【目的】基于网络药理学探究中药白芷治疗痤疮的可能作用机制。【方法】通过中药系统药理学数据库与分析平台(TCMSP)及文献检索获取白芷的活性成分。采用反向分子对接服务器(DRAR-CPI)获取白芷作用靶标,并利用GeneCards和在线人类孟德...【目的】基于网络药理学探究中药白芷治疗痤疮的可能作用机制。【方法】通过中药系统药理学数据库与分析平台(TCMSP)及文献检索获取白芷的活性成分。采用反向分子对接服务器(DRAR-CPI)获取白芷作用靶标,并利用GeneCards和在线人类孟德尔遗传(OMIM)数据库筛选白芷活性成分治疗痤疮的潜在靶标。结合String数据库和Cytoscape的Network Analyzer工具,得出潜在靶标蛋白的相互作用关系。通过Systems Dock Web Site将靶标蛋白分别与白芷的活性成分进行分子对接。利用DAVID数据库,对潜在靶标基因进行基因本体论(GO)分类富集分析与京都基因和基因组百科全书(KEGG)通路富集分析。【结果】从白芷中筛选出活性成分20个,作用于55个靶标,主要通过调控磷脂酰肌醇-3-激酶(PI3K)/丝苏氨酸蛋白激酶Akt、核因子kappa B(NF-κB)、丝裂原活化蛋白激酶(MAPK)、成纤维细胞生长因子受体2(FGFR2)等信号通路来发挥治疗痤疮的作用。【结论】应用网络药理学的方法初步预测出白芷治疗痤疮的可能活性成分和信号通路。展开更多
Ursolic acid(UA) is a pentacyclic triterpene of the ursane type. As a common chemical constituent among species of the family Lamiaceae, UA possesses a broad spectrum of pharmacological properties. This overview focus...Ursolic acid(UA) is a pentacyclic triterpene of the ursane type. As a common chemical constituent among species of the family Lamiaceae, UA possesses a broad spectrum of pharmacological properties. This overview focuses on the anticancer properties of UA against breast cancer(BC) and colorectal cancer(CRC)that are most common among women and men, respectively. In vitro studies have shown that UA inhibited the growth of BC and CRC cell lines through various molecular targets and signaling pathways.There are several in vivo studies on the cytotoxic activity of UA against BC and CRC. UA also inhibits the growth of other types of cancer. Studies on structural modifications of UA have shown that the –OH groups at C3 and at C28 are critical factors influencing the cytotoxic activity of UA and its derivatives.Some needs for future research are suggested. Sources of information were from ScienceDirect, Google Scholar and PubMed.展开更多
文摘【目的】基于网络药理学探究中药白芷治疗痤疮的可能作用机制。【方法】通过中药系统药理学数据库与分析平台(TCMSP)及文献检索获取白芷的活性成分。采用反向分子对接服务器(DRAR-CPI)获取白芷作用靶标,并利用GeneCards和在线人类孟德尔遗传(OMIM)数据库筛选白芷活性成分治疗痤疮的潜在靶标。结合String数据库和Cytoscape的Network Analyzer工具,得出潜在靶标蛋白的相互作用关系。通过Systems Dock Web Site将靶标蛋白分别与白芷的活性成分进行分子对接。利用DAVID数据库,对潜在靶标基因进行基因本体论(GO)分类富集分析与京都基因和基因组百科全书(KEGG)通路富集分析。【结果】从白芷中筛选出活性成分20个,作用于55个靶标,主要通过调控磷脂酰肌醇-3-激酶(PI3K)/丝苏氨酸蛋白激酶Akt、核因子kappa B(NF-κB)、丝裂原活化蛋白激酶(MAPK)、成纤维细胞生长因子受体2(FGFR2)等信号通路来发挥治疗痤疮的作用。【结论】应用网络药理学的方法初步预测出白芷治疗痤疮的可能活性成分和信号通路。
基金funding from UCSI University (Proj-In-FAS-049 Proj-In-FAS-052)+1 种基金the Ministry of Higher Education (MOHE),Malaysia (FRGS/2/2014/SG01/UCSI/02/2 FRGS/1/2018/TK10/UCSI/02/1) for supporting our research group
文摘Ursolic acid(UA) is a pentacyclic triterpene of the ursane type. As a common chemical constituent among species of the family Lamiaceae, UA possesses a broad spectrum of pharmacological properties. This overview focuses on the anticancer properties of UA against breast cancer(BC) and colorectal cancer(CRC)that are most common among women and men, respectively. In vitro studies have shown that UA inhibited the growth of BC and CRC cell lines through various molecular targets and signaling pathways.There are several in vivo studies on the cytotoxic activity of UA against BC and CRC. UA also inhibits the growth of other types of cancer. Studies on structural modifications of UA have shown that the –OH groups at C3 and at C28 are critical factors influencing the cytotoxic activity of UA and its derivatives.Some needs for future research are suggested. Sources of information were from ScienceDirect, Google Scholar and PubMed.
