aid of a semi-structured,self-administered questionnaire.The Chi-square test and binary logistic regression were used to find the association between the independent and dependent variables.The significance level was set at P-value<0.05.Results:Two hundred and twenty-two(70.3%)of the respondents were aged≤40 years,mean age(36±9)years,189(59.8%)were female,306(96.8%)were Christians,and 203(64.2%)were married.Three hundred and fourteen(99.4%)of the respondents were aware of mpox infection.Main sources of information about mpox were medical education(44.0%),radio/television(32.0%)and newspaper(21.0%).However,among those aware of the disease,209(67.0%)demonstrated poor knowledge levels.Longer than 5 years’experience of medical practice was the only significant predictor of higher knowledge level of the disease(OR 1.76,95%CI 1.01-3.06;P=0.046).Conclusions:Despite the high awareness level of mpox infection among healthcare workers,there still exists a huge knowledge gap.It is recommended that targeted intervention could be directed towards continuous medical education and simulation exercises on re-emerging infectious diseases like mpox to improve the knowledge of the healthcare workers.展开更多
Cervical cancer remains a major public health problem accounting for continuous female death in developing countries.Cervical cancer is the second most common cancer in women globally with an estimated number of 500,0...Cervical cancer remains a major public health problem accounting for continuous female death in developing countries.Cervical cancer is the second most common cancer in women globally with an estimated number of 500,000 new cases of cervical cancer and 273,000 mortalities annually.Cervical screening is the best cancer screening test in the history of medicine and most cost-effective of all medical screening tests.The study review aimed to highlight methods of cervical cancer prevention,identify the uptake of cervical screening among women,and explain the role of nurses in uptake of cervical screening.Cervical cancer is preventable and easily treatable if it is detected at early stages,but poor information on prevention and access to screening and treatment contributes to 90%of deaths.In the developing countries such as Nigeria,a large proportion of cervical cancers are diagnosed in advanced stages,with poor rates of survival.The three main methods for preventing cervical cancer are through primary prevention(human papillomavirus vaccination and health education),secondary prevention(cervical screening,early detection of precancerous lesions,and treatment),and tertiary prevention(measures to slow the progression or recurrence,surgical removal,radiotherapy,and chemotherapy).Nurses can help improve the acceptability of this neglected promise by focusing on health education on cervical screening and vaccination in prenatal clinics and infant welfare clinics where there are more women.Inclusion of cyberspace could also serve as a successful and popular platform for this health teaching.All nurses/midwives must preach and fervently work toward the WHO 90–70–90 plan for eradicating cervical cancer.展开更多
Diabetes mellitus is a metabolic disease characterized by high blood glucose levels and a range of other symptomsthat last for a long period of time. It has a rapid prevalence globally, and there is a possibility of t...Diabetes mellitus is a metabolic disease characterized by high blood glucose levels and a range of other symptomsthat last for a long period of time. It has a rapid prevalence globally, and there is a possibility of the statisticdoubling in a few years. This review is aimed at evaluating the mechanism, pathophysiology, and pharmacologyof diabetes mellitus. The data used was sourced through a thorough review of scientific articles published in avariety of databases, including Springer, Scopus, Elsevier, Google Scholar, Wiley, Web of Science, PubMed, andTaylor & Francis. Furthermore, PhD and MSc theses were also used in compiling data. According to the literaturereview, diabetes mellitus is a persistent condition with various risk factors and serious complications that affectthe quality of life. However, research studies have helped in the prognosis, diagnosis, treatment, and managementof its different forms.展开更多
Exercise has well-characterized therapeutic benefits in the management of type 2 diabetes mellitus(T2DM).Most of the beneficial effects of exercise arise from the impact of nuclear factor erythroid 2 related factor-2(...Exercise has well-characterized therapeutic benefits in the management of type 2 diabetes mellitus(T2DM).Most of the beneficial effects of exercise arise from the impact of nuclear factor erythroid 2 related factor-2(Nrf2)activation of glucose metabolism.Nrf2 is an essential controller of cellular anti-oxidative capacity and circadian rhythms.The circadian rhythm of Nrf2 is influenced by circadian genes on its expression,where the timing of exercise effects the activation of Nrf2 and the rhythmicity of Nrf2 and signaling,such that the timing of exercise has differential physiological effects.Exercise in the evening has beneficial effects on diabetes management,such as lowering of blood glucose and weight.The mechanisms responsible for these effects have not yet been associated with the influence of exercise on the circadian rhythm of Nrf2 activity.A better understanding of exercise-induced Nrf2 activation on Nrf2 rhythm and signaling can improve our appreciation of the distinct effects of morning and evening exercise.This review hypothesizes that activation of Nrf2 by exercise in the morning,when Nrf2 level is already at high levels,leads to hyperactivation and decrease in Nrf2 signaling,while activation of Nrf2 in the evening,when Nrf2 levels are at nadir levels,improves Nrf2 signaling and lowers blood glucose levels and increases fatty acid oxidation.Exploring the effects of Nrf2 activators on rhythmic signaling could also provide valuable insights into the optimal timing of their application,while also holding promise for timed treatment of type 2 diabetes.展开更多
