目的全面回顾国内外乳腺癌生存者症状群的调查性研究,系统描述不同治疗阶段症状群及特征。方法计算机检索中国期刊全文数据库(CNKI)、维普中文科技期刊数据库(VIP)、万方科技期刊全文数据库、中国生物医学文献数据库(CBM)、PubMed、Emb...目的全面回顾国内外乳腺癌生存者症状群的调查性研究,系统描述不同治疗阶段症状群及特征。方法计算机检索中国期刊全文数据库(CNKI)、维普中文科技期刊数据库(VIP)、万方科技期刊全文数据库、中国生物医学文献数据库(CBM)、PubMed、Embase、EmBsco、Web of Science等数据库中截至2018年11月20日发表的有关乳腺癌症状群研究的中英文文献。结果最终检索到符合标准的文献21篇,其中12篇为横断面研究、9篇为纵向研究。每篇文献提取的症状群数量为2~7个。发生率最高的前3位依次为胃肠道症状群、心理症状群、神经系统症状群。结论未来症状群研究需规范统一化,在量和结构上保持一致性从而得出具有临床共识的症状群。展开更多
Aims: To examine how symptom cluster subgroups defined by extreme discordant composite scores, cut-off scores, or a median split influence statistical associations with peripheral cytokine levels in women with breast ...Aims: To examine how symptom cluster subgroups defined by extreme discordant composite scores, cut-off scores, or a median split influence statistical associations with peripheral cytokine levels in women with breast cancer. Background: Systemic cytokine dysregulation has been posited as a potential biological mechanism underlying symptom clusters in women with breast cancer. Symptom characteristics may play an important role in identifying cytokines of significant etiological importance, however, there is no consensus regarding to the ideal subgrouping technique to use. Design: A secondary analysis of data collected from a cross-sectional descriptive study of women with stage I-II breast cancer was used to examine and compare the relationships between peripheral cytokine levels and symptom subgroups defined by extreme discordant composite scores, cut-off scores, or a median split. Methods: Participant symptom scores were transformed into a composite score to account for variability in symptom intensity, frequency and interference. Cytokine levels in subgroups defined by composite scores within the highest and lowest 20% were contrasted with those composed from cut-off scores and a median split. Results: Subgroups defined by the composite score or cut-off scores resulted in similar statistical relationships with cytokine levels in contrast to the median split technique. The use of a median split for evaluating relationships between symptoms clusters and cytokine levels may increase the risk of a type I error. Conclusion: Composite and cut-off scores represent best techniques for defining symptom cluster subgroups in women with breast cancer. Using a consistent approach to define symptom clusters across studies may assist in identifying relevant biological mechanisms.展开更多
目的对国内外食管癌症状群的研究进行文献计量学分析,为临床实践及护理研究提供参考。方法计算机检索中国期刊全文数据库(CNKI)、万方科技期刊全文数据库、维普中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM)、PubMed、Web of S...目的对国内外食管癌症状群的研究进行文献计量学分析,为临床实践及护理研究提供参考。方法计算机检索中国期刊全文数据库(CNKI)、万方科技期刊全文数据库、维普中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM)、PubMed、Web of Science数据库中截止2022年2月24日发表的有关食管癌症状群研究的中英文文献,并进行描述性统计分析。结果最终纳入符合标准的文献9篇,其中横断面研究8篇,纵向研究1篇。每篇文献提取的症状群数量为3~6个,其中每个症状群中的症状数目为2~7个。疲乏相关症状群、消化道症状群、进食困难症状群为食管癌患者常见的症状群。结论目前国内外对食管癌症状群的研究尚处于起步阶段,文献数量少且研究结果存在争议。未来症状群研究需进一步规范统一,开展更多高质量的研究,从而探索出具有临床共识的食管癌症状群,促进临床实践中食管癌症状的管理。展开更多
Objective:To explore the general differentiation and treatment of insomnia by Professor Gao Ying through drug clustering and group correspondence analysis,and provide reference for clinical diagnosis and treatment.Met...Objective:To explore the general differentiation and treatment of insomnia by Professor Gao Ying through drug clustering and group correspondence analysis,and provide reference for clinical diagnosis and treatment.Methods:Collect retrospective case data from outpatient system,use SPSS20.0 software to perform frequency and cluster analysis on high-frequency symptoms and drug data,and perform corresponding analysis on the clustered drug syndrome groups.Results:A total of 349 consultations in 204 patients were included.Cluster analysis of 35 symptoms and 40 flavors with a frequency of more than 10%resulted in a corresponding relationship between 7 symptom groups,6 drug groups and 5 drug syndrome groups.The medicine symptom group has a high degree of matching;the doctors distinguish and tre at insomnia with calming,clearing heat,nourishing yin,liver,spleen,qi and phlegm as the core treatment,with consistent decoction,two to pill,lily ground Huang Tang,Lily Zhimu Decoction,Wendan Decoction,Sini San,Xiao Chai Hu Tang,Xiaoyao San,etc.are commonly used prescriptions;the physician's experience is to add or subtract Danshen and Zao Ren drink,which has a wide range of applicability to various insomnia syndrome.Conclusion:Based on the cluster analysis of drug symptoms and group correspondence analysis,it can reveal the pathogenesis,treatment and class information hidden in the data of drug symptoms,which can reflect the general law of physicians'syndrome differentiation and treatment of insomnia.This method has a reference for the exploration of TCM clinical experience significance;The results of this study can provide feedback to guide the clinical diagnosis and treatment of insomnia.展开更多
