Dual hepatitis C virus(HCV)/hepatitis B virus(HBV)infection is found in HBV or HCV endemic areas,and in specific populations exhibiting a high risk of parenteral viral transmission.Clinical observations have revealed ...Dual hepatitis C virus(HCV)/hepatitis B virus(HBV)infection is found in HBV or HCV endemic areas,and in specific populations exhibiting a high risk of parenteral viral transmission.Clinical observations have revealed that HCV/HBV dually infected patients demonstrate a higher risk of liver disease progression compared with HBV or HCV monoinfected patients.The viral activity responsible for liver disease progression can be determined by examining the viral loads of HCV and HBV and by conducting liver biopsy examinations.Recent trials have confirmed that the combination therapy of peginterferon alpha-2a or 2b and ribavirin for dual hepatitis patients with HCV dominance appears to be as effective and safe as it is in patients with HCV monoinfections.Strikingly,approximately 60% of dually infected patients with inactive hepatitis B before treatment develop HBV reactivation after the clearance of the HCV.The clinical significance of this HBV reactivation and the strategy to prevent and treat this event should be determined.Furthermore,approximately 30%of dually infected patients lost hepatitis B surface antigen(HBsAg)within 5 years after the start of peginterferonbased therapy,and 40%of them harbored occult HBV infection.The underlying mechanisms of their accelerating HBsAg seroclearance and the development of occult HBV await further investigations.Moreover,the optimal treatment strategies for dually infected patients who are seropositive for the hepatitis B e antigen must be explored.Finally,the advent of new direct-acting antiviral-based anti-HCV therapy may change the optimal therapies for patients with dual hepatitis in the near future,which warrants further clinical trials.展开更多
An optimized formulation of a sustained release tablet of Gliclazide was developed. The use of Doptimal design with a polynomial statistical model to analyze dissolution data reduced the number of laboratory tests req...An optimized formulation of a sustained release tablet of Gliclazide was developed. The use of Doptimal design with a polynomial statistical model to analyze dissolution data reduced the number of laboratory tests required to obtain an optimal dosage form. The final formulation contained 22 mg of Methocel®E15LV, 16.5 mg Methocel®E15 and 10.0 mg of Dibasic Calcium Phosphate per 30 mg Gliclazide sustained release tablet. Dissolution studies performed on tablets from 5000 tablet test batches released greater than 90 percent of loaded drug in eight hours. Drug release from the optimized tablets followed a pattern more closely similar to zero-order than other mechanisms of drug release tested. Storage of tablets in accelerated and ambient conditions for 6 and 12 months respectively did not alter any of the physico-chemical properties, drug release or the drug release rate compared to initial observations and dissolution data of the prepared tablets. The addition of potassium phosphate and monosodium phosphate to the tablet reduced the effect pH has on Gliclazide dissolution compared to the commercially available product.展开更多
Blue emitting perovskite ink obtained from cesium lead halide quantum dots bearing chlorine(CsPbClxBr3-x,0<x<3)suffers from the low photoluminescence quantum yield and poor stability.Cesium lead bromine(CsPbBr3)...Blue emitting perovskite ink obtained from cesium lead halide quantum dots bearing chlorine(CsPbClxBr3-x,0<x<3)suffers from the low photoluminescence quantum yield and poor stability.Cesium lead bromine(CsPbBr3)quantum dots free of chlori ne have more stable crystalstructure and fewer crystal defects.Precise control of crystal sizes and surface passivation comporients of CsPbBr3 quantum dots is crucial for the best use of quantum confinement effect and blueshift of emission wavelength to blue region.Here,by polymerizing acrylamide under UV-light irradiation to form polymer gel networks in dimethyl sulfoxide(DMSO)with CsPbBr3 precursors and passivating agents trapped,wesuccessfully prepared novel sustained release tablets with different shapes and sizes.Thanks to the limitation of the polymer networks onsolve nt releasi ng,the resulting CsPbBr3 qua ntum dots have the average size of 1.1±0.2 nm.On the basis of the excelle nt quantum confin eme nteffect and optimized surface passivation,the obtained PQD ink can emit high quality blue light for more than 6 weeks.This work elucidates anew and convenient technique to prepare blue emission perovskite quantum dots ink with high stability and photoluminescence qua ntumyield and provides a great potential technology for the preparation of perovskite optoelectronic devices.展开更多