Four diets were formulated to study the influence of varying crude protein levels on the performance, egg quality, serum and haematological characteristics at the first phase of laying cycle of sixty Bovan Nera laying...Four diets were formulated to study the influence of varying crude protein levels on the performance, egg quality, serum and haematological characteristics at the first phase of laying cycle of sixty Bovan Nera laying birds that were randomly allotted to dietary treatments. The four experimental diets had five replicates each and three birds per repli-cate. Diet 1 contained 14% crude protein (CP), while diet 2 contained 15% CP, diets 3 and 4 contained 16% and 17% CP respectively. The experimental birds were fed for 10 weeks and the data collected were statistically analysed. Apparent variations recorded for all the performance characteristics such as Egg number, Hen-day production, Feed Conversion Ratio (FCR) and weight gain were significantly different (p < 0.05). The best FCR value were recorded by birds fed 17% CP (3.45), while the highest weight gain mean value were also recorded by birds fed 17% CP value. Findings indicated a direct relationship between dietary crude protein values and performance.展开更多
BACKGROUND Most occurrences of type 1 diabetes cases in any population are sporadic rather than familial.Hence,type 1 diabetes among siblings is a rare occurrence.Even more rare is for three or more siblings to develo...BACKGROUND Most occurrences of type 1 diabetes cases in any population are sporadic rather than familial.Hence,type 1 diabetes among siblings is a rare occurrence.Even more rare is for three or more siblings to develop type 1 diabetes.In this report,we describe a case of a Nigerian family in which type 1 diabetes occurred in three siblings among four children with neither parent having diabetes.All three siblings are positive for glutamic acid decarboxylase and anti-islet cell antibodies.CASE SUMMARY There were four siblings(three males and one female)born to a couple without a diagnosis of diabetes.The eldest child(male)was diagnosed with diabetes at the age of 15,the second child(female)was diagnosed at the age of 11 and the fourth child(male)was diagnosed at the age of 9.All the siblings presented with similar osmotic symptoms and were diagnosed of diabetic ketoacidosis.All of them had markedly reduced serum C-peptide levels with high levels of glutamic acid decarboxylase and insulinoma-associated protein-2 antibodies.We could not perform genetic analysis of HLA-DR,DQ and CTLA4 in the siblings as well as the parents;hence haplotypes could not be characterized.Both parents of the probands have no prior history of diabetes,and their blood glucose and glycated hemoglobin levels were within normal ranges.The third child(male)has no history suggestive of diabetes,and his blood glucose and glycated hemoglobin have remained within normal ranges.CONCLUSION Although the occurrence of type 1 diabetes in proband siblings is uncommon,screening for diabetes among siblings especially with islet autoantibodies should be encouraged.展开更多
This paper investigates the tolerable sample size needed for Ordinary Least Square (OLS) Estimator to be used when there is presence of Multicollinearity among the exogenous variables of a linear regression model. A r...This paper investigates the tolerable sample size needed for Ordinary Least Square (OLS) Estimator to be used when there is presence of Multicollinearity among the exogenous variables of a linear regression model. A regression model with constant term (β0) and two independent variables (with β1 and β2 as their respective regression coefficients) that exhibit multicollinearity was considered. A Monte Carlo study of 1000 trials was conducted at eight levels of multicollinearity (0, 0.25, 0.5, 0.7, 0.75, 0.8, 0.9 and 0.99) and sample sizes (10, 20, 40, 80, 100, 150, 250 and 500). At each specification, the true regression coefficients were set at unity while 1.5, 2.0 and 2.5 were taken as the hypothesized value. The power value rate was obtained at every multicollinearity level for the aforementioned sample sizes. Therefore, whether the hypothesized values highly depart from the true values or not once the multicollinearity level is very high (i.e. 0.99), the sample size needed to work with in order to have an error free estimation or the inference result must be greater than five hundred.展开更多
Background: Groundwater is an important source of drinking water for the indigenous communities of Ebocha-Obrikom. Access to safe drinking water, in particular, is critical to one’s health and, by extension, one’s i...Background: Groundwater is an important source of drinking water for the indigenous communities of Ebocha-Obrikom. Access to safe drinking water, in particular, is critical to one’s health and, by extension, one’s income and well-being. Underground wells are the primary supply of drinking water in the Niger Delta, and the groundwater is not always treated before consumption. As a result, water continues to be a vital environmental component that affects both humans and other life forms. Objectives: The aims of the research are to trace the sources and affecting factors of groundwater pollution via statistical and multivariate statistical techniques. Method: The investigation made use of standard analytical procedures. All sampling, conservation, transportation and analysis followed standard procedures described in APHA (2012). To prevent degradation of the organic substances, all obtained samples were transferred to the laboratory, while kept in an icebox. Results: The study reveals that the greater the number of principal components extracted the greater variation in geochemical composition of the ground waters. It indicated that 34 parameters were distributed into six (6) and nine (9) principal components (PCs) extracted for groundwater samples for both rainy and dry seasons, potentially suggesting the input of different pollutants from different sources. Gas flaring, mineral dissolution/precipitation and anthropogenic input are the main sources of the physicochemical indices and trace elements in the groundwater. Groundwater chemistry is predominantly regulated by natural processes such as dissolution of carbonates, silicates, and evaporates and soil leaching, followed by human activities. Climatic factors and land use types are also important in affecting groundwater chemistry. Conclusion: Greater efforts should be made to safeguard groundwater, which is hampered by geogenic and anthropogenic activities, in order to achieve sustainable groundwater development. As a result, communities are recommended to m展开更多
