Objective: To explore the specificity of Tongli(HT 5) and Xuanzhong(GB 39) paired acupionts in aspects of Deqi sensation and brain activation patterns during electroacupuncture. Methods: In this study, 15 healthy subj...Objective: To explore the specificity of Tongli(HT 5) and Xuanzhong(GB 39) paired acupionts in aspects of Deqi sensation and brain activation patterns during electroacupuncture. Methods: In this study, 15 healthy subjects were enrolled. All participants suffered two kinds of functional magnetic resonance imaging(f MRI) examinations randomly: Examination A received electro-acupuncture(EA) at the bilateral Tongli(HT5) and Xuanzhong(GB 39) acupoints(ACU), and examination B received EA at bilateral non-acupoints(NAP). The subjects reported the feeling of Deqi at each examination later respectively. A multi-voxel pattern analysis method and Statistical Program for Social Sciences were used to analyze the data. Results: The ACU group(Exam A) reported fullness, heaviness, numbness, soreness and throbbing of significantly greater intensity than the NAP group(Exam B). In addition, there was no statistical significance between two groups in aching, tingling, deep pressure, sharp pain, dull pain, warmness and cold. Meanwhile, f MRI data revealed differences between two groups in discriminating accuracy of brain somatosensory cortex and language-related cortices. Conclusion: Needling HT 5 and GB 39 may modulate language function through a complex brain network, suggesting that it may be beneficial to the recovery of language function in patients with aphasia.展开更多
The functional brain network using blood-oxygen-level-dependent（BOLD） functional magnetic resonance imaging（fMRI） has revealed the potentials for probing brain architecture,as well as for identifying clinical biom...The functional brain network using blood-oxygen-level-dependent（BOLD） functional magnetic resonance imaging（fMRI） has revealed the potentials for probing brain architecture,as well as for identifying clinical biomarkers for brain diseases.In the general context of Brainnetome,this review focuses on the development of approaches for modeling and analyzing functional brain networks with BOLD fMRI.The prospects for these approaches are also discussed.展开更多
Neuroimaging has opened new opportunities to study the neural correlates of consciousness, and provided additional information concerning diagnosis, prognosis, and therapeutic interventions in patients with disorders ...Neuroimaging has opened new opportunities to study the neural correlates of consciousness, and provided additional information concerning diagnosis, prognosis, and therapeutic interventions in patients with disorders of consciousness. Here, we aim to review neuroimaging studies in chronic disorders of consciousness from the viewpoint of the brain network, focusing on positron emission tomogra- phy, functional MRI, functional near-infrared spectroscopy, electrophysiology, and diffusion MRI. To accelerate basic research on disorders of consciousness and provide a panoramic view of unconsciousness, we propose that it is urgent to integrate different techniques at various spatiotemporal scales, and to merge fragmented findings into a uniform ＂Brainnetome＂ （Brain-net-ome） research framework.展开更多
基金Supported by the National Natural Science Foundation of China(No.81072768)the New Century Excellent Talents in University of the Ministry of Education of China(No.NCET-11-0603)Capital Featured Clinical Research of Beijing Municipal Science and Technology,China(No.Z131107002213094)
文摘Objective: To explore the specificity of Tongli(HT 5) and Xuanzhong(GB 39) paired acupionts in aspects of Deqi sensation and brain activation patterns during electroacupuncture. Methods: In this study, 15 healthy subjects were enrolled. All participants suffered two kinds of functional magnetic resonance imaging(f MRI) examinations randomly: Examination A received electro-acupuncture(EA) at the bilateral Tongli(HT5) and Xuanzhong(GB 39) acupoints(ACU), and examination B received EA at bilateral non-acupoints(NAP). The subjects reported the feeling of Deqi at each examination later respectively. A multi-voxel pattern analysis method and Statistical Program for Social Sciences were used to analyze the data. Results: The ACU group(Exam A) reported fullness, heaviness, numbness, soreness and throbbing of significantly greater intensity than the NAP group(Exam B). In addition, there was no statistical significance between two groups in aching, tingling, deep pressure, sharp pain, dull pain, warmness and cold. Meanwhile, f MRI data revealed differences between two groups in discriminating accuracy of brain somatosensory cortex and language-related cortices. Conclusion: Needling HT 5 and GB 39 may modulate language function through a complex brain network, suggesting that it may be beneficial to the recovery of language function in patients with aphasia.
基金supported by the National Basic Research Development Program(973) of China(2011CB707800)the National Natural Science Foundation of China(91132301 and 81101040)
文摘The functional brain network using blood-oxygen-level-dependent（BOLD） functional magnetic resonance imaging（fMRI） has revealed the potentials for probing brain architecture,as well as for identifying clinical biomarkers for brain diseases.In the general context of Brainnetome,this review focuses on the development of approaches for modeling and analyzing functional brain networks with BOLD fMRI.The prospects for these approaches are also discussed.
基金supported by the National Natural Science Foundation of China(81471380,31771076,81501550,91432302,31620103905,and 81501179)the Science Frontier Program of the Chinese Academy of Sciences(QYZDJSSW-SMC019)+4 种基金National Key R&D Program of China(2017YFA0105203,2017YFB1002502)Beijing Municipal Science and Technology Commission(Z161100000216152,Z161100000216139,Z171100000117002,and Z161100000516165)the Shenzhen Peacock Plan(KQTD2015033016104926)the Guangdong Pearl River Talents Plan(2016ZT06S220)Youth Innovation Promotion Association,CAS,China
文摘Neuroimaging has opened new opportunities to study the neural correlates of consciousness, and provided additional information concerning diagnosis, prognosis, and therapeutic interventions in patients with disorders of consciousness. Here, we aim to review neuroimaging studies in chronic disorders of consciousness from the viewpoint of the brain network, focusing on positron emission tomogra- phy, functional MRI, functional near-infrared spectroscopy, electrophysiology, and diffusion MRI. To accelerate basic research on disorders of consciousness and provide a panoramic view of unconsciousness, we propose that it is urgent to integrate different techniques at various spatiotemporal scales, and to merge fragmented findings into a uniform ＂Brainnetome＂ （Brain-net-ome） research framework.
