Since the invention of optical tweezers,optical manipulation has advanced significantly in scientific areas such as atomic physics,optics and biological science.Especially in the past decade,numerous optical beams and...Since the invention of optical tweezers,optical manipulation has advanced significantly in scientific areas such as atomic physics,optics and biological science.Especially in the past decade,numerous optical beams and nanoscale devices have been proposed to mechanically act on nanoparticles in increasingly precise,stable and flexible ways.Both the linear and angular momenta of light can be exploited to produce optical tractor beams,tweezers and optical torque from the microscale to the nanoscale.Research on optical forces helps to reveal the nature of light–matter interactions and to resolve the fundamental aspects,which require an appropriate description of momenta and the forces on objects in matter.In this review,starting from basic theories and computational approaches,we highlight the latest optical trapping configurations and their applications in bioscience,as well as recent advances down to the nanoscale.Finally,we discuss the future prospects of nanomanipulation,which has considerable potential applications in a variety of scientific fields and everyday life.展开更多
Herein,a novel molecular tweezer based on 2,2'-bipyridine-bridged porphyrin subunits was constructed for efficient fullerenes recognition.The syn conformation of the molecule,which was obtained by Zn(Ⅱ)coordinati...Herein,a novel molecular tweezer based on 2,2'-bipyridine-bridged porphyrin subunits was constructed for efficient fullerenes recognition.The syn conformation of the molecule,which was obtained by Zn(Ⅱ)coordination,gives rise to a proper cavity to interact with fullerene guests to form a stable 1:1 complex in toluene solution.It exhibits distinct binding selectivity towards C_(60)over C_(70).Moreover,the fullerene recognition capacity can be adequately suppressed by importing H_(2)PO_(4)^(-)to competitively capture Zn(Ⅱ)along with syn-anti conformational conversion.Subsequently,the molecular tweezer regenerated to bind the fullerene by introducing the Ca^(2+)into the system.Significantly,the association-disassociation process can be switched reversibly and repeatedly.展开更多
The use of‘Electrostatic tweezers'is a promising tool for droplet manipulation,but it faces many limitations in manipulating droplets on superhydrophobic surfaces.Here,we achieve noncontact and multifunctional dr...The use of‘Electrostatic tweezers'is a promising tool for droplet manipulation,but it faces many limitations in manipulating droplets on superhydrophobic surfaces.Here,we achieve noncontact and multifunctional droplet manipulation on Nepenthes-inspired lubricated slippery surfaces via triboelectric electrostatic tweezers(TETs).The TET manipulation of droplets on a slippery surface has many advantages over electrostatic droplet manipulation on a superhydrophobic surface.The electrostatic field induces the redistribution of the charges inside the neutral droplet,which causes the triboelectric charged rod to drive the droplet to move forward under the electrostatic force.Positively or negatively charged droplets can also be driven by TET based on electrostatic attraction and repulsion.TET enables us to manipulate droplets under diverse conditions,including anti-gravity climb,suspended droplets,corrosive liquids,low-surface-tension liquids(e.g.ethanol with a surface tension of 22.3 mN·m^(-1)),different droplet volumes(from 100 nl to 0.5 ml),passing through narrow slits,sliding over damaged areas,on various solid substrates,and even droplets in an enclosed system.Various droplet-related applications,such as motion guidance,motion switching,droplet-based microreactions,surface cleaning,surface defogging,liquid sorting,and cell labeling,can be easily achieved with TETs.展开更多
By recording the fluorescence fraction of the cold atoms remaining in the magneto-optical trap （MOT） as a function of the release time, the release-and-recapture （R＆R） method is utilized to evaluate the effective...By recording the fluorescence fraction of the cold atoms remaining in the magneto-optical trap （MOT） as a function of the release time, the release-and-recapture （R＆R） method is utilized to evaluate the effective temperature of the cold atomic ensemble. We prepare a single atom in a large-magnetic-gradient MOT and then transfer the trapped single atom into a 1064-nm microscopic optical tweezer. The energy of the single atom trapped in the tweezer is further reduced by polarization gradient cooling （PGC） and the effective temperature is evaluated by extending the R-R technique to a single atom tweezer. The typical effective temperature of a single atom in the tweezer is improved from about 105 μK to about 17 μK by applying the optimum PGC phase.展开更多