Oil and gas exploration and production activities (OGEPA) can produce surface disturbances created by the construction of roads, well pads, oil wells, pipelines, production facilities and storage pits. These alteratio...Oil and gas exploration and production activities (OGEPA) can produce surface disturbances created by the construction of roads, well pads, oil wells, pipelines, production facilities and storage pits. These alterations can range from landscape conversion to transformation depending on location, regulations and enforcement, environmental best practices and state vs. multinational management. Though not known as a major oil and gas state, Florida is ranked 23rd in gas and 24th in oil production nationally. Jay oilfield, located in West Florida’s panhandle region, is the largest and top producer in the state. Though production peaked in 1979, a nationwide upsurge is taking place that could affect Florida. The accounting from above approach proposed here is well suited to understand the role that the infrastructure surface footprint has on West Florida’s landscape and how to monitor potential changes underway. It involves remote sensing, GIS techniques and landscape ecology metrics to quantify surface disturbance in Santa Rosa County’s six oilfields and then ranks each field based on environmental performance (sustainability). Findings suggest that agricultural conversion is the leading driver of land-use and land-cover (LULC) change, while OGEPA have created small-scale surface alterations. This paper’s approach can help oil companies, land managers and local government authorities understand the spatial extent of OGEPA onshore alterations and plan future scenarios, particularly as drilling and production increase in the current shale revolution occurring throughout the US, as well as expanded drilling planned for Florida.展开更多
Automotive surface coating manufacturing is one of the most sophisticated and expensive steps in automotive assembly. This step involves generating multiple thin layers of polymeric coatings on the vehicle surface thr...Automotive surface coating manufacturing is one of the most sophisticated and expensive steps in automotive assembly. This step involves generating multiple thin layers of polymeric coatings on the vehicle surface through paint spray and curing in a multistage, dynamically changing environment. Traditionally, the quality control is solely post-process inspection based, and process operational adjustment is only experience based, thus the manufacturing may not be （highly） sustainable. In this article, a multiscale system modeling and analysis methodology is introduced for achieving a sustainable application of polymeric materials through paint spray and film curing in automotive surface coating manufacturing. By this methodology, the correlations among paint material, application processes and coating performance can be identified. The model-based analysis allows a comprehensive and deep study of the dynamic behaviors of the material, process, and product in a wide spectrum of length and time. Case studies illustrate the efficacy of the methodology for sustainable manufacturing.展开更多
From the realism of science, and taking the guide of EINSTEIN’s Relativity as guide, this article called in question the present theory of the sustainable development by the rational thinking of philosophy and a clos...From the realism of science, and taking the guide of EINSTEIN’s Relativity as guide, this article called in question the present theory of the sustainable development by the rational thinking of philosophy and a close logic inference. It is found that there are many paradoxes to the theory. Through more deepening and meticulous inference, we arrived at philosophic language of science about the sustainable development. The sustainable development is "non-sustainable development", and the non-sustainable development is "the best sustainable development". While carrying out philosophical principle thinking and repeating science demonstration for the sustainable development, this article got further confirmation that the existence of human being at the minimum environment cost may help them obtain motive power of the sustainable development. In fact, this foundation motive power exists in the flow of development in different organization levels, meanwhile it exists in strategy of intuition living of the ancient people. Only in relative lower environment cost to live can we get the support system of science for the sustainable development, and be able really to achieve the basic goal of the sustainable development.展开更多
