目的分析3D影像融合技术用于腔内介入治疗主动脉病变的价值。方法回顾性分析18例接受3D影像融合引导腔内介入治疗主动脉病变患者。于Siemens Artis Pheno工作站以Syngo-X-workshop软件将术前主动脉CT血管造影(CTA)与术中锥形束CT(CBCT)...目的分析3D影像融合技术用于腔内介入治疗主动脉病变的价值。方法回顾性分析18例接受3D影像融合引导腔内介入治疗主动脉病变患者。于Siemens Artis Pheno工作站以Syngo-X-workshop软件将术前主动脉CT血管造影(CTA)与术中锥形束CT(CBCT)图像进行融合,分别于T10~L3椎体水平进行冠状位、矢状位及轴位3个维度的配对融合,将最终形成的3D融合影像投射至实时数字减影血管造影(DSA)影像中,用于导引主动脉腔内介入操作。记录治疗用时、碘对比剂用量及射线剂量等。结果18例中,腹主动脉瘤7例、主动脉穿透性溃疡5例、胸主动脉夹层4例、胸主动脉瘤2例;对11例行腹主动脉瘤腔内修复术(EVAR)、7例行胸主动脉腔内修复术(TEVAR),均获得成功,技术成功率100%;治疗用时(124.28±55.95)min,碘对比剂用量(178.89±37.87)ml,辐照时间(20.21±13.20)min,CBCT辐射剂量(225.17±60.10)mGy,总辐射剂量(815.68±439.10)mGy。7例术前合并肾功能不全,术后24 h、出院前及术后1、3个月血肌酐值与术前比较差异均无统计学意义(P均>0.05)。结论3D影像融合技术用于腔内介入治疗主动脉病变安全、可行。展开更多
A new medical image fusion technique is presented.The method is based on three-dimensional reconstruction.After reconstruction,the three-dimensional volume data is normalized by three-dimensional coordinate conversion...A new medical image fusion technique is presented.The method is based on three-dimensional reconstruction.After reconstruction,the three-dimensional volume data is normalized by three-dimensional coordinate conversion in the same way and intercepted through setting up cutting plane including anatomical structure,as a result two images in entire registration on space and geometry are obtained and the images are fused at last.Compared with traditional two-dimensional fusion technique,three-dimensional fusion technique can not only resolve the different problems existed in the two kinds of images,but also avoid the registration error of the two kinds of images when they have different scan and imaging parameter.The research proves this fusion technique is more exact and has no registration,so it is more adapt to arbitrary medical image fusion with different equipments.展开更多
目的探讨基于影像融合和三维表面重建影像后处理技术的术前模拟在颅内动静脉畸形(AVM)治疗中的应用价值。方法回顾性分析2018年1月至2019年12月苏州大学附属第一医院神经外科手术治疗21例AVM患者的临床资料。术前均行头颅CT、3.0 T MRI...目的探讨基于影像融合和三维表面重建影像后处理技术的术前模拟在颅内动静脉畸形(AVM)治疗中的应用价值。方法回顾性分析2018年1月至2019年12月苏州大学附属第一医院神经外科手术治疗21例AVM患者的临床资料。术前均行头颅CT、3.0 T MRI和三维数字减影血管造影(3D-DSA)检查,利用iPlan软件将所有影像学数据配准融合并重建出三维模型,根据模型评估AVM的位置、范围、与功能区的关系以及供血动脉、引流静脉的位置,然后与术中所见进行比对,并在显微镜下切除AVM。术后行头颅MRI和DSA随访,同时检测患者的四肢活动、语言功能及视力情况。结果21例患者均顺利完成术前模型的重建,其中20例利用模型在术中成功辨认AVM、功能区、供血动脉及引流静脉的位置;1例因术野内无明显粗大的血管且脑内血肿造成脑沟受压,脑沟回形态不清晰,无法完成比对。术前模型与术中评估的符合率为95.2%(20/21)。21例患者中,AVM全切除20例,次全切除1例。5例因出血导致肢体活动障碍的患者中,4例于术后3个月内恢复正常;1例因出血导致偏盲的患者,术后3个月复查视野缺损有所改善。1例因术后再出血,出现肢体活动障碍,于2周后恢复正常。21例患者的随访时间为(15.8±6.7)个月(3~25个月),行影像学复查均未发现再出血。4例癫痫起病的患者中有3例术后无发作,1例于术后3个月内仍有发作,经调整抗癫痫药物治疗后发作停止。结论利用影像后处理技术有助于在术前对AVM的位置、范围、与功能区的关系以及供血动脉、引流静脉的位置作出准确评估,可提高AVM的全切除率,减少术后并发症的发生。展开更多
Objective:The aim of our study was to investigate the value of CT/CT image fusion radiation treatment planning in non-small cell lung cancer(NSCLC) and the impact on V20 and radiation pneumonitis(RP).Methods:Patients ...Objective:The aim of our study was to investigate the value of CT/CT image fusion radiation treatment planning in non-small cell lung cancer(NSCLC) and the impact on V20 and radiation pneumonitis(RP).Methods:Patients who were pathologically or cytologically diagnosed of stage IIIA and IIIB NSCLC were treated with three-dimensional conformal radiation therapy(4000 cGy).Forty patients got at least 25% tumor reduction were randomly divided into two groups:group A of regular shrink field radiotherapy(20 cases) and group B of CT/CT image fused shrink