Biofilm-associated microorganisms play crucial roles in terrestrial and aquatic nutrient cycling and in the biodegradation of environmental pollutants. Biofilm formation was determined for a total of 18 bacterial isol...Biofilm-associated microorganisms play crucial roles in terrestrial and aquatic nutrient cycling and in the biodegradation of environmental pollutants. Biofilm formation was determined for a total of 18 bacterial isolates obtained from the biofilms of wastewater treatment systems and of little carpolite in soil. Among these isolates, seven showed strong biofilm-forming capacity. The phylogenetic affiliation of the isolates showing high biofilm formation capacity was determined through 16S rDNA sequencing and the isolates were grouped into 7 bacterial species including Pseudornonas sp., Pseudomonas putida, Aeromonas caviae, Bacillus cereus, Pseudornonas plecoglossicida, Aeromonas hydrophila, and Comamonas testosteroni. The biofilm-forming capacity was closely related with flagella, exopolysaccharide, and extracellular protein. According to the coefficient of determination, the relative importance of the five biological characteristics to biofilm formation was, in order from greatest to least, exopolysaccharide 〉 flagella 〉 N-acyl-homoserine lactones （AHLs） signaling molecules 〉 extracellular protein 〉 swarming motility.展开更多
Oppositional Defiant Disorder(ODD)and Attention Deficit/Hyperactivity Disorder(ADHD)are mental health conditions that have traditionally been managed through behavioral therapies and medication.However,the integration...Oppositional Defiant Disorder(ODD)and Attention Deficit/Hyperactivity Disorder(ADHD)are mental health conditions that have traditionally been managed through behavioral therapies and medication.However,the integration of Artificial Intelligence(AI)has brought about a revolutionary shift in treatment approaches.This article explores the role of AI-driven noninvasive treatments for ODD and ADHD.AI offers personalized treatment plans,predictive analytics,virtual therapeutic platforms,and continuous monitoring,enhancing the effectiveness and accessibility of interventions.Ethical considerations and the need for a balanced approach are discussed.As technology evolves,collaborative efforts between mental health professionals and technologists will shape the future of mental health care for individuals with ODD and ADHD.展开更多
Cancer is a global health problem that is often successfully addressed by therapy, with cancer survivors increasing in numbers and living longer world around. Although new cancer treatment options are continuously exp...Cancer is a global health problem that is often successfully addressed by therapy, with cancer survivors increasing in numbers and living longer world around. Although new cancer treatment options are continuously explored, platinum based chemotherapy agents remain in use due to their efficiency and availability. Unfortunately, all cancer therapies affect normal tissues as well as cancer, and more than 40 specific side effects of platinum based drugs documented so far decrease the quality of life of cancer survivors. Chemotherapy-induced peripheral neuropathy is a frequent side effects of platinum-based chemotherapy agents. This cluster of complications is often so debilitating that patients occasionally have to discontinue the therapy. Sensory neurons of dorsal root ganglia are at the core of chemotherapy-induced peripheral neuropathy symptoms. In these postmitotic cells, DNA damage caused by platinum chemotherapy interferes with normal functioning. Accumulation of DNA-platinum adducts correlates with neurotoxic severity and development of sensation of pain. While biochemistry of DNA-platinum adducts is the same in all cell types, molecular mechanisms affected by DNA-platinum adducts are different in cancer cells and non-dividing cells. This review aims to raise awareness about platinum associated chemotherapy-induced peripheral neuropathy as a medical problem that has remained unexplained for decades. We emphasize the complexity of this condition both from clinical and mechanistical point of view and focus on recent findings about chemotherapy-induced peripheral neuropathy in in vitro and in vivo model systems. Finally, we summarize current perspectives about clinical approaches for chemotherapy-induced peripheral neuropathy treatment.展开更多
Hepatocellular carcinoma(HCC)is a leading cause of morbidity and mortality worldwide,with rising clinical and economic burden as incidence increases.There are a multitude of evolving treatment options,including locore...Hepatocellular carcinoma(HCC)is a leading cause of morbidity and mortality worldwide,with rising clinical and economic burden as incidence increases.There are a multitude of evolving treatment options,including locoregional therapies which can be used alone,in combination with each other,or in combination with systemic therapy.These treatment options have shown to be effective in achieving remission,controlling tumor progression,improving disease free and overall survival in patients who cannot undergo resection and providing a bridge to transplant by debulking tumor burden to downstage patients.Following locoregional therapy(LRT),it is crucial to provide treatment response assessment to guide management and liver transplant candidacy.Therefore,Liver Imaging Reporting and Data Systems(LI-RADS)Treatment Response Algorithm(TRA)was created to provide a standardized assessment of HCC following LRT.LIRADS TRA provides a step by step approach to evaluate each lesion independently for accurate tumor assessment.In this review,we provide an overview of different locoregional therapies for HCC,describe the expected post treatment imaging appearance following treatment,and review the LI-RADS TRA with guidance for its application in clinical practice.Unique to other publications,we will also review emerging literature supporting the use of LI-RADS for assessment of HCC treatment response after LRT.展开更多
