patients with bullous epidermolysis type of drug eruption over the last 8 years were studied,including 5 males and 11 females,aged 1 to 75 years old,Among them,there were 10 patients aged 20 to 30 years old,The main c...patients with bullous epidermolysis type of drug eruption over the last 8 years were studied,including 5 males and 11 females,aged 1 to 75 years old,Among them,there were 10 patients aged 20 to 30 years old,The main causative drugs included antibiotics,antipyretics,sulfonamides and hydrosulfides,All patients presented middle to high fever,loose bullae on skin,dermolysis and tenderness.More than 90% body surface were involved in 13 cases(81 25%),and mucosae were affected in 14 cases(87 5%).There were 10 patients(62 5%)converted from other types of drug eruption,and 4 combined with basal renal diseases,3 cases died at last.The reason of conversion,the key points of treatment and prognosis of thos disease were discussed.展开更多
自身免疫性疾病系由于机体免疫系统失衡,产生针对自身组织的免疫应答并导致自身组织、器官损害的一类疾病。调节性T淋巴细胞(regulatory T cell,Treg)具有免疫应答低下和免疫抑制特性,在维持机体免疫耐受和免疫应答稳态方面具有非常重...自身免疫性疾病系由于机体免疫系统失衡,产生针对自身组织的免疫应答并导致自身组织、器官损害的一类疾病。调节性T淋巴细胞(regulatory T cell,Treg)具有免疫应答低下和免疫抑制特性,在维持机体免疫耐受和免疫应答稳态方面具有非常重要的作用,Treg的异常与多种自身免疫性疾病有关[1]。Foxp3特异性表达于CD4+CD25+Treg细胞,与其发育、成熟以及抑制功能关系密切。但是目前关于该转录因子的表达调控机制却不清楚。本文拟就CD4+CD25+Foxp3 Treg细胞的研究进展及与多种自身免疫性疾病的关系作一综述。展开更多
文摘patients with bullous epidermolysis type of drug eruption over the last 8 years were studied,including 5 males and 11 females,aged 1 to 75 years old,Among them,there were 10 patients aged 20 to 30 years old,The main causative drugs included antibiotics,antipyretics,sulfonamides and hydrosulfides,All patients presented middle to high fever,loose bullae on skin,dermolysis and tenderness.More than 90% body surface were involved in 13 cases(81 25%),and mucosae were affected in 14 cases(87 5%).There were 10 patients(62 5%)converted from other types of drug eruption,and 4 combined with basal renal diseases,3 cases died at last.The reason of conversion,the key points of treatment and prognosis of thos disease were discussed.
文摘自身免疫性疾病系由于机体免疫系统失衡,产生针对自身组织的免疫应答并导致自身组织、器官损害的一类疾病。调节性T淋巴细胞(regulatory T cell,Treg)具有免疫应答低下和免疫抑制特性,在维持机体免疫耐受和免疫应答稳态方面具有非常重要的作用,Treg的异常与多种自身免疫性疾病有关[1]。Foxp3特异性表达于CD4+CD25+Treg细胞,与其发育、成熟以及抑制功能关系密切。但是目前关于该转录因子的表达调控机制却不清楚。本文拟就CD4+CD25+Foxp3 Treg细胞的研究进展及与多种自身免疫性疾病的关系作一综述。
