热休克蛋白70(heat shock protein 70,Hsp70)是一种在应激条件下诱导表达的伴侣蛋白,能帮助细胞内新生蛋白折叠,蛋白细胞内运输、蛋白装配和降解,并能在应激状态下维持蛋白质构象。研究表明,Hsp70与许多疾病有关,如癌症、神经退行性疾...热休克蛋白70(heat shock protein 70,Hsp70)是一种在应激条件下诱导表达的伴侣蛋白,能帮助细胞内新生蛋白折叠,蛋白细胞内运输、蛋白装配和降解,并能在应激状态下维持蛋白质构象。研究表明,Hsp70与许多疾病有关,如癌症、神经退行性疾病、异源移植的排斥、感染等,有望成为新的药物作用靶点。本文综述了Hsp70的结构、家族成员、协同伴侣(co-chaperones)成员及其功能研究进展,并介绍Hsp70抑制剂的研究现况。展开更多
Pore distribution and micro pore-throat structure characteristics are significant for tight oil reservoir evaluation, but their relationship remains unclear. This paper selects the tight sandstone reservoir of the Cha...Pore distribution and micro pore-throat structure characteristics are significant for tight oil reservoir evaluation, but their relationship remains unclear. This paper selects the tight sandstone reservoir of the Chang 7 member of the Xin’anbian Block in the Ordos Basin as the research object and analyzes the pore size distribution and micro pore-throat structure using field emission scanning electron microscopy(FE-SEM), high-pressure mercury injection(HPMI), highpressure mercury injection, and nuclear magnetic resonance(NMR) analyses. The study finds that:(1) Based on the pore size distribution, the tight sandstone reservoir is characterized by three main patterns with different peak amplitudes. The former peak corresponds to the nanopore scale, and the latter peak corresponds to the micropore scale. Then, the tight sandstone reservoir is categorized into three types: type 1 reservoir contains more nanopores with a nanopore-to-micropore volume ratio of 82:18;type 2 reservoir has a nanopore-to-micropore volume ratio of 47:53;and type 3 reservoir contains more micropores with a nanopore-to-micropore volume ratio of 35:65.(2) Affected by the pore size distribution, the throat radius distributions of different reservoir types are notably offset. The type 1 reservoir throat radius distribution curve is weakly unimodal, with a relatively dispersed distribution and peak ranging from 0.01 μm to 0.025 μm. The type 2 reservoir’s throat radius distribution curve is single-peaked with a wide distribution range and peak from 0.1 μm to 0.25 μm. The type 3 reservoir’s throat radius distribution curve is single-peaked with a relatively narrow distribution and peak from 0.1 μm to 0.25 μm. With increasing micropore volume, pore-throat structure characteristics gradually improve.(3) The correlation between micropore permeability and porosity exceeds that of nanopores, indicating that the development of micropores notably influences the seepage capacity. In the type 1 reservoir, only the mean radius and effective poros展开更多
文摘热休克蛋白70(heat shock protein 70,Hsp70)是一种在应激条件下诱导表达的伴侣蛋白,能帮助细胞内新生蛋白折叠,蛋白细胞内运输、蛋白装配和降解,并能在应激状态下维持蛋白质构象。研究表明,Hsp70与许多疾病有关,如癌症、神经退行性疾病、异源移植的排斥、感染等,有望成为新的药物作用靶点。本文综述了Hsp70的结构、家族成员、协同伴侣(co-chaperones)成员及其功能研究进展,并介绍Hsp70抑制剂的研究现况。
基金the National Natural Science Foundation of China(Grant No.41625009)the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA14010404)The authors also extend their thanks to the editors and reviewers for their positive and constructive comments and suggestions.
文摘Pore distribution and micro pore-throat structure characteristics are significant for tight oil reservoir evaluation, but their relationship remains unclear. This paper selects the tight sandstone reservoir of the Chang 7 member of the Xin’anbian Block in the Ordos Basin as the research object and analyzes the pore size distribution and micro pore-throat structure using field emission scanning electron microscopy(FE-SEM), high-pressure mercury injection(HPMI), highpressure mercury injection, and nuclear magnetic resonance(NMR) analyses. The study finds that:(1) Based on the pore size distribution, the tight sandstone reservoir is characterized by three main patterns with different peak amplitudes. The former peak corresponds to the nanopore scale, and the latter peak corresponds to the micropore scale. Then, the tight sandstone reservoir is categorized into three types: type 1 reservoir contains more nanopores with a nanopore-to-micropore volume ratio of 82:18;type 2 reservoir has a nanopore-to-micropore volume ratio of 47:53;and type 3 reservoir contains more micropores with a nanopore-to-micropore volume ratio of 35:65.(2) Affected by the pore size distribution, the throat radius distributions of different reservoir types are notably offset. The type 1 reservoir throat radius distribution curve is weakly unimodal, with a relatively dispersed distribution and peak ranging from 0.01 μm to 0.025 μm. The type 2 reservoir’s throat radius distribution curve is single-peaked with a wide distribution range and peak from 0.1 μm to 0.25 μm. The type 3 reservoir’s throat radius distribution curve is single-peaked with a relatively narrow distribution and peak from 0.1 μm to 0.25 μm. With increasing micropore volume, pore-throat structure characteristics gradually improve.(3) The correlation between micropore permeability and porosity exceeds that of nanopores, indicating that the development of micropores notably influences the seepage capacity. In the type 1 reservoir, only the mean radius and effective poros
