As mining and civil tunneling progresses to depth, excavation-induced seismicity and rockburst problems increase and cannot be prevented. As an important line of defense, ground control measures and burst-resistant ro...As mining and civil tunneling progresses to depth, excavation-induced seismicity and rockburst problems increase and cannot be prevented. As an important line of defense, ground control measures and burst-resistant rock support are used to prevent or minimize damage to excavations and thus to enhance workplace safety. Rock support in burst-prone ground differs from conventional rock support where controlling gravity-induced rockfalls and managing shallow zones of loose rock are the main target. Rock support in burst-prone ground needs to resist dynamic loads and large rock dilation due to violent rock failure. After reviewing the rockburst phenomenon, types of rockbursts, damage mechanisms, and rockburst support design principles and acceptability criteria, this paper describes that the support selection process in burst-prone ground is iterative, requiring design verification and modification based on field observations. An interactive design tool for conducting rockburst support design in underground tunnels is introduced to facilitate cost-effective design.展开更多
The ejection velocity of rock fragments during rock burst, one of the important indexes representing the rock burst strength, is used most conveniently in the supporting design of tunnel with rock burst tendency and i...The ejection velocity of rock fragments during rock burst, one of the important indexes representing the rock burst strength, is used most conveniently in the supporting design of tunnel with rock burst tendency and is often determined by means of observation devices. In order to calculate the average ejection velocity of rock fragments theoretically, the energy of rock burst was divided into damage consuming energy and kinetic energy gained by unit volume of rock firstly, and then the rock burst kinetic proportional coefficient η was brought up which could be determined according to the rock-burst damage energy index W_D , at last the expression of the average ejection velocity of rock fragments during rock burst was obtained and one deep level underground tunnel was researched using the mentioned method. The results show that the calculation method is valid with or without considering the tectonic stress of tunnels, and that the method can be a reference for supporting design of deep mining.展开更多
BACKGROUND: Viral replication in blood cells with nucleases may lead to the damage of lymphocytes genetic apparatus and the beginning of immunopathological reactions. AIM: Of this investigation is to reveal the damage...BACKGROUND: Viral replication in blood cells with nucleases may lead to the damage of lymphocytes genetic apparatus and the beginning of immunopathological reactions. AIM: Of this investigation is to reveal the damage to peripheral blood lymphocytes (PBL) DNA in the patients with chronic liver diseases. MATERIALS AND METHODS: Sixteen-nine patients with chronic liver diseases (37 patients with chronic viral hepatitis, 2 patients with liver cirrhosis of mixed etiology (alcohol+virus G), 30 women with primary biliary cirrhosis-PBC) were examined. The condition of DNA structure of PBL was measured by the fluorescence analysis of DNA unwinding (FADU) technique with modification. Changes of fluorescence (in %) reflected the DNA distractions degree (the presence of DNA single-stranded breaks and alkalinelabile sights). RESULTS AND CONCLUSION: The quantity of DNA single-stranded breaks and alkalinelabile sights in DNA in all patients with chronic viral hepatitis didn't differ from the control group, excluding the patients with chronic hepatitis (CH) C+G. Patients with HGV and TTV monoinfection had demonstrated the increase of the DNA single-stranded breaks PBL quantity. This fact may be connected with hypothesis about the viruses replication in white blood cells discussed in the literature. Tendency to increase quantity of DNA PBL damages in the patients with primary biliary cirrhosis (PBC) accordingly to the alkaline phosphatase activity increase was revealed. Significant decrease of the DNA single-stranded breaks and alkalinelabile sights in the PBC patients that were treated with prednisone was demonstrated. Probably, the tendency to increase the quantity of DNA single stranded breaks and alkalinelabile sights in lymphocytes of the PBC patients was depended on the surplus of the blood bile acid content.展开更多
A new method is proposed to assess the condition of structures under unknown support excitation by simultaneously detecting local damage and identifying the support excitation from several structural dynamic responses...A new method is proposed to assess the condition of structures under unknown support excitation by simultaneously detecting local damage and identifying the support excitation from several structural dynamic responses. The support excitation acting on a structure is modeled by orthogonal polynomial approximations, and the sensitivities of structural dynamic response with respect to its physical parameters and orthogonal coefficients are derived. The identification equation is based on Taylor＇s first order approximation, and is solved with the damped least-squares method in an iterative procedure. A fifteen-story shear building model and a five-story three-dimensional steel frame structure are studied to validate the proposed method. Numerical simulations with noisy measured accelerations show that the proposed method can accurately detect local damage and identify unknown support excitation from only several responses of the structure. This method provides a new approach for detecting structural damage and updating models with unknown input and incomplete measured output information.展开更多
文摘As mining and civil tunneling progresses to depth, excavation-induced seismicity and rockburst problems increase and cannot be prevented. As an important line of defense, ground control measures and burst-resistant rock support are used to prevent or minimize damage to excavations and thus to enhance workplace safety. Rock support in burst-prone ground differs from conventional rock support where controlling gravity-induced rockfalls and managing shallow zones of loose rock are the main target. Rock support in burst-prone ground needs to resist dynamic loads and large rock dilation due to violent rock failure. After reviewing the rockburst phenomenon, types of rockbursts, damage mechanisms, and rockburst support design principles and acceptability criteria, this paper describes that the support selection process in burst-prone ground is iterative, requiring design verification and modification based on field observations. An interactive design tool for conducting rockburst support design in underground tunnels is introduced to facilitate cost-effective design.
