AIM Study on the effects of Fuzheng Huoxue anticancer prescription (Traditional Chinese Medicine) in treating gastric cancer. METHODS Sixty nine patients with gastric cancer of mid or late stage were confirmed his...AIM Study on the effects of Fuzheng Huoxue anticancer prescription (Traditional Chinese Medicine) in treating gastric cancer. METHODS Sixty nine patients with gastric cancer of mid or late stage were confirmed histologically. They were divided into two groups. The treatment group included 35 cases (26 males and 9 females, 2 cases aged from 33～40 years, 18 from 41～60, 15 from 61～75, mean 58 4 years). The control group included 23 males and 11 females, 4 aged 33～40 years, 16 41～60, 14 61～75, averaging 56 8 years. The two groups were not significantly different in sex, age, clinical and pathological stages, operation mode, etc. The two group were given similar treatment. The treatment group was given Fuzheng Huoxue anticancer prescription. The cell line SGC 7901 was inoculated to the back of 30 nude mice under sterile condition. The nude mice were allocated randomly into control, traditional Chinese medicine and chemotherapeutic groups with 10 mice in each group with similar weight. Each nude mouse in control group received 0 5ml saline/day. The Fuzheng Huoxue anticancer prescreption was given to the traditional Chinese medicine group, 0 5ml/day (containing 1 5g crude drug) chamotherapentic group was injected with 1mg 5 Fu intraperitoneally once a week for 8 weeks. RESULTS Before treatment, OKT8 was 45 94±8 45%, OKT4/OKT8 was 0 89±0 19, AT Ⅲ was 29 9mg/dl±7 9mg/dl, Fa was 50 4%±24 4%, β TG was 91 0ng/dl±25 9ng/dl in treatment group; OKT8 was 49 21%±6 60%, OKT4/OKT8 was 0 94±0 20, AT Ⅲ was 32 3mg/dl±7 2mg/dl, Fa was 57 3%±24 6%, β TG was 87 5ng/dl±34 2ng/dl in controls before treatment. After treatment, OKT8 was 33 52%±7 80%, OKT4/OKT8 was 1 47±0 51, AT Ⅲ was 38 8mg/dl±5 5mg/dl, Fa was 102 6%±31 6%, β TG was 62 3ng/dl±15 1ng/dl in treatment group and OKT8 was 42 22%±7 07%, OKT4/OKT8 was 1 12±0 24, AT Ⅲ was 30 9mg/dl±8 0mg/dl, Fa was 64 6%±26 9%, β TG was 67 0ng/dl±42 1ng/dl in controls. After treatment, the T lymp展开更多
IMS To observe the therapeutic effect of Weixibaonizhuan pills on gastric precancerous lesions.METHODS Thirty patients with gastric precancerous lesions were treated with Weixibaonizhuan pills for 3 months. Of the 3...IMS To observe the therapeutic effect of Weixibaonizhuan pills on gastric precancerous lesions.METHODS Thirty patients with gastric precancerous lesions were treated with Weixibaonizhuan pills for 3 months. Of the 36 cases, 13 (361%) were mild atrophic gastritis, 14 (389%) moderate atrophic gastritis and 9 (250%) severe atrophic gastritis; among them 22 (611%) and 27 cases (750%) were accompanied with intestinal metaplasia (IM) and dysplasia (DYS) respectively. Of the 36 patients, 20 were men and 16 women, aged from 30-60 years and those aged 30-59 years accounted for 611%. The course of disease ranged from 3 months to 21 years, and 20 (556%) of them had a course of 5-10 years. The clinical manifestations were fullness of the abdomen (31 cases), abdominalgia (27 cases), anorexia (30 cases), gas eructation (26 cases), acid regurgitation (6 cases) and loose stool (9 cases). When treatment ended, the improvement of patients′ clinical symptoms, atrophy of gastric mucosa, IM and DYS were analysed.RESULTS After 3 months′ treatment with Weixibaonizhuan pills, 7 cases recovered, 11 cases were much improved, 13 cases showed some improvement, and 5 cases were ineffective; the total rate of symptomatic improvement was 861%. Of the 13 cases with mild atrophic gastritis, 11 cases changed into superficial gastritis, and 2 cases had no changes. Of the 14 cases of moderate atrophic gastritis, 4 cases changed into superficial gastritis, 7 cases changed into mild atrophic gastritis, and 3 cases had no changes. Five of 9 cases of severe atrophic gastritis were reduced to moderate atrophic gastritis, and 4 cases had no changes. The total effective rate was 778% in chronic atrophic gastritis. Of the 9 cases with mild IM, IM disappeared in 6 cases and 3 showed no change. Of the 10 cases with moderate IM, it disappeared in 2 cases, 5 cases changed to mild IM, and 3 cases had no change. One of the 4 cases of severe IM changed to moderate IM and 3 had no change. The total effective rate was 636% in IM. Of the 16 cases of mild DYS,展开更多
