本实验用产生OH·体系(Fe^(2+)/抗坏血酸)直接损伤大鼠心肌线粒体,观察丹参素的保护作用。实验结果表明丹参素对线粒体ADP/O,RCR(respiratory control rate,呼吸控制率)、细胞色素氧化酶活性有保护作用,提示丹参素为良好的OH·...本实验用产生OH·体系(Fe^(2+)/抗坏血酸)直接损伤大鼠心肌线粒体,观察丹参素的保护作用。实验结果表明丹参素对线粒体ADP/O,RCR(respiratory control rate,呼吸控制率)、细胞色素氧化酶活性有保护作用,提示丹参素为良好的OH·清除剂。展开更多
Calcium sensing receptors (CaSR) is a member of super-family of G-protein coupling receptors. This review first introduced the concept,construction features,distribution,functions,decision methods,moderators,genetic l...Calcium sensing receptors (CaSR) is a member of super-family of G-protein coupling receptors. This review first introduced the concept,construction features,distribution,functions,decision methods,moderators,genetic locus of CaSR and its relationship with some diseases concisely. Then this article described the investigation progress of CaSR in cardiovascular system intensively,including the expression pattern,role and signal pathways of CaSR in rat myocardium in normal,ischemia-reperfusion injury,apoptosis and cardiac hypertrophy; the role and mechanism of CaSR in calcium homostasis regulation of rat myocardium,endoplasmic reticulum (ER) stress and cardiac ischemic preconditioning and postconditioning. The metabolism rule,physiological significance and pathological action of polyamine in cardiac cells; the increase of CaSR expression in cardiac tissue of artherosclerosic rat and its effect on sensitivity to acute myocardial infarction are also discussed. In the end,the research perspective of CaSR in cardiovascular system was anticipated.展开更多
文摘Calcium sensing receptors (CaSR) is a member of super-family of G-protein coupling receptors. This review first introduced the concept,construction features,distribution,functions,decision methods,moderators,genetic locus of CaSR and its relationship with some diseases concisely. Then this article described the investigation progress of CaSR in cardiovascular system intensively,including the expression pattern,role and signal pathways of CaSR in rat myocardium in normal,ischemia-reperfusion injury,apoptosis and cardiac hypertrophy; the role and mechanism of CaSR in calcium homostasis regulation of rat myocardium,endoplasmic reticulum (ER) stress and cardiac ischemic preconditioning and postconditioning. The metabolism rule,physiological significance and pathological action of polyamine in cardiac cells; the increase of CaSR expression in cardiac tissue of artherosclerosic rat and its effect on sensitivity to acute myocardial infarction are also discussed. In the end,the research perspective of CaSR in cardiovascular system was anticipated.
