Tooth agenesis constitutes one of the most common developmental anomalies in man. Oligodontia is defined as congenital absence of six or more teeth. Based on the studies of our team in cooperation with Peking Universi...Tooth agenesis constitutes one of the most common developmental anomalies in man. Oligodontia is defined as congenital absence of six or more teeth. Based on the studies of our team in cooperation with Peking University Center for Human Disease Genomics in the past five years, this article reviews the current research progress in clinical phenotypes and case collection, epidemiological investigation and etiological genetic studies of oligodontia. The symptoms of oligodontia were classified into syndromic and non-syndromic according to the occurrence of tooth agenesis with or without systemic developmental defects. As for the advancement of theories and techniques of molecular genetics, a number of gene mutations have been identified to be the direct etiological factors causing some specified diseases, especially those with developmental defects. Here, this article summarized the outcomes of molecular genetic study of some cases we collected. Of the systemic oligondontia patients, a new four-base-deletion mutation in PITX2 was identified in a large kindred with typical symptoms of Rieger Syndrome; four different gene mutations in ED1 casing X-linked hypohidrotic ectodermal displasia were found in five nucleus families. Compared with the former, non-syndromic oligodontia has more genetic heterogeneity rather than some specific virulence gene. PAX9 and MSX1 are the identified genes associated with family tooth agenesis without systemic syndrome. Also, in our research, three gene mutations in CBFA1 were detected in four cleidocranial dysplasia families, which is a systemic developmental disease including the symptoms of tooth eruption abnormality and accessory teeth.展开更多
目的试分析修复后前牙美学的临床评价与患者满意度之间的关系,为进一步提高患者满意度提供依据。方法选取个别前牙全瓷修复患者90例,修复后由患者本人评价患者满意度。由医师根据修复体的整体轮廓、表面形态质地、整体色调、颜色分布、...目的试分析修复后前牙美学的临床评价与患者满意度之间的关系,为进一步提高患者满意度提供依据。方法选取个别前牙全瓷修复患者90例,修复后由患者本人评价患者满意度。由医师根据修复体的整体轮廓、表面形态质地、整体色调、颜色分布、切端半透明度、表面个体特征与邻牙的相似程度,对修复体进行分级。采用独立样本 t 检验或方差分析,分析各美学评价指标不同级别间患者满意度的差异。测量修复体与同名天然牙间的色差,分析其与患者满意度的相关关系。结果除整体色调"良"、"中"两个级别间患者满意度的差异无统计学意义外(P=0.553),其他美学评价指标不同级别间患者满意度的差异均有统计学意义(P<0.05)。修复体与同名牙间的总色差、明度差的绝对值及Δa 的绝对值与患者满意度相关,Spearman 相关系数分别为-0.434、-0.371、-0.406(P<0.05)。结论修复后前牙各项美学特征的临床评价与患者满意度均相关,其中表面形态质地、颜色分布、表面个体特征与患者满意度的关系更密切。修复体与同名牙的总色差及明度差与患者满意度有一定的相关性。展开更多
目的探讨对过短前牙行牙冠延长术的手术方法、术后修复时间、适应证及美学效果。方法对22例患者的148颗过短前牙行牙冠延长术后再行修复治疗,用改良 Ryge 标准动态评价牙龈、牙周情况,用 Kay 牙齿美学分类标准评价患牙治疗前后的美观效...目的探讨对过短前牙行牙冠延长术的手术方法、术后修复时间、适应证及美学效果。方法对22例患者的148颗过短前牙行牙冠延长术后再行修复治疗,用改良 Ryge 标准动态评价牙龈、牙周情况,用 Kay 牙齿美学分类标准评价患牙治疗前后的美观效果。结果牙冠延长术结合修复治疗后,22例患者牙齿的美观效果均达 Kay 牙齿美学分类 ClassⅡ-Ⅰ(化妆)或 ClassⅡ-Ⅰ标准。修复后2周复查时约7.4%患牙的牙龈有较明显的炎症。经治疗及口腔卫生保健指导后,98.6%的患牙在修复6个月以上复查时,牙龈、牙周健康状况良好。2例患者随访4年余,其牙龈、牙周均无炎症表现,牙冠比例保持正常。结论通过正确的适应证选择、准确的修复设计、精细的手术操作、术后足够的牙龈恢复期及正规的口腔卫生保健,牙冠延长术结合修复治疗可获得满意的前牙修复美观效果。展开更多
