AIM: To determine the parental transmission of diabetes mellitus (DM) and evaluate its influence on the clinical characteristics. METHODS: This was a cross sectional study. The survey was carried out in urban and semi...AIM: To determine the parental transmission of diabetes mellitus (DM) and evaluate its influence on the clinical characteristics. METHODS: This was a cross sectional study. The survey was carried out in urban and semi-urban primary health care centers. Of the 2400 registered with diagnosed diabetes, 1980 agreed and gave their consent to take part in this study, thus giving a response rate of 82.5%. Face to face interviews were conducted using a structured questionnaire followed by laboratory tests. DM was defined according to the World Health Organization expert group. A trained nurse performedphysical examinations and measurements. RESULTS: Of the study population, 72.9% reported a family history of DM. Family history of DM was significantly higher in females (54.2%; P = 0.04) and in the age group below 30 years (24%; P < 0.001). The prevalence of diabetes was higher among patients with a diabetic mother (25.4% vs 22.1%) and maternal aunts/uncles (31.2% vs 22.2%) compared to patients with a diabetic father and paternal aunts/ uncles. Family history of DM was higher in patients of consanguineous parents (38.5%) than those of non-consanguineous parents (30.2%). The development of type 2 diabetes mellitus (T2DM) complications was higher in patients with either a paternal or maternal history of DM than in those without. No significant difference was observed in the metabolic characteristics of patients with/without family history of DM except for hypertension. Complications were higher in diabetic patients with a family history of DM. CONCLUSION: The present study found a significant maternal effect in transmission of T2DM. Family history is associated with the increased incidence of diabetes.展开更多
目的探讨糖尿病家族史与血脂异常对糖尿病患病风险的交互作用。方法利用2018年江苏省南通市崇川区“国家慢性病综合防控示范区建设”项目调查的13382名居民数据,其中血糖信息获得3209份。Logistic回归模型分析糖尿病家族史、血脂异常与...目的探讨糖尿病家族史与血脂异常对糖尿病患病风险的交互作用。方法利用2018年江苏省南通市崇川区“国家慢性病综合防控示范区建设”项目调查的13382名居民数据,其中血糖信息获得3209份。Logistic回归模型分析糖尿病家族史、血脂异常与糖尿病患病的关系,使用相加模型评估二者交互作用对糖尿病患病风险的影响,并探讨二者交互作用的性别差异。结果本研究糖尿病患病率17.3%,标化患病率12.9%,糖尿病阳性家族史占8.8%,血脂异常者占7.6%。调整年龄、吸烟、饮酒及高脂饮食等混杂因素后,糖尿病家族史与血脂异常对糖尿病患病风险存在协同作用,家族史和血脂异常共同存在时,男、女性人群患病风险分别是二者均不存在者的15.24倍(95%CI:4.57~50.82)和9.84倍(95%CI:4.58~21.12)。男性相对超危险度比(the relative excess risk due to interaction,RERI)为6.59,归因交互作用(the attributable proportion due to interaction,AP)为43.2%,交互作用指数(the synergy index,S)为1.86,纯因子归因交互作用百分比AP×(AB)%为46.3%;女性RERI为4.22,AP%为42.9%,S为1.91,AP×(AB)%为47.7%。结论糖尿病家族史和血脂异常对糖尿病患病风险存在协同作用,且男性人群的交互作用可能大于女性。展开更多
基金Supported by Qatar Diabetic Association and Qatar National Research Fund, QNRF UREP 07-099-3-023
文摘AIM: To determine the parental transmission of diabetes mellitus (DM) and evaluate its influence on the clinical characteristics. METHODS: This was a cross sectional study. The survey was carried out in urban and semi-urban primary health care centers. Of the 2400 registered with diagnosed diabetes, 1980 agreed and gave their consent to take part in this study, thus giving a response rate of 82.5%. Face to face interviews were conducted using a structured questionnaire followed by laboratory tests. DM was defined according to the World Health Organization expert group. A trained nurse performedphysical examinations and measurements. RESULTS: Of the study population, 72.9% reported a family history of DM. Family history of DM was significantly higher in females (54.2%; P = 0.04) and in the age group below 30 years (24%; P < 0.001). The prevalence of diabetes was higher among patients with a diabetic mother (25.4% vs 22.1%) and maternal aunts/uncles (31.2% vs 22.2%) compared to patients with a diabetic father and paternal aunts/ uncles. Family history of DM was higher in patients of consanguineous parents (38.5%) than those of non-consanguineous parents (30.2%). The development of type 2 diabetes mellitus (T2DM) complications was higher in patients with either a paternal or maternal history of DM than in those without. No significant difference was observed in the metabolic characteristics of patients with/without family history of DM except for hypertension. Complications were higher in diabetic patients with a family history of DM. CONCLUSION: The present study found a significant maternal effect in transmission of T2DM. Family history is associated with the increased incidence of diabetes.
文摘目的探讨糖尿病家族史与血脂异常对糖尿病患病风险的交互作用。方法利用2018年江苏省南通市崇川区“国家慢性病综合防控示范区建设”项目调查的13382名居民数据,其中血糖信息获得3209份。Logistic回归模型分析糖尿病家族史、血脂异常与糖尿病患病的关系,使用相加模型评估二者交互作用对糖尿病患病风险的影响,并探讨二者交互作用的性别差异。结果本研究糖尿病患病率17.3%,标化患病率12.9%,糖尿病阳性家族史占8.8%,血脂异常者占7.6%。调整年龄、吸烟、饮酒及高脂饮食等混杂因素后,糖尿病家族史与血脂异常对糖尿病患病风险存在协同作用,家族史和血脂异常共同存在时,男、女性人群患病风险分别是二者均不存在者的15.24倍(95%CI:4.57~50.82)和9.84倍(95%CI:4.58~21.12)。男性相对超危险度比(the relative excess risk due to interaction,RERI)为6.59,归因交互作用(the attributable proportion due to interaction,AP)为43.2%,交互作用指数(the synergy index,S)为1.86,纯因子归因交互作用百分比AP×(AB)%为46.3%;女性RERI为4.22,AP%为42.9%,S为1.91,AP×(AB)%为47.7%。结论糖尿病家族史和血脂异常对糖尿病患病风险存在协同作用,且男性人群的交互作用可能大于女性。