field radiotherapy(20 cases).Dosage reached 6600 cGy.Clinical data,V20 and RP were observed within 3 months after radiotherapy.Statistical analysis was conducted for the NSCLC patients.Results:22.5%(9/40) patients got RP during follow-up.Group A accounted for 6 cases(30%),and group B had 3 cases(15%).There was no marked difference between the two groups(P = 0.256),univariate analysis revealed that the IV20 of A and B groups,and IV20 and CV20 of all patients were statistically related to the incidence of RP(P < 0.05).With Wilcoxon method assay,the ipsilateral lung V20 and contralateral lung V20 had statistical significance between the two groups(P < 0.05).Conclusion:The CT/CT image infusion treatment planning could increase the radical dosage with better tumor control probability but won't increase adverse reaction.展开更多
Three-way junctions are characteristic structures of the tubular endoplasmic reticulum (ER) network. Junctions are formed through atlastin (ATL)-mediated membrane fusion and stabilized by lunapark (Lnp). However, how ...Three-way junctions are characteristic structures of the tubular endoplasmic reticulum (ER) network. Junctions are formed through atlastin (ATL)-mediated membrane fusion and stabilized by lunapark (Lnp). However, how Lnp is preferentially enriched at three-way junctions remains elusiveHere, we showed that Lnp loses its junction localization when ATLs are deleted. Reintroduction of ATL1 R77A and ATL3, which have been shown to cluster at the junctions, but not wild-type ATL1, relocates Lnp to the junctions. Mutations in the Nmyristoylation site or hydrophobic residues in the coiled coil (CC1) of Lnp N-terminus (NT) cause mis-targeting of LnpConversely, deletion of the lunapark motif in the C-terminal zinc fin ger domain, which affects the homooligomerization of Lnp, does not alter its localizationPurified Lnp-NT attaches to the membrane in a myristoylation- dependent manner. The mutation of hydrophobic residues in CC1 does not affect membrane association, but compromises ATL interactionsIn addition, Lnp-NT inhibits ATL-mediated vesicle fusion in vitro. These results suggest that CC1 in Lnp-NT contacts junction-enriched ATLs for proper localization;subsequently, further ATL activity is limited by Lnp after the junction is formed. The proposed mechanism ensures coordinated actions of ATL and Lnp in generating and maintaining three-way junctions.展开更多
Objective： The aim of our study was to explore the shortterm efficacy of platinumbased combined with concur rent chemoradiotherapy for locally advanced nonsmallcell lung cancer （NSCLC）. Methods： Between 2006 to 20...Objective： The aim of our study was to explore the shortterm efficacy of platinumbased combined with concur rent chemoradiotherapy for locally advanced nonsmallcell lung cancer （NSCLC）. Methods： Between 2006 to 2010, 78 cases of locally advanced NSCLC were enrolled into this trial. All patients were given platinumbased chemotherapy combined with concurrent threedimensional conformal radiotherapy （3DCRT）. Chest CT scans were obtained during endexpiratory and endinspiratory pauses when performing positioning. Image fusion was done after the image data was transferred to treat ment plan system （TPS）. The target volume was delineated on the fusion images. The chemotherapy was given on the first day of radiotherapy. Comprehensive examinations were conducted 46 weeks after concurrent chemoradiotherapy to assess shortterm efficacy. Results： Complete remission （CR） was achieved in 8 cases and partial remission （PR） in 54 cases. The efficiency rate reached 79.5%. Grade IllIV radiation esophagitis occurred in 11.5%. No exit and death cases during treat ment. Conclusion： Concurrent chemoradiotherapy could significantly improve the shortterm efficacy and prolong survival of stage III NSCLC, meanwhile the adverse reactions could be tolerated.展开更多