Introduction:Osun River dissecting the Osun-Osogbo Sacred Grove,though inscribed on the World Heritage List,has been rarely assessed for biodiversity values or ecotoxicology.In this study,we investigated the concentra...Introduction:Osun River dissecting the Osun-Osogbo Sacred Grove,though inscribed on the World Heritage List,has been rarely assessed for biodiversity values or ecotoxicology.In this study,we investigated the concentrations of Cu and Zn in the benthic sediments and two dominant gastropod species(Melanoides tuberculata and Lanistes varicus)of the Osun River.Benthic sediment and gastropod samples were collected on quarterly basis from June 2015 to March 2016 along the longitudinal stretch of the river.Dry samples were digested and analysed for Cu and Zn using the atomic absorption spectrophotometry.Results:With the exception of September sampling period,the two metals recorded higher values in the animals than in the sediments.Cu(1.23±0.81μg/g)was much lower(p<0.01)than zinc(6.29±2.15μg/g)in the benthic sediments.In the same vein,Cu was significantly lower(p<0.01)than Zn in both species.Both metals recorded much lower values than their average concentrations in the Earth’s crust as well as the recommended limits for freshwater life.Comparatively,L.varicus recorded higher bioaccumulation factor than M.tuberculata.Conclusions:Findings from this study suggest that both metals posed no toxicological risk to the freshwater system of Osun River.Concentrations of both metals in the sediments as well as their accumulation factors in both gastropod species were indicative of an unimpacted freshwater system.展开更多
Objective:The objective of this study is to assess the knowledge and self-care practices of people living with type 2 diabetes mellitus(T2DM).Materials and Methods:The study was conducted in a clinic in Southwestern N...Objective:The objective of this study is to assess the knowledge and self-care practices of people living with type 2 diabetes mellitus(T2DM).Materials and Methods:The study was conducted in a clinic in Southwestern Nigeria.It adopted a cross-sectional design.The sample consists of 107 people living with T2DM.Data were collected using Diabetes Knowledge Questionnaire and Revised Self-care Inventory Scale.Results:The mean diabetes knowledge of the participants was 16.2±3.0 and 70.1%had inadequate knowledge of T2DM.The mean diabetes self-care practice score among the participants was 49.9±4.9,and 89.7%reported poor diabetes self-care practice.There is no significant difference in the knowledge of diabetes between male(16.42±3.42)and female(16.12±2.8)participants(t=0.45;P=0.65),and no significant difference in self-care practice of male(49.23±4.51)and female(50.06±5.07)participants(t=0.75,P=0.46).In addition,there is no correlation between age and knowledge of diabetes(r=-0.18,P=0.07)and self-care practices(r=0.08,P=0.38)of participants.No significant relationship was found between knowledge of diabetes and diabetes selfcare practices(χ^(2)=1.605,P=0.448)Conclusion:Knowledge of diabetes and self-care practices of people living with T2DM in this study were poor.Effort should be directed at improving their diabetes knowledge and self-care practices.展开更多
Tapioca is a cassava-based food product made in the form of irregular lumps of partly gelatinized starch grits. Tapioca was enriched with varying proportions of soybean flour (0, 85% - 15%, 75% - 25%, 50% - 50%) to pr...Tapioca is a cassava-based food product made in the form of irregular lumps of partly gelatinized starch grits. Tapioca was enriched with varying proportions of soybean flour (0, 85% - 15%, 75% - 25%, 50% - 50%) to produce Soy-tapioca (ST). Nutrient and anti-nutrient composition of ST were determined by standard methods, while sensory evaluation was also carried out. Results showed significant increase in protein, fat and mineral contents of tapioca as the level of soy-substitution increased. There was a decrease in the cyanogenic potential and an increase in the level of trypsin inhibitor as soy-substitution increased. Tannin, phytic acid and oxalate contents of the soy-tapioca samples were below minimum levels of safety. ST (50% - 50%) was more nutrient dense than the other products, but ST (85% - 15%) was more accepted in terms of colour, taste and texture. ST suggests a safe, nutritious and acceptable food product that can enhance food and nutrition security among cassava consuming populations.展开更多
Purpose: To compare the effect of chlorhexidine-alcohol and povidone iodine on surgical site infection (SSI) after caesarean section. Methodology: A randomized control trial of 374 patients (188 in the chlorhexidine-a...Purpose: To compare the effect of chlorhexidine-alcohol and povidone iodine on surgical site infection (SSI) after caesarean section. Methodology: A randomized control trial of 374 patients (188 in the chlorhexidine-alcohol group and 186 in the povidone iodine group) who had elective caesarean section with no overt risk for SSI was done. Patients were followed up until thirty days after delivery to assess for symptoms and signs of SSI. Results: Fifty-one (13.6%) of the study population developed SSI. Although the incidence of SSI was lower in the chlorhexidine-alcohol group than the povidone iodine group (12.2% vs. 15.1%;p = 0.26);the difference was not statistically significant. The incidence of adverse skin reaction in Chlorhexidine-alcohol vs. povidone iodine was also not statistically significant (4.0% vs. 5.4%;p = 0.40). Conclusion: The study demonstrates that there was no statistically significant difference in antiseptic property and side effect profile of chlorhexidine-alcohol and povidone-iodine when used as skin antisepsis in caesarean section.展开更多