The defect-free neutral atom array has emerged as an ideal platform to investigate complex many-body physics of interacting quantum particles,offering the opportunities for quantum simulation and quantum-enhanced metr...The defect-free neutral atom array has emerged as an ideal platform to investigate complex many-body physics of interacting quantum particles,offering the opportunities for quantum simulation and quantum-enhanced metrology.To fast build a large-scale quantum system,we design a sorting-atom algorithm with maximum parallelisms.Compared with previous protocols,our method saves the rearrangement time by sorting row-by-row and is also universal to arbitrary periodic patterns with no need to change the hardware.We present the generation of a defect-free square and other periodic geometries and demonstrate the potential to scale up a defect-free array to 2500 atoms with only about 180 steps of rearrangement.展开更多
The incorporation of mechanophores,motifs that transform mechanical stimulus into chemical reaction or optical variation,allows creating materials with stressresponsive properties.The most widely used mechanophore gen...The incorporation of mechanophores,motifs that transform mechanical stimulus into chemical reaction or optical variation,allows creating materials with stressresponsive properties.The most widely used mechanophore generally features a weak bond,but its cleavage is typical an irreversible process.Here,we showed that this problem can be solved by folding–unfolding of a molecular tweezer.We systematically studied the mechanochromic properties of polyurethanes with cyano-substituted oligo(p-phenylene)vinylene(COP)tweezer(DPU).As a control experiment,a class of polyurethanes containing only a single COP moiety(MPU)was also prepared.The DPU showed prominent mechanochromic properties,due to the intramolecular folding–unfolding of COP tweezer under mechanical stimulus.The process was efficient,reversible and optical detectable.However,due to the disability to form either intramolecular folding or intermolecular aggregation,the MPU sample was mechanical inert.展开更多
Acoustic tweezers have gained considerable attention due to their potential and important role in various applications.A costeffective and precise method for manipulating particles is using 3D-printed acoustic hologra...Acoustic tweezers have gained considerable attention due to their potential and important role in various applications.A costeffective and precise method for manipulating particles is using 3D-printed acoustic holographic lenses.However,this technique is limited in its determined function for particle manipulation with a single holographic lens.We propose a method to overcome this limitation by constructing a multi-functional acoustic tweezer,which is capable of achieving diverse functions of particle manipulation.We demonstrate the ability to achieve fixed-angle rotation of a rectangular particle,multi-pattern particles arrangement,selectable left-right movement of a particle on a line,and completing two distinct trajectories with a single particle.Our proposed method offers a flexible and real-time controlling approach for acoustic tweezers,which can partially substitute the phased arrays with high circuit complexity.展开更多
An efficient and simple method for the synthesis of new chiral aromatic amide molecular tweezers by irradiation with microwave under solvent-free conditions has been developed. Its main advantages are short reaction t...An efficient and simple method for the synthesis of new chiral aromatic amide molecular tweezers by irradiation with microwave under solvent-free conditions has been developed. Its main advantages are short reaction times, good conversions and the environmentally friendly nature of the process.展开更多
1H NMR studies have been made on the effects of complexation of tweezer molecule (2s, 8s)-bis(2-naphthoyl aminomethyl)-1,5,9-triazabicyclo[4,4,0] dec-5-ene chloride with the salts of p-nitrobenzoate, p-methoxybenzoate...1H NMR studies have been made on the effects of complexation of tweezer molecule (2s, 8s)-bis(2-naphthoyl aminomethyl)-1,5,9-triazabicyclo[4,4,0] dec-5-ene chloride with the salts of p-nitrobenzoate, p-methoxybenzoate and (L)-N-acetyltryptophan. The stability constants of these complexes nave been determined in CDCl3. The results show that the tweezer molecule and aromatic carboxylates are self-associated by hydrogen bonding, electrostatic interaction and aromatic π-π stacking interaction, forming sandwich supramolecular complexes.展开更多
Three 3,3＇-di（4-substituted-phenyl）-1,1＇-isophthaloylbis（thiourea） compounds were designed as novel neutral anion receptors, and synthesized by simple steps in good yields. The single crystal structure of recept...Three 3,3＇-di（4-substituted-phenyl）-1,1＇-isophthaloylbis（thiourea） compounds were designed as novel neutral anion receptors, and synthesized by simple steps in good yields. The single crystal structure of receptor 1 shows that a solvent molecule was captured by the host molecule through intermolecular hydrogen bonding. Moreover, it was self-assembled as a supramolecular system for the presence of abundant inter- and intramolecular hydrogen bonding and π-π interactions between phenyl groups. Their application as anion receptors has been examined by UV-Vis and ^1H NMR spectroscopy, showing that they had a higher selectivity for fluoride than other halides. The host and guest formed a 1 ： 1 stoichiometry complex through hydrogen bonding interactions in the first step, then following a process of deprotonation in presence of an excess of F^- in the solvent of DMF.展开更多
