AIM: To evaluate the therapeutic effect of the combined use of early short-term somatostatin and conventional integrated Chinese and Western medicine in treating severe acute pancreatitis. METHODS: Sixty patients with...AIM: To evaluate the therapeutic effect of the combined use of early short-term somatostatin and conventional integrated Chinese and Western medicine in treating severe acute pancreatitis. METHODS: Sixty patients with severe acute pancreatitis were divided at random into a somatostatin group and a basic treatment group. Both groups received integrated traditional Chinese and Western medicine without surgery. For patients in the somatostatin group, somatostatin was infused intravenously 250 μg/h for 72 h; other medications were the same as in the basic treatment group. In both groups, comparisons of therapeutic effectiveness were made in terms of morbidity of organic dysfunction and mortality rate, and severity of the disease according to serum levels of C-reaction protein, scores of acute physiology and chronic health evaluation (APACHE Ⅱ), and scores of Balthazar-CT. RESULTS: The indexes for C-reaction protein levels on the fourth and seventh clays, and APACHE II scores on the seventh day after treatment, were significantly improved in the somatostatin group than in the basic treatment group. The morbidity of organic dysfunction was lower in the somatostatin group than in the basic treatment group, although the difference was not statistically significant. There was no significant difference in mortality between the two groups. CONCLUSION: We conclude that combined traditional Chinese and Western medicines with an early short-term use of somatostatin can improve the condition of patients with severe acute pancreatitis.展开更多
Postprandial glucose responses provide vital information on an individual’s risk of major diet-related chronic diseases.This study features digital health technology,namely Continuous Glucose Monitoring(CGM)sensors,a...Postprandial glucose responses provide vital information on an individual’s risk of major diet-related chronic diseases.This study features digital health technology,namely Continuous Glucose Monitoring(CGM)sensors,along with mobile devices(iPhones running an app)used to collect data from individuals and their environment,specifically nutritional informa-tion on what they eat and drink.The paper presents a retrospective analysis of data collected during an investigation into the use of a functional drink taken as a supplement with a standardized meal to reduce postprandial responses to that meal.Given that there are consequential differences between individuals in their postprandial glucose responses,these real-world data are analyzed at the level of the individual.The aim of the study was to assess the feasibility of collecting real-world data on supplements and postprandial glucose responses outside of a controlled laboratory environment,synthesizing the data from the different sources,and producing individualized results.Of the 40 individuals invited to conduct 6 tests,3 with and 3 without the supplement,19 provided from 1 to 6 valid tests,producing 0 to 6 comparisons each.Four individuals contributed at least 5 comparisons each,the minimum number required for the exact 1-sided Wilcoxon signed-rank test.The conclusion is that a real-world study of supplements and postprandial glucose responses is feasible,with an increase in the number of tests requested of each individual,a simplification of the testing protocol,and steps taken to reduce the number of invalid tests.展开更多
基金Supported by the Foundation of Sichuan Provincial Administration of Traditional Chinese Medicine, No.200213
文摘AIM: To evaluate the therapeutic effect of the combined use of early short-term somatostatin and conventional integrated Chinese and Western medicine in treating severe acute pancreatitis. METHODS: Sixty patients with severe acute pancreatitis were divided at random into a somatostatin group and a basic treatment group. Both groups received integrated traditional Chinese and Western medicine without surgery. For patients in the somatostatin group, somatostatin was infused intravenously 250 μg/h for 72 h; other medications were the same as in the basic treatment group. In both groups, comparisons of therapeutic effectiveness were made in terms of morbidity of organic dysfunction and mortality rate, and severity of the disease according to serum levels of C-reaction protein, scores of acute physiology and chronic health evaluation (APACHE Ⅱ), and scores of Balthazar-CT. RESULTS: The indexes for C-reaction protein levels on the fourth and seventh clays, and APACHE II scores on the seventh day after treatment, were significantly improved in the somatostatin group than in the basic treatment group. The morbidity of organic dysfunction was lower in the somatostatin group than in the basic treatment group, although the difference was not statistically significant. There was no significant difference in mortality between the two groups. CONCLUSION: We conclude that combined traditional Chinese and Western medicines with an early short-term use of somatostatin can improve the condition of patients with severe acute pancreatitis.
文摘Postprandial glucose responses provide vital information on an individual’s risk of major diet-related chronic diseases.This study features digital health technology,namely Continuous Glucose Monitoring(CGM)sensors,along with mobile devices(iPhones running an app)used to collect data from individuals and their environment,specifically nutritional informa-tion on what they eat and drink.The paper presents a retrospective analysis of data collected during an investigation into the use of a functional drink taken as a supplement with a standardized meal to reduce postprandial responses to that meal.Given that there are consequential differences between individuals in their postprandial glucose responses,these real-world data are analyzed at the level of the individual.The aim of the study was to assess the feasibility of collecting real-world data on supplements and postprandial glucose responses outside of a controlled laboratory environment,synthesizing the data from the different sources,and producing individualized results.Of the 40 individuals invited to conduct 6 tests,3 with and 3 without the supplement,19 provided from 1 to 6 valid tests,producing 0 to 6 comparisons each.Four individuals contributed at least 5 comparisons each,the minimum number required for the exact 1-sided Wilcoxon signed-rank test.The conclusion is that a real-world study of supplements and postprandial glucose responses is feasible,with an increase in the number of tests requested of each individual,a simplification of the testing protocol,and steps taken to reduce the number of invalid tests.
