Objective To evaluate the fetal cardiac function in gestational diabetes mellitus （GDM） pregnancies under different maternal glycemic controls. Methods Forty four GDM mothers received 78 fetal echocardiographic eval...Objective To evaluate the fetal cardiac function in gestational diabetes mellitus （GDM） pregnancies under different maternal glycemic controls. Methods Forty four GDM mothers received 78 fetal echocardiographic evaluations at three gestational periods （〈28, 28-34 and ≥34 weeks） and were divided into poorly-（DM1） and well-（DM2） controlled groups according to their glycemic control at examination. Seventy uncomplicated mothers were selected as controls. Parameters of fetal cardiac anatomy and function were measured and analyzed. Results GDM fetuses＇ cardiac ventricular walls were thicker than controls＇, and the differences between DM1 and DM2 were not significant except for end-diastolic left ventricular walls. In both GDM groups, the aortic flow velocities increased earlier than pulmonary artery and DM1 fetuses changed earlier than DM2 ones. GDM fetuses＇ left atrial shortening fraction was smaller than the controls＇ in the period of ≥34 weeks and negatively correlated with thicknesses of left ventricular walls and interventricular septum in DM1 fetuses （r=-0.438 and -0.506）. The right ventricular diastolic function in DM1 and DM2 fetuses decreased after the period of 28-34 weeks and in the period of ≥34 weeks respectively. Tel index of both left and right ventricles increased in DM1 group after the period of 〈28 weeks and in DM2 group only in the period of ≥ 34 weeks, with no significant differences between DM1 and DM2 groups in this period. Conclusion Fetuses of GDM mothers showed cardiac function impairments. Good maternal glycemic control may delay the impairments, but cannot reduce the degree. Some cardiac changes in GDM fetuses were similar to those in pregestational diabetic pregnancies except for several parameters and their changing time.展开更多
为促进我国技术与工程教育的发展,提升学生科学与技术素养水平,实现“以评促教”“以评促学”,从框架目标和项目特点两方面出发,比较分析ICILS 2018与NAEP TEL 2018两种典型模式的异同,得出两者在维度划分、重视情境、采用量规等方面存...为促进我国技术与工程教育的发展,提升学生科学与技术素养水平,实现“以评促教”“以评促学”,从框架目标和项目特点两方面出发,比较分析ICILS 2018与NAEP TEL 2018两种典型模式的异同,得出两者在维度划分、重视情境、采用量规等方面存在相似点,在评估重点、试题分布、编制依据等方面存在不同点的结论。结合我国实际,提出了科学与技术素养评估今后的发展思路:统一课程标准,完善评估体系;明确评估目标,构建三维架构;营造真实情境,提升解决能力;凸显整体平衡,科学编制试题;重视人机交互,增强现实体验;强化过程评价,实现“质”“量”结合;重视环境影响,改进后续教学。展开更多
In order to investigate the IFN-γ and IL-4 expression of CD8^＋T lymphoeytes in the peripheral blood from patients with recurrent genital herpes （RGH） at different clinical periods and their relationship with the p...In order to investigate the IFN-γ and IL-4 expression of CD8^＋T lymphoeytes in the peripheral blood from patients with recurrent genital herpes （RGH） at different clinical periods and their relationship with the pathogenesis of RGH, flow cytometry was used to detect the intracellular cytokines （IFN-γ and IL-4） of CD8^＋ T lymphocytes in the peripheral blood of 30 patients with RGH at acute period, 20 patients with RGH at recovery period and 15 healthy volunteers. The results showed that RGH patients at acute period had a lower percentage of Tcl subsets in peripheral blood than that of healthy controls （P〈0. 001）, especially a remarkable decreased percentage of Tc1 subsets （P〈0. 001） among those RGH patients with recurrent number more than 3 in the recent half a year. Tc1/Tc2 ratio in the RGH patients at acute period was significantly decreased as conapared with normal control group （P〈0.05）. The recurrent number of acute patients in the recent half a year was significantly correlated with the percentage of Tc1 subsets and the ratio of Tc1/Tc2 （P〈 0.05）. A decreased percentage of Tc1 subsets was found among the RGH patients with recurrent number more than 3 in the recent half a year at recovery period in comparison with healthy volunteers （P〈0.05）, and it was significantly correlated with the recurrent number in the recent half a year （P〈0.05）. It is concluded that there are Tc1/Tc2 imbalance and a low level of Tc1 subsets in RGH patients who are relapsing repeatedly in the near period. The low level of Tc1 subsets may be an important factor for the recurrence of RGH and the reactivation of latent herpesvirus infection.展开更多
