The large size of lasers limits their applications in confined spaces,such as in biosensing and in vivo brain tissue imaging.In this regard,micron-sized lasers have been developed.They exhibit great potential for biol...The large size of lasers limits their applications in confined spaces,such as in biosensing and in vivo brain tissue imaging.In this regard,micron-sized lasers have been developed.They exhibit great potential for biological detecting,remote sensing,and depth tracking due to their small sizes,sensitive properties of their spectral fingerprints,and flexible positional modulation in the microenvironment.Lanthanide-based luminescent materials that possess long excited-state lifetime,narrow emission bandwidth,and upconversion behaviors are promising as gain mediums for novel microlasers.In addition,lanthanide-based microlasers could be generated under natural ambient conditions with pumped or continuous light sources,which significantly promotes the practical applications of microlasers.Recent progress in the design,synthesis,and biomedical applications of lanthanide-based microlasers has been outlined in this review.Lanthanide ions doped and upconverted lanthanide-based microlasers are highlighted,which exhibit advantageous structures,miniaturized dimensions,and high lasing performance.The applications of lanthanide-based microlasers are further discussed,the upconverted microlasers show great advantages for biological applications owing to their tunable excitation and emission characteristics and excellent environmental stability.Moreover,perspectives and challenges in the field of lanthanide-based microlasers are presented.展开更多
Photoelectric synaptic devices could emulate synaptic behaviors utilizing photoelectric effects and offer promising prospects with their high-speed operation and low crosstalk. In this study, we introduced a novel InG...Photoelectric synaptic devices could emulate synaptic behaviors utilizing photoelectric effects and offer promising prospects with their high-speed operation and low crosstalk. In this study, we introduced a novel InGaZnO-based photoelectric memristor. Under both electrical and optical stimulation, the device successfully emulated synaptic characteristics including excitatory postsynaptic current (EPSC), paired-pulse facilitation (PPF), long-term potentiation (LTP), and long-term depression (LTD). Furthermore, we demonstrated the practical application of our synaptic devices through the recognition of handwritten digits. The devices have successfully shown their ability to modulate synaptic weights effectively through light pulse stimulation, resulting in a recognition accuracy of up to 93.4%. The results illustrated the potential of IGZO-based memristors in neuromorphic computing, particularly their ability to simulate synaptic functionalities and contribute to image recognition tasks.展开更多
Spherical nucleic acids(SNAs)are a 3D spherical nanostructure composed of highly oriented,dense layers of oligonucleotides conjugated to a hollow or solid core.This structure allows SNAs to show resistance to nuclease...Spherical nucleic acids(SNAs)are a 3D spherical nanostructure composed of highly oriented,dense layers of oligonucleotides conjugated to a hollow or solid core.This structure allows SNAs to show resistance to nuclease degradation,enter into nearly all cells without transfection agents and enable precise interactions with target molecules.Based on superior biological properties,SNAs can be tailored for diverse biological applications,rendering them a flexible and biosafe tool for biological applications as well as an enabling platform for therapy.In this review,we mainly discuss the structure and conjugation mode of SNAs and focus on recent advances in their applications,such as biomedical detection,imaging,and drug delivery.Finally,the remaining challenges and future directions of SNAs are also discussed and proposed.展开更多
DNA hydrogels are three-dimensional polymer networks constructed using DNA as the structural building block.Due to the tight binding between hydrophilic groups on DNA chains and water molecules,they exhibit outstandin...DNA hydrogels are three-dimensional polymer networks constructed using DNA as the structural building block.Due to the tight binding between hydrophilic groups on DNA chains and water molecules,they exhibit outstanding plasticity and fluid thermodynamic properties,making them one of the best choices for mimicking natural biological tissues.By controlling the backbone building blocks,gelation conditions,and cross-linking methods of DNA hydrogels,hydrogels with different mechanical strengths can be obtained,thus expanding their applications in the field of biology.This review first introduces the relationship between the mechanical properties of DNA hydrogels and their structure,elucidates the approaches and strategies for mechanical property modulation,and focuses on the scheme of controllable design to modulate the mechanical properties of DNA hydrogels for applications in biosensing,cellular function regulation,and bone tissue engineering.Furthermore,this review outlines the future development directions and challenges faced in the mechanical property modulation of DNA hydrogels,providing useful information for the precise design of DNA hydrogels for biological research.展开更多