In order to substitute fossil resources in activated carbon(AC)production,recent efforts have focused on the utilization of renewable raw materials.Regions with important wood industries offer two potentially underest...In order to substitute fossil resources in activated carbon(AC)production,recent efforts have focused on the utilization of renewable raw materials.Regions with important wood industries offer two potentially underestimated resource types:forestry residue biomass(FRB)and waste wood(WW).Although these materials are widely available(approx.130 mio.m3a-1 FRB,approx.50 mio.ta^(-1) WW in the EU),they are mostly valorised through energy production,as they are high in ashes and may be contaminated with organics and heavy metals.In this study,both FRB and WW were treated via one-step pyrolysis for AC production.ZnCl_(2) was applied as activating agent at pyrolysis temperatures varying from 400 to 600℃ and residence times between 1 and 3 h.Overall,76 samples were prepared and characterized thoroughly via elemental analysis,N_(2)/CO_(2) ad/-desorption,thermogravimetric analysis(TGA),scanning electron microscopy(SEM),and infrared spectroscopy(FTIR).The produced carbons showed specific surface areas of up to 1430 m2g1 and a pore size distribution with a micropore share of up to 80%.The presence of oxygen-containing functional groups was confirmed via FTIR.Potential feedstock contamination can be mitigated,as minerals and heavy metals could be leached out(up to-99.15%)by an additional wash step and organic contamination undergoes thermal cracking during pyrolysis.The presented study could be a next step in upcycling considerable waste streams from the wood sector through localised and non-fossil-based AC production.展开更多
Using vegetated facade systems(VFS)as a sustainable solution for existing and new buildings and evaluating thermal performance of these sytems are not a new concept.However,there is a gap in literature about measuring...Using vegetated facade systems(VFS)as a sustainable solution for existing and new buildings and evaluating thermal performance of these sytems are not a new concept.However,there is a gap in literature about measuring thermal performance of VFS applied on an insulated wall.Also,in the research literature,there are few studies measuring thermal performance of felt type VFS in temperate climates,and data about the thermal performance of VFS during winter periods is still scarce.Thus,the aim of the present study is to measure the thermal performance of a felt type VFS applied on a thermal insulated existing wall that us located in Kocaeli,Turkey,under Csa climate conditions during heating and cooling periods.Test results indicate that the felt type VFS acts as a shading device and has a positive contribution to the thermal performance of building walls during a cooling period.In daytime when there is a high amount of solar radiation,felt type VFS decreased exterior surface temperatures of the insulated existing wall by a maximum of 24.4℃,32.2℃ and 37.2℃,in spring,summer and fall periods,respectively.Additionally,indoor air temperatures of the vegetated facade were lower than indoor air temperatures of the reference facade with the maximum difference of 1.8℃ during the cooling period.Also,test results indicate that the vegetated facade never dropped to below 0℃ while exterior surface temperatures of the reference facade dropped below 0℃ at nighttime in the winter period.Thus,it can be claimed that the felt type VFS behaves as a thermal buffer and enhances the thermal performance of the exterior wall of the existing building during heating periods at nighttime.As a conclusion,although differences between exterior surface temperatures of vegetated and reference walls were high,differences between interior surface temperatures of vegetated and reference walls were not meaningful.That is due to the fact that the existing building exterior wall assembly includes 5 cm thickness thermal insulation material which展开更多
Water is the important resource to guarantee the existence and development of oases in arid areas. To improve the utilization efficiency of water resources in Manas River Basin, this paper investigated the trends and ...Water is the important resource to guarantee the existence and development of oases in arid areas. To improve the utilization efficiency of water resources in Manas River Basin, this paper investigated the trends and periods of runoff based on the runoff and climate data for the past 50 years. Subsequently, with the socioeconomic and water resources data, we studied a comprehensive evaluation on the water security in this area. The results indicated that the stream flows in the three hydrological stations of Hongshanzui, Kensiwat and Bajiahu have sig- nificantly increased and undergone abrupt changes, with periods of 18 and 20 years. According to assessment, water security in the Manas River Basin was at an unsafe level in 2008. In criterion layer, the ecological security index and the index of supply-demand situation are both at the relatively secure level; the quantity index and so- cioeconomic index of water resources are at the unsafe level and basic security level, respectively. Therefore, in order to achieve sustainable economic and social development within the Manas River Basin, it is vital to take a series of effective measures to improve the status of water security.展开更多