A single atom in a magneto--optical trap （MOT） with trap size （hundreds of micrometers） can be transferred into an optical microscopic tweezer with a probability of -100%, The ability to transfer a single atom int...A single atom in a magneto--optical trap （MOT） with trap size （hundreds of micrometers） can be transferred into an optical microscopic tweezer with a probability of -100%, The ability to transfer a single atom into two traps back and forth allows us to study the loading process. The loading probability is found to be insensitive to the geometric overlap of the MOT and the tweezer. It is therefore possible to perform simultaneously loading of a single atom into all sites of the tweezer array for many qubits. In particular, we present a simulation of the one-dimensional and two-dimensional arrays of an optical microscopic tweezer. We find the same qualitative behavior for all of the trap parameters.展开更多
Coordination-driven self-assembly strategy has demonstrated the efficiency and versatility to construct well-ordered supramolecular coordination complexes （SCCs） such as discrete metallacycles and metallacages. In r...Coordination-driven self-assembly strategy has demonstrated the efficiency and versatility to construct well-ordered supramolecular coordination complexes （SCCs） such as discrete metallacycles and metallacages. In recent years, it has aroused tremendous interest to build more complexed self-assembled structures via the implementation of additional non-covalent recognition motifs on the SCCs platform. In this work, we have successfully attained this objective, with the elaborate manipulation of non-interfering pyridine-Pt2＋ and molecular tweezer/guest complexation in a hierarchical self-assembly manner. The resulting SCCs-based linear supramolecular polymers exhibit intriguing NIR-emissive behaviors, primarily attributed to the presence of intermolecular Pt（II）-Pt（II） metal-metal interactions in the non-covalent tweezering structure. Hence, supramolecular engineering of multiple non-covalent interactions offers a feasible avenue toward functional materials with tailored properties.展开更多
A novel type of chiral molecular tweezers has been designed and synthesized by using deoxycholic acid as backbone and ethanoyl and the chiral unsymmetrical urea unit as arms. Their structures were characterized by 1H ...A novel type of chiral molecular tweezers has been designed and synthesized by using deoxycholic acid as backbone and ethanoyl and the chiral unsymmetrical urea unit as arms. Their structures were characterized by 1H NMR, IR, MS spectra and elemental analysis. These molecular tweezers showed good binding ability for neutral molecules and chiral molecules.展开更多
A novel type of host-guest recognition systems have been developed on the basis of a Au(Ⅲ) molecular tweezer receptor and chiral Pt(Ⅱ) guests. The complementary host-guest motifs display high non-covalent binding af...A novel type of host-guest recognition systems have been developed on the basis of a Au(Ⅲ) molecular tweezer receptor and chiral Pt(Ⅱ) guests. The complementary host-guest motifs display high non-covalent binding affinity (Ka: ∼10^(4) L/mol) due to the participation of two-fold intermolecular π-π stacking interactions. Both phosphorescence and chirality signals of the Pt(Ⅱ) guests strengthen in the resulting host-guest complexes, because of the cooperative rigidifying and shielding effects rendered by the tweezer receptor. Their intensities can be reversibly switched toward pH changes, by taking advantage of the electronic repulsion effect between the protonated form of tweezer receptor and the positive-charged guests in acidic environments. Overall, the current study demonstrates the feasibility to enhance and modulate phosphorescence and chirality signals simultaneously via molecular tweezer-based host-guest recognition.展开更多
For future micro-and nanotechnologies,the manufacturing of miniaturized,functionalized,and integrated devices is indispensable.In this paper,an assembly technique based on a bottom-up strategy that enables the manufac...For future micro-and nanotechnologies,the manufacturing of miniaturized,functionalized,and integrated devices is indispensable.In this paper,an assembly technique based on a bottom-up strategy that enables the manufacturing of complex microsystems using only optical methods is presented.A screw connection is transferred to the micrometer range and used to assemble screwand nut-shaped microcomponents.Micro-stereolithography is performed by means of two-photon polymerization,and microstructures are fabricated and subsequently trapped,moved,and screwed together using optical forces in a holographic optical tweezer set-up.The design and construction of interlocking microcomponents and the verification of a stable and releasable joint form the main focus of this paper.The assembly technique is also applied to a microfluidic system to enable the pumping or intermixing of fluids on a microfluidic chip.This strategy not only enables the assembly of microcomponents but also the combination of different materials and features to form complex hybrid microsystems.展开更多