Bacterial infections and excessive oxidative stress seriously hinder the healing of skin wounds.Traditional wound dressings can only serve as physical barriers and lack active molecules essential for actively promotin...Bacterial infections and excessive oxidative stress seriously hinder the healing of skin wounds.Traditional wound dressings can only serve as physical barriers and lack active molecules essential for actively promoting wound healing.Herein,an antibacterial and antioxidant liquid metal inorganic active material is developed for wound repair through in situ polymerization of chitosan/acrylic acid precursor solution initiated by tannic acid-coated liquid metal nanoparticles,without extra initiators and ultraviolet (UV) light.The tannic acid component enables the inorganic active material to exhibit antioxidant property,which can remove 90% of free radicals and relieve cellular oxidative stress.The chitosan component endows the inorganic active material with antibacterial property,effectively inhibiting the growth of Staphylococcus aureus and Escherichia coli (killing ratio: 90%).In vivo experiment demonstrates that this inorganic active material can promote the healing of Staphylococcus aureus-infected wound,achieving a closure rate of 98.16% on the 9th day.Meanwhile,this inorganic active material exhibits good electrical conductivity,enabling timely and stable monitoring of human joint movements.This work offers a simple strategy for developing multifunctional inorganic active material,which holds great potential for wound repair and motion monitoring.展开更多
胆肠吻合术后肠内容物可返流入胆道引起胆管炎。1981年7月～1994年6月,作者设计采用胆管空肠吻合活瓣成形术116例。该术式分 Y 形法、袢式法和间置法三种,于肠肠吻合口处附加活瓣成形术,旨在将肠内容物于返流的起始部即予阻断。本组病...胆肠吻合术后肠内容物可返流入胆道引起胆管炎。1981年7月～1994年6月,作者设计采用胆管空肠吻合活瓣成形术116例。该术式分 Y 形法、袢式法和间置法三种,于肠肠吻合口处附加活瓣成形术,旨在将肠内容物于返流的起始部即予阻断。本组病例术后无住院期间死亡和胆瘘发生,随访无胆道症状复发92例(79.3%)效果满意。展开更多
基金supported by the National Natural Science Foundation of China(Nos.22020102003,22207104,and 22125701)the National Key R&D Program of China(Nos.2022YFF071000 and 2021YFF0701800)+2 种基金Natural Science Foundation of Jilin Province(No.20230101102JC)China Postdoctoral Science Foundation(Nos.2020M681055 and 2022T150634)Young Elite Scientists Sponsorship Program by CAST(Nos.2021-2023QNRC and YESS20210067).
文摘The large size of lasers limits their applications in confined spaces,such as in biosensing and in vivo brain tissue imaging.In this regard,micron-sized lasers have been developed.They exhibit great potential for biological detecting,remote sensing,and depth tracking due to their small sizes,sensitive properties of their spectral fingerprints,and flexible positional modulation in the microenvironment.Lanthanide-based luminescent materials that possess long excited-state lifetime,narrow emission bandwidth,and upconversion behaviors are promising as gain mediums for novel microlasers.In addition,lanthanide-based microlasers could be generated under natural ambient conditions with pumped or continuous light sources,which significantly promotes the practical applications of microlasers.Recent progress in the design,synthesis,and biomedical applications of lanthanide-based microlasers has been outlined in this review.Lanthanide ions doped and upconverted lanthanide-based microlasers are highlighted,which exhibit advantageous structures,miniaturized dimensions,and high lasing performance.The applications of lanthanide-based microlasers are further discussed,the upconverted microlasers show great advantages for biological applications owing to their tunable excitation and emission characteristics and excellent environmental stability.Moreover,perspectives and challenges in the field of lanthanide-based microlasers are presented.
基金supported by the National Key Research and Development Program of China (2021YFA1202600)the NSFC (92064009, 22175042)+3 种基金the Science and Technology Commission of Shanghai Municipality (22501100900)the China Postdoctoral Science Foundation (2022TQ0068, 2023M740644)the Shanghai Sailing Program (23YF1402200, 23YF1402400)the Qilu Young Scholar Program of Shandong University。
文摘Photoelectric synaptic devices could emulate synaptic behaviors utilizing photoelectric effects and offer promising prospects with their high-speed operation and low crosstalk. In this study, we introduced a novel InGaZnO-based photoelectric memristor. Under both electrical and optical stimulation, the device successfully emulated synaptic characteristics including excitatory postsynaptic current (EPSC), paired-pulse facilitation (PPF), long-term potentiation (LTP), and long-term depression (LTD). Furthermore, we demonstrated the practical application of our synaptic devices through the recognition of handwritten digits. The devices have successfully shown their ability to modulate synaptic weights effectively through light pulse stimulation, resulting in a recognition accuracy of up to 93.4%. The results illustrated the potential of IGZO-based memristors in neuromorphic computing, particularly their ability to simulate synaptic functionalities and contribute to image recognition tasks.