文摘AIM Study on the effects of Fuzheng Huoxue anticancer prescription (Traditional Chinese Medicine) in treating gastric cancer. METHODS Sixty nine patients with gastric cancer of mid or late stage were confirmed histologically. They were divided into two groups. The treatment group included 35 cases (26 males and 9 females, 2 cases aged from 33～40 years, 18 from 41～60, 15 from 61～75, mean 58 4 years). The control group included 23 males and 11 females, 4 aged 33～40 years, 16 41～60, 14 61～75, averaging 56 8 years. The two groups were not significantly different in sex, age, clinical and pathological stages, operation mode, etc. The two group were given similar treatment. The treatment group was given Fuzheng Huoxue anticancer prescription. The cell line SGC 7901 was inoculated to the back of 30 nude mice under sterile condition. The nude mice were allocated randomly into control, traditional Chinese medicine and chemotherapeutic groups with 10 mice in each group with similar weight. Each nude mouse in control group received 0 5ml saline/day. The Fuzheng Huoxue anticancer prescreption was given to the traditional Chinese medicine group, 0 5ml/day (containing 1 5g crude drug) chamotherapentic group was injected with 1mg 5 Fu intraperitoneally once a week for 8 weeks. RESULTS Before treatment, OKT8 was 45 94±8 45%, OKT4/OKT8 was 0 89±0 19, AT Ⅲ was 29 9mg/dl±7 9mg/dl, Fa was 50 4%±24 4%, β TG was 91 0ng/dl±25 9ng/dl in treatment group; OKT8 was 49 21%±6 60%, OKT4/OKT8 was 0 94±0 20, AT Ⅲ was 32 3mg/dl±7 2mg/dl, Fa was 57 3%±24 6%, β TG was 87 5ng/dl±34 2ng/dl in controls before treatment. After treatment, OKT8 was 33 52%±7 80%, OKT4/OKT8 was 1 47±0 51, AT Ⅲ was 38 8mg/dl±5 5mg/dl, Fa was 102 6%±31 6%, β TG was 62 3ng/dl±15 1ng/dl in treatment group and OKT8 was 42 22%±7 07%, OKT4/OKT8 was 1 12±0 24, AT Ⅲ was 30 9mg/dl±8 0mg/dl, Fa was 64 6%±26 9%, β TG was 67 0ng/dl±42 1ng/dl in controls. After treatment, the T lymp
文摘IMS To observe the therapeutic effect of Weixibaonizhuan pills on gastric precancerous lesions.METHODS Thirty patients with gastric precancerous lesions were treated with Weixibaonizhuan pills for 3 months. Of the 36 cases, 13 (361%) were mild atrophic gastritis, 14 (389%) moderate atrophic gastritis and 9 (250%) severe atrophic gastritis; among them 22 (611%) and 27 cases (750%) were accompanied with intestinal metaplasia (IM) and dysplasia (DYS) respectively. Of the 36 patients, 20 were men and 16 women, aged from 30-60 years and those aged 30-59 years accounted for 611%. The course of disease ranged from 3 months to 21 years, and 20 (556%) of them had a course of 5-10 years. The clinical manifestations were fullness of the abdomen (31 cases), abdominalgia (27 cases), anorexia (30 cases), gas eructation (26 cases), acid regurgitation (6 cases) and loose stool (9 cases). When treatment ended, the improvement of patients′ clinical symptoms, atrophy of gastric mucosa, IM and DYS were analysed.RESULTS After 3 months′ treatment with Weixibaonizhuan pills, 7 cases recovered, 11 cases were much improved, 13 cases showed some improvement, and 5 cases were ineffective; the total rate of symptomatic improvement was 861%. Of the 13 cases with mild atrophic gastritis, 11 cases changed into superficial gastritis, and 2 cases had no changes. Of the 14 cases of moderate atrophic gastritis, 4 cases changed into superficial gastritis, 7 cases changed into mild atrophic gastritis, and 3 cases had no changes. Five of 9 cases of severe atrophic gastritis were reduced to moderate atrophic gastritis, and 4 cases had no changes. The total effective rate was 778% in chronic atrophic gastritis. Of the 9 cases with mild IM, IM disappeared in 6 cases and 3 showed no change. Of the 10 cases with moderate IM, it disappeared in 2 cases, 5 cases changed to mild IM, and 3 cases had no change. One of the 4 cases of severe IM changed to moderate IM and 3 had no change. The total effective rate was 636% in IM. Of the 16 cases of mild DYS,