Background Congenital heart disease （CHD） is a diverse group of diseases determined by genetic and environmental factors. Considerable research has been done on genes associated with the development of the heart. Re...Background Congenital heart disease （CHD） is a diverse group of diseases determined by genetic and environmental factors. Considerable research has been done on genes associated with the development of the heart. Recently, focus is on the role of transcription factor NFATcl in the development of proper valve and septa. As part of a larger study, high density single nucleotide polymorphism （SNP） scanning was used to explore the relationship between NFATcl gene polymorphism and susceptibility to ventricular septal defect （VSD） in the Chinese Hart population. Methods One hundred and ninety-two pediatric patients with congenital VSD and 192 matching healthy control subjects were studied. The haplotype reconstructions were calculated by PHASE2.0 software. Haploview software was used to perform linkage disequilibrium assessment and define haplotype blocks. The algorithm used for defining the blocks was the confidence interval method. Results The NFATcl gene region can be divided into 11 haplotype blocks. Strong linkage disequilibrium existed within blocks 6, 8, 9, and 11. Three SNPs （rs7240256, rs11665469, and rs754505） within the NFATcl gene had significant correlation with VSD by single marker association analysis. In addition, two haplotypes correlated with VSD. Conclusions NFATcl is associated with the occurrence of VSD and it may be a predisposing gene to CHD in Hart Chinese. This finding has set a direction for further genetic and functional studies.展开更多
A strange phenomenon of fire taking place at Arruhban area west Bahr-Al Najaf area in Iraq was noticed in 2010 and smoke continued many months;this phenomenon reappeared many years later. This site is part of Bahr-Al ...A strange phenomenon of fire taking place at Arruhban area west Bahr-Al Najaf area in Iraq was noticed in 2010 and smoke continued many months;this phenomenon reappeared many years later. This site is part of Bahr-Al Najaf-Iraq NE Arabian plate, located in flat area near an archeological site of Christian temple called Tel Arruhban. To understand the causes for this fire in a non-residential area, field observations from repeated visits between 2010 and 2018 and on-site excavation operations were conducted. The results of analysis of soil samples, and on-site detection for gases and vapors showed that the phenomenon of burning and smoke generated at this site was due to external influences and that the presence of soil rich with organic materials helped to the existence of this phenomenon.展开更多
基金supported by the National Natural Science Foundation of China (81001228)National High Technology Research and Development Program of China (863 Program)(2007AA02Z442)
文摘Objective To evaluate the fetal cardiac function in gestational diabetes mellitus （GDM） pregnancies under different maternal glycemic controls. Methods Forty four GDM mothers received 78 fetal echocardiographic evaluations at three gestational periods （〈28, 28-34 and ≥34 weeks） and were divided into poorly-（DM1） and well-（DM2） controlled groups according to their glycemic control at examination. Seventy uncomplicated mothers were selected as controls. Parameters of fetal cardiac anatomy and function were measured and analyzed. Results GDM fetuses＇ cardiac ventricular walls were thicker than controls＇, and the differences between DM1 and DM2 were not significant except for end-diastolic left ventricular walls. In both GDM groups, the aortic flow velocities increased earlier than pulmonary artery and DM1 fetuses changed earlier than DM2 ones. GDM fetuses＇ left atrial shortening fraction was smaller than the controls＇ in the period of ≥34 weeks and negatively correlated with thicknesses of left ventricular walls and interventricular septum in DM1 fetuses （r=-0.438 and -0.506）. The right ventricular diastolic function in DM1 and DM2 fetuses decreased after the period of 28-34 weeks and in the period of ≥34 weeks respectively. Tel index of both left and right ventricles increased in DM1 group after the period of 〈28 weeks and in DM2 group only in the period of ≥ 34 weeks, with no significant differences between DM1 and DM2 groups in this period. Conclusion Fetuses of GDM mothers showed cardiac function impairments. Good maternal glycemic control may delay the impairments, but cannot reduce the degree. Some cardiac changes in GDM fetuses were similar to those in pregestational diabetic pregnancies except for several parameters and their changing time.