Obtaining rapid access in emergency situations for infusion of IV fluids, blood and blood products or medications is vital in using various methods. These include venopuncture, intraosseous infusion, percutanous centr...Obtaining rapid access in emergency situations for infusion of IV fluids, blood and blood products or medications is vital in using various methods. These include venopuncture, intraosseous infusion, percutanous central venous access and peripheral venous cut-down. We report a case of a 30-year-old woman who developed severe obstetric hemorrhage and had peripheral venous cut-down that was complicated by bilateral femoral osteomyelitis. This is a rare occurrence and this case report shows the need for strict adherence to safety precautions to prevent complications such as that from the procedure.展开更多
The ability of physical activity to ameliorate cardiovascular disease and improve cardiovascular health is well accepted,but many aspects of the molecular mechanisms underlying these benefits are incompletely understo...The ability of physical activity to ameliorate cardiovascular disease and improve cardiovascular health is well accepted,but many aspects of the molecular mechanisms underlying these benefits are incompletely understood.Exercise increases the levels of reactive oxygen species(ROS)through various mechanisms.This triggers the activation of Nrf2,a redox-sensitive transcription factor activated by increases in oxidative stress.Activation of Nrf2 mitigates oxidative stress by increasing the nuclear transcription of many antioxidant genes while also mediating additional beneficial effects through the cytoprotective nature of Nrf2 signaling.Understanding the transcriptional patterns of Nrf2 caused by exercise can help in the design of pharmacological mimicry of the process in patients who are unable to exercise for various reasons.展开更多
<strong>Background:</strong><span style="font-family:Verdana;"> Worldwide, the burden of cardiovascular (CV) risk factors is rising with devastating impacts on the productive workforce. In ...<strong>Background:</strong><span style="font-family:Verdana;"> Worldwide, the burden of cardiovascular (CV) risk factors is rising with devastating impacts on the productive workforce. In developing nations, it has further led to an unstable population pyramid as a result of premature deaths of her workforce leading to the continued tapering of the pyramidal apex. Inspite of this, many studies were conducted among the general population neglecting the local government civil servants who are seen as policy implementers. Therefore, the study assessed the pattern of CV risk factors in South-western Nigeria.</span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> A cross-sectional study was conducted among 260 local government workers selected by multistage sampling technique from July to September 2017. A pretested, interviewer-administered questionnaire was administered to obtain socio-demographic and behavioural information. Lipid analysis, anthropometric, blood pressure, fasting blood glucose measurements were done according to protocols. Data were analyzed using IBM SPSS version 25;bivariate analysis was done using Chi-square. Level of significance was at 5%. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> The mean age of respondents was 46.0 </span><span style="font-family:Verdana;">±</span><span style="font-family:Verdana;"> 6.7 years. The proportion of participants with good knowledge of risk factors was 57.7%. The proportion of respondent with hypertension, visceral obesity, general obesity, diabetes, smoking and physical inactivity was 40.4%, 35.0%, 52.2%, 38.2%, 5.8% and 75.8% respectively. The prevalence of elevated total cholesterol (</span><span style="font-family:Verdana;">↑</span><span style="font-family:Verdana;">TC)</span><span style="font-family:Verdana;">, raised low-density lipoprotein (</span><span style="font-family:Verdana;">↑</span><span style="font-f展开更多
The musculo-skeletal system is commonly affected in sickle cell disease, manifesting itself as bone infarction, femoral head osteonecrosis, osteomyelitis, myonecrosis, myofibrosis and fascitis. Myositis and fasciitis ...The musculo-skeletal system is commonly affected in sickle cell disease, manifesting itself as bone infarction, femoral head osteonecrosis, osteomyelitis, myonecrosis, myofibrosis and fascitis. Myositis and fasciitis are observed during a vaso-occlusive crisis in 4% of patients. Pain and swelling of bilateral proximal groups of muscles of upper and lower limbs are common presenting complaints due to prolonged sickling crises [1]. We report a case of 30-year old known HbSS patient with bilateral knee stiffness of two months duration, with associated swelling and warmth of both thighs. No preceding history of trauma. He was said to suffer at least two sickling crises in a month with the last one occurring one week prior to presentation. X-ray of the thigh showed no calcification in muscle groups. He was commenced on flexion-extension exercises.展开更多
文摘Male infertility has become a problem worldwide,and recent research has emphasized the development of more effective therapy options.Among natural compounds,rutin has been widely studied for its potential to treat dysfunction related to male infertility,including a reduction in sperm quality,spermatogenesis disruption and structural disruption in the testis.A thorough review of scientific literature published in several databases,including Google Scholar,PubMed/MEDLINE and Scopus,was used to synthesize the present state of research on the role of rutin in male reproductive health.Rutin has been shown to possess antiapoptotic,antioxidant and anti-inflammatory activities,among others,which are crucial in the management of male infertility.Numerous investigations have shown that rutin protects against male infertility and have explored the underlying mechanisms involved.The present review,therefore,assesses the therapeutic mechanisms involved in male infertility treatment using rutin.Rutin was able to mitigate the induced oxidative stress,apoptosis,inflammation,and related physiological processes that can cause testicular dysfunction.