基金Supported by Grants from the National Taiwan UniversityDe-partment of Health,Executive Yuan,TaiwanTaiwan Liver Disease Consortium(TLC),National Research Program for Bio-pharmaceuticals(NRPB),Taiwan,NSC100-2325-B-002-052
文摘Dual hepatitis C virus(HCV)/hepatitis B virus(HBV)infection is found in HBV or HCV endemic areas,and in specific populations exhibiting a high risk of parenteral viral transmission.Clinical observations have revealed that HCV/HBV dually infected patients demonstrate a higher risk of liver disease progression compared with HBV or HCV monoinfected patients.The viral activity responsible for liver disease progression can be determined by examining the viral loads of HCV and HBV and by conducting liver biopsy examinations.Recent trials have confirmed that the combination therapy of peginterferon alpha-2a or 2b and ribavirin for dual hepatitis patients with HCV dominance appears to be as effective and safe as it is in patients with HCV monoinfections.Strikingly,approximately 60% of dually infected patients with inactive hepatitis B before treatment develop HBV reactivation after the clearance of the HCV.The clinical significance of this HBV reactivation and the strategy to prevent and treat this event should be determined.Furthermore,approximately 30%of dually infected patients lost hepatitis B surface antigen(HBsAg)within 5 years after the start of peginterferonbased therapy,and 40%of them harbored occult HBV infection.The underlying mechanisms of their accelerating HBsAg seroclearance and the development of occult HBV await further investigations.Moreover,the optimal treatment strategies for dually infected patients who are seropositive for the hepatitis B e antigen must be explored.Finally,the advent of new direct-acting antiviral-based anti-HCV therapy may change the optimal therapies for patients with dual hepatitis in the near future,which warrants further clinical trials.
文摘An optimized formulation of a sustained release tablet of Gliclazide was developed. The use of Doptimal design with a polynomial statistical model to analyze dissolution data reduced the number of laboratory tests required to obtain an optimal dosage form. The final formulation contained 22 mg of Methocel®E15LV, 16.5 mg Methocel®E15 and 10.0 mg of Dibasic Calcium Phosphate per 30 mg Gliclazide sustained release tablet. Dissolution studies performed on tablets from 5000 tablet test batches released greater than 90 percent of loaded drug in eight hours. Drug release from the optimized tablets followed a pattern more closely similar to zero-order than other mechanisms of drug release tested. Storage of tablets in accelerated and ambient conditions for 6 and 12 months respectively did not alter any of the physico-chemical properties, drug release or the drug release rate compared to initial observations and dissolution data of the prepared tablets. The addition of potassium phosphate and monosodium phosphate to the tablet reduced the effect pH has on Gliclazide dissolution compared to the commercially available product.
基金The work is supported by the National Natural Science Foundation of China(No.21761132007)the National Key R&D Program of China(No.2016YFE0114900).
文摘Blue emitting perovskite ink obtained from cesium lead halide quantum dots bearing chlorine(CsPbClxBr3-x,0<x<3)suffers from the low photoluminescence quantum yield and poor stability.Cesium lead bromine(CsPbBr3)quantum dots free of chlori ne have more stable crystalstructure and fewer crystal defects.Precise control of crystal sizes and surface passivation comporients of CsPbBr3 quantum dots is crucial for the best use of quantum confinement effect and blueshift of emission wavelength to blue region.Here,by polymerizing acrylamide under UV-light irradiation to form polymer gel networks in dimethyl sulfoxide(DMSO)with CsPbBr3 precursors and passivating agents trapped,wesuccessfully prepared novel sustained release tablets with different shapes and sizes.Thanks to the limitation of the polymer networks onsolve nt releasi ng,the resulting CsPbBr3 qua ntum dots have the average size of 1.1±0.2 nm.On the basis of the excelle nt quantum confin eme nteffect and optimized surface passivation,the obtained PQD ink can emit high quality blue light for more than 6 weeks.This work elucidates anew and convenient technique to prepare blue emission perovskite quantum dots ink with high stability and photoluminescence qua ntumyield and provides a great potential technology for the preparation of perovskite optoelectronic devices.