In this article, the dynamical process of the dielectric particle in the optical tweezer using the counter-propagating Gaussian pulses is investigated by the Langevin equation concerning the Brownian motion. The tempo...In this article, the dynamical process of the dielectric particle in the optical tweezer using the counter-propagating Gaussian pulses is investigated by the Langevin equation concerning the Brownian motion. The temporal stabilities of particle is simulated. The influence of the duration, repetition period and delay time between pulses on stability is discussed.展开更多
The optical rotation technique arose in the 1990 s.Optical tweezer brought an ideal platform for research on the angular momentum of laser beams.For decades,the optical rotation technique has been widely applied in la...The optical rotation technique arose in the 1990 s.Optical tweezer brought an ideal platform for research on the angular momentum of laser beams.For decades,the optical rotation technique has been widely applied in laboratory optical manipulation and the fields of biology and optofluidics.Recently,it has attracted much attention for its potential in the classical and quantum regimes.In this work,we review the progress of experiments and applications of optically induced rotation.First,we introduce the basic exploration of angular momentum.Then,we cover the development and application of optical rotation induced by orbital angular momentum,and the spin angular momentum is presented.Finally,we elaborate on recent applications of the optical rotation technique in high vacuum.As precise optical manipulation in a liquid medium enters its maturity,optical tweezers in high vacuum open a new path for the high-speed micro-rotor.展开更多
α-catenin is an adhesion protein located at the cadherin-based cell-cell adherens junction.α-catenin cross-linksβ-catenin and actin fiber in the adhesion protein complex,and plays an important role in the formation...α-catenin is an adhesion protein located at the cadherin-based cell-cell adherens junction.α-catenin cross-linksβ-catenin and actin fiber in the adhesion protein complex,and plays an important role in the formation and modulation of cell-cell adhesion.The central modulation domains can be unfolded to expose binding site of vinculin when stretching force is applied.Here,we studied the force-induced unfolding dynamics ofα-catenin modulation domains under different loading rates from which the unfolding distance of M2 and M3 domains is determined to be 5-7 nm,and an unfolding intermediate state is identified.We also found that the folding process of M1-M3 domains goes through different pathways with cooperativity.展开更多
Up to now there are many works investigated the stretched state of deoxyribonucleic axid （DNA） by optical trap. The main purpose of mentioned works is to find out the elastic force-extension characterisitic approxim...Up to now there are many works investigated the stretched state of deoxyribonucleic axid （DNA） by optical trap. The main purpose of mentioned works is to find out the elastic force-extension characterisitic approximatelly based on the experimental parameters. In experiments, the optical force is seem as an apply force, but not an own elastic force of DNA molecules. To use sufficiently optical tweezer to manipulate and hold the DNA molecules keeping in stretched state, it is necessary to use the elastic as one force contributing to process trapping it, and consequently, the term describing elastic force must be present in the general Langevin equation （GLE） describing the dynamic of driven bead linking to DNA molecule. In this paper, the finite difference equation of GLE is derived for simulation the dynamic of bead linking to DNA molecule embedded in the fluid. The process manipulation of polystyrene bead to tweezer center is simulated and discussed. From results, the role of Brownian force, elastic force and optical force on process trapping driven bead is evaluated. Moreover, the trapping time, velocity of bead are discussed, too.展开更多
基金support from the National University of Singapore(no.R-263-000-678-133)supported by the Spanish MINECO grants FIS2012-36113-C03-03,FIS2014-55563-REDC and FIS2015-69295-C3-1-P+2 种基金support from the National Natural Science Foundation of China(no.11504252)the Natural Science Foundation for the Youth of Jiangsu Province(no.BK20150306)the Natural Science Foundation for Colleges and Universities in Jiangsu Province of China(no.15KJB140008).
