Aviation kerosene is commonly used in combustion and regenerative engine cooling processes in propulsion and power-generation systems,including rocket,scramjet,and advanced gas turbine engines.In this paper,many surro...Aviation kerosene is commonly used in combustion and regenerative engine cooling processes in propulsion and power-generation systems,including rocket,scramjet,and advanced gas turbine engines.In this paper,many surrogate models proposed in the open literature are examined for their applicability and accuracy in calculating thermodynamic and transport properties of the China aviation kerosene RP-3 at supercritical pressures,based on the extended corresponding-states methods.The enthalpy change from endothermic decomposition and low heating value from combustion of the jet fuel are also evaluated.Results from a number of simple and representative surrogate models,which contain species components ranging from 1 to10,are analyzed in detail.Data analyses indicate that a surrogate model with four species is the best choice for thermophysical property calculations under the tested conditions,with fluid temperature up to 650 K at various supercritical pressures.The surrogate model is particularly accurate in predicting the pseudo-critical temperature of aviation kerosene RP-3 at a supercritical pressure.A simple surrogate model containing the n-decane species and a surrogate model containing 10 species are the other two acceptable options.The work conducted herein is of practical importance for theoretical analyses and numerical simulations of various physicochemical processes at engine operating conditions.展开更多
OBJECTIVE: To investigate in vivo survival of retinal ganglion cells (RGCs) after partial blockage of optic nerve (ON) axoplasmic flow by sub-retinal space or vitreous cavity injection of brain-derived neural factor (...OBJECTIVE: To investigate in vivo survival of retinal ganglion cells (RGCs) after partial blockage of optic nerve (ON) axoplasmic flow by sub-retinal space or vitreous cavity injection of brain-derived neural factor (BDNF) produced by genetically modified neural progenitor cells (NPCs). METHODS: Adult Sprague-Dawley (SD) rat RGCs were labeled with granular blue (GB) applied to their main targets in the brain. Seven days later, the left ON was intra-obitally crushed with a 40 g power forceps to partially block ON axoplasmic flow. Animals were randomized to three groups. The left eye of each rat received a sham injection, NPCs injection or an injection of genetically modified neural progenitors producing BDNF (BDNF-NPCs). Seven, 15 and 30 days after ON crush, retinas were examined under a fluorescence microscope. By calculating and comparing the average RGCs densities and RGC apoptosis density, RGC survival was estimated and the neuro-protective effect of transplanted cells was evaluated. RESULTS: Seven, 15 and 30 days after crush, in the intra-vitreous injection group, mean RGC densities had decreased to 1885 +/- 68, 1562 +/- 20, 1380 +/- 7 and 1837 +/- 46, 1561 +/- 58, 1370 +/- 16, respectively with sham injection or neural progenitors injection. However, RGCs density in the groups treated with intra-vitreous injection of BDNF-NPC was 2101 +/- 15, 1809 +/- 19 and 1625 +/- 34. Similar results were found in groups after sub-retinal injection. Higher densities were observed in groups treated with BDNF-NPCs. There were statistically significant differences among groups through nonparametric tests followed by the Mann-Whitely test. RGC apoptosis density in BDNF-NPC at each follow-up time was less than in other groups. CONCLUSIONS: A continuous supply of neurotrophic factors by the injection of genetically modified neural progenitors presents a highly effective approach to counteract optic neuropathy and RGC degeneration after partial ON axoplasmic flow blockage.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.11372277)
文摘Aviation kerosene is commonly used in combustion and regenerative engine cooling processes in propulsion and power-generation systems,including rocket,scramjet,and advanced gas turbine engines.In this paper,many surrogate models proposed in the open literature are examined for their applicability and accuracy in calculating thermodynamic and transport properties of the China aviation kerosene RP-3 at supercritical pressures,based on the extended corresponding-states methods.The enthalpy change from endothermic decomposition and low heating value from combustion of the jet fuel are also evaluated.Results from a number of simple and representative surrogate models,which contain species components ranging from 1 to10,are analyzed in detail.Data analyses indicate that a surrogate model with four species is the best choice for thermophysical property calculations under the tested conditions,with fluid temperature up to 650 K at various supercritical pressures.The surrogate model is particularly accurate in predicting the pseudo-critical temperature of aviation kerosene RP-3 at a supercritical pressure.A simple surrogate model containing the n-decane species and a surrogate model containing 10 species are the other two acceptable options.The work conducted herein is of practical importance for theoretical analyses and numerical simulations of various physicochemical processes at engine operating conditions.
基金ThisstudywassupportedbygrantsfromtheNationalNaturalSciencFoundationofChina (No 3 9670 775or39770811)andGuangdongKeyProgram (1998)
文摘OBJECTIVE: To investigate in vivo survival of retinal ganglion cells (RGCs) after partial blockage of optic nerve (ON) axoplasmic flow by sub-retinal space or vitreous cavity injection of brain-derived neural factor (BDNF) produced by genetically modified neural progenitor cells (NPCs). METHODS: Adult Sprague-Dawley (SD) rat RGCs were labeled with granular blue (GB) applied to their main targets in the brain. Seven days later, the left ON was intra-obitally crushed with a 40 g power forceps to partially block ON axoplasmic flow. Animals were randomized to three groups. The left eye of each rat received a sham injection, NPCs injection or an injection of genetically modified neural progenitors producing BDNF (BDNF-NPCs). Seven, 15 and 30 days after ON crush, retinas were examined under a fluorescence microscope. By calculating and comparing the average RGCs densities and RGC apoptosis density, RGC survival was estimated and the neuro-protective effect of transplanted cells was evaluated. RESULTS: Seven, 15 and 30 days after crush, in the intra-vitreous injection group, mean RGC densities had decreased to 1885 +/- 68, 1562 +/- 20, 1380 +/- 7 and 1837 +/- 46, 1561 +/- 58, 1370 +/- 16, respectively with sham injection or neural progenitors injection. However, RGCs density in the groups treated with intra-vitreous injection of BDNF-NPC was 2101 +/- 15, 1809 +/- 19 and 1625 +/- 34. Similar results were found in groups after sub-retinal injection. Higher densities were observed in groups treated with BDNF-NPCs. There were statistically significant differences among groups through nonparametric tests followed by the Mann-Whitely test. RGC apoptosis density in BDNF-NPC at each follow-up time was less than in other groups. CONCLUSIONS: A continuous supply of neurotrophic factors by the injection of genetically modified neural progenitors presents a highly effective approach to counteract optic neuropathy and RGC degeneration after partial ON axoplasmic flow blockage.