文摘Introduction: COVID-19 vaccine uptake and acceptance have been a major global concern due to the prevalent misinformation and disinformation that has characterized the vaccine rollout worldwide. This study aimed to assess COVID-19 vaccine uptake and acceptance, and associated factors among selected community members in two states in southwestern Nigeria. Method: We conducted a cross-sectional study using a multistage sampling technique. Fifty catchment settlements of 10 health facilities in each of Oyo and Ogun States targeted for a COVID-19 infection prevention and control intervention were randomly selected. Four households were targeted per settlement. All households that refused access were replaced, to ensure a minimum of four households randomly selected per settlement. The primary household decision-maker was interviewed in each household. Information elicited included respondents’ sociodemographic characteristics, health history, knowledge, risk and benefit perception about the COVID-19 vaccine, vaccine uptake, and willingness to be vaccinated. The study was conducted from July–August 2021. Data were analyzed using SPSS IBM version 23. Result: Four hundred household decision-makers were surveyed in Oyo and Ogun states, after replacement. The mean age of the respondents was 43.0 ± 11.0 years. The majority, 346 (86.5%) had heard about COVID-19 vaccination, but only 47 (13.6%) had received a COVID-19 vaccination. Of the 299 respondents who reported not receiving a COVID-19 vaccination, 166 (55.5%) were willing to be vaccinated. In univariate analysis, respondents who were female had tertiary education, perceived that COVID-19 vaccines are free and accessible, perceived that COVID-19 vaccines have minimal side effects, and perceived higher benefits of COVID-19 vaccination had higher odds of being vaccinated. In contrast, younger respondents, respondents with higher knowledge scores on COVID-19 preventive measures, and with chronic illness had lower likelihoods of being vaccinated. In multivariate analy
基金College Students’Innovation and Entrepreneurship Training Program Project“Innovation of Zhuang Medical Culture in An All-Round Well-Off Perspective-Cloud Platform to Help Medical Treatment and Publicity”(Project No.202313645016)。
文摘Based on the inheritance and development of Zhuang medicine culture from the perspective of a comprehensive well-off society,traditional Chinese medicine is a treasure of Chinese civilization.The inheritance,innovation,and development of traditional Chinese medicine are crucial to the cause of socialism with Chinese characteristics in the new era.By engaging young people,reducing the aging of the medical team,and understanding the views and suggestions of various groups on Zhuang medicine culture,questionnaire surveys,field interviews,literature searches,and other methods were employed to gather and analyze public opinions and suggestions on Zhuang medicine.Additionally,online consultations were conducted to assess the popularity of Zhuang medicine and identify existing problems.Based on these findings,recommendations and strategies for improvement were formulated.Furthermore,the design of an online consultation app is proposed to enhance the role and effectiveness of Zhuang medicine’s inheritance and development.
文摘Background:Increasing number of people globally gives in to indiscriminate consumption of excess alcohol as a coping mechanism to relieve any form of physical or psychological stress.Previously,ethnomedicinal use of Zingiber officinale Roscoe(Ginger)have been shown to exhibit broad range of pharmacological benefits but no data has reported the phytotherapeutic treatment of Zingiber officinale methanol extract(MEZO)on alcohol-use disorder(AUD)and post-traumatic stress disorder(PTSD)-induced oxidative and inflammatory stress relevant to disruption of kidney functions in animal model.Objective:To investigate the protective effect of MEZO on kidney-oxidative and inflammatory biomarkers in sub-chronic alcohol exacerbation of PTSD symptoms in mice.Methods:Male Swiss mice were administered 30%ethanol for two weeks and thereafter introduced to single pro-longed stress to induce AUD and PTSD respectively prior to post-treatment with MEZO and vitamin C.Markers of oxidative stress,inflammatory cytokines,kidney functions,HPA-axis signaling molecules,vasodilator substance,and histopathology of the kidney were evaluated.Results:Sub-chronic alcohol intoxication heightened PTSD-induced oxido-inflammatory stress,altered the kidney function indices and HPA-axis,and reduced nitric oxide production,which were ameliorated by the phytother-apeutic treatment with MEZO.Furthermore,severe degeneration and atrophy of renal tubules were observed.Meanwhile,MEZO interventions strongly abated all these effects.Conclusions:Herein,the study shows that phytotherapeutic treatment with MEZO prevents the damaging effects of co-exposure to sub-chronic alcohol intoxication and PTSD.
文摘Objective:To identify the knowledge and awareness level of human mpox viral infection among healthcare workers in southwestern Nigeria.Methods:A cross-sectional study was conducted in Ekiti State,southwest Nigeria among 316 healthcare workers that were selected through a systematic random sampling.Data were collected with the aid of a semi-structured,self-administered questionnaire.The Chi-square test and binary logistic regression were used to find the association between the independent and dependent variables.The significance level was set at P-value<0.05.Results:Two hundred and twenty-two(70.3%)of the respondents were aged≤40 years,mean age(36±9)years,189(59.8%)were female,306(96.8%)were Christians,and 203(64.2%)were married.Three hundred and fourteen(99.4%)of the respondents were aware of mpox infection.Main sources of information about mpox were medical education(44.0%),radio/television(32.0%)and newspaper(21.0%).However,among those aware of the disease,209(67.0%)demonstrated poor knowledge levels.Longer than 5 years’experience of medical practice was the only significant predictor of higher knowledge level of the disease(OR 1.76,95%CI 1.01-3.06;P=0.046).Conclusions:Despite the high awareness level of mpox infection among healthcare workers,there still exists a huge knowledge gap.It is recommended that targeted intervention could be directed towards continuous medical education and simulation exercises on re-emerging infectious diseases like mpox to improve the knowledge of the healthcare workers.