文摘Since the invention of optical tweezers,optical manipulation has advanced significantly in scientific areas such as atomic physics,optics and biological science.Especially in the past decade,numerous optical beams and nanoscale devices have been proposed to mechanically act on nanoparticles in increasingly precise,stable and flexible ways.Both the linear and angular momenta of light can be exploited to produce optical tractor beams,tweezers and optical torque from the microscale to the nanoscale.Research on optical forces helps to reveal the nature of light–matter interactions and to resolve the fundamental aspects,which require an appropriate description of momenta and the forces on objects in matter.In this review,starting from basic theories and computational approaches,we highlight the latest optical trapping configurations and their applications in bioscience,as well as recent advances down to the nanoscale.Finally,we discuss the future prospects of nanomanipulation,which has considerable potential applications in a variety of scientific fields and everyday life.
基金the financial support of the National Natural Science Foundation of China(No.21801060)Natural Science Foundation of Hebei Province(Nos.B2019205172,226Z1501G)+1 种基金China Postdoctoral Science Foundation(No.2020TQ0087)the support from the National Demonstration Center for Experimental Chemistry Education of Hebei Normal University。
文摘Herein,a novel molecular tweezer based on 2,2'-bipyridine-bridged porphyrin subunits was constructed for efficient fullerenes recognition.The syn conformation of the molecule,which was obtained by Zn(Ⅱ)coordination,gives rise to a proper cavity to interact with fullerene guests to form a stable 1:1 complex in toluene solution.It exhibits distinct binding selectivity towards C_(60)over C_(70).Moreover,the fullerene recognition capacity can be adequately suppressed by importing H_(2)PO_(4)^(-)to competitively capture Zn(Ⅱ)along with syn-anti conformational conversion.Subsequently,the molecular tweezer regenerated to bind the fullerene by introducing the Ca^(2+)into the system.Significantly,the association-disassociation process can be switched reversibly and repeatedly.
基金supported by the USTC Research Funds of the Double First-Class Initiative(Nos.YD2090002013,YD234000009)the National Natural Science Foundation of China(Nos.61927814,62325507,52122511,U20A20290,62005262)。
文摘The use of‘Electrostatic tweezers'is a promising tool for droplet manipulation,but it faces many limitations in manipulating droplets on superhydrophobic surfaces.Here,we achieve noncontact and multifunctional droplet manipulation on Nepenthes-inspired lubricated slippery surfaces via triboelectric electrostatic tweezers(TETs).The TET manipulation of droplets on a slippery surface has many advantages over electrostatic droplet manipulation on a superhydrophobic surface.The electrostatic field induces the redistribution of the charges inside the neutral droplet,which causes the triboelectric charged rod to drive the droplet to move forward under the electrostatic force.Positively or negatively charged droplets can also be driven by TET based on electrostatic attraction and repulsion.TET enables us to manipulate droplets under diverse conditions,including anti-gravity climb,suspended droplets,corrosive liquids,low-surface-tension liquids(e.g.ethanol with a surface tension of 22.3 mN·m^(-1)),different droplet volumes(from 100 nl to 0.5 ml),passing through narrow slits,sliding over damaged areas,on various solid substrates,and even droplets in an enclosed system.Various droplet-related applications,such as motion guidance,motion switching,droplet-based microreactions,surface cleaning,surface defogging,liquid sorting,and cell labeling,can be easily achieved with TETs.
基金Project supported by the National Natural Science Foundation of China (Grant Nos.60978017,61078051 and 10974125)the Science Fund for Creative Research Groups of the National Natural Science Foundation of China (Grant No.60821004)the Program for New Century Excellent Talents of Ministry of Education of China (Grant No.NCET-07-0524)
文摘By recording the fluorescence fraction of the cold atoms remaining in the magneto-optical trap （MOT） as a function of the release time, the release-and-recapture （R＆R） method is utilized to evaluate the effective temperature of the cold atomic ensemble. We prepare a single atom in a large-magnetic-gradient MOT and then transfer the trapped single atom into a 1064-nm microscopic optical tweezer. The energy of the single atom trapped in the tweezer is further reduced by polarization gradient cooling （PGC） and the effective temperature is evaluated by extending the R-R technique to a single atom tweezer. The typical effective temperature of a single atom in the tweezer is improved from about 105 μK to about 17 μK by applying the optimum PGC phase.
