Higher requirements are put forward for interlayer bonding property with the increase of traffic load, including bearing capacity and durability. Typical diseases caused by insufficient adhesion between layers are sli...Higher requirements are put forward for interlayer bonding property with the increase of traffic load, including bearing capacity and durability. Typical diseases caused by insufficient adhesion between layers are slippage cracking, de-bonding and pavement deformation. The correct characterization of bonding property becomes necessary with evolving concerns of interlayer failure and material innovations. In the past forty years, many researches have focused on the evaluation of interlayer bonding property, and some valuable conclusions have been drawn. In this review, the mechanism, evaluation method and influencing factors of the interlayer bond strength are reviewed. The common test equipment can be classified into the shear, pull-off and torsion test. Different influence factors are analyzed including tack coat property, temperature, asphalt aging and surface condition. It is recommended to select the appropriate tack coat rate, and apply the tack coat under the conditions of clean, dry, high surface texture and good compaction. However, the interlayer failure mechanism and the interaction between the different influencing factors need to be further studied. The future work can focus on the correlation between different test methods and evaluation parameters, which would address the lack of harmonization or consistency among various evaluation approaches. Meanwhile, it is significant to add the evaluation of interlayer bonding property into the system of pavement design.展开更多
Liposomes are known to have considerable potential as drug carriers such as liposomal suspension, freeze dried and cream-based systems among many other liposomal formulations. In this study a new drug-in-adhesive patc...Liposomes are known to have considerable potential as drug carriers such as liposomal suspension, freeze dried and cream-based systems among many other liposomal formulations. In this study a new drug-in-adhesive patch was fabricated using liposome-based nanocarrier. Transfersomes as ultra-deformable liposomes are based on phosphatidylcholin 95% (phospholipon 90G) and phosphatidylcholin 50% (phosal 50PG) were prepared and further optimized in a final acrylic patch system for effective adhesion. The prepared liposomes were added to an acrylic adhesive to obtain a new hybrid transdermal patch termed as “lipo-drug-in-adhesive” patch system. The sodium diclofenac was selected as a model drug and the permeation of the drug across rat skin was evaluated (P > 0.05), using the lipo-drug-in-adhesive patch system with various percentages of transfersomes (4% - 8%w/w) and constant concentration of the drug (2% w/w). The peel strength and tack value of samples were also examined and quantified. The maximum flux of sodium diclofenac was observed in samples containing 8% (w/w) phosphatidylcholin 50%. The peel strength and tack value in samples containing phosphatidylcholin 50% were lower than those samples containing phosphatidylcholin 95%. It was observed that with increased amount of liposome in drug-in-adhesive patch system, the rate of skin permeation of the drug was also increased. It can be concluded that the developed lipo-drug-in-adhesive patch system enhances the drug release potential of transdermal delivering systems.展开更多
Acupuncture as a vital component of traditional medical systems of the Far East has been used to restore and maintain health for over three millennia. However, the neurobiological correlates of this therapy remain lar...Acupuncture as a vital component of traditional medical systems of the Far East has been used to restore and maintain health for over three millennia. However, the neurobiological correlates of this therapy remain largely unknown. The purpose of this study was therefore to determine the effect of enpishin acupuncture (press tack needles (PTN)) on autonomic function, WBC count, and oxidative stress between subjects that received either verum or placebo PTN treatment. Twenty men (mean(SD) age: 36.7(5.1) years) who provided oral consent were randomized to receive either verum PTN (n = 9) or placebo PTN (n = 11). Bi-Digital O-Ring Test (BDORT) was used to select the acupoints for each participant. Autonomic function and oxidative stress level were analyzed before and after the treatment via heart rate variability (HRV) and free radical analysis system (FRAS4), respectively. Pre- and post-treatment WBC count was also evaluated. Verum PTN group had a statistically significant increase (p = 0.008) in Ln TP, an index of overall autonomic activity. Subjects in this group also had a significantly greater (p = 0.006) variation in Ln TP than the placebo PTN group in response to the treatment. Similarly, Ln HF of subjects receiving verum PTN showed a marked increase (p = 0.0026) after the treatment. Moreover, a significantly greater (p < 0.001) variation in mean Ln HF before and after the treatment was noted in the verum group than the placebo group, reflecting a greater parasympathetic activation in the former. In contrast, sympathetic activity was not significantly influenced by verum PTN based on the lack of observed changes in LF/HF ratio. In addition, both groups failed to demonstrate significant variations in pre- and post-treatment mean Ln LF/HF ratio. Further, no significant intergroup difference was found with regard to mean variation in Ln LF/HF ratio. Verum PTN did not induce significant changes in WBC count and markers of oxidative stress, namely reactive oxygen species (ROM) and biological antioxidant potential (展开更多
The mix design method of asphalt rubber open-graded friction course （AR-OGFC） by the Marshall test and key technologies of AR-OGFC overlay are studied. Based on the draindown test, the stripping test and the Marshal...The mix design method of asphalt rubber open-graded friction course （AR-OGFC） by the Marshall test and key technologies of AR-OGFC overlay are studied. Based on the draindown test, the stripping test and the Marshall test by different beating times, the asphalt content estimating method and Marshall beat criterion are studied. It is found that the asphalt content of AR-OGFC can be estimated by the formula of Arizona, and the proper Marshall test criterion for AR-OGFC is 50 beats on both sides. By analyzing the influence of gradation on OGFC performance, the gradation of AR-OGFC is recommended, and the amount of aggregate passing 4. 75 mm should be minimized for AR-OGFC. Through investigation of AR-OGFC overlay projects, key technologies such as the treatment of underlying pavement and the selection of tack coat are advanced, and modified emulsified asphalt should be used in AR-OGFC overlay tack coat.展开更多
基金supported by Special Fund for Basic Scientific Research of Central College of Chang’an University (No. 300102219316 and 300102219308)National Key Research and Development Program of China (No. 2018YFE0103800)。
文摘Higher requirements are put forward for interlayer bonding property with the increase of traffic load, including bearing capacity and durability. Typical diseases caused by insufficient adhesion between layers are slippage cracking, de-bonding and pavement deformation. The correct characterization of bonding property becomes necessary with evolving concerns of interlayer failure and material innovations. In the past forty years, many researches have focused on the evaluation of interlayer bonding property, and some valuable conclusions have been drawn. In this review, the mechanism, evaluation method and influencing factors of the interlayer bond strength are reviewed. The common test equipment can be classified into the shear, pull-off and torsion test. Different influence factors are analyzed including tack coat property, temperature, asphalt aging and surface condition. It is recommended to select the appropriate tack coat rate, and apply the tack coat under the conditions of clean, dry, high surface texture and good compaction. However, the interlayer failure mechanism and the interaction between the different influencing factors need to be further studied. The future work can focus on the correlation between different test methods and evaluation parameters, which would address the lack of harmonization or consistency among various evaluation approaches. Meanwhile, it is significant to add the evaluation of interlayer bonding property into the system of pavement design.