文摘Cervical cancer remains a major public health problem accounting for continuous female death in developing countries.Cervical cancer is the second most common cancer in women globally with an estimated number of 500,000 new cases of cervical cancer and 273,000 mortalities annually.Cervical screening is the best cancer screening test in the history of medicine and most cost-effective of all medical screening tests.The study review aimed to highlight methods of cervical cancer prevention,identify the uptake of cervical screening among women,and explain the role of nurses in uptake of cervical screening.Cervical cancer is preventable and easily treatable if it is detected at early stages,but poor information on prevention and access to screening and treatment contributes to 90%of deaths.In the developing countries such as Nigeria,a large proportion of cervical cancers are diagnosed in advanced stages,with poor rates of survival.The three main methods for preventing cervical cancer are through primary prevention(human papillomavirus vaccination and health education),secondary prevention(cervical screening,early detection of precancerous lesions,and treatment),and tertiary prevention(measures to slow the progression or recurrence,surgical removal,radiotherapy,and chemotherapy).Nurses can help improve the acceptability of this neglected promise by focusing on health education on cervical screening and vaccination in prenatal clinics and infant welfare clinics where there are more women.Inclusion of cyberspace could also serve as a successful and popular platform for this health teaching.All nurses/midwives must preach and fervently work toward the WHO 90–70–90 plan for eradicating cervical cancer.
文摘Diabetes mellitus is a metabolic disease characterized by high blood glucose levels and a range of other symptomsthat last for a long period of time. It has a rapid prevalence globally, and there is a possibility of the statisticdoubling in a few years. This review is aimed at evaluating the mechanism, pathophysiology, and pharmacologyof diabetes mellitus. The data used was sourced through a thorough review of scientific articles published in avariety of databases, including Springer, Scopus, Elsevier, Google Scholar, Wiley, Web of Science, PubMed, andTaylor & Francis. Furthermore, PhD and MSc theses were also used in compiling data. According to the literaturereview, diabetes mellitus is a persistent condition with various risk factors and serious complications that affectthe quality of life. However, research studies have helped in the prognosis, diagnosis, treatment, and managementof its different forms.
文摘Exercise has well-characterized therapeutic benefits in the management of type 2 diabetes mellitus(T2DM).Most of the beneficial effects of exercise arise from the impact of nuclear factor erythroid 2 related factor-2(Nrf2)activation of glucose metabolism.Nrf2 is an essential controller of cellular anti-oxidative capacity and circadian rhythms.The circadian rhythm of Nrf2 is influenced by circadian genes on its expression,where the timing of exercise effects the activation of Nrf2 and the rhythmicity of Nrf2 and signaling,such that the timing of exercise has differential physiological effects.Exercise in the evening has beneficial effects on diabetes management,such as lowering of blood glucose and weight.The mechanisms responsible for these effects have not yet been associated with the influence of exercise on the circadian rhythm of Nrf2 activity.A better understanding of exercise-induced Nrf2 activation on Nrf2 rhythm and signaling can improve our appreciation of the distinct effects of morning and evening exercise.This review hypothesizes that activation of Nrf2 by exercise in the morning,when Nrf2 level is already at high levels,leads to hyperactivation and decrease in Nrf2 signaling,while activation of Nrf2 in the evening,when Nrf2 levels are at nadir levels,improves Nrf2 signaling and lowers blood glucose levels and increases fatty acid oxidation.Exploring the effects of Nrf2 activators on rhythmic signaling could also provide valuable insights into the optimal timing of their application,while also holding promise for timed treatment of type 2 diabetes.
文摘Four diets were formulated to study the influence of varying crude protein levels on the performance, egg quality, serum and haematological characteristics at the first phase of laying cycle of sixty Bovan Nera laying birds that were randomly allotted to dietary treatments. The four experimental diets had five replicates each and three birds per repli-cate. Diet 1 contained 14% crude protein (CP), while diet 2 contained 15% CP, diets 3 and 4 contained 16% and 17% CP respectively. The experimental birds were fed for 10 weeks and the data collected were statistically analysed. Apparent variations recorded for all the performance characteristics such as Egg number, Hen-day production, Feed Conversion Ratio (FCR) and weight gain were significantly different (p < 0.05). The best FCR value were recorded by birds fed 17% CP (3.45), while the highest weight gain mean value were also recorded by birds fed 17% CP value. Findings indicated a direct relationship between dietary crude protein values and performance.
文摘BACKGROUND Most occurrences of type 1 diabetes cases in any population are sporadic rather than familial.Hence,type 1 diabetes among siblings is a rare occurrence.Even more rare is for three or more siblings to develop type 1 diabetes.In this report,we describe a case of a Nigerian family in which type 1 diabetes occurred in three siblings among four children with neither parent having diabetes.All three siblings are positive for glutamic acid decarboxylase and anti-islet cell antibodies.CASE SUMMARY There were four siblings(three males and one female)born to a couple without a diagnosis of diabetes.The eldest child(male)was diagnosed with diabetes at the age of 15,the second child(female)was diagnosed at the age of 11 and the fourth child(male)was diagnosed at the age of 9.All the siblings presented with similar osmotic symptoms and were diagnosed of diabetic ketoacidosis.All of them had markedly reduced serum C-peptide levels with high levels of glutamic acid decarboxylase and insulinoma-associated protein-2 antibodies.We could not perform genetic analysis of HLA-DR,DQ and CTLA4 in the siblings as well as the parents;hence haplotypes could not be characterized.Both parents of the probands have no prior history of diabetes,and their blood glucose and glycated hemoglobin levels were within normal ranges.The third child(male)has no history suggestive of diabetes,and his blood glucose and glycated hemoglobin have remained within normal ranges.CONCLUSION Although the occurrence of type 1 diabetes in proband siblings is uncommon,screening for diabetes among siblings especially with islet autoantibodies should be encouraged.
