Objective:To investigate the role of ^(99m)Tc-TRODAT-1 SPECT in diagnosis and assessing severity of idiopathicParkinson's disease(PD).Methods:Thirty-eight patients with primary,tentative diagnosis of PD and eighte...Objective:To investigate the role of ^(99m)Tc-TRODAT-1 SPECT in diagnosis and assessing severity of idiopathicParkinson's disease(PD).Methods:Thirty-eight patients with primary,tentative diagnosis of PD and eighteen age-matchednormal controls were studied with ^(99m)Tc-TRODAT-1 SPECT imaging.The regions of interests(ROIs)were drawn manually oncerebellum(CB),occipital cortex(OC)and three transverse plane slice-views of striatums,the semiquantitative BG(back-ground)/[(OC+CB)/2]were then calculated.Results:A lower uptake of ^(99m)Tc-TRODAT-1 in striatums were displayed inthirty-six out of thirty-eight PD patients by visual inspection,compared to controls.In twenty-four PD cases with HYS(Hoehn andYahr scale)stage Ⅰ,a greater loss of DAT uptake was found in striatum and its subregions contralateral striatum to the affectedlimbs than in the same regions of the controls,although the striatal uptake was bilaterally reduced.Using Spearman correlationanalysis showed that the reduction of the uptake ratios significantly correlated with the UPDRS in striatum and all its subregions inthe PD group(P<0.05),a similar change was also found in the putamen by using the rating scale of Hoehn and Yahr (P<0.05).However,analysis of variance(ANOVA)did not show any relationship between the decreasing uptake of ^(99m)Tc-TRODAT-1 andincreasing severity of PD patients,although the specific uptake of ^(99m)Tc-TRODAT-1 was continuously decreased in the striatumby visual inspection with the progress of PD from HYS stage Ⅰ to Ⅲ.Conclusion:^(99m)Tc-TRODAT-1 SPECT imaging may serve asa useful method for improving the correct diagnosis of PD.In assessing the role of ^(99m)Tc-TRODAT-1 SPECT in disease severity ofPD,UPDRS can offer a comprehensive index,although the Hoehn and Yahr assessment may be available in part.展开更多
In this paper, an approximate analytical algorithm in the form of direct Fourier reconstruction is obtained for the recon- struction of data functions arisen from ^-scheme short-scan sin- gle-photon emission computed ...In this paper, an approximate analytical algorithm in the form of direct Fourier reconstruction is obtained for the recon- struction of data functions arisen from ^-scheme short-scan sin- gle-photon emission computed tomography（SPECT） with uniform attenuation, and the modified central slice theorem is developed. Numerical simulations are conducted to demonstrate the effec- tiveness of the developed method.展开更多
It is difficult to diagnose primary hyperparathyroidism because of its variable symptoms and limited understanding of doctors.We reported one case of double parathyroid adenomas and one case of ectopic mediastinal par...It is difficult to diagnose primary hyperparathyroidism because of its variable symptoms and limited understanding of doctors.We reported one case of double parathyroid adenomas and one case of ectopic mediastinal parathyroid adenoma.Serum calcium and parathyroid hormone(PTH) was screened.99mTc sestamibi scintigraphy single photon emission computed tomography(SPECT) had been taken to find the parathyroid adenoma.Combined with ultrasonography or CT,we localized parathyroid adenomas precisely.After the operation,both patients developed hypocalcaemia,they were treated medically,and followed up.展开更多
In the last several years,the rate of innovation in cardiac imaging techniques has accelerated signifi cantly.Advances have been seen in all 4 major modalities;echocardiography,nuclear(positron emission tomography(PET...In the last several years,the rate of innovation in cardiac imaging techniques has accelerated signifi cantly.Advances have been seen in all 4 major modalities;echocardiography,nuclear(positron emission tomography(PET)and single photon emission computed tomography(SPECT),cardiac magnetic resonance imaging(CMR),and computed tomographic angiography(CTA).This issue of Cardiovascular Innovations and Applications will highlight many of these advances.展开更多
Radionuclide imaging is now the premier imaging method in clinical practice for its high sensitivity and tomographic capability.Current clinically available radio imaging methods mostly use positron-emission tomograph...Radionuclide imaging is now the premier imaging method in clinical practice for its high sensitivity and tomographic capability.Current clinically available radio imaging methods mostly use positron-emission tomography(PET)and single-photon emission computed tomography(SPECT)to detect anatomic abnormalities that conventional imaging techniques typically have challenges for visualizing.Contrast agents are indispensable for radionuclide imaging,and the radionuclide is always attached to a suitable vector that achieves targeted delivery.Nowadays,peptides have attracted increasing interest in targeting vectors of contrast agents,mainly due to their high specificity for target receptors at nanomolar concentrations and low toxicity.Radiolabeled peptide probes as kinds of PET/SPECT tracers had become essential tools for clinical radionuclide diagnosis.This review mainly summarizes radiolabeled peptide probes for bioimaging,including fundamental concepts of radiolabeled peptide probe design,some typical peptide analogs radiocontrast agents for PET,SPECT,and the combination imaging.展开更多
