AIM： To determine whether any changes have occurred on the patterns of colorectal cancer in China. METHODS： Data from 21 Chinese articles published from 1980 to 1999, were used to analyze the time trend of colorecta...AIM： To determine whether any changes have occurred on the patterns of colorectal cancer in China. METHODS： Data from 21 Chinese articles published from 1980 to 1999, were used to analyze the time trend of colorectal cancer according to the patients＇age at diagnosis, sex, the site of the tumor, stage, and the pathology. RESULTS： From 1980s to 1990s, the mean age of the colorectal cancer patients has increased. The percentage of the female patients rose. The distribution of colorectal carcinoma shows a predominance of rectal cancer. However, the proportion of proximal colon cancer （induding transverse and ascending colon） increased significantly accompanied by a decline in the percentage of rectal cancer. Similarity in the percentage of distal colon cancer between two decades was revealed. In the 1990s, statistically more Stage B patients were found than those in 1980s. In addition, databases show a significant decrease in the Stage D cases. The proportion of adenocarcinoma increased, but the mucinous adenocarcinoma decreased during two decades. CONCLUSION： These findings indicate that the pattern of colorectal cancer in China has been changing. Especially, a proximal shift due to the increasing proportion of ascending and transverse colon cancer has occurred in China.展开更多
Introduction:Colorectal cancer(CRC) is the third most common cancer in China.The incidence of CRC has been increasing in recent years.The aim of this study was to explore the incidence trends and the age distribution ...Introduction:Colorectal cancer(CRC) is the third most common cancer in China.The incidence of CRC has been increasing in recent years.The aim of this study was to explore the incidence trends and the age distribution of CRC by subsite in Guangzhou between 2000 and 2011.Methods:A total of 22,432 incident cases of CRC between 2000 and 2011 from Guangzhou Cancer Registry were identified.Crude incidence and age-standardized rates(ASRs),using the Segi’s world standard population,were calculated for CRC and CRC subsites.The incidence trend was analyzed and the annual percentage change(APC) in incidence was calculated by using JoinPoint software.Results:The crude incidence increased significantly from 23.4/10~5 in 2000 to 37.4/10~5 in 2011 for males and from20.9/10~5 to 30.5/10~5 for females.The ASRs of CRC incidence stabilized during the period of 2000-2011 for both males and females.The ages at the onset of CRC for both males and females during 2010-2011 were significantly higher compared with those during 2000-2002(males:f = 1.95,P = 0.05;females:f = 6.03,P < 0.01).For males aged50-64 years,the CRC incidence increased by 8.50%annually(P = 0.04) during 2000-2004 and by 1.68%annually(P = 0.03) during 2005-2011.For females aged 65 years and older,the CRC incidence increased by 5.77%annually(P = 0.03) during 2000-2004.There were no significant changes for the CRC incidences in males aged 49 and younger and 65 years and older and females aged 64 years and younger during 2000-2004,or for those in all females as well as males aged 49 years and younger and 65 years and older during 2005-2011.The percentage of colon cancer in all CRCs increased significantly for both males and females between the periods of 2000-2002 and 2010-2011.The ASRs of descending colon and sigmoid colon cancer incidences increased significantly for females during 2005-2011(APC,5.51%and 1.08%,respectively,both P < 0.05).Conclusions:The crude incidence of CRC increased significantly between 2000 and 2011 because of the aging,whereas the ASRs kept stabl展开更多
It is well known that the severe epidemic respiratory disease COVID-19 was caused by the novel coronavirus SARS-CoV-2.Lianhua Qingwen Formula(LQF);as a traditional Chinese medicine(TCM)formula,exerts anti-coronavirus ...It is well known that the severe epidemic respiratory disease COVID-19 was caused by the novel coronavirus SARS-CoV-2.Lianhua Qingwen Formula(LQF);as a traditional Chinese medicine(TCM)formula,exerts anti-coronavirus activity by suppressing viral replication and activating anti-inflammatory effects.In this work,the unknown molecular inhibition mechanism of LQF ingredients on the main protease(Mpro)of SARS-CoV-2 was investigated.From the screening of pharmacophore model,docking,molecular dynamics(MD)simulations and molecular mechanics Poisson-Boltzmann surface area(MM/PBSA)calculations,it is found that Isoliquiritin apioside,Liquiritin apioside,Forsythoside E,Rutin,and Isoliquiritin possess much larger binding free energies than reference X77.These five hit molecules are characterized by multi-hydroxyl groups,which facilitate the formation of hydrogen bonds with polar amino acid residues at S1'subsite and rationalize their primary binding to Mpro with electrostatic rather than usual van der Waals(vdW)interaction.In addition,the Isoliquiritin apioside,Liquiritin apioside,and Rutin were also identified as potential inhibitors on SARS-CoV Mpro,possessing much larger binding free energies with large electrostatic interaction than that of reference ENB.The present study can not only enrich the scaffolds of Mpro of SARS-CoV family inhibitors,but also provide an idea for the new drug development.展开更多
文摘AIM： To determine whether any changes have occurred on the patterns of colorectal cancer in China. METHODS： Data from 21 Chinese articles published from 1980 to 1999, were used to analyze the time trend of colorectal cancer according to the patients＇age at diagnosis, sex, the site of the tumor, stage, and the pathology. RESULTS： From 1980s to 1990s, the mean age of the colorectal cancer patients has increased. The percentage of the female patients rose. The distribution of colorectal carcinoma shows a predominance of rectal cancer. However, the proportion of proximal colon cancer （induding transverse and ascending colon） increased significantly accompanied by a decline in the percentage of rectal cancer. Similarity in the percentage of distal colon cancer between two decades was revealed. In the 1990s, statistically more Stage B patients were found than those in 1980s. In addition, databases show a significant decrease in the Stage D cases. The proportion of adenocarcinoma increased, but the mucinous adenocarcinoma decreased during two decades. CONCLUSION： These findings indicate that the pattern of colorectal cancer in China has been changing. Especially, a proximal shift due to the increasing proportion of ascending and transverse colon cancer has occurred in China.
