In this study, we aimed to （1） identify white matter （WM） deficits underlying the consciousness level in patients with disorders of consciousness （DOCs） using diffusion tensor imaging （DTI）, and （2） evaluate...In this study, we aimed to （1） identify white matter （WM） deficits underlying the consciousness level in patients with disorders of consciousness （DOCs） using diffusion tensor imaging （DTI）, and （2） evaluate the relationship between DTI metrics and clinical measures of the consciousness level in DOC patients. With a cohort of 8 comatose, 8 unresponsive wakefulness syndrome/ vegetative state, and 14 minimally conscious state patients and 25 patient controls, we performed group comparisons of the DTI metrics in 48 core WM regions of interest （ROIs）, and examined the clinical relevance using correlation analysis. We identified multiple abnormal WM ROIs in DOC patients compared with normal controls, and the DTI metrics in these ROIs were significantly correlated with clinical measures of the consciousness level. Therefore, our findings suggested that multiple WM tracts are involved in the impaired consciousness levels in DOC patients and demonstrated the clinical relevance of DTI for DOC patients.展开更多
目的研究血清神经元特异性烯醇化酶(neuron specific enolase,NSE)、S100钙结合蛋白β(S100β蛋白)、脑红蛋白对早产儿脑白质损伤的临床诊断价值。方法收集2016年12月至2019年12月入住的早产儿60例,根据颅脑B超或影像学检查结果,将60例...目的研究血清神经元特异性烯醇化酶(neuron specific enolase,NSE)、S100钙结合蛋白β(S100β蛋白)、脑红蛋白对早产儿脑白质损伤的临床诊断价值。方法收集2016年12月至2019年12月入住的早产儿60例,根据颅脑B超或影像学检查结果,将60例早产儿分为脑损伤组(n=29)及非脑损伤组(n=31)。采用化学发光法测定血清NES和S100β蛋白值,采用ELISA法动态检测脑红蛋白值,分析其临床意义。结果脑损伤组的血清S100β蛋白、NSE及NGβ水平均明显高于对照组(P<0.05)。血清NSE、S100β蛋白、脑红蛋白值与脑损伤呈线性正相关(r值分别为0.827、0.818、0.728,P<0.05)。三种指标联合检测灵敏度、特异度均高于单项检测。结论对血清NSE、S100β蛋白、脑红蛋白值的测定,对早产儿脑损伤的临床诊断效果较为突出。展开更多
基金supported by the Natural Science Foundation of China (81571025)International Cooperation Project from Shanghai Science Foundation (18410711300)+13 种基金the National Science Foundation for Distinguished Young Scholars of China (81025013)National Basic Research Development Program (973 Program) of China (2012CB720700, 2010CB945500, 2012CB966300, and 2009CB941100)the National Natural Science Foundation of China (81322021)the Beijing Nova Program (Z121110002512032)the Project for National 985 Engineering of China (985III-YFX0102)the ‘‘Dawn Tracking’’ Program of Shanghai Education Commission (10GG01)the Shanghai Natural Science Foundation (08411952000 and 10ZR1405400)the National Natural Science Young Foundation in China (81201033)the grants of Shanghai Health Bureau (20114358)the National High-Technology Development Project (863 Project) of China (2015AA020501)the Program for New Century Excellent Talents in University of China (NCET-10-0356)the National Program for the Support of TopNotch Young Professionalssupported by the Michael Smith Foundation, the CRC, and the CIHRsupported by the China Scholarship Council
文摘In this study, we aimed to （1） identify white matter （WM） deficits underlying the consciousness level in patients with disorders of consciousness （DOCs） using diffusion tensor imaging （DTI）, and （2） evaluate the relationship between DTI metrics and clinical measures of the consciousness level in DOC patients. With a cohort of 8 comatose, 8 unresponsive wakefulness syndrome/ vegetative state, and 14 minimally conscious state patients and 25 patient controls, we performed group comparisons of the DTI metrics in 48 core WM regions of interest （ROIs）, and examined the clinical relevance using correlation analysis. We identified multiple abnormal WM ROIs in DOC patients compared with normal controls, and the DTI metrics in these ROIs were significantly correlated with clinical measures of the consciousness level. Therefore, our findings suggested that multiple WM tracts are involved in the impaired consciousness levels in DOC patients and demonstrated the clinical relevance of DTI for DOC patients.
文摘目的研究血清神经元特异性烯醇化酶(neuron specific enolase,NSE)、S100钙结合蛋白β(S100β蛋白)、脑红蛋白对早产儿脑白质损伤的临床诊断价值。方法收集2016年12月至2019年12月入住的早产儿60例,根据颅脑B超或影像学检查结果,将60例早产儿分为脑损伤组(n=29)及非脑损伤组(n=31)。采用化学发光法测定血清NES和S100β蛋白值,采用ELISA法动态检测脑红蛋白值,分析其临床意义。结果脑损伤组的血清S100β蛋白、NSE及NGβ水平均明显高于对照组(P<0.05)。血清NSE、S100β蛋白、脑红蛋白值与脑损伤呈线性正相关(r值分别为0.827、0.818、0.728,P<0.05)。三种指标联合检测灵敏度、特异度均高于单项检测。结论对血清NSE、S100β蛋白、脑红蛋白值的测定,对早产儿脑损伤的临床诊断效果较为突出。
