BACKGROUND Time-restricted eating(TRE)is a dietary approach that limits eating to a set number of hours per day.Human studies on the effects of TRE intervention on cardiometabolic health have been contradictory.Hetero...BACKGROUND Time-restricted eating(TRE)is a dietary approach that limits eating to a set number of hours per day.Human studies on the effects of TRE intervention on cardiometabolic health have been contradictory.Heterogeneity in subjects and TRE interventions have led to inconsistency in results.Furthermore,the impact of the duration of eating/fasting in the TRE approach has yet to be fully explored.AIM To analyze the existing literature on the effects of TRE with different eating durations on anthropometrics and cardiometabolic health markers in adults with excessive weight and obesity-related metabolic diseases.METHODS We reviewed a series of prominent scientific databases,including Medline,Scopus,Web of Science,Academic Search Complete,and Cochrane Library articles to identify published clinical trials on daily TRE in adults with excessive weight and obesity-related metabolic diseases.Randomized controlled trials were assessed for methodological rigor and risk of bias using version 2 of the Cochrane risk-of-bias tool for randomized trials(RoB-2).Outcomes of interest include body weight,waist circumference,fat mass,lean body mass,fasting glucose,insulin,HbA1c,homeostasis model assessment for insulin resistance(HOMA-IR),lipid profiles,C-reactive protein,blood pressure,and heart rate.RESULTS Fifteen studies were included in our systematic review.TRE significantly reduces body weight,waist circumference,fat mass,lean body mass,blood glucose,insulin,and triglyceride.However,no significant changes were observed in HbA1c,HOMA-IR,total cholesterol,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,heart rate,systolic and diastolic blood pressure.Furthermore,subgroup analyses based on the duration of the eating window revealed significant variation in the effects of TRE intervention depending on the length of the eating window.CONCLUSION TRE is a promising chrononutrition-based dietary approach for improving anthropometric and cardiometabolic health.However,further clinical trials are needed to det展开更多
Intermittent fasting is a novel dietary intervention that has been demonstrated to improve the efficacy of cancer therapy and reduce complications.Time-restricted eating is a specific form of intermittent fasting.It u...Intermittent fasting is a novel dietary intervention that has been demonstrated to improve the efficacy of cancer therapy and reduce complications.Time-restricted eating is a specific form of intermittent fasting.It usually restricts only the daily eating window and not the amount of calories consumed.In addition to providing a means for weight management and improving metabolism like other intermittent fasting methods,time-restricted eating also synchronizes circadian rhythms and affects autophagy levels,which has potential antiaging effects.Some studies have shown that time-restricted eating can prevent tumorigenesis and slow tumor progression.Moreover,because of its simplicity and mild adverse effects,time-restricted eating is safe and has a high rate of compliance.It may be used an adjuvant therapy and may be part of a healthy lifestyle suitable for long term by cancer patients or those at high risk of developing specific cancers.This article expounds on the potential impact of time-restricted eating on the prevention and treatment of cancer,as well as the potential mechanism(s)of action.There are 3 main aspects considered to be impacted by time-restricted eating:improving obesity and metabolic disorders,synchronizing the circadian rhythm,and upregulating autophagy.We herein present the current research progress related to the effects of time-restricted eating on malignant tumors.The purpose of this review is to provide a theoretical basis and direction for future research to explore the potential of time-restricted eating as a nutritional intervention to prevent the occurrence of cancer and as a treatment or adjuvant therapy for cancer.We believe that this approach may be conducive to improving the nutritional status of cancer patients and improving their prognosis and quality of life.展开更多
Timing of eating is a life strategy that requires special considerations in healthy nutritional programs. Human body tolerates less glucose as evening begins, mainly because glucose is demanded most during more active...Timing of eating is a life strategy that requires special considerations in healthy nutritional programs. Human body tolerates less glucose as evening begins, mainly because glucose is demanded most during more active times or daytime. A recommendation is being developed to avoid large night meals to help reduce risks of visceral adiposity, type-2 diabetes mellitus, hypertension, and cardiovascular issues. Optimal understanding of physiology in any given species requires optimal understanding of comparative animal-human physiology. Optimal animal physiology is understood with optimal perception of ruminant physiology with its unique complex systems biology. Thus, ruminants as irreplaceable human food producers are metabolically and economically suitable models to study cell, organ and whole body physiology. Evening vs. morning feeding of lactating cows increases eating rate, postprandial levels of rumen and peripheral metabolism, and milk and meat production. External cues and internal physiology may thus be synchronized to optimize production and health. Effective education will enable the public to be adequately cognizant of time of eating as a feasible strategy for the success of nutritional programs in optimizing health status.展开更多