文摘目的分析3D影像融合技术用于腔内介入治疗主动脉病变的价值。方法回顾性分析18例接受3D影像融合引导腔内介入治疗主动脉病变患者。于Siemens Artis Pheno工作站以Syngo-X-workshop软件将术前主动脉CT血管造影(CTA)与术中锥形束CT(CBCT)图像进行融合,分别于T10~L3椎体水平进行冠状位、矢状位及轴位3个维度的配对融合,将最终形成的3D融合影像投射至实时数字减影血管造影(DSA)影像中,用于导引主动脉腔内介入操作。记录治疗用时、碘对比剂用量及射线剂量等。结果18例中,腹主动脉瘤7例、主动脉穿透性溃疡5例、胸主动脉夹层4例、胸主动脉瘤2例;对11例行腹主动脉瘤腔内修复术(EVAR)、7例行胸主动脉腔内修复术(TEVAR),均获得成功,技术成功率100%;治疗用时(124.28±55.95)min,碘对比剂用量(178.89±37.87)ml,辐照时间(20.21±13.20)min,CBCT辐射剂量(225.17±60.10)mGy,总辐射剂量(815.68±439.10)mGy。7例术前合并肾功能不全,术后24 h、出院前及术后1、3个月血肌酐值与术前比较差异均无统计学意义(P均>0.05)。结论3D影像融合技术用于腔内介入治疗主动脉病变安全、可行。
文摘A new medical image fusion technique is presented.The method is based on three-dimensional reconstruction.After reconstruction,the three-dimensional volume data is normalized by three-dimensional coordinate conversion in the same way and intercepted through setting up cutting plane including anatomical structure,as a result two images in entire registration on space and geometry are obtained and the images are fused at last.Compared with traditional two-dimensional fusion technique,three-dimensional fusion technique can not only resolve the different problems existed in the two kinds of images,but also avoid the registration error of the two kinds of images when they have different scan and imaging parameter.The research proves this fusion technique is more exact and has no registration,so it is more adapt to arbitrary medical image fusion with different equipments.
文摘目的探讨基于影像融合和三维表面重建影像后处理技术的术前模拟在颅内动静脉畸形(AVM)治疗中的应用价值。方法回顾性分析2018年1月至2019年12月苏州大学附属第一医院神经外科手术治疗21例AVM患者的临床资料。术前均行头颅CT、3.0 T MRI和三维数字减影血管造影(3D-DSA)检查,利用iPlan软件将所有影像学数据配准融合并重建出三维模型,根据模型评估AVM的位置、范围、与功能区的关系以及供血动脉、引流静脉的位置,然后与术中所见进行比对,并在显微镜下切除AVM。术后行头颅MRI和DSA随访,同时检测患者的四肢活动、语言功能及视力情况。结果21例患者均顺利完成术前模型的重建,其中20例利用模型在术中成功辨认AVM、功能区、供血动脉及引流静脉的位置;1例因术野内无明显粗大的血管且脑内血肿造成脑沟受压,脑沟回形态不清晰,无法完成比对。术前模型与术中评估的符合率为95.2%(20/21)。21例患者中,AVM全切除20例,次全切除1例。5例因出血导致肢体活动障碍的患者中,4例于术后3个月内恢复正常;1例因出血导致偏盲的患者,术后3个月复查视野缺损有所改善。1例因术后再出血,出现肢体活动障碍,于2周后恢复正常。21例患者的随访时间为(15.8±6.7)个月(3~25个月),行影像学复查均未发现再出血。4例癫痫起病的患者中有3例术后无发作,1例于术后3个月内仍有发作,经调整抗癫痫药物治疗后发作停止。结论利用影像后处理技术有助于在术前对AVM的位置、范围、与功能区的关系以及供血动脉、引流静脉的位置作出准确评估,可提高AVM的全切除率,减少术后并发症的发生。
文摘Objective:The aim of our study was to investigate the value of CT/CT image fusion radiation treatment planning in non-small cell lung cancer(NSCLC) and the impact on V20 and radiation pneumonitis(RP).Methods:Patients who were pathologically or cytologically diagnosed of stage IIIA and IIIB NSCLC were treated with three-dimensional conformal radiation therapy(4000 cGy).Forty patients got at least 25% tumor reduction were randomly divided into two groups:group A of regular shrink field radiotherapy(20 cases) and group B of CT/CT image fused shrink field radiotherapy(20 cases).Dosage reached 6600 cGy.Clinical data,V20 and RP were observed within 3 months after radiotherapy.Statistical analysis was conducted for the NSCLC patients.Results:22.5%(9/40) patients