文摘目的全面回顾国内外乳腺癌生存者症状群的调查性研究,系统描述不同治疗阶段症状群及特征。方法计算机检索中国期刊全文数据库(CNKI)、维普中文科技期刊数据库(VIP)、万方科技期刊全文数据库、中国生物医学文献数据库(CBM)、PubMed、Embase、EmBsco、Web of Science等数据库中截至2018年11月20日发表的有关乳腺癌症状群研究的中英文文献。结果最终检索到符合标准的文献21篇,其中12篇为横断面研究、9篇为纵向研究。每篇文献提取的症状群数量为2~7个。发生率最高的前3位依次为胃肠道症状群、心理症状群、神经系统症状群。结论未来症状群研究需规范统一化,在量和结构上保持一致性从而得出具有临床共识的症状群。
文摘Aims: To examine how symptom cluster subgroups defined by extreme discordant composite scores, cut-off scores, or a median split influence statistical associations with peripheral cytokine levels in women with breast cancer. Background: Systemic cytokine dysregulation has been posited as a potential biological mechanism underlying symptom clusters in women with breast cancer. Symptom characteristics may play an important role in identifying cytokines of significant etiological importance, however, there is no consensus regarding to the ideal subgrouping technique to use. Design: A secondary analysis of data collected from a cross-sectional descriptive study of women with stage I-II breast cancer was used to examine and compare the relationships between peripheral cytokine levels and symptom subgroups defined by extreme discordant composite scores, cut-off scores, or a median split. Methods: Participant symptom scores were transformed into a composite score to account for variability in symptom intensity, frequency and interference. Cytokine levels in subgroups defined by composite scores within the highest and lowest 20% were contrasted with those composed from cut-off scores and a median split. Results: Subgroups defined by the composite score or cut-off scores resulted in similar statistical relationships with cytokine levels in contrast to the median split technique. The use of a median split for evaluating relationships between symptoms clusters and cytokine levels may increase the risk of a type I error. Conclusion: Composite and cut-off scores represent best techniques for defining symptom cluster subgroups in women with breast cancer. Using a consistent approach to define symptom clusters across studies may assist in identifying relevant biological mechanisms.
文摘目的对国内外食管癌症状群的研究进行文献计量学分析,为临床实践及护理研究提供参考。方法计算机检索中国期刊全文数据库(CNKI)、万方科技期刊全文数据库、维普中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM)、PubMed、Web of Science数据库中截止2022年2月24日发表的有关食管癌症状群研究的中英文文献,并进行描述性统计分析。结果最终纳入符合标准的文献9篇,其中横断面研究8篇,纵向研究1篇。每篇文献提取的症状群数量为3~6个,其中每个症状群中的症状数目为2~7个。疲乏相关症状群、消化道症状群、进食困难症状群为食管癌患者常见的症状群。结论目前国内外对食管癌症状群的研究尚处于起步阶段,文献数量少且研究结果存在争议。未来症状群研究需进一步规范统一,开展更多高质量的研究,从而探索出具有临床共识的食管癌症状群,促进临床实践中食管癌症状的管理。
基金Traditional Chinese Medicine Inheritance and Innovation"Hundreds of Millions"Talent Project(QiHuang Project)-Qihuang Scholars(National Education and Development of Traditional Chinese Medicine[2018]No.12)。
文摘Objective:To explore the general differentiation and treatment of insomnia by Professor Gao Ying through drug clustering and group correspondence analysis,and provide reference for clinical diagnosis and treatment.Methods:Collect retrospective case data from outpatient system,use SPSS20.0 software to perform frequency and cluster analysis on high-frequency symptoms and drug data,and perform corresponding analysis on the clustered drug syndrome groups.Results:A total of 349 consultations in 204 patients were included.Cluster analysis of 35 symptoms and 40 flavors with a frequency of more than 10%resulted in a corresponding relationship between 7 symptom groups,6 drug groups and 5 drug syndrome groups.The medicine symptom group has a high degree of matching;the doctors distinguish and tre at insomnia with calming,clearing heat,nourishing yin,liver,spleen,qi and phlegm as the core treatment,with consistent decoction,two to pill,lily ground Huang Tang,Lily Zhimu Decoction,Wendan Decoction,Sini San,Xiao Chai Hu Tang,Xiaoyao San,etc.are commonly used prescriptions;the physician's experience is to add or subtract Danshen and Zao Ren drink,which has a wide range of applicability to various insomnia syndrome.Conclusion:Based on the cluster analysis of drug symptoms and group correspondence analysis,it can reveal the pathogenesis,treatment and class information hidden in the data of drug symptoms,which can reflect the general law of physicians'syndrome differentiation and treatment of insomnia.This method has a reference for the exploration of TCM clinical experience significance;The results of this study can provide feedback to guide the clinical diagnosis and treatment of insomnia.