The increasing prevalence of childhood overweight and obesity has been associated with an increased risk for cardiovascular disease(CVD).While several studies examined the effect of single behaviors such as physical a...The increasing prevalence of childhood overweight and obesity has been associated with an increased risk for cardiovascular disease(CVD).While several studies examined the effect of single behaviors such as physical activity(PA),sedentary behavior or diet on CVD risk,there is a lack of research on combined associations,specifically in children.Therefore,the purpose of this study was to examine the joint association of PA or screen time(ST)and diet on CVD risk factors in children.PA,STand diet were assessed via questionnaire in 210 fifth grade students(age:10.6±0.4 years).The healthy eating index(HEI)was subsequently calculated as indicator for diet quality.Height,weight,% body fat,and resting blood pressure were measured according to standard procedures and blood samples obtained via fingerprick were assayed for blood lipids.Total cholesterol HDL ratio(TC:HDL),mean arterial pressure(MAP),and % body fat were used as indicators of CVD risk.55% of children did not meet current PA recommendations on at least 5 days/week and 70% exceeded current recommendations for ST.Further,only 2.5% possessed a“good”diet(HEI>80).There was no significant association of PA or STand diet on CVD risk score.Neither TC:HDL,MAP,and % body fat nor the total CVD risk score was significantly correlated with diet,PA,or ST.Children in the high PA group,however,had significantly better diet scores.Despite the fact that self-reported PA,ST,or dietary intake were not directly related to CVD risk in this sample,higher activity levels were associated with a healthier diet and lower ST indicating an overall healthier lifestyle of this subgroup.展开更多
目的探讨蒲地蓝消炎口服液联合重组人干扰素α1b注射液治疗普通型手足口病的临床疗效。方法选取2013年10月—2015年10月在苏州市立医院进行治疗的普通型手足口病患儿97例,按照治疗方式的不同分为对照组（42例）和治疗组（55例）。对照...目的探讨蒲地蓝消炎口服液联合重组人干扰素α1b注射液治疗普通型手足口病的临床疗效。方法选取2013年10月—2015年10月在苏州市立医院进行治疗的普通型手足口病患儿97例,按照治疗方式的不同分为对照组（42例）和治疗组（55例）。对照组肌肉注射重组人干扰素α1b注射液,10μg/次,1次/d。治疗组在对照组基础上口服蒲地蓝消炎口服液,5-10 m L/次,3次/d。两组患儿均治疗7 d。观察两组的临床疗效,比较两组的症状消失时间和进食情况。结果治疗后,对照组和治疗组的总有效率分别为80.95%、94.55%,两组比较差异有统计学意义（P〈0.05）。治疗后,治疗组退热时间、皮疹消退时间、口腔黏膜充血和溃疡恢复时间、总病程均明显短于对照组,两组比较差异有统计学意义（P〈0.05）。治疗3、5 d后,对照组进食为＂好＂的占比分别为42.86%、69.05%;治疗组进食为＂好＂的占比分别为56.36%、81.82%,两组比较差异有统计学意义（P〈0.05）。结论蒲地蓝消炎口服液联合重组人干扰素α1b注射液治疗普通型手足口病具有较好的临床疗效,可改善临床症状,缩短病程,改善患儿进食情况,具有一定的临床推广应用价值。展开更多
文摘BACKGROUND Time-restricted eating(TRE)is a dietary approach that limits eating to a set number of hours per day.Human studies on the effects of TRE intervention on cardiometabolic health have been contradictory.Heterogeneity in subjects and TRE interventions have led to inconsistency in results.Furthermore,the impact of the duration of eating/fasting in the TRE approach has yet to be fully explored.AIM To analyze the existing literature on the effects of TRE with different eating durations on anthropometrics and cardiometabolic health markers in adults with excessive weight and obesity-related metabolic diseases.METHODS We reviewed a series of prominent scientific databases,including Medline,Scopus,Web of Science,Academic Search Complete,and Cochrane Library articles to identify published clinical trials on daily TRE in adults with excessive weight and obesity-related metabolic diseases.Randomized controlled trials were assessed for methodological rigor and risk of bias using version 2 of the Cochrane risk-of-bias tool for randomized trials(RoB-2).Outcomes of interest include body weight,waist circumference,fat mass,lean body mass,fasting glucose,insulin,HbA1c,homeostasis model assessment for insulin resistance(HOMA-IR),lipid profiles,C-reactive protein,blood pressure,and heart rate.RESULTS Fifteen studies were included in our systematic review.TRE significantly reduces body weight,waist circumference,fat mass,lean body mass,blood glucose,insulin,and triglyceride.However,no significant changes were observed in HbA1c,HOMA-IR,total cholesterol,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,heart rate,systolic and diastolic blood pressure.Furthermore,subgroup analyses based on the duration of the eating window revealed significant variation in the effects of TRE intervention depending on the length of the eating window.CONCLUSION TRE is a promising chrononutrition-based dietary approach for improving anthropometric and cardiometabolic health.However,further clinical trials are needed to det
基金This work was supported by grants from the National Natural Science Foundation of China(No.81870299).
