Deep geothermal resources mainly refer to the thermal energy stored in subsurface rocks and fluids therein at a depth of 3-10 km,which is a kind of renewable and sustainable clean energy unaffected by weather and seas...Deep geothermal resources mainly refer to the thermal energy stored in subsurface rocks and fluids therein at a depth of 3-10 km,which is a kind of renewable and sustainable clean energy unaffected by weather and seasonal changes.Large scale exploitation of the deep geothermal resources is of great significance to ensuring national energy security and achieving the“Carbon Peak and Carbon Neutrality”.Based on the latest terrestrial heat flow data,this paper estimated the potential of deep geothermal resources in the terrestrial areas of China,and the results show that the total amount of geothermal resources within 3e10 km under the Earth's surface in the terrestrial areas of China is 24.6×10^(15)GJ.In line with climate zones categorized,the geothermal resource proportion is 43.81%for severe cold regions,29.19%for cold regions,6.92%for mild regions,13.82%for hot summer and cold winter regions,and 6.26%for hot summer and warm winter regions.Statistics according to the burial depth range reveal that the resources within depth ranges of 3-5 km,5-7 km and 7-10 km under the Earth's surface are 4.3119×10^(15)GJ,6.37674×10^(15)GJ and 13.89594×10^(15)GJ respectively,showing an increasing trend of geothermal potential with increasing burial depth.The deep geothermal resources are mainly of medium-to-high temperature reserves,and the energy supply strategy can be optimized by combining the climate conditions and population distribution,as well as considering power generation.In regions of cold or severe cold climate,the geothermal resources may be applied to geothermal power generation and district heating in combination;in regions of hot summer and cold winter or mild climates,the resources can be used for geothermal power generation combined with cooling and heating;in regions of hot summer and warm winter climates,the resources may be applied to geothermal power generation combined with cooling and industrial and agricultural utilization.Exploitation of deep geothermal resources also can be combined with carbon d展开更多
Advances in novel drugs,therapies,and genetic techniques have revolutionized the diagnosis and treatment of cancers,substantially improving cancer patients’prognosis.Although rare tumors account for a non-negligible ...Advances in novel drugs,therapies,and genetic techniques have revolutionized the diagnosis and treatment of cancers,substantially improving cancer patients’prognosis.Although rare tumors account for a non-negligible number,the practice of precision medicine and development of novel therapies are largely hampered by many obstacles.Their low incidence and drastic regional disparities result in the difficulty of informative evidence-based diagnosis and subtyping.Sample exhaustion due to difficulty in diagnosis also leads to a lack of recommended therapeutic strategies in clinical guidelines,insufficient biomarkers for prognosis/efficacy,and inability to identify potential novel therapies in clinical trials.Herein,by reviewing the epidemiological data of Chinese solid tumors and publications defining rare tumors in other areas,we proposed a definition of rare tumor in China,including 515 tumor types with incidences of less than 2.5/100000 per year.We also summarized the current diagnosis process,treatment recommendations,and global developmental progress of targeted drugs and immunotherapy agents on the status quo.Lastly,we pinpointed the current recommendation chance for patients with rare tumors to be involved in a clinical trial by NCCN.With this informative report,we aimed to raise awareness on the importance of rare tumor investigations and guarantee a bright future for rare tumor patients.展开更多
推荐系统将符合用户兴趣分布的项目推荐给用户.目前对推荐系统的研究大多集中于对个体用户进行推荐.然而在实际生活中,很多活动是由多个用户共同参与的.因此,组推荐系统逐渐成为研究的热点.本文提出一种基于用户签到行为的群组兴趣点推...推荐系统将符合用户兴趣分布的项目推荐给用户.目前对推荐系统的研究大多集中于对个体用户进行推荐.然而在实际生活中,很多活动是由多个用户共同参与的.因此,组推荐系统逐渐成为研究的热点.本文提出一种基于用户签到行为的群组兴趣点推荐模型(Group POI recommendation model based on the User Check-in behavior,GPUC),该模型首先采用协同过滤的推荐算法挖掘组内成员可能感兴趣的项目,并基于TF-IDF(term frequency-inverse document frequency)的思想预测用户对项目的评分,生成个人推荐列表.在融合组内成员兴趣偏好时,提出一种加权混合融合策略,兼顾考虑不同组员在群组中的权重以及群组偏好差异度的大小.本文采用Gowalla网站的真实数据集验证了推荐模型的准确性,与算法HAaB相比,基于用户签到行为的群组兴趣点推荐模型GPUC的准确率提高了4. 03%,为群组用户提供了更有效的推荐.展开更多
基金supported by the Joint Petrochemical Fund project of National Natural Science Foundation of China”Deep Geological Processes and Resource Effects in the Basin”(Fund No.U20B6001).