got RP during follow-up.Group A accounted for 6 cases(30%),and group B had 3 cases(15%).There was no marked difference between the two groups(P = 0.256),univariate analysis revealed that the IV20 of A and B groups,and IV20 and CV20 of all patients were statistically related to the incidence of RP(P < 0.05).With Wilcoxon method assay,the ipsilateral lung V20 and contralateral lung V20 had statistical significance between the two groups(P < 0.05).Conclusion:The CT/CT image infusion treatment planning could increase the radical dosage with better tumor control probability but won't increase adverse reaction.
基金National Key Research and Development Program (Grant No. 2016YFA0500201)the National Natural Science Foundation of China (Grant Nos. 31225006 and 3142100024).
文摘Three-way junctions are characteristic structures of the tubular endoplasmic reticulum (ER) network. Junctions are formed through atlastin (ATL)-mediated membrane fusion and stabilized by lunapark (Lnp). However, how Lnp is preferentially enriched at three-way junctions remains elusiveHere, we showed that Lnp loses its junction localization when ATLs are deleted. Reintroduction of ATL1 R77A and ATL3, which have been shown to cluster at the junctions, but not wild-type ATL1, relocates Lnp to the junctions. Mutations in the Nmyristoylation site or hydrophobic residues in the coiled coil (CC1) of Lnp N-terminus (NT) cause mis-targeting of LnpConversely, deletion of the lunapark motif in the C-terminal zinc fin ger domain, which affects the homooligomerization of Lnp, does not alter its localizationPurified Lnp-NT attaches to the membrane in a myristoylation- dependent manner. The mutation of hydrophobic residues in CC1 does not affect membrane association, but compromises ATL interactionsIn addition, Lnp-NT inhibits ATL-mediated vesicle fusion in vitro. These results suggest that CC1 in Lnp-NT contacts junction-enriched ATLs for proper localization;subsequently, further ATL activity is limited by Lnp after the junction is formed. The proposed mechanism ensures coordinated actions of ATL and Lnp in generating and maintaining three-way junctions.
文摘Objective： The aim of our study was to explore the shortterm efficacy of platinumbased combined with concur rent chemoradiotherapy for locally advanced nonsmallcell lung cancer （NSCLC）. Methods： Between 2006 to 2010, 78 cases of locally advanced NSCLC were enrolled into this trial. All patients were given platinumbased chemotherapy combined with concurrent threedimensional conformal radiotherapy （3DCRT）. Chest CT scans were obtained during endexpiratory and endinspiratory pauses when performing positioning. Image fusion was done after the image data was transferred to treat ment plan system （TPS）. The target volume was delineated on the fusion images. The chemotherapy was given on the first day of radiotherapy. Comprehensive examinations were conducted 46 weeks after concurrent chemoradiotherapy to assess shortterm efficacy. Results： Complete remission （CR） was achieved in 8 cases and partial remission （PR） in 54 cases. The efficiency rate reached 79.5%. Grade IllIV radiation esophagitis occurred in 11.5%. No exit and death cases during treat ment. Conclusion： Concurrent chemoradiotherapy could significantly improve the shortterm efficacy and prolong survival of stage III NSCLC, meanwhile the adverse reactions could be tolerated.