文摘This paper investigates the tolerable sample size needed for Ordinary Least Square (OLS) Estimator to be used when there is presence of Multicollinearity among the exogenous variables of a linear regression model. A regression model with constant term (β0) and two independent variables (with β1 and β2 as their respective regression coefficients) that exhibit multicollinearity was considered. A Monte Carlo study of 1000 trials was conducted at eight levels of multicollinearity (0, 0.25, 0.5, 0.7, 0.75, 0.8, 0.9 and 0.99) and sample sizes (10, 20, 40, 80, 100, 150, 250 and 500). At each specification, the true regression coefficients were set at unity while 1.5, 2.0 and 2.5 were taken as the hypothesized value. The power value rate was obtained at every multicollinearity level for the aforementioned sample sizes. Therefore, whether the hypothesized values highly depart from the true values or not once the multicollinearity level is very high (i.e. 0.99), the sample size needed to work with in order to have an error free estimation or the inference result must be greater than five hundred.
文摘Background: Groundwater is an important source of drinking water for the indigenous communities of Ebocha-Obrikom. Access to safe drinking water, in particular, is critical to one’s health and, by extension, one’s income and well-being. Underground wells are the primary supply of drinking water in the Niger Delta, and the groundwater is not always treated before consumption. As a result, water continues to be a vital environmental component that affects both humans and other life forms. Objectives: The aims of the research are to trace the sources and affecting factors of groundwater pollution via statistical and multivariate statistical techniques. Method: The investigation made use of standard analytical procedures. All sampling, conservation, transportation and analysis followed standard procedures described in APHA (2012). To prevent degradation of the organic substances, all obtained samples were transferred to the laboratory, while kept in an icebox. Results: The study reveals that the greater the number of principal components extracted the greater variation in geochemical composition of the ground waters. It indicated that 34 parameters were distributed into six (6) and nine (9) principal components (PCs) extracted for groundwater samples for both rainy and dry seasons, potentially suggesting the input of different pollutants from different sources. Gas flaring, mineral dissolution/precipitation and anthropogenic input are the main sources of the physicochemical indices and trace elements in the groundwater. Groundwater chemistry is predominantly regulated by natural processes such as dissolution of carbonates, silicates, and evaporates and soil leaching, followed by human activities. Climatic factors and land use types are also important in affecting groundwater chemistry. Conclusion: Greater efforts should be made to safeguard groundwater, which is hampered by geogenic and anthropogenic activities, in order to achieve sustainable groundwater development. As a result, communities are recommended to m
文摘Introduction:Osun River dissecting the Osun-Osogbo Sacred Grove,though inscribed on the World Heritage List,has been rarely assessed for biodiversity values or ecotoxicology.In this study,we investigated the concentrations of Cu and Zn in the benthic sediments and two dominant gastropod species(Melanoides tuberculata and Lanistes varicus)of the Osun River.Benthic sediment and gastropod samples were collected on quarterly basis from June 2015 to March 2016 along the longitudinal stretch of the river.Dry samples were digested and analysed for Cu and Zn using the atomic absorption spectrophotometry.Results:With the exception of September sampling period,the two metals recorded higher values in the animals than in the sediments.Cu(1.23±0.81μg/g)was much lower(p<0.01)than zinc(6.29±2.15μg/g)in the benthic sediments.In the same vein,Cu was significantly lower(p<0.01)than Zn in both species.Both metals recorded much lower values than their average concentrations in the Earth’s crust as well as the recommended limits for freshwater life.Comparatively,L.varicus recorded higher bioaccumulation factor than M.tuberculata.Conclusions:Findings from this study suggest that both metals posed no toxicological risk to the freshwater system of Osun River.Concentrations of both metals in the sediments as well as their accumulation factors in both gastropod species were indicative of an unimpacted freshwater system.
文摘Objective:The objective of this study is to assess the knowledge and self-care practices of people living with type 2 diabetes mellitus(T2DM).Materials and Methods:The study was conducted in a clinic in Southwestern Nigeria.It adopted a cross-sectional design.The sample consists of 107 people living with T2DM.Data were collected using Diabetes Knowledge Questionnaire and Revised Self-care Inventory Scale.Results:The mean diabetes knowledge of the participants was 16.2±3.0 and 70.1%had inadequate knowledge of T2DM.The mean diabetes self-care practice score among the participants was 49.9±4.9,and 89.7%reported poor diabetes self-care practice.There is no significant difference in the knowledge of diabetes between male(16.42±3.42)and female(16.12±2.8)participants(t=0.45;P=0.65),and no significant difference in self-care practice of male(49.23±4.51)and female(50.06±5.07)participants(t=0.75,P=0.46).In addition,there is no correlation between age and knowledge of diabetes(r=-0.18,P=0.07)and self-care practices(r=0.08,P=0.38)of participants.No significant relationship was found between knowledge of diabetes and diabetes selfcare practices(χ^(2)=1.605,P=0.448)Conclusion:Knowledge of diabetes and self-care practices of people living with T2DM in this study were poor.Effort should be directed at improving their diabetes knowledge and self-care practices.