基金supported by the National Key Research and Development Program of China(2023YFA0915200)the National Natural Science Foundation of China(12305400,12105352)+1 种基金the Natural Science Foundation of Shanghai,China(22ZR1470600)the Xiangfu Lab Research Project(XF012022E0100).
文摘Spherical nucleic acids(SNAs)are a 3D spherical nanostructure composed of highly oriented,dense layers of oligonucleotides conjugated to a hollow or solid core.This structure allows SNAs to show resistance to nuclease degradation,enter into nearly all cells without transfection agents and enable precise interactions with target molecules.Based on superior biological properties,SNAs can be tailored for diverse biological applications,rendering them a flexible and biosafe tool for biological applications as well as an enabling platform for therapy.In this review,we mainly discuss the structure and conjugation mode of SNAs and focus on recent advances in their applications,such as biomedical detection,imaging,and drug delivery.Finally,the remaining challenges and future directions of SNAs are also discussed and proposed.
基金supported by the National Key Research and Development Program of China(2023YFB3208204)the National Natural Science Foundation of China(12305400,12105352)+2 种基金the Natural Science Foundation of Shanghai,China(22ZR1470600)the Natural Science Foundation of Shandong Province(ZR2019MB068,ZR2022MB012,ZR2021QE167)the Xiangfu Lab Research Project(XF012022E0100).
文摘DNA hydrogels are three-dimensional polymer networks constructed using DNA as the structural building block.Due to the tight binding between hydrophilic groups on DNA chains and water molecules,they exhibit outstanding plasticity and fluid thermodynamic properties,making them one of the best choices for mimicking natural biological tissues.By controlling the backbone building blocks,gelation conditions,and cross-linking methods of DNA hydrogels,hydrogels with different mechanical strengths can be obtained,thus expanding their applications in the field of biology.This review first introduces the relationship between the mechanical properties of DNA hydrogels and their structure,elucidates the approaches and strategies for mechanical property modulation,and focuses on the scheme of controllable design to modulate the mechanical properties of DNA hydrogels for applications in biosensing,cellular function regulation,and bone tissue engineering.Furthermore,this review outlines the future development directions and challenges faced in the mechanical property modulation of DNA hydrogels,providing useful information for the precise design of DNA hydrogels for biological research.
基金supported by the National Natural Science Foundation of China (Nos.52222214,52372274,22388101,22020102003,22125701)the National Key Research and Development Program of China (No.2020YFA0908900)+4 种基金the Natural Science Foundation of Jilin Province,China (Nos.20240101175JC,20210101366JC)the Young Elite Scientists Sponsorship Program by the China Association for Science and Technology (No.2022QNRC001)the Beijing Natural Science Foundation,China (No.2244071)the Xiangfu Lab Research Project,China (No.XF012022C0200)the Funding from China Postdoctoral Science Foundation (No.2022M721802).
文摘Bacterial infections and excessive oxidative stress seriously hinder the healing of skin wounds.Traditional wound dressings can only serve as physical barriers and lack active molecules essential for actively promoting wound healing.Herein,an antibacterial and antioxidant liquid metal inorganic active material is developed for wound repair through in situ polymerization of chitosan/acrylic acid precursor solution initiated by tannic acid-coated liquid metal nanoparticles,without extra initiators and ultraviolet (UV) light.The tannic acid component enables the inorganic active material to exhibit antioxidant property,which can remove 90% of free radicals and relieve cellular oxidative stress.The chitosan component endows the inorganic active material with antibacterial property,effectively inhibiting the growth of Staphylococcus aureus and Escherichia coli (killing ratio: 90%).In vivo experiment demonstrates that this inorganic active material can promote the healing of Staphylococcus aureus-infected wound,achieving a closure rate of 98.16% on the 9th day.Meanwhile,this inorganic active material exhibits good electrical conductivity,enabling timely and stable monitoring of human joint movements.This work offers a simple strategy for developing multifunctional inorganic active material,which holds great potential for wound repair and motion monitoring.
文摘胆肠吻合术后肠内容物可返流入胆道引起胆管炎。1981年7月～1994年6月,作者设计采用胆管空肠吻合活瓣成形术116例。该术式分 Y 形法、袢式法和间置法三种,于肠肠吻合口处附加活瓣成形术,旨在将肠内容物于返流的起始部即予阻断。本组病例术后无住院期间死亡和胆瘘发生,随访无胆道症状复发92例(79.3%)效果满意。
