AIM: To reveal the correlation between the functional differentiation phenotypes of gastric carcinoma cells and the invasion and metastasis by a new way of cell-function classification.METHODS:Surgically resected spec...AIM: To reveal the correlation between the functional differentiation phenotypes of gastric carcinoma cells and the invasion and metastasis by a new way of cell-function classification.METHODS:Surgically resected specimens of 361 gastric carcinomas(GC) were investigated with enzyme-, mucin-, and tumor-related marker immunohistochemistry. According to the direction of cell-function differentiation, stomach carcinomas were divided into five functionally differentiated types. RESULTS: (1) Absorptive function differentiation type (AFDT): there were 82 (22.7%) patients including 76 (92.7%) aged 45 years. Sixty-nine (84.1%) cases belonged to the intestinal type. Thirty-eight (46.3%) expressed CD44v6 and 9 (13.6%) of 66 male patients developed liver metastasis.The 5-year survival rate of patients in this group (58.5%) was higher than those with the other types (P【0.01). (2) Mucin secreting function differentiation type (MSFDT): 54 (15%) cases. Fifty-three (98.1%) tumors had penetrated the serosa, 12 (22.2%) expressed ER and 22 (40.7%) expressed CD44v6. The postoperative 5-year survival rate was 28.6%. (3) Absorptive and mucin-producing function differentiation type (AMPFDT): there were 180 (49.9%) cases, including 31 (17.2%) aged younger than 45 years. The tumor was more common in women (62, 34.4%,) and expressed more frequently estrogen receptors (ER) (129, 81.7%) than other types (P【0.01). Ovary metastasis was found in 12 (19.4%) out of 62 female subjects. The patients with this type GC had the lowest 5-year survival rate (24.7%) among all types. (4) Specific function differentiation type (SFDT): 13 (3.6%) cases. Nine (69.2%) tumors of this type derived from APUD system, the other 4 (30.7%) were of different histological differentiation. Sixty per cent of the patients survived at least five years. (5) Non-function differentiation type (NFDT): 32 (8.9%) cases. Nineteen (59.4%) cases had lymph node metastases but no one with liver or ovary metastasis. The 5-year survival rate was 28.1%. CONCLUSION: This new cell-f展开更多
Six plots were investigated and field data were obtained with the contiguous grid quadrate method in a natural Populus euphratica forest in the upper reaches of the Tarim river.We developed a static life table and a s...Six plots were investigated and field data were obtained with the contiguous grid quadrate method in a natural Populus euphratica forest in the upper reaches of the Tarim river.We developed a static life table and a survival function of Populus pruinosa population based on the population life table and a theory of survival analysis.Survivorship curves,and the mortality rate were determined,and population dynamics were analyzed by using the spectral analysis.The results showed that:1)Survival numbers of P.pruinosa populations were decreased with the increasing of age,and the expecting life of individuals with DBH larger than 40 cm declined obviously.2)The Survivorship curve of the populations was Deevey Ⅲ.Four survival functions showed that the P.pruinosa population declined in young age and stabilized in old age.3)There were two peaks of mortality rate existed in the lifespan:respectively occarred at the first and 11th age class periods.Seedling shortage was the restricting factor of development.4) The spectral analysis of the populations showed that there was a marked periodic fluctuation in the process of natural regeneration.5)The higher mortality rate of P.pruinosa seedlings might be integrated by the interplay of biological characteristics of P.pruinosa and deteriorating habitat(groundwater level decreasing).展开更多
基金Project supported by the National Natural Science Foundation of China, No. 39270300. No. 39370772Training Program for Trans-Century Talents by the State Education Commission of China
文摘AIM: To reveal the correlation between the functional differentiation phenotypes of gastric carcinoma cells and the invasion and metastasis by a new way of cell-function classification.METHODS:Surgically resected specimens of 361 gastric carcinomas(GC) were investigated with enzyme-, mucin-, and tumor-related marker immunohistochemistry. According to the direction of cell-function differentiation, stomach carcinomas were divided into five functionally differentiated types. RESULTS: (1) Absorptive function differentiation type (AFDT): there were 82 (22.7%) patients including 76 (92.7%) aged 45 years. Sixty-nine (84.1%) cases belonged to the intestinal type. Thirty-eight (46.3%) expressed CD44v6 and 9 (13.6%) of 66 male patients developed liver metastasis.The 5-year survival rate of patients in this group (58.5%) was higher than those with the other types (P【0.01). (2) Mucin secreting function differentiation type (MSFDT): 54 (15%) cases. Fifty-three (98.1%) tumors had penetrated the serosa, 12 (22.2%) expressed ER and 22 (40.7%) expressed CD44v6. The postoperative 5-year survival rate was 28.6%. (3) Absorptive and mucin-producing function differentiation type (AMPFDT): there were 180 (49.9%) cases, including 31 (17.2%) aged younger than 45 years. The tumor was more common in women (62, 34.4%,) and expressed more frequently estrogen receptors (ER) (129, 81.7%) than other types (P【0.01). Ovary metastasis was found in 12 (19.4%) out of 62 female subjects. The patients with this type GC had the lowest 5-year survival rate (24.7%) among all types. (4) Specific function differentiation type (SFDT): 13 (3.6%) cases. Nine (69.2%) tumors of this type derived from APUD system, the other 4 (30.7%) were of different histological differentiation. Sixty per cent of the patients survived at least five years. (5) Non-function differentiation type (NFDT): 32 (8.9%) cases. Nineteen (59.4%) cases had lymph node metastases but no one with liver or ovary metastasis. The 5-year survival rate was 28.1%. CONCLUSION: This new cell-f
文摘Six plots were investigated and field data were obtained with the contiguous grid quadrate method in a natural Populus euphratica forest in the upper reaches of the Tarim river.We developed a static life table and a survival function of Populus pruinosa population based on the population life table and a theory of survival analysis.Survivorship curves,and the mortality rate were determined,and population dynamics were analyzed by using the spectral analysis.The results showed that:1)Survival numbers of P.pruinosa populations were decreased with the increasing of age,and the expecting life of individuals with DBH larger than 40 cm declined obviously.2)The Survivorship curve of the populations was Deevey Ⅲ.Four survival functions showed that the P.pruinosa population declined in young age and stabilized in old age.3)There were two peaks of mortality rate existed in the lifespan:respectively occarred at the first and 11th age class periods.Seedling shortage was the restricting factor of development.4) The spectral analysis of the populations showed that there was a marked periodic fluctuation in the process of natural regeneration.5)The higher mortality rate of P.pruinosa seedlings might be integrated by the interplay of biological characteristics of P.pruinosa and deteriorating habitat(groundwater level decreasing).