文摘The ejection velocity of rock fragments during rock burst, one of the important indexes representing the rock burst strength, is used most conveniently in the supporting design of tunnel with rock burst tendency and is often determined by means of observation devices. In order to calculate the average ejection velocity of rock fragments theoretically, the energy of rock burst was divided into damage consuming energy and kinetic energy gained by unit volume of rock firstly, and then the rock burst kinetic proportional coefficient η was brought up which could be determined according to the rock-burst damage energy index W_D , at last the expression of the average ejection velocity of rock fragments during rock burst was obtained and one deep level underground tunnel was researched using the mentioned method. The results show that the calculation method is valid with or without considering the tectonic stress of tunnels, and that the method can be a reference for supporting design of deep mining.
基金Grant source is the budget of the Central Research Institute of Gastroenterology that was supported by Department of Moscow Public Health.
文摘BACKGROUND: Viral replication in blood cells with nucleases may lead to the damage of lymphocytes genetic apparatus and the beginning of immunopathological reactions. AIM: Of this investigation is to reveal the damage to peripheral blood lymphocytes (PBL) DNA in the patients with chronic liver diseases. MATERIALS AND METHODS: Sixteen-nine patients with chronic liver diseases (37 patients with chronic viral hepatitis, 2 patients with liver cirrhosis of mixed etiology (alcohol+virus G), 30 women with primary biliary cirrhosis-PBC) were examined. The condition of DNA structure of PBL was measured by the fluorescence analysis of DNA unwinding (FADU) technique with modification. Changes of fluorescence (in %) reflected the DNA distractions degree (the presence of DNA single-stranded breaks and alkalinelabile sights). RESULTS AND CONCLUSION: The quantity of DNA single-stranded breaks and alkalinelabile sights in DNA in all patients with chronic viral hepatitis didn't differ from the control group, excluding the patients with chronic hepatitis (CH) C+G. Patients with HGV and TTV monoinfection had demonstrated the increase of the DNA single-stranded breaks PBL quantity. This fact may be connected with hypothesis about the viruses replication in white blood cells discussed in the literature. Tendency to increase quantity of DNA PBL damages in the patients with primary biliary cirrhosis (PBC) accordingly to the alkaline phosphatase activity increase was revealed. Significant decrease of the DNA single-stranded breaks and alkalinelabile sights in the PBC patients that were treated with prednisone was demonstrated. Probably, the tendency to increase the quantity of DNA single stranded breaks and alkalinelabile sights in lymphocytes of the PBC patients was depended on the surplus of the blood bile acid content.
基金National Natural Science Foundation of China Under Grant No.50579008Joint Research Fund for Overseas Chinese, Hong Kong and Macao Young Scholars Under Grant No.50429802+1 种基金Program for New Century Excellent Talents in University by State Education Commission Under Grant No.NCET-04-0323a research grant from the Hong Kong Polytechnic University
文摘A new method is proposed to assess the condition of structures under unknown support excitation by simultaneously detecting local damage and identifying the support excitation from several structural dynamic responses. The support excitation acting on a structure is modeled by orthogonal polynomial approximations, and the sensitivities of structural dynamic response with respect to its physical parameters and orthogonal coefficients are derived. The identification equation is based on Taylor＇s first order approximation, and is solved with the damped least-squares method in an iterative procedure. A fifteen-story shear building model and a five-story three-dimensional steel frame structure are studied to validate the proposed method. Numerical simulations with noisy measured accelerations show that the proposed method can accurately detect local damage and identify unknown support excitation from only several responses of the structure. This method provides a new approach for detecting structural damage and updating models with unknown input and incomplete measured output information.