基金supported by the National Key R&D Program of China(No.2020YFA0309400)the National Natural Science Foundation of China(Nos.12222409,12174081,and 11974228)+1 种基金the Key Research and Development Program of Shanxi Province(No.202101150101025)the financial support from the Royal Society Newton International Fellowship Alumni(AL201024)。
文摘The defect-free neutral atom array has emerged as an ideal platform to investigate complex many-body physics of interacting quantum particles,offering the opportunities for quantum simulation and quantum-enhanced metrology.To fast build a large-scale quantum system,we design a sorting-atom algorithm with maximum parallelisms.Compared with previous protocols,our method saves the rearrangement time by sorting row-by-row and is also universal to arbitrary periodic patterns with no need to change the hardware.We present the generation of a defect-free square and other periodic geometries and demonstrate the potential to scale up a defect-free array to 2500 atoms with only about 180 steps of rearrangement.
基金This work was financially supported by the National Natural Science Foundation of China(Grant Nos.52103141 and 51803090)the Natural Science Foundation of Jiangsu Province(Grant Nos.BK20181025 and BK20191022)for financial support.
文摘The incorporation of mechanophores,motifs that transform mechanical stimulus into chemical reaction or optical variation,allows creating materials with stressresponsive properties.The most widely used mechanophore generally features a weak bond,but its cleavage is typical an irreversible process.Here,we showed that this problem can be solved by folding–unfolding of a molecular tweezer.We systematically studied the mechanochromic properties of polyurethanes with cyano-substituted oligo(p-phenylene)vinylene(COP)tweezer(DPU).As a control experiment,a class of polyurethanes containing only a single COP moiety(MPU)was also prepared.The DPU showed prominent mechanochromic properties,due to the intramolecular folding–unfolding of COP tweezer under mechanical stimulus.The process was efficient,reversible and optical detectable.However,due to the disability to form either intramolecular folding or intermolecular aggregation,the MPU sample was mechanical inert.
基金supported by the National Natural Science Foundation of China(Grant Nos.12074287,12274327,and 11834008)the Shanghai Natural Science Foundation(Grant No.23ZR1468100)+1 种基金the Shanghai Science&Technology Development Foundationthe Fundamental Research Funds for the Central Universities。
文摘Acoustic tweezers have gained considerable attention due to their potential and important role in various applications.A costeffective and precise method for manipulating particles is using 3D-printed acoustic holographic lenses.However,this technique is limited in its determined function for particle manipulation with a single holographic lens.We propose a method to overcome this limitation by constructing a multi-functional acoustic tweezer,which is capable of achieving diverse functions of particle manipulation.We demonstrate the ability to achieve fixed-angle rotation of a rectangular particle,multi-pattern particles arrangement,selectable left-right movement of a particle on a line,and completing two distinct trajectories with a single particle.Our proposed method offers a flexible and real-time controlling approach for acoustic tweezers,which can partially substitute the phased arrays with high circuit complexity.
基金supported by the Doctors Innovation Foundation of Southwest University for Nationalities(No.08NBS002).
文摘An efficient and simple method for the synthesis of new chiral aromatic amide molecular tweezers by irradiation with microwave under solvent-free conditions has been developed. Its main advantages are short reaction times, good conversions and the environmentally friendly nature of the process.
基金Project supported by the National Natural Science Foundation of China
文摘1H NMR studies have been made on the effects of complexation of tweezer molecule (2s, 8s)-bis(2-naphthoyl aminomethyl)-1,5,9-triazabicyclo[4,4,0] dec-5-ene chloride with the salts of p-nitrobenzoate, p-methoxybenzoate and (L)-N-acetyltryptophan. The stability constants of these complexes nave been determined in CDCl3. The results show that the tweezer molecule and aromatic carboxylates are self-associated by hydrogen bonding, electrostatic interaction and aromatic π-π stacking interaction, forming sandwich supramolecular complexes.