文摘Objective:To investigate the role of ^(99m)Tc-TRODAT-1 SPECT in diagnosis and assessing severity of idiopathicParkinson's disease(PD).Methods:Thirty-eight patients with primary,tentative diagnosis of PD and eighteen age-matchednormal controls were studied with ^(99m)Tc-TRODAT-1 SPECT imaging.The regions of interests(ROIs)were drawn manually oncerebellum(CB),occipital cortex(OC)and three transverse plane slice-views of striatums,the semiquantitative BG(back-ground)/[(OC+CB)/2]were then calculated.Results:A lower uptake of ^(99m)Tc-TRODAT-1 in striatums were displayed inthirty-six out of thirty-eight PD patients by visual inspection,compared to controls.In twenty-four PD cases with HYS(Hoehn andYahr scale)stage Ⅰ,a greater loss of DAT uptake was found in striatum and its subregions contralateral striatum to the affectedlimbs than in the same regions of the controls,although the striatal uptake was bilaterally reduced.Using Spearman correlationanalysis showed that the reduction of the uptake ratios significantly correlated with the UPDRS in striatum and all its subregions inthe PD group(P<0.05),a similar change was also found in the putamen by using the rating scale of Hoehn and Yahr (P<0.05).However,analysis of variance(ANOVA)did not show any relationship between the decreasing uptake of ^(99m)Tc-TRODAT-1 andincreasing severity of PD patients,although the specific uptake of ^(99m)Tc-TRODAT-1 was continuously decreased in the striatumby visual inspection with the progress of PD from HYS stage Ⅰ to Ⅲ.Conclusion:^(99m)Tc-TRODAT-1 SPECT imaging may serve asa useful method for improving the correct diagnosis of PD.In assessing the role of ^(99m)Tc-TRODAT-1 SPECT in disease severity ofPD,UPDRS can offer a comprehensive index,although the Hoehn and Yahr assessment may be available in part.
基金Supported by the National Natural Science Foundation of China(61271398)the Natural Science Foundation of Ningbo(2012A610031)
文摘In this paper, an approximate analytical algorithm in the form of direct Fourier reconstruction is obtained for the recon- struction of data functions arisen from ^-scheme short-scan sin- gle-photon emission computed tomography（SPECT） with uniform attenuation, and the modified central slice theorem is developed. Numerical simulations are conducted to demonstrate the effec- tiveness of the developed method.
文摘It is difficult to diagnose primary hyperparathyroidism because of its variable symptoms and limited understanding of doctors.We reported one case of double parathyroid adenomas and one case of ectopic mediastinal parathyroid adenoma.Serum calcium and parathyroid hormone(PTH) was screened.99mTc sestamibi scintigraphy single photon emission computed tomography(SPECT) had been taken to find the parathyroid adenoma.Combined with ultrasonography or CT,we localized parathyroid adenomas precisely.After the operation,both patients developed hypocalcaemia,they were treated medically,and followed up.
文摘In the last several years,the rate of innovation in cardiac imaging techniques has accelerated signifi cantly.Advances have been seen in all 4 major modalities;echocardiography,nuclear(positron emission tomography(PET)and single photon emission computed tomography(SPECT),cardiac magnetic resonance imaging(CMR),and computed tomographic angiography(CTA).This issue of Cardiovascular Innovations and Applications will highlight many of these advances.
基金supported by the National Key R&D Program of China(No.2018YFE0205400)。
文摘Radionuclide imaging is now the premier imaging method in clinical practice for its high sensitivity and tomographic capability.Current clinically available radio imaging methods mostly use positron-emission tomography(PET)and single-photon emission computed tomography(SPECT)to detect anatomic abnormalities that conventional imaging techniques typically have challenges for visualizing.Contrast agents are indispensable for radionuclide imaging,and the radionuclide is always attached to a suitable vector that achieves targeted delivery.Nowadays,peptides have attracted increasing interest in targeting vectors of contrast agents,mainly due to their high specificity for target receptors at nanomolar concentrations and low toxicity.Radiolabeled peptide probes as kinds of PET/SPECT tracers had become essential tools for clinical radionuclide diagnosis.This review mainly summarizes radiolabeled peptide probes for bioimaging,including fundamental concepts of radiolabeled peptide probe design,some typical peptide analogs radiocontrast agents for PET,SPECT,and the combination imaging.