文摘Liposomes are known to have considerable potential as drug carriers such as liposomal suspension, freeze dried and cream-based systems among many other liposomal formulations. In this study a new drug-in-adhesive patch was fabricated using liposome-based nanocarrier. Transfersomes as ultra-deformable liposomes are based on phosphatidylcholin 95% (phospholipon 90G) and phosphatidylcholin 50% (phosal 50PG) were prepared and further optimized in a final acrylic patch system for effective adhesion. The prepared liposomes were added to an acrylic adhesive to obtain a new hybrid transdermal patch termed as “lipo-drug-in-adhesive” patch system. The sodium diclofenac was selected as a model drug and the permeation of the drug across rat skin was evaluated (P > 0.05), using the lipo-drug-in-adhesive patch system with various percentages of transfersomes (4% - 8%w/w) and constant concentration of the drug (2% w/w). The peel strength and tack value of samples were also examined and quantified. The maximum flux of sodium diclofenac was observed in samples containing 8% (w/w) phosphatidylcholin 50%. The peel strength and tack value in samples containing phosphatidylcholin 50% were lower than those samples containing phosphatidylcholin 95%. It was observed that with increased amount of liposome in drug-in-adhesive patch system, the rate of skin permeation of the drug was also increased. It can be concluded that the developed lipo-drug-in-adhesive patch system enhances the drug release potential of transdermal delivering systems.
文摘Acupuncture as a vital component of traditional medical systems of the Far East has been used to restore and maintain health for over three millennia. However, the neurobiological correlates of this therapy remain largely unknown. The purpose of this study was therefore to determine the effect of enpishin acupuncture (press tack needles (PTN)) on autonomic function, WBC count, and oxidative stress between subjects that received either verum or placebo PTN treatment. Twenty men (mean(SD) age: 36.7(5.1) years) who provided oral consent were randomized to receive either verum PTN (n = 9) or placebo PTN (n = 11). Bi-Digital O-Ring Test (BDORT) was used to select the acupoints for each participant. Autonomic function and oxidative stress level were analyzed before and after the treatment via heart rate variability (HRV) and free radical analysis system (FRAS4), respectively. Pre- and post-treatment WBC count was also evaluated. Verum PTN group had a statistically significant increase (p = 0.008) in Ln TP, an index of overall autonomic activity. Subjects in this group also had a significantly greater (p = 0.006) variation in Ln TP than the placebo PTN group in response to the treatment. Similarly, Ln HF of subjects receiving verum PTN showed a marked increase (p = 0.0026) after the treatment. Moreover, a significantly greater (p < 0.001) variation in mean Ln HF before and after the treatment was noted in the verum group than the placebo group, reflecting a greater parasympathetic activation in the former. In contrast, sympathetic activity was not significantly influenced by verum PTN based on the lack of observed changes in LF/HF ratio. In addition, both groups failed to demonstrate significant variations in pre- and post-treatment mean Ln LF/HF ratio. Further, no significant intergroup difference was found with regard to mean variation in Ln LF/HF ratio. Verum PTN did not induce significant changes in WBC count and markers of oxidative stress, namely reactive oxygen species (ROM) and biological antioxidant potential (
文摘The mix design method of asphalt rubber open-graded friction course （AR-OGFC） by the Marshall test and key technologies of AR-OGFC overlay are studied. Based on the draindown test, the stripping test and the Marshall test by different beating times, the asphalt content estimating method and Marshall beat criterion are studied. It is found that the asphalt content of AR-OGFC can be estimated by the formula of Arizona, and the proper Marshall test criterion for AR-OGFC is 50 beats on both sides. By analyzing the influence of gradation on OGFC performance, the gradation of AR-OGFC is recommended, and the amount of aggregate passing 4. 75 mm should be minimized for AR-OGFC. Through investigation of AR-OGFC overlay projects, key technologies such as the treatment of underlying pavement and the selection of tack coat are advanced, and modified emulsified asphalt should be used in AR-OGFC overlay tack coat.