文摘Oil and gas exploration and production activities (OGEPA) can produce surface disturbances created by the construction of roads, well pads, oil wells, pipelines, production facilities and storage pits. These alterations can range from landscape conversion to transformation depending on location, regulations and enforcement, environmental best practices and state vs. multinational management. Though not known as a major oil and gas state, Florida is ranked 23rd in gas and 24th in oil production nationally. Jay oilfield, located in West Florida’s panhandle region, is the largest and top producer in the state. Though production peaked in 1979, a nationwide upsurge is taking place that could affect Florida. The accounting from above approach proposed here is well suited to understand the role that the infrastructure surface footprint has on West Florida’s landscape and how to monitor potential changes underway. It involves remote sensing, GIS techniques and landscape ecology metrics to quantify surface disturbance in Santa Rosa County’s six oilfields and then ranks each field based on environmental performance (sustainability). Findings suggest that agricultural conversion is the leading driver of land-use and land-cover (LULC) change, while OGEPA have created small-scale surface alterations. This paper’s approach can help oil companies, land managers and local government authorities understand the spatial extent of OGEPA onshore alterations and plan future scenarios, particularly as drilling and production increase in the current shale revolution occurring throughout the US, as well as expanded drilling planned for Florida.
基金Supported in part by US NSF (CBET 0647113 and 0730383, CMMI 0700178, and DUE 0736739)the Institute of Manufacturing Research of Wayne State University.
文摘Automotive surface coating manufacturing is one of the most sophisticated and expensive steps in automotive assembly. This step involves generating multiple thin layers of polymeric coatings on the vehicle surface through paint spray and curing in a multistage, dynamically changing environment. Traditionally, the quality control is solely post-process inspection based, and process operational adjustment is only experience based, thus the manufacturing may not be （highly） sustainable. In this article, a multiscale system modeling and analysis methodology is introduced for achieving a sustainable application of polymeric materials through paint spray and film curing in automotive surface coating manufacturing. By this methodology, the correlations among paint material, application processes and coating performance can be identified. The model-based analysis allows a comprehensive and deep study of the dynamic behaviors of the material, process, and product in a wide spectrum of length and time. Case studies illustrate the efficacy of the methodology for sustainable manufacturing.
基金Under the auspices of National Excellent Youth Foundation of China(No.40125003)
文摘From the realism of science, and taking the guide of EINSTEIN’s Relativity as guide, this article called in question the present theory of the sustainable development by the rational thinking of philosophy and a close logic inference. It is found that there are many paradoxes to the theory. Through more deepening and meticulous inference, we arrived at philosophic language of science about the sustainable development. The sustainable development is "non-sustainable development", and the non-sustainable development is "the best sustainable development". While carrying out philosophical principle thinking and repeating science demonstration for the sustainable development, this article got further confirmation that the existence of human being at the minimum environment cost may help them obtain motive power of the sustainable development. In fact, this foundation motive power exists in the flow of development in different organization levels, meanwhile it exists in strategy of intuition living of the ancient people. Only in relative lower environment cost to live can we get the support system of science for the sustainable development, and be able really to achieve the basic goal of the sustainable development.
基金The financial support by the Austrian Federal Ministry for Digital and Economic Affairs and the National Foundation for Research,Technology and Development,the Christian Doppler Research Association as well as the participating companies is gratefully acknowledged.
