基金supported by the Natural Science Foundation of Hunan Province for Young Scientists(2019JJ50784,2020JJ5404)the Hunan Health Commission Research Grant(202080,202108011054)+2 种基金the Young Teacher’s Institutional Grant from Xiangya School of Stomatology and Xiangya Stomatological Hospital,Central South University(2018YQ02,2019YQ01)the Open Sharing Fund for the Large-scale Instruments and Equipments of Central South University(CSUZC202107)the College Students’Innovative Entrepreneurial Training Plan Program(S2020150330417),China。