Twenty nine novel N-4-methyl-1,2,3-thiadiazole-5-carbonyl-N＇-phenyl ureas were designed and synthesized, and their structures were confirmed by proton nuclear magnetic resonance （1H NMR）, infra red spectroscopy （I...Twenty nine novel N-4-methyl-1,2,3-thiadiazole-5-carbonyl-N＇-phenyl ureas were designed and synthesized, and their structures were confirmed by proton nuclear magnetic resonance （1H NMR）, infra red spectroscopy （IR） and high-resolution mass spectroscopy （HRMS）. Compounds V-9, V-11, V-12, V-15, V-19, V-21, V-22 and V-24 exhibit excellent activity against Culex pipiens pallens. Compounds V-12 and V-22 present good insecticidal activity against Plutella xylostella L. Their median lethal concentrations （LC50） are 164.15 and 89.69 mg-L^-1, respec- tively. Compound V-11 also has potential wide spectrum of fungicide activity. Its median effective concentrations （ECs0） detected from 3.82 μg·mL 1 against Physalospora piricola to 31.60 μg·mL-i against Cercospora arachidi- cola. Compounds V-15 and V-24 show outstanding induction activities as same as positive controls TDL and ning- nanmycin, furthermore V-24 has the highest induction activity of 41.85%±4.43%. To elucidate the structure activity relationship in these compounds, a 3D-QSAR model has been built. The established model showed a reliable predicting ability with q2 values of 0.643 and r2 values of 0.982.展开更多
A series of novel 1,3,4-thiadiazole derivatives based on benzisoselenazolone were synthesized and evaluated for their cytotoxicity in vitro against human liver cancer cell SSMC-7721,human breast cancer cell MCF-7 and ...A series of novel 1,3,4-thiadiazole derivatives based on benzisoselenazolone were synthesized and evaluated for their cytotoxicity in vitro against human liver cancer cell SSMC-7721,human breast cancer cell MCF-7 and human lung cancer cell A549 by CCK-8 assay.The results showed mat compounds 7e,7f,7h,7k,71 and 7m displayed good cytotoxicity against MCF-7 cell lines.Compound 71 exhibited the most potent antitumor activities among the tested compounds.展开更多
基金This study was funded in part by grants from the Na- tional Natural Science Foundation of China （No. 20872071）, the Tianjin Natural Science Foundation （No. 10JCZDJC17500）, the National Key Project for Basic Research （No. 2010CB126105）, the National Key Technology Research and Development Program （No. 2011BAE06B02） and the Foundation of Achievements Transformation and Spreading of Tianjin Agricultural Science and Technology （No. 201002250）, Tianjin Key Technology Research and Development Program （No. 11ZCGYNC00100）.
文摘Twenty nine novel N-4-methyl-1,2,3-thiadiazole-5-carbonyl-N＇-phenyl ureas were designed and synthesized, and their structures were confirmed by proton nuclear magnetic resonance （1H NMR）, infra red spectroscopy （IR） and high-resolution mass spectroscopy （HRMS）. Compounds V-9, V-11, V-12, V-15, V-19, V-21, V-22 and V-24 exhibit excellent activity against Culex pipiens pallens. Compounds V-12 and V-22 present good insecticidal activity against Plutella xylostella L. Their median lethal concentrations （LC50） are 164.15 and 89.69 mg-L^-1, respec- tively. Compound V-11 also has potential wide spectrum of fungicide activity. Its median effective concentrations （ECs0） detected from 3.82 μg·mL 1 against Physalospora piricola to 31.60 μg·mL-i against Cercospora arachidi- cola. Compounds V-15 and V-24 show outstanding induction activities as same as positive controls TDL and ning- nanmycin, furthermore V-24 has the highest induction activity of 41.85%±4.43%. To elucidate the structure activity relationship in these compounds, a 3D-QSAR model has been built. The established model showed a reliable predicting ability with q2 values of 0.643 and r2 values of 0.982.
基金supported by the National NaturalScience Foundation of China(No.20971097)
文摘A series of novel 1,3,4-thiadiazole derivatives based on benzisoselenazolone were synthesized and evaluated for their cytotoxicity in vitro against human liver cancer cell SSMC-7721,human breast cancer cell MCF-7 and human lung cancer cell A549 by CCK-8 assay.The results showed mat compounds 7e,7f,7h,7k,71 and 7m displayed good cytotoxicity against MCF-7 cell lines.Compound 71 exhibited the most potent antitumor activities among the tested compounds.