文摘Introduction:Colorectal cancer(CRC) is the third most common cancer in China.The incidence of CRC has been increasing in recent years.The aim of this study was to explore the incidence trends and the age distribution of CRC by subsite in Guangzhou between 2000 and 2011.Methods:A total of 22,432 incident cases of CRC between 2000 and 2011 from Guangzhou Cancer Registry were identified.Crude incidence and age-standardized rates(ASRs),using the Segi’s world standard population,were calculated for CRC and CRC subsites.The incidence trend was analyzed and the annual percentage change(APC) in incidence was calculated by using JoinPoint software.Results:The crude incidence increased significantly from 23.4/10~5 in 2000 to 37.4/10~5 in 2011 for males and from20.9/10~5 to 30.5/10~5 for females.The ASRs of CRC incidence stabilized during the period of 2000-2011 for both males and females.The ages at the onset of CRC for both males and females during 2010-2011 were significantly higher compared with those during 2000-2002(males:f = 1.95,P = 0.05;females:f = 6.03,P < 0.01).For males aged50-64 years,the CRC incidence increased by 8.50%annually(P = 0.04) during 2000-2004 and by 1.68%annually(P = 0.03) during 2005-2011.For females aged 65 years and older,the CRC incidence increased by 5.77%annually(P = 0.03) during 2000-2004.There were no significant changes for the CRC incidences in males aged 49 and younger and 65 years and older and females aged 64 years and younger during 2000-2004,or for those in all females as well as males aged 49 years and younger and 65 years and older during 2005-2011.The percentage of colon cancer in all CRCs increased significantly for both males and females between the periods of 2000-2002 and 2010-2011.The ASRs of descending colon and sigmoid colon cancer incidences increased significantly for females during 2005-2011(APC,5.51%and 1.08%,respectively,both P < 0.05).Conclusions:The crude incidence of CRC increased significantly between 2000 and 2011 because of the aging,whereas the ASRs kept stabl
基金supported by the National Key R&D Program of China(No.2023YFC2604404)the Science and Technology Plan Project of Shantou City,China(No.2020-7)the 2020 Li Ka Shing Foundation Cross-Disciplinary Research Grant(No.2020LKSFG07B).
文摘It is well known that the severe epidemic respiratory disease COVID-19 was caused by the novel coronavirus SARS-CoV-2.Lianhua Qingwen Formula(LQF);as a traditional Chinese medicine(TCM)formula,exerts anti-coronavirus activity by suppressing viral replication and activating anti-inflammatory effects.In this work,the unknown molecular inhibition mechanism of LQF ingredients on the main protease(Mpro)of SARS-CoV-2 was investigated.From the screening of pharmacophore model,docking,molecular dynamics(MD)simulations and molecular mechanics Poisson-Boltzmann surface area(MM/PBSA)calculations,it is found that Isoliquiritin apioside,Liquiritin apioside,Forsythoside E,Rutin,and Isoliquiritin possess much larger binding free energies than reference X77.These five hit molecules are characterized by multi-hydroxyl groups,which facilitate the formation of hydrogen bonds with polar amino acid residues at S1'subsite and rationalize their primary binding to Mpro with electrostatic rather than usual van der Waals(vdW)interaction.In addition,the Isoliquiritin apioside,Liquiritin apioside,and Rutin were also identified as potential inhibitors on SARS-CoV Mpro,possessing much larger binding free energies with large electrostatic interaction than that of reference ENB.The present study can not only enrich the scaffolds of Mpro of SARS-CoV family inhibitors,but also provide an idea for the new drug development.