文摘Tooth agenesis constitutes one of the most common developmental anomalies in man. Oligodontia is defined as congenital absence of six or more teeth. Based on the studies of our team in cooperation with Peking University Center for Human Disease Genomics in the past five years, this article reviews the current research progress in clinical phenotypes and case collection, epidemiological investigation and etiological genetic studies of oligodontia. The symptoms of oligodontia were classified into syndromic and non-syndromic according to the occurrence of tooth agenesis with or without systemic developmental defects. As for the advancement of theories and techniques of molecular genetics, a number of gene mutations have been identified to be the direct etiological factors causing some specified diseases, especially those with developmental defects. Here, this article summarized the outcomes of molecular genetic study of some cases we collected. Of the systemic oligondontia patients, a new four-base-deletion mutation in PITX2 was identified in a large kindred with typical symptoms of Rieger Syndrome; four different gene mutations in ED1 casing X-linked hypohidrotic ectodermal displasia were found in five nucleus families. Compared with the former, non-syndromic oligodontia has more genetic heterogeneity rather than some specific virulence gene. PAX9 and MSX1 are the identified genes associated with family tooth agenesis without systemic syndrome. Also, in our research, three gene mutations in CBFA1 were detected in four cleidocranial dysplasia families, which is a systemic developmental disease including the symptoms of tooth eruption abnormality and accessory teeth.
文摘目的试分析修复后前牙美学的临床评价与患者满意度之间的关系,为进一步提高患者满意度提供依据。方法选取个别前牙全瓷修复患者90例,修复后由患者本人评价患者满意度。由医师根据修复体的整体轮廓、表面形态质地、整体色调、颜色分布、切端半透明度、表面个体特征与邻牙的相似程度,对修复体进行分级。采用独立样本 t 检验或方差分析,分析各美学评价指标不同级别间患者满意度的差异。测量修复体与同名天然牙间的色差,分析其与患者满意度的相关关系。结果除整体色调"良"、"中"两个级别间患者满意度的差异无统计学意义外(P=0.553),其他美学评价指标不同级别间患者满意度的差异均有统计学意义(P<0.05)。修复体与同名牙间的总色差、明度差的绝对值及Δa 的绝对值与患者满意度相关,Spearman 相关系数分别为-0.434、-0.371、-0.406(P<0.05)。结论修复后前牙各项美学特征的临床评价与患者满意度均相关,其中表面形态质地、颜色分布、表面个体特征与患者满意度的关系更密切。修复体与同名牙的总色差及明度差与患者满意度有一定的相关性。
文摘目的探讨对过短前牙行牙冠延长术的手术方法、术后修复时间、适应证及美学效果。方法对22例患者的148颗过短前牙行牙冠延长术后再行修复治疗,用改良 Ryge 标准动态评价牙龈、牙周情况,用 Kay 牙齿美学分类标准评价患牙治疗前后的美观效果。结果牙冠延长术结合修复治疗后,22例患者牙齿的美观效果均达 Kay 牙齿美学分类 ClassⅡ-Ⅰ(化妆)或 ClassⅡ-Ⅰ标准。修复后2周复查时约7.4%患牙的牙龈有较明显的炎症。经治疗及口腔卫生保健指导后,98.6%的患牙在修复6个月以上复查时,牙龈、牙周健康状况良好。2例患者随访4年余,其牙龈、牙周均无炎症表现,牙冠比例保持正常。结论通过正确的适应证选择、准确的修复设计、精细的手术操作、术后足够的牙龈恢复期及正规的口腔卫生保健,牙冠延长术结合修复治疗可获得满意的前牙修复美观效果。