文摘Tapioca is a cassava-based food product made in the form of irregular lumps of partly gelatinized starch grits. Tapioca was enriched with varying proportions of soybean flour (0, 85% - 15%, 75% - 25%, 50% - 50%) to produce Soy-tapioca (ST). Nutrient and anti-nutrient composition of ST were determined by standard methods, while sensory evaluation was also carried out. Results showed significant increase in protein, fat and mineral contents of tapioca as the level of soy-substitution increased. There was a decrease in the cyanogenic potential and an increase in the level of trypsin inhibitor as soy-substitution increased. Tannin, phytic acid and oxalate contents of the soy-tapioca samples were below minimum levels of safety. ST (50% - 50%) was more nutrient dense than the other products, but ST (85% - 15%) was more accepted in terms of colour, taste and texture. ST suggests a safe, nutritious and acceptable food product that can enhance food and nutrition security among cassava consuming populations.
文摘Purpose: To compare the effect of chlorhexidine-alcohol and povidone iodine on surgical site infection (SSI) after caesarean section. Methodology: A randomized control trial of 374 patients (188 in the chlorhexidine-alcohol group and 186 in the povidone iodine group) who had elective caesarean section with no overt risk for SSI was done. Patients were followed up until thirty days after delivery to assess for symptoms and signs of SSI. Results: Fifty-one (13.6%) of the study population developed SSI. Although the incidence of SSI was lower in the chlorhexidine-alcohol group than the povidone iodine group (12.2% vs. 15.1%;p = 0.26);the difference was not statistically significant. The incidence of adverse skin reaction in Chlorhexidine-alcohol vs. povidone iodine was also not statistically significant (4.0% vs. 5.4%;p = 0.40). Conclusion: The study demonstrates that there was no statistically significant difference in antiseptic property and side effect profile of chlorhexidine-alcohol and povidone-iodine when used as skin antisepsis in caesarean section.
文摘Obtaining rapid access in emergency situations for infusion of IV fluids, blood and blood products or medications is vital in using various methods. These include venopuncture, intraosseous infusion, percutanous central venous access and peripheral venous cut-down. We report a case of a 30-year-old woman who developed severe obstetric hemorrhage and had peripheral venous cut-down that was complicated by bilateral femoral osteomyelitis. This is a rare occurrence and this case report shows the need for strict adherence to safety precautions to prevent complications such as that from the procedure.
文摘The ability of physical activity to ameliorate cardiovascular disease and improve cardiovascular health is well accepted,but many aspects of the molecular mechanisms underlying these benefits are incompletely understood.Exercise increases the levels of reactive oxygen species(ROS)through various mechanisms.This triggers the activation of Nrf2,a redox-sensitive transcription factor activated by increases in oxidative stress.Activation of Nrf2 mitigates oxidative stress by increasing the nuclear transcription of many antioxidant genes while also mediating additional beneficial effects through the cytoprotective nature of Nrf2 signaling.Understanding the transcriptional patterns of Nrf2 caused by exercise can help in the design of pharmacological mimicry of the process in patients who are unable to exercise for various reasons.
文摘<strong>Background:</strong><span style="font-family:Verdana;"> Worldwide, the burden of cardiovascular (CV) risk factors is rising with devastating impacts on the productive workforce. In developing nations, it has further led to an unstable population pyramid as a result of premature deaths of her workforce leading to the continued tapering of the pyramidal apex. Inspite of this, many studies were conducted among the general population neglecting the local government civil servants who are seen as policy implementers. Therefore, the study assessed the pattern of CV risk factors in South-western Nigeria.</span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> A cross-sectional study was conducted among 260 local government workers selected by multistage sampling technique from July to September 2017. A pretested, interviewer-administered questionnaire was administered to obtain socio-demographic and behavioural information. Lipid analysis, anthropometric, blood pressure, fasting blood glucose measurements were done according to protocols. Data were analyzed using IBM SPSS version 25;bivariate analysis was done using Chi-square. Level of significance was at 5%. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> The mean age of respondents was 46.0 </span><span style="font-family:Verdana;">±</span><span style="font-family:Verdana;"> 6.7 years. The proportion of participants with good knowledge of risk factors was 57.7%. The proportion of respondent with hypertension, visceral obesity, general obesity, diabetes, smoking and physical inactivity was 40.4%, 35.0%, 52.2%, 38.2%, 5.8% and 75.8% respectively. The prevalence of elevated total cholesterol (</span><span style="font-family:Verdana;">↑</span><span style="font-family:Verdana;">TC)</span><span style="font-family:Verdana;">, raised low-density lipoprotein (</span><span style="font-family:Verdana;">↑</span><span style="font-f
文摘The musculo-skeletal system is commonly affected in sickle cell disease, manifesting itself as bone infarction, femoral head osteonecrosis, osteomyelitis, myonecrosis, myofibrosis and fascitis. Myositis and fasciitis are observed during a vaso-occlusive crisis in 4% of patients. Pain and swelling of bilateral proximal groups of muscles of upper and lower limbs are common presenting complaints due to prolonged sickling crises [1]. We report a case of 30-year old known HbSS patient with bilateral knee stiffness of two months duration, with associated swelling and warmth of both thighs. No preceding history of trauma. He was said to suffer at least two sickling crises in a month with the last one occurring one week prior to presentation. X-ray of the thigh showed no calcification in muscle groups. He was commenced on flexion-extension exercises.
