Tat, an essential human immumodeficiency virus type 1 protein interacts with the transactivation response element(TAR) and stimulates transcription from the viral long-terminal repeat(LTR). Blockage of Tat-TAR interac...Tat, an essential human immumodeficiency virus type 1 protein interacts with the transactivation response element(TAR) and stimulates transcription from the viral long-terminal repeat(LTR). Blockage of Tat-TAR interaction halts viral transcription and hence replication. In recent years a numbe of studies have suggested various chemicals and /or genetic inhibitors targeting TAR RNA for inhibition of Tat-activated transcription. Here, we report these research works.展开更多
文摘Tat, an essential human immumodeficiency virus type 1 protein interacts with the transactivation response element(TAR) and stimulates transcription from the viral long-terminal repeat(LTR). Blockage of Tat-TAR interaction halts viral transcription and hence replication. In recent years a numbe of studies have suggested various chemicals and /or genetic inhibitors targeting TAR RNA for inhibition of Tat-activated transcription. Here, we report these research works.