基金Project supported by the National Natural Science Foundation of China （No. 20671077）, the Key Scientific and Technical Research Project of Ministry of Education of China （No. 205161）, the Youth Foundation of Gansu Province （No. 3YS051-A25-010）, the Natural Science Foundation of Gansu Province in China （No. 3ZS061-A25-027） and the Scientific Research Fund of Education Department of Gansu Province （No. 0601-24）.
文摘Three 3,3＇-di（4-substituted-phenyl）-1,1＇-isophthaloylbis（thiourea） compounds were designed as novel neutral anion receptors, and synthesized by simple steps in good yields. The single crystal structure of receptor 1 shows that a solvent molecule was captured by the host molecule through intermolecular hydrogen bonding. Moreover, it was self-assembled as a supramolecular system for the presence of abundant inter- and intramolecular hydrogen bonding and π-π interactions between phenyl groups. Their application as anion receptors has been examined by UV-Vis and ^1H NMR spectroscopy, showing that they had a higher selectivity for fluoride than other halides. The host and guest formed a 1 ： 1 stoichiometry complex through hydrogen bonding interactions in the first step, then following a process of deprotonation in presence of an excess of F^- in the solvent of DMF.
基金Project supported by the National Major Scientific Research Program of China(Grant No.2012CB921601)the National Natural Science Foundation of China(Grant Nos.61205215,11274213,and 61475091)
文摘A single atom in a magneto--optical trap （MOT） with trap size （hundreds of micrometers） can be transferred into an optical microscopic tweezer with a probability of -100%, The ability to transfer a single atom into two traps back and forth allows us to study the loading process. The loading probability is found to be insensitive to the geometric overlap of the MOT and the tweezer. It is therefore possible to perform simultaneously loading of a single atom into all sites of the tweezer array for many qubits. In particular, we present a simulation of the one-dimensional and two-dimensional arrays of an optical microscopic tweezer. We find the same qualitative behavior for all of the trap parameters.
基金financially supported by the National Natural Science Foundation of China(No.21674106)the Fundamental Research Funds for the Central Universities(No.WK3450000001)CAS Youth Innovation Promotion Association(No.2015365)
文摘Coordination-driven self-assembly strategy has demonstrated the efficiency and versatility to construct well-ordered supramolecular coordination complexes （SCCs） such as discrete metallacycles and metallacages. In recent years, it has aroused tremendous interest to build more complexed self-assembled structures via the implementation of additional non-covalent recognition motifs on the SCCs platform. In this work, we have successfully attained this objective, with the elaborate manipulation of non-interfering pyridine-Pt2＋ and molecular tweezer/guest complexation in a hierarchical self-assembly manner. The resulting SCCs-based linear supramolecular polymers exhibit intriguing NIR-emissive behaviors, primarily attributed to the presence of intermolecular Pt（II）-Pt（II） metal-metal interactions in the non-covalent tweezering structure. Hence, supramolecular engineering of multiple non-covalent interactions offers a feasible avenue toward functional materials with tailored properties.
文摘A novel type of chiral molecular tweezers has been designed and synthesized by using deoxycholic acid as backbone and ethanoyl and the chiral unsymmetrical urea unit as arms. Their structures were characterized by 1H NMR, IR, MS spectra and elemental analysis. These molecular tweezers showed good binding ability for neutral molecules and chiral molecules.
基金financially supported by the National Natural Science Foundation of China(Nos.21922110 and 21871245)the Fundamental Research Funds for the Central Universities(No.WK3450000005)the Starry Night Science Fund at Shanghai Institute for Advanced Study,Zhejiang University(No.SNZJU-SIAS-006)。
文摘A novel type of host-guest recognition systems have been developed on the basis of a Au(Ⅲ) molecular tweezer receptor and chiral Pt(Ⅱ) guests. The complementary host-guest motifs display high non-covalent binding affinity (Ka: ∼10^(4) L/mol) due to the participation of two-fold intermolecular π-π stacking interactions. Both phosphorescence and chirality signals of the Pt(Ⅱ) guests strengthen in the resulting host-guest complexes, because of the cooperative rigidifying and shielding effects rendered by the tweezer receptor. Their intensities can be reversibly switched toward pH changes, by taking advantage of the electronic repulsion effect between the protonated form of tweezer receptor and the positive-charged guests in acidic environments. Overall, the current study demonstrates the feasibility to enhance and modulate phosphorescence and chirality signals simultaneously via molecular tweezer-based host-guest recognition.