Nonalcoholic fatty liver disease(NAFLD) is a complex disorder that has evolved in recent years as the leading global cause of chronic liver damage. The main obstacle to better disease management pertains to the lack o...Nonalcoholic fatty liver disease(NAFLD) is a complex disorder that has evolved in recent years as the leading global cause of chronic liver damage. The main obstacle to better disease management pertains to the lack of approved pharmacological interventions for the treatment of nonalcoholic steatohepatitis(NASH) and NASH-fibrosis-the severe histological forms. Over the past decade,tremendous advances have been made in NAFLD research, resulting in the discovery of disease mechanisms and novel therapeutic targets. Hence, a large number of pharmacological agents are currently being tested for safety and efficacy. These drugs are in the initial pharmacological phases(phase 1 and 2),which involve testing tolerability, therapeutic action, and pharmacological issues.It is thus reasonable to assume that the next generation of NASH drugs will not be available for clinical use for foreseeable future. The expected delay can be mitigated by drug repurposing or repositioning, which essentially relies on identifying and developing new uses for existing drugs. Here, we propose a drug candidate selection method based on the integration of molecular pathways of disease pathogenesis into network analysis tools that use OMICs data as well as multiples sources, including text mining from the medical literature.展开更多
HSLA steels need extremely low levels of tramp elements like P,S,H and O t.During tapping the steel is deoxidized with aluminum and in the secondary metallurgy sulphur (【 10 ppm) and hydrogen (【 1 ppm) are extracted...HSLA steels need extremely low levels of tramp elements like P,S,H and O t.During tapping the steel is deoxidized with aluminum and in the secondary metallurgy sulphur (【 10 ppm) and hydrogen (【 1 ppm) are extracted.After tank degassing the steel is strongly Ca-treated by wire feeding to form CaS instead of MnS.Non-metallic inclusions in the steel and centre segregation with MnS are sinks for hydrogen which result in HIC (Hydrogen Induced Cracking).Therefore these steels ask for excellent oxide cleanness and S-contents of 【 10 ppm.Macro inclusions of 】 50 μm are harmful for the product.These large inclusions are seldom and difficult to be detected.Small inclusions of 【 15 μm do no harm to the product.The origin of non-metallic inclusions is,roughly spoken,one third each of de-oxidation-/reoxidation products,refractory and casting powder.Slag carry-over is mainly avoided by sensitive electronic devices.Slag covers and shrouding systems of the steel stream during the transfer of metal between ladle,tundish and mold are effective to avoid reoxidation.Systems to control the flow of steel in tundish and mold favor the floatation of inclusions and their even distribution in the strand.展开更多
基金supported by the National Natural Science Foundation of China (No.30600016)the Environment Protection Department of Jiangsu Province,China (No.2004007)
文摘Biofilm-associated microorganisms play crucial roles in terrestrial and aquatic nutrient cycling and in the biodegradation of environmental pollutants. Biofilm formation was determined for a total of 18 bacterial isolates obtained from the biofilms of wastewater treatment systems and of little carpolite in soil. Among these isolates, seven showed strong biofilm-forming capacity. The phylogenetic affiliation of the isolates showing high biofilm formation capacity was determined through 16S rDNA sequencing and the isolates were grouped into 7 bacterial species including Pseudornonas sp., Pseudomonas putida, Aeromonas caviae, Bacillus cereus, Pseudornonas plecoglossicida, Aeromonas hydrophila, and Comamonas testosteroni. The biofilm-forming capacity was closely related with flagella, exopolysaccharide, and extracellular protein. According to the coefficient of determination, the relative importance of the five biological characteristics to biofilm formation was, in order from greatest to least, exopolysaccharide 〉 flagella 〉 N-acyl-homoserine lactones （AHLs） signaling molecules 〉 extracellular protein 〉 swarming motility.
文摘Oppositional Defiant Disorder(ODD)and Attention Deficit/Hyperactivity Disorder(ADHD)are mental health conditions that have traditionally been managed through behavioral therapies and medication.However,the integration of Artificial Intelligence(AI)has brought about a revolutionary shift in treatment approaches.This article explores the role of AI-driven noninvasive treatments for ODD and ADHD.AI offers personalized treatment plans,predictive analytics,virtual therapeutic platforms,and continuous monitoring,enhancing the effectiveness and accessibility of interventions.Ethical considerations and the need for a balanced approach are discussed.As technology evolves,collaborative efforts between mental health professionals and technologists will shape the future of mental health care for individuals with ODD and ADHD.