文摘Intermittent fasting is a novel dietary intervention that has been demonstrated to improve the efficacy of cancer therapy and reduce complications.Time-restricted eating is a specific form of intermittent fasting.It usually restricts only the daily eating window and not the amount of calories consumed.In addition to providing a means for weight management and improving metabolism like other intermittent fasting methods,time-restricted eating also synchronizes circadian rhythms and affects autophagy levels,which has potential antiaging effects.Some studies have shown that time-restricted eating can prevent tumorigenesis and slow tumor progression.Moreover,because of its simplicity and mild adverse effects,time-restricted eating is safe and has a high rate of compliance.It may be used an adjuvant therapy and may be part of a healthy lifestyle suitable for long term by cancer patients or those at high risk of developing specific cancers.This article expounds on the potential impact of time-restricted eating on the prevention and treatment of cancer,as well as the potential mechanism(s)of action.There are 3 main aspects considered to be impacted by time-restricted eating:improving obesity and metabolic disorders,synchronizing the circadian rhythm,and upregulating autophagy.We herein present the current research progress related to the effects of time-restricted eating on malignant tumors.The purpose of this review is to provide a theoretical basis and direction for future research to explore the potential of time-restricted eating as a nutritional intervention to prevent the occurrence of cancer and as a treatment or adjuvant therapy for cancer.We believe that this approach may be conducive to improving the nutritional status of cancer patients and improving their prognosis and quality of life.
文摘Timing of eating is a life strategy that requires special considerations in healthy nutritional programs. Human body tolerates less glucose as evening begins, mainly because glucose is demanded most during more active times or daytime. A recommendation is being developed to avoid large night meals to help reduce risks of visceral adiposity, type-2 diabetes mellitus, hypertension, and cardiovascular issues. Optimal understanding of physiology in any given species requires optimal understanding of comparative animal-human physiology. Optimal animal physiology is understood with optimal perception of ruminant physiology with its unique complex systems biology. Thus, ruminants as irreplaceable human food producers are metabolically and economically suitable models to study cell, organ and whole body physiology. Evening vs. morning feeding of lactating cows increases eating rate, postprandial levels of rumen and peripheral metabolism, and milk and meat production. External cues and internal physiology may thus be synchronized to optimize production and health. Effective education will enable the public to be adequately cognizant of time of eating as a feasible strategy for the success of nutritional programs in optimizing health status.
文摘The increasing prevalence of childhood overweight and obesity has been associated with an increased risk for cardiovascular disease(CVD).While several studies examined the effect of single behaviors such as physical activity(PA),sedentary behavior or diet on CVD risk,there is a lack of research on combined associations,specifically in children.Therefore,the purpose of this study was to examine the joint association of PA or screen time(ST)and diet on CVD risk factors in children.PA,STand diet were assessed via questionnaire in 210 fifth grade students(age:10.6±0.4 years).The healthy eating index(HEI)was subsequently calculated as indicator for diet quality.Height,weight,% body fat,and resting blood pressure were measured according to standard procedures and blood samples obtained via fingerprick were assayed for blood lipids.Total cholesterol HDL ratio(TC:HDL),mean arterial pressure(MAP),and % body fat were used as indicators of CVD risk.55% of children did not meet current PA recommendations on at least 5 days/week and 70% exceeded current recommendations for ST.Further,only 2.5% possessed a“good”diet(HEI>80).There was no significant association of PA or STand diet on CVD risk score.Neither TC:HDL,MAP,and % body fat nor the total CVD risk score was significantly correlated with diet,PA,or ST.Children in the high PA group,however,had significantly better diet scores.Despite the fact that self-reported PA,ST,or dietary intake were not directly related to CVD risk in this sample,higher activity levels were associated with a healthier diet and lower ST indicating an overall healthier lifestyle of this subgroup.
文摘目的探讨蒲地蓝消炎口服液联合重组人干扰素α1b注射液治疗普通型手足口病的临床疗效。方法选取2013年10月—2015年10月在苏州市立医院进行治疗的普通型手足口病患儿97例,按照治疗方式的不同分为对照组（42例）和治疗组（55例）。对照组肌肉注射重组人干扰素α1b注射液,10μg/次,1次/d。治疗组在对照组基础上口服蒲地蓝消炎口服液,5-10 m L/次,3次/d。两组患儿均治疗7 d。观察两组的临床疗效,比较两组的症状消失时间和进食情况。结果治疗后,对照组和治疗组的总有效率分别为80.95%、94.55%,两组比较差异有统计学意义（P〈0.05）。治疗后,治疗组退热时间、皮疹消退时间、口腔黏膜充血和溃疡恢复时间、总病程均明显短于对照组,两组比较差异有统计学意义（P〈0.05）。治疗3、5 d后,对照组进食为＂好＂的占比分别为42.86%、69.05%;治疗组进食为＂好＂的占比分别为56.36%、81.82%,两组比较差异有统计学意义（P〈0.05）。结论蒲地蓝消炎口服液联合重组人干扰素α1b注射液治疗普通型手足口病具有较好的临床疗效,可改善临床症状,缩短病程,改善患儿进食情况,具有一定的临床推广应用价值。