基金We thank the German Research Foundation DFG(Deutsche Forschungsgesellschaft)for their generous support within the Reinhardt Koselleck project(OS 188/28-1).
文摘For future micro-and nanotechnologies,the manufacturing of miniaturized,functionalized,and integrated devices is indispensable.In this paper,an assembly technique based on a bottom-up strategy that enables the manufacturing of complex microsystems using only optical methods is presented.A screw connection is transferred to the micrometer range and used to assemble screwand nut-shaped microcomponents.Micro-stereolithography is performed by means of two-photon polymerization,and microstructures are fabricated and subsequently trapped,moved,and screwed together using optical forces in a holographic optical tweezer set-up.The design and construction of interlocking microcomponents and the verification of a stable and releasable joint form the main focus of this paper.The assembly technique is also applied to a microfluidic system to enable the pumping or intermixing of fluids on a microfluidic chip.This strategy not only enables the assembly of microcomponents but also the combination of different materials and features to form complex hybrid microsystems.
文摘In this article, the dynamical process of the dielectric particle in the optical tweezer using the counter-propagating Gaussian pulses is investigated by the Langevin equation concerning the Brownian motion. The temporal stabilities of particle is simulated. The influence of the duration, repetition period and delay time between pulses on stability is discussed.
基金supported by the National Natural Science Foundation of China(Nos.11304282 and 10947104)the National Program for Special Support of Top-Notch Young Professionals,China+1 种基金the Fundamental Research Fund for the Central Universities,China(No.2018XZZX001-08)the Major Scientific Research Project of Zhejiang Lab,China(No.2019MB0AD01)。
文摘The optical rotation technique arose in the 1990 s.Optical tweezer brought an ideal platform for research on the angular momentum of laser beams.For decades,the optical rotation technique has been widely applied in laboratory optical manipulation and the fields of biology and optofluidics.Recently,it has attracted much attention for its potential in the classical and quantum regimes.In this work,we review the progress of experiments and applications of optically induced rotation.First,we introduce the basic exploration of angular momentum.Then,we cover the development and application of optical rotation induced by orbital angular momentum,and the spin angular momentum is presented.Finally,we elaborate on recent applications of the optical rotation technique in high vacuum.As precise optical manipulation in a liquid medium enters its maturity,optical tweezers in high vacuum open a new path for the high-speed micro-rotor.
基金the National Nature Science Foundation of China(Grant Nos.11474237 and 11574310)the 111 Project(Grant No.B16029).
文摘α-catenin is an adhesion protein located at the cadherin-based cell-cell adherens junction.α-catenin cross-linksβ-catenin and actin fiber in the adhesion protein complex,and plays an important role in the formation and modulation of cell-cell adhesion.The central modulation domains can be unfolded to expose binding site of vinculin when stretching force is applied.Here,we studied the force-induced unfolding dynamics ofα-catenin modulation domains under different loading rates from which the unfolding distance of M2 and M3 domains is determined to be 5-7 nm,and an unfolding intermediate state is identified.We also found that the folding process of M1-M3 domains goes through different pathways with cooperativity.
文摘Up to now there are many works investigated the stretched state of deoxyribonucleic axid （DNA） by optical trap. The main purpose of mentioned works is to find out the elastic force-extension characterisitic approximatelly based on the experimental parameters. In experiments, the optical force is seem as an apply force, but not an own elastic force of DNA molecules. To use sufficiently optical tweezer to manipulate and hold the DNA molecules keeping in stretched state, it is necessary to use the elastic as one force contributing to process trapping it, and consequently, the term describing elastic force must be present in the general Langevin equation （GLE） describing the dynamic of driven bead linking to DNA molecule. In this paper, the finite difference equation of GLE is derived for simulation the dynamic of bead linking to DNA molecule embedded in the fluid. The process manipulation of polystyrene bead to tweezer center is simulated and discussed. From results, the role of Brownian force, elastic force and optical force on process trapping driven bead is evaluated. Moreover, the trapping time, velocity of bead are discussed, too.