基金supported by grant from the Ministry of Education,Science and Technological Development,Republic of Serbia(173051)supported by a UICC Yamagiwa-Yoshida Memorial International Cancer Study Grant(YY2/2015/381414)
文摘Cancer is a global health problem that is often successfully addressed by therapy, with cancer survivors increasing in numbers and living longer world around. Although new cancer treatment options are continuously explored, platinum based chemotherapy agents remain in use due to their efficiency and availability. Unfortunately, all cancer therapies affect normal tissues as well as cancer, and more than 40 specific side effects of platinum based drugs documented so far decrease the quality of life of cancer survivors. Chemotherapy-induced peripheral neuropathy is a frequent side effects of platinum-based chemotherapy agents. This cluster of complications is often so debilitating that patients occasionally have to discontinue the therapy. Sensory neurons of dorsal root ganglia are at the core of chemotherapy-induced peripheral neuropathy symptoms. In these postmitotic cells, DNA damage caused by platinum chemotherapy interferes with normal functioning. Accumulation of DNA-platinum adducts correlates with neurotoxic severity and development of sensation of pain. While biochemistry of DNA-platinum adducts is the same in all cell types, molecular mechanisms affected by DNA-platinum adducts are different in cancer cells and non-dividing cells. This review aims to raise awareness about platinum associated chemotherapy-induced peripheral neuropathy as a medical problem that has remained unexplained for decades. We emphasize the complexity of this condition both from clinical and mechanistical point of view and focus on recent findings about chemotherapy-induced peripheral neuropathy in in vitro and in vivo model systems. Finally, we summarize current perspectives about clinical approaches for chemotherapy-induced peripheral neuropathy treatment.
文摘Hepatocellular carcinoma(HCC)is a leading cause of morbidity and mortality worldwide,with rising clinical and economic burden as incidence increases.There are a multitude of evolving treatment options,including locoregional therapies which can be used alone,in combination with each other,or in combination with systemic therapy.These treatment options have shown to be effective in achieving remission,controlling tumor progression,improving disease free and overall survival in patients who cannot undergo resection and providing a bridge to transplant by debulking tumor burden to downstage patients.Following locoregional therapy(LRT),it is crucial to provide treatment response assessment to guide management and liver transplant candidacy.Therefore,Liver Imaging Reporting and Data Systems(LI-RADS)Treatment Response Algorithm(TRA)was created to provide a standardized assessment of HCC following LRT.LIRADS TRA provides a step by step approach to evaluate each lesion independently for accurate tumor assessment.In this review,we provide an overview of different locoregional therapies for HCC,describe the expected post treatment imaging appearance following treatment,and review the LI-RADS TRA with guidance for its application in clinical practice.Unique to other publications,we will also review emerging literature supporting the use of LI-RADS for assessment of HCC treatment response after LRT.
文摘Nonalcoholic fatty liver disease(NAFLD) is a complex disorder that has evolved in recent years as the leading global cause of chronic liver damage. The main obstacle to better disease management pertains to the lack of approved pharmacological interventions for the treatment of nonalcoholic steatohepatitis(NASH) and NASH-fibrosis-the severe histological forms. Over the past decade,tremendous advances have been made in NAFLD research, resulting in the discovery of disease mechanisms and novel therapeutic targets. Hence, a large number of pharmacological agents are currently being tested for safety and efficacy. These drugs are in the initial pharmacological phases(phase 1 and 2),which involve testing tolerability, therapeutic action, and pharmacological issues.It is thus reasonable to assume that the next generation of NASH drugs will not be available for clinical use for foreseeable future. The expected delay can be mitigated by drug repurposing or repositioning, which essentially relies on identifying and developing new uses for existing drugs. Here, we propose a drug candidate selection method based on the integration of molecular pathways of disease pathogenesis into network analysis tools that use OMICs data as well as multiples sources, including text mining from the medical literature.
文摘HSLA steels need extremely low levels of tramp elements like P,S,H and O t.During tapping the steel is deoxidized with aluminum and in the secondary metallurgy sulphur (【 10 ppm) and hydrogen (【 1 ppm) are extracted.After tank degassing the steel is strongly Ca-treated by wire feeding to form CaS instead of MnS.Non-metallic inclusions in the steel and centre segregation with MnS are sinks for hydrogen which result in HIC (Hydrogen Induced Cracking).Therefore these steels ask for excellent oxide cleanness and S-contents of 【 10 ppm.Macro inclusions of 】 50 μm are harmful for the product.These large inclusions are seldom and difficult to be detected.Small inclusions of 【 15 μm do no harm to the product.The origin of non-metallic inclusions is,roughly spoken,one third each of de-oxidation-/reoxidation products,refractory and casting powder.Slag carry-over is mainly avoided by sensitive electronic devices.Slag covers and shrouding systems of the steel stream during the transfer of metal between ladle,tundish and mold are effective to avoid reoxidation.Systems to control the flow of steel in tundish and mold favor the floatation of inclusions and their even distribution in the strand.