文摘Deep geothermal resources mainly refer to the thermal energy stored in subsurface rocks and fluids therein at a depth of 3-10 km,which is a kind of renewable and sustainable clean energy unaffected by weather and seasonal changes.Large scale exploitation of the deep geothermal resources is of great significance to ensuring national energy security and achieving the“Carbon Peak and Carbon Neutrality”.Based on the latest terrestrial heat flow data,this paper estimated the potential of deep geothermal resources in the terrestrial areas of China,and the results show that the total amount of geothermal resources within 3e10 km under the Earth's surface in the terrestrial areas of China is 24.6×10^(15)GJ.In line with climate zones categorized,the geothermal resource proportion is 43.81%for severe cold regions,29.19%for cold regions,6.92%for mild regions,13.82%for hot summer and cold winter regions,and 6.26%for hot summer and warm winter regions.Statistics according to the burial depth range reveal that the resources within depth ranges of 3-5 km,5-7 km and 7-10 km under the Earth's surface are 4.3119×10^(15)GJ,6.37674×10^(15)GJ and 13.89594×10^(15)GJ respectively,showing an increasing trend of geothermal potential with increasing burial depth.The deep geothermal resources are mainly of medium-to-high temperature reserves,and the energy supply strategy can be optimized by combining the climate conditions and population distribution,as well as considering power generation.In regions of cold or severe cold climate,the geothermal resources may be applied to geothermal power generation and district heating in combination;in regions of hot summer and cold winter or mild climates,the resources can be used for geothermal power generation combined with cooling and heating;in regions of hot summer and warm winter climates,the resources may be applied to geothermal power generation combined with cooling and industrial and agricultural utilization.Exploitation of deep geothermal resources also can be combined with carbon d
基金supported by the Chinese Academy of Medical Sciences(No.2019XK320068)Chinese Academy of Medical Sciences(No.2020-I2M-2-007)+3 种基金Chinese Academy of Medical SciencesInnovation Fund for Medical Sciences(Construction and Application of Clinical Trial and Institution Evaluation System 2021-I2M-1-045)Beijing Municipal Commission of HealthBeijing Demonstration Research Ward BCRW20200303.
文摘Advances in novel drugs,therapies,and genetic techniques have revolutionized the diagnosis and treatment of cancers,substantially improving cancer patients’prognosis.Although rare tumors account for a non-negligible number,the practice of precision medicine and development of novel therapies are largely hampered by many obstacles.Their low incidence and drastic regional disparities result in the difficulty of informative evidence-based diagnosis and subtyping.Sample exhaustion due to difficulty in diagnosis also leads to a lack of recommended therapeutic strategies in clinical guidelines,insufficient biomarkers for prognosis/efficacy,and inability to identify potential novel therapies in clinical trials.Herein,by reviewing the epidemiological data of Chinese solid tumors and publications defining rare tumors in other areas,we proposed a definition of rare tumor in China,including 515 tumor types with incidences of less than 2.5/100000 per year.We also summarized the current diagnosis process,treatment recommendations,and global developmental progress of targeted drugs and immunotherapy agents on the status quo.Lastly,we pinpointed the current recommendation chance for patients with rare tumors to be involved in a clinical trial by NCCN.With this informative report,we aimed to raise awareness on the importance of rare tumor investigations and guarantee a bright future for rare tumor patients.
文摘推荐系统将符合用户兴趣分布的项目推荐给用户.目前对推荐系统的研究大多集中于对个体用户进行推荐.然而在实际生活中,很多活动是由多个用户共同参与的.因此,组推荐系统逐渐成为研究的热点.本文提出一种基于用户签到行为的群组兴趣点推荐模型(Group POI recommendation model based on the User Check-in behavior,GPUC),该模型首先采用协同过滤的推荐算法挖掘组内成员可能感兴趣的项目,并基于TF-IDF(term frequency-inverse document frequency)的思想预测用户对项目的评分,生成个人推荐列表.在融合组内成员兴趣偏好时,提出一种加权混合融合策略,兼顾考虑不同组员在群组中的权重以及群组偏好差异度的大小.本文采用Gowalla网站的真实数据集验证了推荐模型的准确性,与算法HAaB相比,基于用户签到行为的群组兴趣点推荐模型GPUC的准确率提高了4. 03%,为群组用户提供了更有效的推荐.