文摘In order to substitute fossil resources in activated carbon(AC)production,recent efforts have focused on the utilization of renewable raw materials.Regions with important wood industries offer two potentially underestimated resource types:forestry residue biomass(FRB)and waste wood(WW).Although these materials are widely available(approx.130 mio.m3a-1 FRB,approx.50 mio.ta^(-1) WW in the EU),they are mostly valorised through energy production,as they are high in ashes and may be contaminated with organics and heavy metals.In this study,both FRB and WW were treated via one-step pyrolysis for AC production.ZnCl_(2) was applied as activating agent at pyrolysis temperatures varying from 400 to 600℃ and residence times between 1 and 3 h.Overall,76 samples were prepared and characterized thoroughly via elemental analysis,N_(2)/CO_(2) ad/-desorption,thermogravimetric analysis(TGA),scanning electron microscopy(SEM),and infrared spectroscopy(FTIR).The produced carbons showed specific surface areas of up to 1430 m2g1 and a pore size distribution with a micropore share of up to 80%.The presence of oxygen-containing functional groups was confirmed via FTIR.Potential feedstock contamination can be mitigated,as minerals and heavy metals could be leached out(up to-99.15%)by an additional wash step and organic contamination undergoes thermal cracking during pyrolysis.The presented study could be a next step in upcycling considerable waste streams from the wood sector through localised and non-fossil-based AC production.
文摘Using vegetated facade systems(VFS)as a sustainable solution for existing and new buildings and evaluating thermal performance of these sytems are not a new concept.However,there is a gap in literature about measuring thermal performance of VFS applied on an insulated wall.Also,in the research literature,there are few studies measuring thermal performance of felt type VFS in temperate climates,and data about the thermal performance of VFS during winter periods is still scarce.Thus,the aim of the present study is to measure the thermal performance of a felt type VFS applied on a thermal insulated existing wall that us located in Kocaeli,Turkey,under Csa climate conditions during heating and cooling periods.Test results indicate that the felt type VFS acts as a shading device and has a positive contribution to the thermal performance of building walls during a cooling period.In daytime when there is a high amount of solar radiation,felt type VFS decreased exterior surface temperatures of the insulated existing wall by a maximum of 24.4℃,32.2℃ and 37.2℃,in spring,summer and fall periods,respectively.Additionally,indoor air temperatures of the vegetated facade were lower than indoor air temperatures of the reference facade with the maximum difference of 1.8℃ during the cooling period.Also,test results indicate that the vegetated facade never dropped to below 0℃ while exterior surface temperatures of the reference facade dropped below 0℃ at nighttime in the winter period.Thus,it can be claimed that the felt type VFS behaves as a thermal buffer and enhances the thermal performance of the exterior wall of the existing building during heating periods at nighttime.As a conclusion,although differences between exterior surface temperatures of vegetated and reference walls were high,differences between interior surface temperatures of vegetated and reference walls were not meaningful.That is due to the fact that the existing building exterior wall assembly includes 5 cm thickness thermal insulation material which
基金supported by the National Natural Science Foundation of China (41001066)the National Basic Research Program of China (Program 973) (2009CB421308)the Ministry of Water Resources’ Special Funds for Scientific Research on Public Causes (201101049)
文摘Water is the important resource to guarantee the existence and development of oases in arid areas. To improve the utilization efficiency of water resources in Manas River Basin, this paper investigated the trends and periods of runoff based on the runoff and climate data for the past 50 years. Subsequently, with the socioeconomic and water resources data, we studied a comprehensive evaluation on the water security in this area. The results indicated that the stream flows in the three hydrological stations of Hongshanzui, Kensiwat and Bajiahu have sig- nificantly increased and undergone abrupt changes, with periods of 18 and 20 years. According to assessment, water security in the Manas River Basin was at an unsafe level in 2008. In criterion layer, the ecological security index and the index of supply-demand situation are both at the relatively secure level; the quantity index and so- cioeconomic index of water resources are at the unsafe level and basic security level, respectively. Therefore, in order to achieve sustainable economic and social development within the Manas River Basin, it is vital to take a series of effective measures to improve the status of water security.