文摘为促进我国技术与工程教育的发展,提升学生科学与技术素养水平,实现“以评促教”“以评促学”,从框架目标和项目特点两方面出发,比较分析ICILS 2018与NAEP TEL 2018两种典型模式的异同,得出两者在维度划分、重视情境、采用量规等方面存在相似点,在评估重点、试题分布、编制依据等方面存在不同点的结论。结合我国实际,提出了科学与技术素养评估今后的发展思路:统一课程标准,完善评估体系;明确评估目标,构建三维架构;营造真实情境,提升解决能力;凸显整体平衡,科学编制试题;重视人机交互,增强现实体验;强化过程评价,实现“质”“量”结合;重视环境影响,改进后续教学。
文摘In order to investigate the IFN-γ and IL-4 expression of CD8^＋T lymphoeytes in the peripheral blood from patients with recurrent genital herpes （RGH） at different clinical periods and their relationship with the pathogenesis of RGH, flow cytometry was used to detect the intracellular cytokines （IFN-γ and IL-4） of CD8^＋ T lymphocytes in the peripheral blood of 30 patients with RGH at acute period, 20 patients with RGH at recovery period and 15 healthy volunteers. The results showed that RGH patients at acute period had a lower percentage of Tcl subsets in peripheral blood than that of healthy controls （P〈0. 001）, especially a remarkable decreased percentage of Tc1 subsets （P〈0. 001） among those RGH patients with recurrent number more than 3 in the recent half a year. Tc1/Tc2 ratio in the RGH patients at acute period was significantly decreased as conapared with normal control group （P〈0.05）. The recurrent number of acute patients in the recent half a year was significantly correlated with the percentage of Tc1 subsets and the ratio of Tc1/Tc2 （P〈 0.05）. A decreased percentage of Tc1 subsets was found among the RGH patients with recurrent number more than 3 in the recent half a year at recovery period in comparison with healthy volunteers （P〈0.05）, and it was significantly correlated with the recurrent number in the recent half a year （P〈0.05）. It is concluded that there are Tc1/Tc2 imbalance and a low level of Tc1 subsets in RGH patients who are relapsing repeatedly in the near period. The low level of Tc1 subsets may be an important factor for the recurrence of RGH and the reactivation of latent herpesvirus infection.
基金This work was supported by a grant from the National Natural Science Foundation of China （No. 30872701）.
文摘Background Congenital heart disease （CHD） is a diverse group of diseases determined by genetic and environmental factors. Considerable research has been done on genes associated with the development of the heart. Recently, focus is on the role of transcription factor NFATcl in the development of proper valve and septa. As part of a larger study, high density single nucleotide polymorphism （SNP） scanning was used to explore the relationship between NFATcl gene polymorphism and susceptibility to ventricular septal defect （VSD） in the Chinese Hart population. Methods One hundred and ninety-two pediatric patients with congenital VSD and 192 matching healthy control subjects were studied. The haplotype reconstructions were calculated by PHASE2.0 software. Haploview software was used to perform linkage disequilibrium assessment and define haplotype blocks. The algorithm used for defining the blocks was the confidence interval method. Results The NFATcl gene region can be divided into 11 haplotype blocks. Strong linkage disequilibrium existed within blocks 6, 8, 9, and 11. Three SNPs （rs7240256, rs11665469, and rs754505） within the NFATcl gene had significant correlation with VSD by single marker association analysis. In addition, two haplotypes correlated with VSD. Conclusions NFATcl is associated with the occurrence of VSD and it may be a predisposing gene to CHD in Hart Chinese. This finding has set a direction for further genetic and functional studies.
文摘A strange phenomenon of fire taking place at Arruhban area west Bahr-Al Najaf area in Iraq was noticed in 2010 and smoke continued many months;this phenomenon reappeared many years later. This site is part of Bahr-Al Najaf-Iraq NE Arabian plate, located in flat area near an archeological site of Christian temple called Tel Arruhban. To understand the causes for this fire in a non-residential area, field observations from repeated visits between 2010 and 2018 and on-site excavation operations were conducted. The results of analysis of soil samples, and on-site detection for gases and vapors showed that the phenomenon of burning and smoke generated at this site was due to external influences and that the presence of soil rich with organic materials helped to the existence of this phenomenon.
